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Important Deadlines
Workshop Applications Nov 15, 2016
Abstract Submission March 30, 2017
Travel Award Applications March 30, 2017
Author Presentation Notification May 16, 2017
Early Registration May 18, 2017
Housing Reservation May 18, 2017

 

Plenary & Platform Sessions and Workshops Listing

 


 
Wednesday, June 21   2:30 PM – 3:30 PM
Grand Horizon Ballroom
Teaching Workshop - What is a PUI and how do I get a job at one?

Faculty speakers:
Paula Checchi, Marist College
Sara Olson, Pomona College
Stephanie Maiden, Truman State University
Glen Ernstrom, Middlebury College
Edith Myers, Fairleigh Dickinson University


 
Wednesday, June 21   2:30 PM – 5:30 PM
Northwest Auditorium
Parasitic Nematodes: 3rd Bridging the Divide Workshop

Elissa Hallem: "Sensory behaviors of parasitic nematodes."
Dick Davis: “Ascaris: Resources, Tools, and Experimental Questions”
Conor Caffrey: A high-content screening platform for the flatworm pathogen causing schistosomiasis.”
Sara Lustigman: “The role of 'omics' and other molecular tools in the quest to eliminate human filariasis”
Malina Bakowski: “Identification of Anti-Wolbachia Compounds to Cure Parasitic Worm Disease.”
Adrian Wolstenholme: “Drugs & Resistance, Parasites & Models”



 
Wednesday, June 21   3:30 PM – 4:30 PM
Grand Horizon Ballroom
Teaching Workshop - Navigating the PUI: Teaching vs Research, Politics and Earning Tenure

Faculty speakers:
Leilani Miller, Santa Clara University
Jared Young, Mills College
Jennifer Kowalski, Butler University
Daryl Hurd, St. John Fisher College


 
Wednesday, June 21   4:30 PM – 5:30 PM
Grand Horizon Ballroom
Teaching Workshop - Teaching Resources Available to Incorporate C. elegans into the Classroom

Special Guest:
David J. Marcey
Fletcher Jones Professor of Developmental Biology
California Lutheran University


 
Wednesday, June 21   6:50 PM – 10:00 PM
Royce Hall
Plenary Session 1
Co-chairs:  Hinrich Schulenburg, University of Kiel, and
Lihsia Chen, University of Minnesota

Presentations:

6:50    Welcome and Opening Remarks.

1 7:00    Resist or die. Jonathan Ewbank

2 7:30    Natural C. elegans infection by oomycetes reveals a new pathogen-specific immune response. Michael Fasseas

3 7:42    A wolf in sheep’s clothing: a selfish element disguised as a linked pair of developmental genes underlies a genetic incompatibility in C. elegans. Eyal Ben-David

4 7:54    Evolution of developmental plasticity regulation by competing dosage of signal-modifying enzymes. Erik Ragsdale

5 8:06    A family of novel sulfolipids drives C. elegans defensive responses to a predator. Amy Pribadi

6 8:18    Dissecting the foundations of commensalism using C. elegans and its natural microbiome. Fan Zhang

7 8:30    Evolutionary insights into the C. elegans biology from the morphology, ecology and genome of the sister species Caenorhabditis sp. 34. Taisei Kikuchi

8:42    Break

8 9:06    The C. elegans natural diversity resource. Erik Andersen

9 9:12    The C. elegans multiparent experimental evolution mapping panel. Luke Noble

10 9:18    Real-Time Lineaging and the Optical Manipulation of Single Cells in Development. Pavak Shah

11 9:24    Model organism Encyclopedia of Regulatory Networks (modERN). Valerie Reinke

12 9:30    De-completing the C. elegans genome. Erich Schwarz

13 9:36    Balancer chromosome toolkit for C. elegans. Katsufumi Dejima

14 9:42    Caenorhabditis Genetics Center. Ann Rougvie

15 9:48    WormBase 2017: innovations and alliances. Paul Sternberg


 
Thursday, June 22   8:30 AM – 11:30 AM
Northwest Auditorium
Germline: Meiosis and Development
Co-chairs:  Judith Yanowitz, MWRI/ University of Pittsburgh, and
Yumi Kim, Johns Hopkins University

16 8:30    C. elegans germ cells divide and differentiate in a folded epithelium. Hannah Seidel

17 8:42    A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development. Alicia Meléndez

18 8:54    Regulation of germline stem cell maintenance by S6-Kinase. Debasmita Roy

19 9:06    Development of germline tumors after extended starvation during L1 arrest. James Jordan

20 9:18    Analysis of DLC-1 mediated regulation of the tumor suppressor protein GLD-1. Mary Ellenbecker

21 9:30    SCFPROM-1 acts in parallel to the gld-1 & gld-2 pathways to promote initiation of meiotic development. Ariz Mohd

9:42    Break

22 10:06    Analyzing DNA organization during meiotic chromosome pairing. Sreejith Ramakrishnan

23 10:18    Meiotic chromosome axis assembly requires active DNA Damage Response (DDR) during C. elegans meiosis. Zhouliang Yu

24 10:30    Trisomy correction occurs during both meiosis I and meiosis II. Francis McNally

25 10:42    A novel role for heterotrimeric G protein alpha subunits in C. elegans ovulation. Alyssa Cecchetelli

26 10:54    A translational repression-to-activation switch controls oocyte meiotic maturation and the oocyte-to-embryo transition in Caenorhabditis elegans. Tatsuya Tsukamoto

27 11:06    Sex, Secretion, Muscle, and Males. Daniela Chavez

28 11:18    The ZIPT-7.1 transporter mediates zinc signaling to promote sperm activation in C. elegans. Chieh-Hsiang Tan


 
Thursday, June 22   8:30 AM – 11:30 AM
Grand Horizon Ballroom
Metabolism and Stress
Co-chairs:  Supriya Srinivasan, The Scripps Research Institute, and
Dengke Ma, University of California, SF

29 8:30    Eukaryotic de novo NAD+ biosynthesis from tryptophan in the absence of a QPRTase homolog. Melanie McReynolds

30 8:42    Discovery and biosynthesis of hybrid polyketide-nonribosomal peptides in nematodes. Likui Feng

31 8:54    PEGCs: novel glycosphingolipids that mobilize cholesterol in Caenorhabditis elegans. Sebastian Boland

32 9:06    Does C. elegans benefit from physical exercise? Effects of acute and long-term swim training. Ricardo Laranjeiro

33 9:18    Exercise in Caenorhabditis elegans promotes mitochondrial maintenance and protects against chemical-induced mitotoxicity. Jessica Hartman

34 9:30    Microfluidics-based evaluation of neuromuscular healthspan in C.elegans. Mizanur Rahman

9:42    Break

35 10:06    Mitochondrial accumulation of saccharopine, an intermediate of lysine metabolism, induces mitochondria damage in C. elegans. Junxiang Zhou

36 10:18    Metabolic defects caused by hypomorphic gut specification are mediated by an NHR gene. Morris Maduro

37 10:30    Function and regulation of the elongation factor kinase efk-1/eEF2K in starvation response. Forum Bhanshali

38 10:42    Specific tissues coordinate changes in organismal growth, longevity and resilience to stress in response to reduced mRNA translation in C. elegans. Aric Rogers

39 10:54    Longevity from dietary restriction and reduced insulin/IGF-1 signaling requires modulation of p38/ATF-7 innate immunity. Ziyun Wu

40 11:06    C. elegans neurons package neurodegenerative disease-associated toxic peptides into bioactive, chaperone-filled exosomes that are secreted into the external environment. Josh Russell

41 11:18    High-throughput screening technology identifies dronedarone HCl as proteostasis regulator in C. elegans polyglutamine aggregation models. Sudip Mondal


 
Thursday, June 22   8:30 AM – 11:30 AM
Carnesale Palisades Ballroom
Neuronal Development and Cell Biology
Co-chairs:  Yingchuan (Billy) Qi, Hangzhou Normal University, and
Meital Oren-Suissa, Weizmann Institute of Science

42 8:30    A DM domain gene and the Ubiquitin-Proteasome System control the balance between sex-specific synapse maintenance and pruning. Meital Oren-Suissa

43 8:42    Conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in the C. elegans male. Byunghyuk Kim

44 8:54    The degenerins and mechanosensory experience determine dendritic arborization and behavior. Sharon Inberg

45 9:06    HPO-30/Claudin forms a co-receptor complex with DMA-1 to promote dendritic branching in C. elegans PVD neurons. Wei Zou

46 9:18    MIG-14/Wntless Regulates Dendrite Self-Avoidance via Actin Asssembly and Independent of Wnt. Chien-Po Liao

47 9:30    The synaptic organizer neurexin coordinates cholinergic synaptic connectivity with GABAergic motor neurons. Alison Philbrook

9:42    Break

48 10:06    Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution. Shaul Yogev

49 10:18    RHO-1 and the activator RHGF-1/RhoGEF are required for EBP-2 distribution in growth cones. Mahekta Gujar

50 10:30    Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. Chaogu Zheng

51 10:42    Myrf ER-bound transcription factors drive C. elegans synaptic plasticity via cleavage-dependent nuclear translocation. Yingchuan Qi

52 10:54    An importin protein controls asymmetric olfactory neuron differentiation by mediating nuclear transport of a homoeodomain transcription factor for sox-2 expression. Amel Alqadah

53 11:06    Conserved transcriptional regulatory rules define the serotonergic-neuron identity. Carla Lloret

54 11:18    Biogenesis and Function of Social Extracellular Vesicles (EVs). Juan Wang


 
Thursday, June 22   8:30 AM – 11:30 AM
De Neve Auditorium
Genome Stability, Gene Expression and Technologies
Co-chairs:  Sam Gu, Rutgers University, and
Anna Zinovyeva, Kansas State University

55 8:30    A role for RNA processing proteins in maintaining genome stability. Juliette Kamp

56 8:42    SMRC-1, a putative annealing helicase, links chromatin regulation and DNA repair in the C. elegans germ line. Bing Yang

57 8:54    Polymerase Θ is a key driver of genome evolution, of CRISPR/Cas9-mediated mutagenesis and of mutagen-induced deletion allele formation. Robin van Schendel

58 9:06    Use of the Million Mutation Project to study transposons and genome biology. Stephen Frenk

59 9:18    EMR-1/emerin is involved in tissue-specific anchoring of chromatin to the nuclear envelope and neuromuscular junction activity. Celia Muñoz Jiménez

60 9:30    Developmental regulation of H3K9me2 and chromatin compaction by C. elegans synMuv B proteins. Meghan Fealey

9:42    Break

61 10:06    Programmed DNA Elimination in Nematodes. Richard Davis

62 10:18    Long-distance cooperation and hierarchy between recruitment sites specify the X chromosome for dosage compensation. Sevinc Ercan

63 10:30    Expression profiling of synchronized cell-type populations during embryonic development. Adam Warner

64 10:42    Targeted, high-throughput interrogation of regulatory elements in C. elegans. Jonathan Froehlich

65 10:54    Meta analysis of RNAseq datasets provides quantitative measurement of alternative exons usage in C. elegans. Denis Dupuy

66 11:06    Cell type-specific transcriptome profiling using the Translating Ribosome Affinity Purification technique. Xicotencatl Gracida

67 11:18    MIP-MAP: Targeted sequencing for high-throughput mapping of C. elegans mutant TS alleles. Calvin Mok


 
Thursday, June 22   1:00 PM – 2:30 PM
De Neve Plaza Room
Long lost friends: reuniting C. elegans and its natural microbiome in the lab

Organizer: Buck Samuel, Baylor College of Medicine
 
1:00 Identification of the core microbiome of C. elegans: perspectives and resources, Buck Samuel
1:12  Modeling microbiome assembly in the lab using microcosms, Michael Shapira
1:24 Multi-omics assessment of C. elegans-microbiome interactions, Hinrich Schulenburg
1:36 Systems biology of microbiome interactions, Marian Walhout
1:48 Sampling and sharing a diversity of C. elegans associated organisms, Marie-Anne Felix 
2:00 General discussion



 
Thursday, June 22   1:00 PM – 2:30 PM
Grand Horizon Ballroom
Mapping synaptic and extrasynaptic neural signaling in C. elegans

Organizers: Michael Koelle, Yale University, and Oliver Hobert, Columbia University

A multi-level map of signaling in the C. elegans nervous system is emerging from efforts in a number of labs. These efforts include identifying the synaptic connections made by neurons, identifying the small molecule neurotransmitters and neuropeptides released by each neuron, identifying the neurotransmitter and neuropeptide receptors expressed by each neuron, and analyzing all of the above data to extract its meaning. This workshop will feature brief presentations from several labs carrying out such work, followed by a period in which the presenters and audience have an open discussion.
 
1:00 The Mind of a Worm 2.0. Scott Emmons, Albert Einstein College of Medicine
1:13 A neurotransmitter map of the hermaphrodite and male nervous system. Laura Pereira and Oliver Hobert, Columbia University
1:26 A G protein coupled neurotransmitter receptor map. Robert Fernandez and Michael Koelle, Yale University
1:39 Network analysis of neurotransmitter signaling. William Schafer, MRC Laboratory of Molecular Biology
1:52 Mapping neuropeptide-receptor interactions by large-scale GPCR deorphanization. Isabel Beets and Liliane Schoofs, KU Leuven
2:05 General discussion, moderated by Michael Koelle and Oliver Hobert



 
Thursday, June 22   1:00 PM – 2:30 PM
De Neve Auditorium
Technologies for lifespan and healthspan evaluation

Organizers: Monica Driscoll, Rutgers University and Patrick Phillips, University of Oregon

The purpose of this workshop is for the community to report on approaches, exchange data, and discuss challenges in efforts to measure lifespan and how well nematodes age. After a set of short talks designed to introduce the audience to aspects of available technologies (advantages and disadvantages), we will have a group discussion of questions and challenges in the hope of fostering possible synergy/collaboration and/or new thoughts about moving forward in this area. The last 30 minutes will feature a panel discussion with all presenters.
This session is funded in part by the National Institute on Aging.
 
1:00 Gordon Lithgow. Overview and Caenorhabditis Intervention Testing Program-progress and challenges
1:10 Christopher Fang-Yen. Automated longitudinal assays of aging using the WorMotel
1:20 Zach Pincus. Relating health and life in aging C. elegans
1:30 Kim Le. Chip applications in biology and aging
1:40 Siva Vanapalli. A microfluidic platform for multi-dimensional phenotyping of C. elegans across lifespan
1:50 Adela Ben-Yakar. Large–scale microfluidics providing high resolution and high throughput screening capabilities.
2:00 General group discussion



 
Thursday, June 22   1:00 PM – 2:30 PM
Carnesale Palisades Ballroom
Bipartite Expression Systems for Temporal and Spatial Transgene Control in C. elegans

Organizers: Han Wang and Jonathan Liu, California Institute of Technology

Bipartite expression systems are powerful and efficient tools for controlling transgene expression. In the past several few years, the application of several such systems (FLP/FRT, Cre/LoxP, cGAL system) have been described in the C. elegans field. However, none of these genetic tools has been widely adopted in our field yet (unlike GAL4-UAS in Drosophila). The purpose of this workshop is to present the status of each system, discuss the pros, cons and practical tricks for each, and seek input from the community to push these genetic tools forward for the field.
 
1:00 Cre/LoxP- mediated conditional knockout in C. elegans: toolkit and limits, Shohei Mitani, Tokyo Women’s Medical University School of Medicine
1:12 Tissue-specific tagging and knockout of endogenous genes using the FLP/FRT system, Matt Schwartz, University of Utah
1:24 Expanding the bipartite toolkit for C. elegans, Theadora Tolkin, New York University School of Medicine, Skirball Institute of Biomolecular Medicine
1:36 Applying the Q system for spatiotemporal gene expression in adult C. elegans, Xingyu She, SBP Medical Discovery Institute
1:48 cGAL and intersectional strategies for transgene control in C. elegans, Jonathan Liu, California Institute of Technology
2:00 General discussion



 
Thursday, June 22   1:00 PM – 2:30 PM
Northwest Auditorium
WormBase: Tools, Content and Community Annotation

Organizers: Ranjana Kishore and Kevin Howe, WormBase Consortium.

This workshop aims to discuss the different tools available for querying and visualizing data related to C. elegans and parasitic nematodes. We will also discuss how the community can submit data to us using the various forms available at WormBase.
 
1:00 How to curate your data for WormBase - Mary Ann Tuli and Chris Grove
1:10 Micropublication: a new mode of scholarly communication - Daniela Raciti
1:20 Introducing the Alliance of Genome Resources portal - Kevin Howe
1:30 Using WormBase Tools:
Introduction: summary of available tools - Todd Harris
JBrowse: new features for genome browsing - Scott Cain
Gene Set Analysis tool for Gene Ontology (GO), Phenotype, and Tissue Enrichment - David Angeles
The SOBA tool: visualizing Ontology based Annotations - Raymond Lee
2:05 Data Mining tools:
WormMine and SimpleMine for C. elegans data - Chris Grove
ParaSite BioMart for multi-species genome data - Bruce Bolt
Programmatic access to WormBase and Parasite - Sibyl Gao and Bruce Bolt



 
Thursday, June 22   5:00 PM – 5:12 PM
Royce Hall
GSA Edward Novitski Prize presented to
Jonathan Hodgkin, University of Oxford



 
Friday, June 23   7:30 AM – 8:30 AM
Covel Study Lounge
Publishing Tips and Tricks Continental Breakfast

Hear the ins-and-outs of getting your articles published, featuring editors from various journals, including GENETICS and G3: Genes|Genomes|Genetics. This is an excellent opportunity for graduate students, postdoctoral fellows and undergraduate students to have informal conversations with journal editors about the peer-review and scientific publishing process in general, and more specifically, the GSA's two journals.
 


 
Friday, June 23   8:30 AM – 11:30 AM
Northwest Auditorium
Evolution and Ecology
Co-chairs:  Erik Andersen, Northwestern University, and
Yen-Ping Hsueh, Academia Sinica

80 8:30    Some C. elegans wild isolates display a heat-triggered mortal germ line phenotype. Lise Frézal

81 8:42    CRISPR/Cas9-based dissection of a genetically complex, pleiotropic chromatin-remodeling gene under selection in laboratory growth conditions. Wen Xu

82 8:54    Distinct genetic mechanisms underlie natural variation in left-right arrangement of the major organs in males and hermaphrodites of C. elegans. Agustin Lopez Santos

83 9:06    Mapping complex traits in C. elegans using a bulk segregant approach. Alejandro Burga

84 9:18    C. elegans microbiomics. Hinrich Schulenburg

85 9:30    Ecology of bacterial community assembly in a C. elegans host model. Nic Vega

9:42    Break

86 10:06    Phenotypic switching between nematode mutualism and insect pathogenesis by the bacterium Xenorhabdus nematophila. Mengyi Cao

87 10:18    Some like it hot: temperature-driven host seeking in human-parasitic nematodes. Astra Bryant

88 10:30    Intron loss and gain in the genus Caenorhabditis. Lewis Stevens

89 10:42    Diverse types of regulatory mutations drive the evolution of sex in nematode germ cells. Ronald Ellis

90 10:54    Transcriptome analysis reveals a predominant role of cis-elements in regulating allele-specific expression in F1 hybrids between C. briggsae and C. nigoni. Runsheng Li

91 11:06    Self-fertility triggers rapid genome shrinkage and loss of sperm competition proteins. Eric Haag

92 11:18    A conserved regulatory network for lateral neural borders from worm to vertebrate. Xiao Liu


 
Friday, June 23   8:30 AM – 11:30 AM
Grand Horizon Ballroom
Aging and Longevity
Co-chairs:  Javier Apfeld, Northeastern University, and
Collin Ewald, ETH Zurich

93 8:30    A novel stress and age-responsive lysosomal protease inhibitor affecting proteostasis in neurodegeneration. Victoria Butler

94 8:42    Expression patterns and functions of the daf-2 isoforms. Wenhong Zhang

95 8:54    DAF-16 requires Protein Phosphatase 4 to initiate the transcription of stress resistance and longevity promoting genes. Ilke Sen

96 9:06    Using the CRISPR/Cas9 technology to dissect the spatial-temporal expression patterns and the functions of DAF-16 isoforms. Yanping Zhang

97 9:18    Identification of new pathways involved in the regulation of the UPRmt reveals a crosstalk between mitochondrial stress response and insulin signaling. Blanca Hernando-Rodriguez

98 9:30    Glutamine 5’-tRNA-drived small RNAs promote longevity via increasing mitochondrial activity through AMPK. Wooseon Hwang

9:42    Break

99 10:06    Mating and male pheromone kill Caenorhabditis males through distinct mechanisms. Cheng Shi

100 10:18    Sexual interactions promote early death in C. elegans. Lauren Booth

101 10:30    Sex-specific regulation of lifespan in C. elegans. Veerle Rottiers

102 10:42    Longitudinal imaging of C. elegans with the WorMotel reveals variation in behavioral decline during aging. Matthew Churgin

103 10:54    A Caenorhabditis elegans Model to Study Age-related Complications Associated with Diabetes and Parkinson’s Disease. Neelanjan Bose

104 11:06    The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through the HSF-1 chaperone network and TORC1-restricted autophagy. Andrew Samuelson

105 11:18    Spatiotemporal regulation of autophagy in C. elegans aging. Malene Hansen


 
Friday, June 23   8:30 AM – 11:30 AM
De Neve Auditorium
Behavior
Co-chairs:  Christopher Fang-Yen, University of Pennsylvania, and
Jin Il Lee, Yonsei University

106 8:30    C. elegans detect the color of pigmented food sources to guide foraging decisions. Debtirtho Ghosh

107 8:42    The chaotic worm: Capturing the continuous complexity of natural behavior in the movement of C. elegans. Tosif Ahamed

108 8:54    Neuropeptide signalling is required to regulate arousal in C. elegans. Yee Lian Chew

109 9:06    A global brain state underlies C. elegans sleep-like behaviour. Annika Nichols

110 9:18    Regulation of locomotion quiescence during stress-induced sleep by FMRFamide-like peptide FLP-24. Han Wang

111 9:30    Activation of Gαq signaling extends memory 10-fold via enhanced consolidation. Rachel Arey

9:42    Break

112 10:06    Temporal structure of mechanosensory signal and current behavioral state determine locomotory response. Mochi Liu

113 10:18    OFF-responding interneurons controls stimulus strength-dependent sensory processing. Sayaka Hori

114 10:30    Neural pulses code chemical gradients dictating chemotaxis strategy. Rotem Ruach

115 10:42    The C. elegans MAST Kinase Acts through Stomatin and Diacylglycerol Kinase to Regulate Thermotaxis Behavior. Shunji Nakano

116 10:54    Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans. Zoe Hilbert

117 11:06    Insulin-like signaling regulates the prioritization of feeding behavior by regulating the chemoreceptor ODR-10 in C. elegans. Emily Wexler

118 11:18    Nitric oxide sensation and avoidance in C. elegans. Wenxing Yang


 
Friday, June 23   8:30 AM – 11:30 AM
Carnesale Palisades Ballroom
Cell Biology
Co-chairs:  Ann Wehman, University of Würzburg, and
Francois Robin, Institut de Biologie Paris-Seine

119 8:30    Reconstitution of the PAR polarity networks in a heterologous cell system. Fumio Motegi

120 8:42    Spatiotemporal control of gene knock-out and protein-protein heterodimerization to study mitotic spindle positioning. Lars-Eric Fielmich

121 8:54    The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4. Ahna Skop

122 9:06    Mitochondrial redox signaling induces polarization in the C. elegans embryo. Sasha De Henau

123 9:18    A potential role for midbodies in developing tissues of C. elegans. Xiaofei Bai

124 9:30    Cilia length and Intraflagellar transport regulation by kinases PKG-1 and GCK-2 in C. elegans sensory neurons. Prerana Bhan

9:42    Break

125 10:06    An unexpected link between fusogen activity and intracellular lumen elongation. Fabien Soulavie

126 10:18    The fusogen EFF-1 promotes a novel cell process-specific engulfment program. Piya Ghose

127 10:30    NEK kinases regulates clathrin-mediated endocytosis in association with the AP2 adaptor complex. David Fay

128 10:42    Retromer-associated proteins and PAD-1 control TAT-5 flippase activity to inhibit extracellular vesicle budding. Ann Wehman

129 10:54    The lysosomal endoribonuclease RNST-2 degrades ribosomal RNA to support embryonic and larval development in C. elegans. Yubing Liu

130 11:06    Interdependent accumulation of Cadherin-Catenin complexes and WAVE/SCAR branched actin regulators at the apical junction promotes epithelial morphogenesis. Shashikala Sasidharan

131 11:18    Linker cell migration uses neuronal signaling through the muscarinic acetylcholine receptor GAR-3. Mihoko Kato


 
Friday, June 23   1:00 PM – 2:30 PM
Northwest Auditorium
New Frontiers in the C. elegans Nucleus

Organizers: Peter Askjaer (Andalusian Center for Developmental Biology, Spain) and Orna Cohen-Fix (NIH/NIDDK)

In recent years, advances in technology have led to a better understanding of nuclear structure and function. This workshop focuses on new methodologies as well as new areas of investigation related to the biology of the nucleus.
 
1:00 Single molecule techniques for visualizing nascent transcription in the C. elegans gonad.Christian Lanctôt (Charles University, Czech Republic) 
1:14 Investigation of cellular signaling and epigenetic dynamics via optogenetic control of nuclear cytoplasmic distribution. Hayretin Yumerefendi (University of North Carolina)
1:28  Following nuclei by live imaging using photoconversion. Simona Rosu (NIH/NIDDK)
1:38 Chromosome conformation capture (Hi-C) to analyze DNA organization in germcell nuclei of C. elegans. Sreejith Ramakrishnan (Stanford University)
1:52 An improved INTACT protocol for isolation of cell-type specific nuclei. Dylan Rahe (Columbia University)
2:06 Tools for spatiotemporal analysis of nuclear organization. Peter Askjaer (Andalusian Center for Developmental Biology, Spain)
2:15 General Discussion



 
Friday, June 23   1:00 PM – 2:30 PM
Carnesale Palisades Ballroom
CRISPR: New Techniques and Best Practices

Organizers: Jordan Ward, University of California, Santa Cruz and Mike Boxem, Utrecht University

This workshop will bring together experts in CRISPR to discuss new approaches that they are developing, and to provide practical guidance and best practices for groups hoping to get CRISPR working efficiently in their labs.
 
1:00 Opening remarks-Jordan Ward and Mike Boxem
1:05 Reliable CRISPR/Cas9 Genome Engineering in Caenorhabditis elegans Using a Single Efficient sgRNA and an Easily Recognisable Phenotype. Thomas Boulin
1:15 Strategies for improving the efficiency of precise genome editing across nematode species using CRISPR/Cas9. Bobby Farboud
1:25 SapTrap: high-throughput gene modification in C. elegans. Matt Schwartz
1:35 Genome editing using Cas9 ribonucleoprotein complexes and linear repair templates. Alex Paix
1:45 Jordan Ward CRISPR best practice overview and emerging/needed technologies
1:55 Questions



 
Friday, June 23   1:00 PM – 2:30 PM
Grand Horizon Ballroom
A Framework for the Mind of the Worm: Open Source Computing Tools and Data Platform

Organizers: Andre Brown, Imperial College London and Stephen Larson, OpenWorm Foundation

Predicting worm behaviour from its wiring diagram has been an enduring challenge since the Mind of the Worm was published 30 years ago. There are two main limitations that have prevented more progress. The first is a lack of software and computing power and the second is a lack of comprehensive data on gene expression and neural physiology. There have been significant advances on both the computational and experimental fronts, making 2017 an ideal time for a focused workshop to synthesize recent results and discuss next steps, including open source software development and opportunities to share functional data. This workshop will have three purposes: 1) To present available tools for simulating C. elegans at cellular resolution. 2) Review the current knowledge of the neuronal genome, brain-wide nervous system imaging, and behaviour quantification. 3) Discuss how these two strands can be most productively combined as well as how the most important gaps in our knowledge can be filled.
 
1:00 Introduction, Stephen Larson, OpenWorm Foundation and Andre Brown, Imperial College London
1:05 Effective models. Netta Cohen, Leeds University
1:18 Neural Imaging. Eviatar Yemini, Columbia University
1:31 Gene Expression . Coleen Murphy, Princeton University
1:44 Behavior and open source analysis Andre Brown, Imperial College London
1:57 Multi-scale modeling and open source computing tools. Stephen Larson, OpenWorm Foundation
2:10 Panel Discussion



 
Friday, June 23   1:00 PM – 2:30 PM
De Neve Auditorium
C. elegans Metabolomics and Metabolic Networks

Organizers: Art Edison, University of Georgia (chair), Charlie Baer, University of Florida, Frank Schroeder, Cornell University and Paul Sternberg, Caltech

This workshop provides an overview of metabolomics, methods for small molecule analysis, metabolic networks, and discussions to organize and coordinate efforts in worm metabolomics.
 
1:00 Overview of metabolomics, Art Edison
1:20 Methods in C. elegans for small molecule analysis, Frank Schroeder
1:40 Reconstructed C. elegans metabolic network and flux balance analysis, Lutfu Safak Yilmaz and Marian Walhout 
2:00 Organizing the community, Paul Sternberg and others 
2:00 Discussion

 
 
   
 
 


 
Friday, June 23   1:00 PM – 2:30 PM
De Neve Plaza Room
The Caenorhabditis Genomes Project

Organizers: Lewis Stevens and Mark Blaxter, University of Edinburgh

This workshop aims to update the community on the developments of the Caenorhabditis Genomes Project, including new and improved genome assemblies, phylogenomic analyses, accessing and using our data, and a discussion about how we should move the project forward.
 
1:00 Introduction and current status of the CGP, Mark Blaxter
1:10 The next step: Long-read data for genome assembly: lessons from C. nigoni, C. tropicalis and C. wallacei, Erich Schwarz (Cornell University)
1:25 A genome phylogeny of Caenorhabditis, Lewis Stevens
1:35 Using the CGP data for discovery science, Toni Beltran (Imperial College London)
1:50 Accessing and using CGP data, Lewis Stevens
2:00 30 minute open discussion
2:30 Close



 
Friday, June 23   1:00 PM – 2:30 PM
Southbay
Workshop on Navigating the Career Decision Making Process

Organizer: Sonia Hall, Genetics Society of America

This interactive career planning workshop will engage participants in thinking about how their skills, interests and values can be used to inform their career planning and decisions.


 
Friday, June 23   5:00 PM – 6:00 PM
Royce Hall
Keynote Address
Judith Kimble, University of Wisconsin, Madison
Chair:  Susan Mango, Harvard University

Presentations:

139 5:00    Of niches and naïveté. Judith Kimble


 
Saturday, June 24   8:30 AM – 11:30 AM
Grand Horizon Ballroom
Germline: Small RNAs and Chromatin
Co-chairs:  Alyson Ashe, University of Sydney, Australia, and
Germano Cecere, Institut Pasteur

140 8:30    Global profiling reveals new sub-classes of microRNAs and identifies germline microRNAome. Amanda Gervaise

141 8:42    GTSF-1 is required for the formation of small RNA-producing complexes. Miguel Vasconcelos Almeida

142 8:54    The highly conserved factor ZNFX-1, regulates gene silencing and crosstalk between germline small RNA pathways in C.elegans. Takao Ishidate

143 9:06    Dissecting 21U RNA biogenesis and activity in the germline and the early embryo. Rene Ketting

144 9:18    Rules for PIWI targeting and a practical approach to prevent transgene silencing by avoiding piRNA recognition. Heng-Chi Lee

145 9:30    Evolutionary analysis of piRNA genomic organisation reveals two fundamental modes of piRNA biogenesis in nematodes. Antoni Beltran

9:42    Break

146 10:06    A potential role for RSD-3-coated extracellular vesicles in trafficking RNA from the soma to the germline. Daniel Pagano

147 10:18    Transcription alterations associated with nuclear Argonautes pathways are accompanied by chromatin reorganization. Ekaterina Gushchanskaia

148 10:30    The conserved intron binding Protein EMB-4 plays differential roles in germline small RNA pathways. Julie Claycomb

149 10:42    A P-granule-localized Argonaute protein transmits siRNA from germline to zygote to promote transgenerational inheritance of RNAi. Shouhong Guang

150 10:54    Sperm-inherited chromatin states shape gene expression in offspring. Kiyomi Kaneshiro

151 11:06    Temperature increases cause transposon-associated DNA damage specifically during spermatogenesis. Nicole Codd

152 11:18    Developmental relaxation of nuclear RNAi targeted LTR retrotransposons in C. elegans germ cells. Julie Ni


 
Saturday, June 24   8:30 AM – 11:30 AM
Northwest Auditorium
Interactions with Pathogens and the Environment
Co-chairs:  Michalis Barkoulas, Imperial College London, and
Patricija van Oosten-Hawle, University of Leeds

153 8:30    Identification of an evolutionarily conserved pathway essential for virus infection using Orsay virus infection of C. elegans. Hongbing Jiang

154 8:42    Genetic and chemical modulation of C. elegans intestinal antiviral innate immunity. Weiwei Zhong

155 8:54    Mitochondria as a Hub for Cellular Surveillance. Natalia Kirienko

156 9:06    Role of host damage and bacterial genomic diversity in the interaction between P. aeruginosa and C. elegans. Alejandro Vasquez-Rifo

157 9:18    The Patched-related protein PTR-15 (BUS-13) is essential for larval viability (in the intestine) and pathogen resistance (in the epidermis). Patricia Kuwabara

158 9:30    Intestinal colonization by bacteria alters chemosensory responses to alcohols. Mike O'Donnell

9:42    Break

159 10:06    Complex dynamic subcellular patterning underlies the innate immune response. Clara Taffoni

160 10:18    Probing organismal proteostasis through the response to intracellular infection. Kirthi Reddy

161 10:30    Characterization of neuronal receptor NPR-8 for its role in regulating C. elegans immunity. Durai Sellegounder

162 10:42    Large-scale deorphanization of neuropeptide receptors reveals an ancient TRH-like neuropeptide pathway that regulates growth. Isabel Beets

163 10:54    Serotonergic control of the conserved heat shock factor transcription factor (HSF-1). Veena Prahlad

164 11:06    Mechanisms of cell-to-cell and animal-to-animal variation in gene expression in isogenic C. elegans. Nikolay Burnaevskiy

165 11:18    Electron microscopy based high resolution nuclear atlas of C. elegans dauer. Ella Bahry


 
Saturday, June 24   8:30 AM – 11:30 AM
Carnesale Palisades Ballroom
Neuronal Degeneration, Regeneration, Synapses and Circuits
Co-chairs:  Anindya Ghosh-Roy, National Brain Research Centre, and
Shangbang Gao, Huazhong University of Sci. & Tech.

166 8:30    The epidermis protects sensory axons from degeneration. Sean Coakley

167 8:42    Deciphering the mechanisms of the ZIG-10 immunoglobulin-domain superfamily protein in maintaining synapse density. Salvatore Cherra

168 8:54    UNC-16 inhibits the function of regeneration promoting isoform of DLK-1. Sandhya Koushika

169 9:06    O-linked N-beta-aceytlglucosamine (O-GlcNAc) post-translational modifications dynamically enhance axon regeneration. Daniel Taub

170 9:18    Inhibition of axon regeneration by aggregation of the prion-like domain containing protein TIAR-2. Matt Andrusiak

171 9:30    Fifty years of levamisole: do we really know how it works? Maelle Jospin

9:42    Break

172 10:06    Motor neuron coupling by the presynaptic gap junction protein INX-1 ensures robustness of calcium oscillation generation during a rhythmic behavior. Ukjin Choi

173 10:18    UNC-7 innexin hemichannels function as mechanosensors in gentle touch and nociception in Caenorhabditis elegans. Denise Walker

174 10:30    Clarinet (CLA-1), a novel synaptic active zone protein in C. elegans. Zhao Xuan

175 10:42    The HSN command neuron co-releases serotonin and NLP-3 neuropeptides to activate egg laying. Michael Koelle

176 10:54    A compressed C. elegans locomotory circuit utilizes excitatory motor neurons as local central pattern generators for reversal locomotion. Shangbang Gao

177 11:06    Repetitive behavior mediated by glutamate is controlled by astrocyte-like glia in C. elegans. Menachem Katz

178 11:18    Plasticity of the electrical synapse network under environmental stress. Abhishek Bhattacharya


 
Saturday, June 24   8:30 AM – 11:30 AM
De Neve Auditorium
Development
Co-chairs:  Xantha Karp, Central Michigan University, and
Hannah Seidel, Eastern Michigan University

179 8:30    An automated method for analyzing 4D high content imaging data to profile the gene set controlling C. elegans embryonic development. Renat Khaliullin

180 8:42    A community-driven probabilistic atlas for cell identification in C. elegans. Saul Kato

181 8:54    Rotating and elongating embryos: SPIM microscopy reveals how planar polarity could be established during morphogenesis. Xinyi YANG

182 9:06    PCP and SAX-3/Robo pathways cooperate to regulate convergent extension-based nerve cord assembly. Antonio Colavita

183 9:18    A “bHLH code” for sexually dimorphic form and function of the C. elegans somatic gonad. Hana Littleford

184 9:30    Multiple noise sources drive the stochastic AC/VU decision during C. elegans development. Jeroen van Zon

9:42    Break

185 10:06    A real-time biosensor for MPK-1/ERK activity reveals signaling dynamics during C. elegans cell fate specification. Claire de la Cova

186 10:18    LET-60/Ras recruits its 2°-promoting effector, RGL-1/RalGEF, specifically to the apical plasma membrane of presumptive 2° cells. David Reiner

187 10:30    Deconstructing eutely: mechanisms of phenotypic robustness in the seam. Dimitris Katsanos

188 10:42    Controlling a stem cell division pattern in the C. elegans epidermis. Suzanne van der Horst

189 10:54    Turning a “killer” into a developmental timing regulator: Coupling N-end rule E3 ubiquitin ligase UBR-1 to CED-3 caspase promotes recognition and degradation of LIN-28. Benjamin Weaver

190 11:06    FACT is a reprogramming barrier in C. elegans and human cells. Ena Kolundzic

191 11:18    Decoding two Paths from Glia-to-Neuron. Michele Sammut