Presentation/Session Information

Session Information

Session Title: Physiology: Aging and Stress I Session Type: Parallel
Session Location: Grand Horizon Ballroom Session Time: Thu, Jun 25 8:30AM - 11:30AM

Presentation Information

Program Number: 31 Presentation Time: 10:42AM - 10:54AM

Presentation Content

Environmental temperature differentially modulates C. elegans longevity through a thermosensitive channel.Bi Zhang 1,2, Rui Xiao 1, Elizabeth A. Ronan 1, Yongqun He 3, Jianfeng Liu 2, X.Z. Shawn Xu 1. 1)Life Sciences Institute, Ann Arbor, MI; 2)College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China; 3)Unit for Laboratory Animal Medicine and Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA

Temperature profoundly affects aging in both poikilotherms and homeotherms.  A general belief is that lower temperatures extend lifespan while higher temperatures shorten it.  Though this “temperature law” has been widely accepted, it has not been extensively tested.  Here, we carefully evaluated the role of temperature in lifespan regulation in C. elegans.  We found that while exposure to low temperatures at the adult stage promotes longevity, low temperature treatment at the larval stage surprisingly reduces lifespan.  Interestingly, this differential effect of temperature on lifespan in larvae and adults is mediated by the same thermosensitive channel TRPA-1 that signals to the transcription factor DAF-16/FOXO, a master regulator of lifespan.  DAF-16/FOXO and TRPA-1 act in larvae to shorten lifespan, but extend lifespan in adulthood.  Notably, DAF-16/FOXO differentially regulates gene expression in larvae and adults in a temperature-dependent manner. Our results uncover unexpected complexity underlying temperature modulation of longevity, demonstrating that temperature differentially regulates lifespan at different stages of life.

Please note: Abstract shown here should NOT be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.

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