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Important Dates:

 
September 24, 2013
Abstract Submission Opens

Conference Registration Opens

 
November 5, 2013
Deadline for Workshop Requests
 
December 9, 2013
Abstract Submission Deadline
 
December 22, 2013
Larry Sandler Award Submission Deadline
 
February 3, 2014
Deadline for Early (Discounted) Conference Registration
 
February 28, 2014
Deadline for Hotel Reservations
 

 

2014 Meeting Organizers:

 

Daniela Drummond-Barbosa
Elissa Lei
Mihaela Serpe
Mark Van Doren
 

Poster Session Listing

 

POSTER SESSIONS LISTING

 

Cell Biology and Cytoskeleton


157A
The role of Orc6 in septin complex functions in Drosophila. Katarina Akhmetova1,2, Maxim Balasov1, Richard Huijbregts1, Igor Chesnokov1. 1) Biochemistry and Molecular Genetics, UAB, Birmingham, AL; 2) Institute of Cytology and Genetics, Novosibirsk, Russia.

158B
Tubulation and furrow ingression during epithelial formation is directed by Rab8. J. Todd Blankenship, Lauren Mavor, Zach Zuo. Biological Sciences, University of Denver, Denver, CO.

159C
NMNAT Regulates Neuronal Microtubule Assembly State. Jennifer M. Brazill, Brandon M. Kitay, Yousuf O. Ali, R. Grace Zhai. Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL.

160A
Functions of tropomyosin in vivo. Aeri Cho, Denise Montell. University of California, Santa Barbara, Santa Barbara, CA.

161B
Drak is required for actomyosin assembly or organization during Drosophila cellularization. Ashish B. Chougule1, Mary Catherine Hastert2, Jeffrey H. Thomas1. 1) Cell Biology and Biochemistry, TTUHSC, Lubbock, TX; 2) Biological Sciences Imaging Center, TTU, Lubbock, TX.

162C
Ena and Dynein Light Chain 90F may Function Together during Head Involution. Brittany Duran, Julie Gates. Biology Dept., Bucknell University, Lewisburg, PA.

163A
Garz may Function with Ena During Epithelial Morphogenesis. Rachel Franz, Julie Gates. Biology Dept., Bucknell University, Lewisburg, PA.

164B
Presenilin and GSK-3β control motor-cargo movement on microtubules. Kunsang Dolma, Gary Iacobucci, Kan Hong Zheng, Joseph White, Shermali D. Gunawardena. Biological Sciences, SUNY at Buffalo, Buffalo, NY.

165C
Integrin regulation of filopodia during muscle migration. Yoshiko Inoue1,3, Jenny Gallop1,3, Nicholas Brown1,2. 1) The Gurdon Institute, Cambridge, United Kingdom; 2) Dept. of Biochemistry, University of Cambridge; 3) Dept. of PDN, University of Cambridge.

166A
A genetic screen to identify dominant modifiers of Abl signaling during cell migration. Megan Jackson, Kristina M. Reiss, Christopher S. Moline, Traci L. Stevens. Biology, Randolph-Macon College, Ashland, VA.

167B
Exploring the role of α-Actinin and Cheerio during Ventral Furrow Invagination and Dorsal Closure. Jaime Jurado-Gomez1, Michael Tworoger2, Adam C. Martin2, Nicole Gorfinkiel1. 1) Centro Biologia Molecular 'Severo Ochoa', Madrid, Spain; 2) Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

168C
Molecular dissection of the PINCH-RSU1 interaction in Drosophila. Julie L. Kadrmas1,2, Stephen M. Pronovost1. 1) Huntsman Cancer Institute; 2) Oncological Sci, Univ Utah, Salt Lake City, UT.

169A
Flapwing may Function with Ena during Head Involution and Dorsal Closure. Rebecca LeShay, Julie Gates. Biology Dept., Bucknell University, Lewisburg, PA.

170B
Identifying a Kelch-Cullin3 ubiquitin ligase substrate. Katelynn M. Mannix, Andrew Hudson, Lynn Cooley. Genetics Dept., Yale University, New Haven, CT.

171C
The role of microtubule-based motor proteins in Drosophila bristle development. Anna Melkov, Yasmin Simchoni, Anna Bakhart, Uri Abdu. Ben Gurion University, Israel, Beer Sheva, Israel.

172A
Asymmetric distribution of the homophilic cell surface molecule Echinoid polarizes the actin cytoskeleton. Arsida Nocka, Laura Nilson. Biology Department, McGill University, Montreal, Quebec, Canada.

173B
Epithelial Cell Alignment: A model of concerted cell shape changes. Katy Lauren Ong, Stephen DiNardo. Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA.

174C
The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis. Juan José Pérez-Moreno1, Marcus Bischoff2, María Dolores Martín-Bermudo1, Beatriz Estrada1. 1) Centro Andaluz de Biología del Desarrollo (CSIC/UPO), Seville, Spain; 2) Biomolecular Sciences Building, University of St Andrews, Scotland, UK.

175A
Ovhts-RC modulates cytoplasmic actin filaments in developing oocytes. Nancy J. Pokrywka. Dept of Biology, Vassar College, Poughkeepsie, NY.

176B
The role for Spire in phosphoinositide-regulated hemocyte membrane trafficking and cortical remodeling. Anette Pykalainen, Amy Kiger. Biology, University of California, San Diego, 9500 Gilman Dr., La Jolla, 92093 CA.

177C
The role of ER-specific proteins reticulon, lunapark, and atlastin in the early Drosophila melanogaster embryo. Amanda M. Sims, Rachel Coombs, Blake Riggs. San Francisco State University 1600 Holloway Avenue San Francisco, CA 94132.

178A
Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair. Jeffrey M. Verboon, Maria Abreu-Blanco, Susan Parkhurst. Fred Hutchinson Cancer Research Institute, Seattle, WA.

179B
Coordinating the pulsed and ratcheted contractions that drive collective apical constrictions during Drosophila gastrulation. Shicong Xie1, Adam Martin2. 1) PhD program in Computational & Systems Biology, Massachusetts Institute of Technology, Cambridge, MA; 2) Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.

180C
PIP2 regulates stability of cleavage furrow-associated proteins during cytokinesis. Sukriye Yildirim1, Lacramioara Fabian1, Raymond Wong1,2, Ho-Chun Wei1, Gordon Polevoy1, Julie A. Brill1,2,3. 1) CELL BIOLOGY PROGRAM, THE HOSPITAL FOR SICK CHILDREN; 2) INSTITUTE OF MEDICAL SCIENCE, UNIVERSITY OF TORONTO; 3) DEPARTMENT OF MOLECULAR GENETICS, UNIVERSITY OF TORONTO.

181A
The Role of the Drosophila Formin Frl in the Establishment of Planar Cell Polarity. Austen A. Barnett1, Saw-Myat Maung1, Gretchen Dollar1, Cathie Pfleger2, Andreas Jenny1. 1) Molecular and Developmental Biology, Albert Einstein College of Medicine, Yeshiva University, New York, NY; 2) Department of Oncological Sciences, Icahn School of Medicine, Mt. Sinai Hospital, New York, NY.

182B
The polarity protein aPKC physically interacts with Nuf regulating vesicle trafficking. Francisco J. Calero, Sol Sotillos. CABD, Seville (Spain).

183C
Structure-function analysis of Crumbs. Shradha Das, Elisabeth Knust. Max Planck Institute-CBG, Dresden, Saxony, Germany.

184A
The Role of Cell Polarity in the Engulfment of Dying Germ Cells. Sarah E. Kleinsorge1, Sandy Serizier2, Tracy Meehan2, Jeffrey Taylor2, Kim McCall2. 1) GPGG, BUSM, Boston, MA; 2) Dept of Biology, Boston University, Boston, MA.

185B
Characterization of novel interactors of the Drosophila Crumbs complex. Ya-Huei Lin, Elisabeth Knust. MPI-CBG, Dresden, Germany.

186C
The Drosophila planar polarity gene multiple wing hairs regulates actin cytoskeleton. Qiuheng Lu, Dorothy Schafer, Paul Adler. Biology Department, Department of Cell Biology and Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, Virginia, 22904.

187A
Apical Localization of the Integrin Heterodimer, αPS3βPS, Promotes Engulfment and Cell Corpse Processing in the Drosophila Ovary. Tracy Meehan1, Allison Timmons1, Sarah Kleinsorge2, Jeffrey Taylor1, Sarah Yunes1, Kimberly McCall1. 1) Department of Biology, Boston University, Boston, MA; 2) Graduate Program in Genetics and Genomics, Boston University, Boston, MA.

188B
Cell polarity and Notch signaling - an "EXTRA" job for Crumbs. Linda Nemetschke, Elisabeth Knust. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, Dresden, Germany.

189C
A Flamingo isoform lacking part of the Flamingo extracellular domain can send PCP signals in Fz -independent manner. Jun Wu, Marek Mlodzik. Dept. of Developmental and Regenerative Biology, Icahn Sch Medicine at Mount Sinai, New York, NY 10029.

190A
A genetic screen identifies Rab35 and membrane trafficking regulators that control Transverse-tubule membrane remodeling required for muscle function. Naonobu Fujita, Wilson Huang, Amy Kiger. Section of Cell and Developmental Biology, UCSD, San Diego, CA.

191B
Rabs and Vacuoles : The role of Abd-B in male accessory glands trafficking. Elodie Prince1, Marko Brankatschk2, Dragan Gligorov1, Robert K. Maeda1, Suzanne R. Eaton2, François Karch1. 1) Genetics & Evolution, University of Geneva, GENEVA, GE, Switzerland; 2) Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

192C
Egalitarian links oskar mRNA to motor complexes in Drosophila oocyte. Paulomi B. Sanghavi1, Caryn Navarro2, Graydon Gonsalvez1. 1) Cellular Biology and Anatomy, Georgia Regents University, Augusta, GA; 2) Biomedical Genetics Boston University School of Medicine, Boston, MA 02118.

193A
The role of N-Cadherin in myoblast adhesion and its regulation during fusion. Carina Braukmann1, Christine Dottermusch-Heidel1, Verena Groth2, Julia Hamp1, Marco Rust3, Susanne-Filiz Önel1. 1) Developmental Biology, Philipps Universität Marburg, Marburg, Hessen, Germany; 2) Christian-Albrechts-Universität zu Kiel, Institut für Humanernährung und Lebensmittelkunde, Molekulare Prävention, Kiel, Germany; 3) Institut für Physiologische Chemie, Philipps Universität Marburg, Hessen, Germany.

194B
Exocyst complex are required for fusion of dense exocytotic rods to lacuna membrane in Drosophila nephrocytes to maintain highly dynamic endocytic cycling. Fujian Zhang1, Ying Zhao1, Tiffany Chang1, Yufang Cao1, Katherine Muir1, Zhe Han1,2. 1) Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI; 2) Sanford Burnham Medical Research Institute, La Jolla, CA.

195C
Dynamin acts downstream of Tramtrack69 in the Drosophila ovary to promote epithelial tube expansion. Nathaniel C. Peters, Celeste A. Berg. Department of Genome Sciences / Molecular and Cellular Biology Program, University of Washington, Seattle, WA.

196A
Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of Oskar. Yi-Cheng Tsai1, Wei Chiang1, Willisa Liou4, Wei-Hao Lee1, Yu-Wei Chang1, Pei-Yu Wang2,3, Yi-Chen Li1, Tsubasa Tanaka5, Akira Nakamura5, Li-Mei Pai1,2,3. 1) Graduate Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Taiwan; 2) Department of Biochemistry, Chang Gung University, Tao-Yuan, Taiwan; 3) Chang Gung Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan; 4) Department of Anatomy, College of Medicine, Chang Gung University, Tao-Yua; 5) Department of Germline Development, Division of Organogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University 2-2-1 Honjo, Kumamoto 860-0811 Japan.

197B
Dop/MAST2 kinase promotes protrusion formation during the collective migration of border cells. George Aranjuez1,2, Alistair Langlands3, Arno Müller3, Jocelyn McDonald1,2. 1) Molecular Genetics, Cleveland Clinic Foundation, Cleveland, OH; 2) Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH; 3) Cell and Developmental Biology, University of Dundee, UK.

198C
Mechanical feedback through E-cadherin amplifies guidance signaling in collective border cell migration. Danfeng Cai1,2, Mohit Prasad1,3, Shann-Ching Chen4, Li He1,5, Xiaobo Wang1,6, Valerie Choesmel-Cadamuro6, Jessica Sawyer1,7, Gaudenz Danuser8, Denise Montell1,2. 1) Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD; 2) Molecular, Cellular and Developmental Biology Department University of California, Santa Barbara, CA; 3) Department of Biological Sciences, IISER-Kolkata, West Bengal 741252, India; 4) Life Technologies, South San Francisco, CA; 5) Department of Genetics, Harvard Medical School, Boston, MA; 6) Université P. Sabatier Toulouse III, 31062 Toulouse cedex9. FRANCE; 7) Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC; 8) Department of Cell Biology, Harvard Medical School, Boston, MA.

199A
Epithelial rotation promotes the global alignment of contractile actin filaments during Drosophila egg chamber elongation. Maureen P. Cetera1, Guillermina R. Ramirez-San Juan1, Patrick W. Oakes1, Lindsay Lewellyn1,3, Michael J. Fairchild2, Guy Tanentzapf2, Margaret L. Gardel1, Sally Horne-Badovinac1. 1) University of Chicago, Chicago, IL; 2) University of British Columbia, Vancouver, BC, Canada; 3) Butler University, Indianapolis, IN.

200B
Cytoskeletal and signaling factors act non-autonomously to regulate dorsal appendage morphogenesis. Sandra G. Zimmerman, Celeste A. Berg. Deptartment of Gemone Sciences, University of Washington, Seattle, WA.

201C
Regulation of Eyes shut trafficking and rhabdomere separation by O-glucose. Amanda Haltom1,2, Tom Lee2, Beth Harvey3, Jessica Leonardi2,4, Yi-Jiun Chen5, Yang Hong5, Robert Haltiwanger3, Hamed Jafar-Nejad1,2,4. 1) Program in Genes and Development, University of Texas Health Science Center, Houston, TX; 2) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 3) Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY; 4) Program in Developmental Biology, Baylor College of Medicine, Houston, TX; 5) Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

202A
Actomyosin contraction assists lumen formation and expansion in Drosophila photoreceptor cells. Jing Nie, Simpla Mahato, Andrew Zelhof. Department of Biology, Indiana University Bloomington, Bloomington, IN.

203B
Investigating the role of Mmp1 in cell migration using a larval epidermis wound healing model. Erica Shannon, Joshua Clanton, Andrea Page-McCaw. Vanderbilt University Medical Center, Nashville, TN.

204C
Differential Roles of Dock Family Members in Development. Bridget H. Biersmith1, Erika R. Geisbrecht1,2. 1) University of Missouri - Kansas City, Kansas City, MO; 2) Kansas State Univerity, Manhattan, KS.

205A
Novel, tension-responsive adhesive structures mediate cell attachment to the ECM during dorsal closure. Stephanie J. Ellis, Katie Goodwin, Emily Lostchuck, Guy Tanentzapf. Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

206B
Functional analysis of Cell-ECM adhesion during Dorsal Closure using quantitative imaging and mathematical modeling. Katharine Goodwin, Stephanie Ellis, Emily Lostchuck, Qiming Wang, James Feng, Guy Tanentzapf. University of British Columbia, Vancouver, Canada.

207C
Analysis of the role of talin in force-mediated regulation of integrin turnover. Gudlaug K. Hakonardottir1, Raibatak Das3, Pablo Lopez1, Stefan Czerniecki1, Daniel Coombs2, Guy Tanentzapf1. 1) Department of Cellular and Physiological Sciences, University of British Columbia, Life Science Institute, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada; 2) Department of Mathematics and Institute of Applied Mathematics, 1984 Mathematics Road, University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada; 3) Integrative Biology, University of Colorado Denver, Denver, CO.

208A
The stability of the integrin adhesion complex is modulated by mechanical force. Pablo López Ceballos1, Guðlaug Katrín Hákonardóttir1, Stefan Czerniecki1, Alejandra Herrera Reyes2, Raibatak Das3, Daniel Coombs2, Guy Tanentzapf1. 1) Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC; 2) Mathematics, University of British Columbia, Vancouver, BC; 3) Integrative Biology, University of Colorado Denver, Denver, CO.

209B
PDZ-GEF/Rap1 regulate dynamic cell adhesion during border cell collective migration. Ketki Sawant1,2, George Aranjuez1,3, Jocelyn McDonald1,2,3. 1) Molecular Genetics, Lerner research institute, cleveland, OH; 2) Cleveland State university, Cleveland , Ohio; 3) Department of Genetics, School of Medicine, case Western Reserve University, OH.

210C
Automated multidimensional image analysis reveals a role for Abl in embryonic wound repair. Teresa Zulueta-Coarasa1, Rodrigo Fernandez-Gonzalez1,2,3. 1) Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON; 2) Department of Cell and Systems Biology, University of Toronto, Toronto, ON; 3) Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON.

211A
Quantification of mechanical force driving left-right asymmetric morphogenesis of the embryonic gut. Mai Adachi1, Naotaka Nakazawa1,2, Reo Maeda2, Shukei Sugita3, Takeo Matsumoto3, Kenji Matsuno1. 1) Biological Sciences, Osaka University, Toyonaka, Japan; 2) Biological Science & Technology, Tokyo University of Science, Katsushika, Japan; 3) Mechanical Engineering, Nagoya Institute of Technology, Nagoya, Japan.

212B
Huntingtin transports a novel class of vesicles on Drosophila larval axons. Joseph White, Shruthi Srinivasan, Kan Hong Zheng, Shermali D. Gunawardena. Biological Sciences, SUNY at Buffalo, Buffalo, NY.

213C
An analysis of maternally expressed Blastoderm specific gene 25D in oogenesis and early Drosophila embryogenesis. Michelle A. Kowanda1, Stephanie Yee1, Julie Bergalet2, Michal Wieczorek1, Gary Brouhard1, Eric Lécuyer2, Paul Lasko1. 1) McGill University, Montreal, Quebec, Canada; 2) Institut de Recherches Cliniques de Montréal, Montreal, Canada.

214A
Dynamic Actin-based Extensions Mediate Myoblast Fusion in Developing Flight Muscles. Dagan Segal, Benny Shilo, Eyal Schejter. Department of Molecuar Genetics, Weizmann Institute of Science, Rehovot, Israel.

215B
Fondue and Tiggrin Interaction at Muscle-Muscle Attachments. Nicole Green1, Nadia Odell2, Clara Bazjek3, Shufei Zhuang4, Mitch Dushay3, Erika Geisbrecht1. 1) Biochemistry & Molecular Biophysics Dept., Kansas State University, Manhattan, KS; 2) Cell Biology & Biophysics Dept., University of Missouri-Kansas City, Kansas City, MO; 3) Biology Dept., Illinois Institute of Technology, Chicago, IL; 4) University of Kansas Cancer Center, Kansas University Medical Center, Kansas City, KS.

Cell Biology and Signal Transduction


216C
Hyperphosphorylation and high levels of activity of the GPCR Smoothened are regulated by the Fused kinase. Isabelle Becam1, Matthieu Sanial1, Line Hofmann1, Julien Béhague1, Vanessa Gourhand1, Robert Holmgren2, Anne Plessis1. 1) Institut Jacques Monod, CNRS, Univ Paris Diderot, F-75205 Paris, France; 2) Dept. of Mol. Biosc., Northwestern Univ., Evanston, IL 60208-3500, USA.

217A
Phosphorylation of the Smo tail is controlled by membrane localization and is dispensable for clustering. Adam P. Kupinski2, Isabel Raabe1, Marcus Michel1, Christian Boekel1. 1) CRTD, TU Dresden, Dresden, Germany; 2) Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

218B
Characterization of a novel Wnt signaling factor regulating tissue homeostasis in the intestine of Drosophila melanogaster. Anna-Lisa Boettcher, Teresa Eichenlaub, Jun Zhou, Michael Boutros. Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Baden-Wurttemberg, Germany.

219C
Self-association of the APC tumor suppressor is required for the assembly, stability and activity of the Wnt signaling destruction complex. Ezgi Kunttas-Tatli1, David Roberts2, Brooke M. McCartney1. 1) Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213; 2) Department of Biology, Franklin and Marshall College, Lancaster, PA 17604.

220A
Genetic control of cardiac inflow tract formation. Dalea Nodal, Gloriana Trujillo, Richard Cripps. Biology, Univ New Mexico, Albuquerque, NM.

221B
An in vivo kinome and phosphatome RNAi screen in the Drosophila wing imaginal disc identifies a novel regulator of Wnt/Wg secretion. Tirthadipa Pradhan, Esther Verheyen. SSB7152,MBB, Simon Fraser Unversity, Burnaby, BC, Canada.

222C
Drosophila Matrix Metalloproteinase 2 inhibits Wingless signaling and the proliferation of follicle stem cells via processing of Dally-like protein. Xiaoxi Wang, Andrea Page-McCaw. Vanderbilt University Medical Center, Nashville, TN.

223A
Testing the models: Direct binding of β-catenin to the 20 amino acid repeats of APC is dispensible for Wnt regulation. Robert Yamulla, Eric Kane, Alexandra Moody, Kristin Politi, Andrew Foley, David Roberts. Franklin & Marshall College, Lancaster, PA.

224B
A pilot screen for deficiencies that alter wing phenotypes from overexpression of a hyperactive Smad gene. Leeda Barikzi1,2, Carla Cortez1,2, Lina Truong1,2, Laurel Raftery1. 1) School of Life Sciences, University of Nevada, Las Vegas, NV; 2) Authors contributed equally to this work.

225C
BMP signaling and extracellular matrix in the pupal wing are regulated by the receptor guanylyl cyclase Gyc76C and the cGMP-dependent kinase Foraging. Justin Schleede, Seth S. Blair. Dept Zoology, Univ Wisconsin, Madison, WI.

226A
An Inwardly Rectifying K+ channel regulates Dpp Release. Giri Raj Dahal, Emily Bates. Developmental Biology-PEDS, Univ Colorado Denver Anschutz Medical Campus, Aurora, CO.

227B
Mad linker phosphorylation controls the range of BMP activity in the wing imaginal disc. Edward Eivers, Marlyn Rios, Matthew Juarez, Fletcher Przybyla, Daniel Lee, Ashley Su, Abigail Aleman. Department of Biological Sciences, California State University Los Angeles, Los Angeles, CA. 90032-8201. USA.

228C
A Novel Role for UDP-GlcNAc in Dpp Signal Antagonism. Matthew J. Moulton, Gregory B. Humphreys, Anthea Letsou. Human Genetics, University of Utah, Salt Lake City, UT.

229A
Linker domain phosphorylation of Mad reduces its activity, independent of effects on protein levels. Seema Patel, Travis Parsons, Alexi Brooks, Laurel Raftery. School of Life Sciences, University of Nevada, Las Vegas, Las Vegas, NV.

230B
Identification of novel maternal neurogenic genes that are potential components of Notch signaling in Drosophila. Takuma Gushiken1,2, Kenjiroo Matsumoto2, Ryo Hatori2, Tomoko Yamakawa2, Takeshi Sasamura2, Kenji Matsuno2. 1) Department of Biological Science and Technology, Tokyo University of Science, Japan; 2) Department of Biological Science, Osaka university, Japan.

231C
Xylose is a novel ligand-specific regulator of Notch signaling in Drosophila. Tom Van Lee1, Hamed Jafar-Nejad1,2. 1) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 2) Program in Developmental Biology, Baylor College of Medicine, Houston, TX.

232A
Roles of glycan modifications of Notch receptor in Drosophila Notch signaling. Kenjiroo Matsumoto, Akira Ishio, Takeshi Sasamura, Tomoko Yamakawa, Kenji Matsuno. Biological Science, Osaka University, Toyonaka, Osaka, Japan.

233B
Drosophila TRAF2 physically interacts with Notch receptor and downregulates its signaling activity. Abhinava K. Mishra, Nalani Sachan, Ashim Mukherjee. Molecular and Human Genetics, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

234C
Functions of a neurogenic gene, pecanex in Notch signaling. Tomoko Yamakawa, Yu Atsumi, Shiori Kubo, Kenji Matsuno. Osaka Univ, Osaka, Japan.

235A
Ack regulates Dock localization to promote Drosophila spermatogenesis. Abbas Abdallah, James Clemens, Henry Chang. Purdue University, West Lafayette, IN.

236B
Rap1 and PDZ-GEF contribute to the apical localization of the Sevenless receptor tyrosine kinase during Drosophila eye development. Caroline Baril, Martin Lefrançois, Marc Therrien. IRIC-University of Montreal, Montreal, PQ, Canada.

237C
Investigation of novel epidermal growth factor receptor target genes implicated in multiple aspects of Drosophila development. Luke Dombert, Kristopher Krawchuk, Sean Thomas, Connor Zale, Lisa Kadlec. Department of Biology, Wilkes University, Wilkes-Barre, PA.

238A
Screening for novel PLCγ inhibitors in Drosophila melanogaster. Chitra Naidu, Claire Rosenwasser, Todd Rosenberg, Michelle Latino, Justin Thackeray. Biology Department, Clark University, Worcester, MA.

239B
The dorsal ridge: a TGF-alpha-like mediated morphological novelty on the Drosophila eggshell. Matthew G. Niepielko, Nir Yakoby. CCIB, Rutgers University, Camden, NJ.

240C
PVR receptor tyrosine kinase is required for dorsal closure in parallel with JNK signaling. Rebecca Garlena1, Ashley Lennox2, Beth Stronach1. 1) Dept Micro & Mol Genetics, Univ Pittsburgh Sch Medicine, Pittsburgh, PA; 2) Dept Mol Genetics & Micro, Duke Univ Med Cntr, Durham, NC.

241A
Src-kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila. Vasilios Tsarouhas, Liqun Yao, Christos Samakovlis. Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

242B
An in vivo RNAi screen identifies new regulators of invasive cell specification. Afsoon Saadin, Michelle Starz-Gaiano. University of Maryland Baltimore County, Baltimore, MD.

243C
Localization of Insulin Receptor Function in Metabolic Regulation of Sleep. Wesley L. Bollinger1, Katelyn Offerdahl1, Pavel Masek1, Yoon-Joon Kim2, Alex Keene1. 1) Biology, University of Nevada, Reno, Reno, NV; 2) Life Science, Gwangju University, Gwangju, South Korea.

244A
Pri peptides mediate ecdysone developmental timing for epidermal morphogenesis. Helene Chanut-Delalande1,2, Yoshiko Hashimoto5, Anne Pélissier-Monier1,2, Rebecca Spokony3, Azza Dib1,2, Jérôme Bohère1,2, Yvan Latapie1,2, Philippe Valenti1,2, Cédric Polesello1,2, Bernard Moussian4, Kevin White3, Serge Plaza1,2, Yugi Kageyama5, François Payre1,2. 1) Centre de Biologie du Développement, Toulouse, France; 2) CNRS, UMR5547, Centre de Biologie du Développement, Toulouse, France; 3) Institute for Genomics and Systems Biology and Department of Human Genetics, University of Chicago, Illinois, USA; 4) Animal Genetics, Interfaculty Institute for Cell Biology, University of Tübingen, Germany; 5) Research Center for Environmental Genomics, Organization of Advanced Science and Technology, Kobe University, Japan.

245B
Inhibition of JNK pathway by Myc under stress in Drosophila. Jiuhong Huang1,2, Li He2, Norbert Perrimon2, Lei Xue1. 1) School of Life Science and Technology, Tongji University, Shanghai, China; 2) Department of Genetics, Harvard Medical School, Boston, MA.

246C
Raw-Mediated JNK Signaling Antagonism: Keeping hyperactive JNK signaling in check. Molly C. Jud, Anthea Letsou. Human Genetics, University of Utah, Salt Lake City, UT.

247A
Rab GTPases and their role in glue secretion in the larval salivary gland. Kathryn Lantz, Christopher Hardy, Andrew Andres. University of Nevada, Las Vegas, LAS VEGAS, NV.

248B
Dual functionality of O-GlcNAc transferase is required for Drosophila development. Daniel N. Mariyappa1, Xiaowei Zheng1, Arno Muller2, Daan van Aalten1,3. 1) MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Angus, United Kingdom; 2) Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Angus, United Kingdom; 3) Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Angus, United Kingdom.

249C
Hemocyte-mediated repair: promoting retinal repair with MANF. Joana Neves, Deepak Lamba, Heinrich Jasper. Buck Institute for Research on Aging, Novato, CA.

250A
PS2 Integrins are important for glia cell migration into the eye imaginal disc. Ligia Tavares, Emiliana Pereira, Rui Traquete, Andreia Correia, Nuno Amaral, João B. Relvas, Paulo S. Pereira. IBMC, Porto, Porto, Portugal.

251B
A novel tool to monitor and specifically manipulate cells in which Yorkie is nuclear. Ryohei Yagi, Marc Debrunner, Franz Mayer, Konrad Basler. Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.

252C
Characterization of the subcellular localization of BMP receptors. Ilaria Alborelli, Markus Affolter. Biozentrum, Basel, Switzerland.

253A
JNK and DPP act in a feed-forward loop to achieve robustness during Dorsal Closure. Antoine Ducuing, Bertrand Mollereau, Stephane Vincent. LBMC, Ecole Normale Supérieure de Lyon, Lyon, France.

254B
The Polarized Deposition of Basement Membrane Proteins Depends on Phosphatidylinositol Synthase and the Levels of Phosphatidylinositol 4,5-bisphosphate. Olivier Devergne, Karen Tsung, Gail Barcelo, Trudi Schüpbach. HHMI/Molecular Biology, Princeton University, Princeton, NJ.

255C
An examination of the requirement for septate junction components during morphogenesis in Drosophila melanogaster. Sonia Hall, Beth Jarvis, Robert Ward. Molecular Biosciences, University of Kansas, Lawrence, KS.

256A
The Drosophila T-box Transcription Factor Midline Functions within the Insulin Receptor Activated Signaling Pathway to Regulate Interommatidial Bristle Formation and Cell Survival. Sandra M. Leal, Qichuan Chen, Sudeshna Das, Yan Zong, Robert Smith, Kelly Odom, Wisam Buti, Brielle Menegazzi. Dept Biological Sci, Univ Southern Mississippi, Hattiesburg, MS.

257B
Functional specificity in highly conserved Drosophila zinc transport genes. Christopher D. Richards, Jessica Lye, Richard Burke. School of Biological Science, Monash University, Melbourne, Australia.

258C
Digitor, an Essential Protein with Homology to Mammalian ATMIN is Involved in Brain Development and Oxidative Stress Pathways in Drosophila. Saheli Sengupta, Changfu Yao, Uttama Rath, Jack Girton, Jorgen Johansen, Kristen Johansen. Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, IA.

259A
Drosophila Acinus: A Genetic Link Between Autophagy and Hippo Signaling. Lauren K. Tyra1, Nilay Nandi1, Gabrielle Zuniga2, Cecilia Esquivel3, Helmut Krämer1. 1) Neuroscience, UT Southwestern Medical Center, Dallas, TX; 2) SURF Program, UT Southwestern Medical Center, Dallas, TX; 3) STARS Program, UT Southwestern Medical Center, Dallas, TX.

Cell Cycle and Cell Death


260B
Mitotic role of SCFSkp2 in maintaining genome stability. Biju Vasavan, Nilanjana Das, Andrew Swan. Biological Sciences, University of Windsor, Windsor, Ontario, Canada.

261C
The roles of mir-2a in Drosophila eye development. Su-Wen Cheng2,3, Y. Henry Sun2,3, Yu-Chen Tsai1. 1) Dept Life Science, Tung-hai Univ, Taichung, Taiwan; 2) Institute of Genetics, Yang-Ming Unv, Taipei, Taiwan; 3) Institute of Mol., Bio., Academia Sinica, Taipei, Taiwan.

262A
Evaluating the Roles of Blm and rtel in Homologous Recombination in D. melanogaster. Christopher Rota, Susan McMahan, Jeff Sekelsky. Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

263B
Mutations in C-terminal domain of Orc6 affect origin recognition complex function. Maxim Balasov1, Franziska Bleichert2, Michael Botchan3, James Berger3, Igor Chesnokov1. 1) Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine; 2) Miller Institute for Basic Research in Science, University of California, Berkeley; 3) Department of Molecular and Cell Biology, University of California, Berkeley.

264C
Evaluating the requirement of Mcm10’s expanded CTD in D. melanogaster. Michael C. Reubens, Tim W. Christensen. Biology, East Carolina University, Greenville, NC.

265A
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster. Wayne Rummings, Michael Reubens, Lucas Hopkins, Tim Christensen. Biology, East Carolina University, Greenville, NC.

266B
Essential role of the BLM helicase in syncytial cycles. Eric P. Stoffregen1, Kathryn P. Kohl1,2, Susan McMahon1, Jeff Sekelsky1,2. 1) Department of Biology, University of North Carolina, Chapel Hill, NC 27599; 2) Curriculum in Genetics and Molecular Biology.

267C
Intrinsic and extrinsic signals activate neural stem cell apoptosis through coordinated cell death gene expression. Richa Arya, Tatevik Keshishyan, Kristin White. CBRC, MGH/HARVARD, CHARLESTOWN, MA.

268A
The role of pro-apoptotic genes in the developing Drosophila optic lobe cell death. Hidenobu Tsujimura1, Ayaka Tsutsumi1, Kengo Beppu1, Yu Togane1, Yusuke Hara1, Hiromi Akagawa1,2, Ryo Iiduka1. 1) Dept Dev Biol, Tokyo Univ Agric & Tech, Fuchu-si, Tokyo, Japan; 2) Department of Biological Production Science, Tokyo University of Agriculture and Technology.

269B
Drosophila MOF and genome stability: a chromatin modifier to the rescue. Arpita Sarkar1, Sncvl Pushpavalli1, Manika Pal-Bhadra1, Utpal Bhadra2. 1) chemical biology, IICT, Hyderabad, Andhra Pradesh, India; 2) Centre for Cellular and Molecular Biology,Hyderabad.

270C
NuA4 Acts as a Timer in the Transition to a Postmitotic State. Kerry Flegel, Olga Grushko, Kelsey Bolin, Ellen Griggs, Laura Buttitta. University of Michigan, Ann Arbor, MI.

271A
Regulation of cell death in the Drosophila ovary by Snail family genes. Victoria Kathryn Jenkins, Kim McCall. Department of Biology, Boston University, Boston, MA.

272B
Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring Helix-Loop-Helix regulation. Lan-Hsin Wang1, Nicholas Baker1,2,3. 1) Genetics Dept, Albert Einstein College of Medicine, NY; 2) Developmental and Molecular Biology Dept, Albert Einstein College of Medicine; 3) Ophthalmology and Visual Sciences Dept, Albert Einstein College of Medicine.

273C
The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB. Sharon M. Gorski1,2, Lindsay DeVorkin1,2, Nancy Erro Go1,2, Claire Hou1,2, Annie Moradian1, Gregg B. Morin1,2. 1) Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada; 2) Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.

274A
A novel Fizzy/Cdc20-dependent mechanism suppresses necrosis in neural stem cells. Chaoyuan Kuang1, Krista Golden2, John Damrath2, Claudio Simon2, Laura Buttitta5, Cheng-Yu Lee1,2,3,4. 1) Program in Cellular and Molecular Biology; 2) Life Sciences Institute; 3) Department of Internal Medicine; 4) Department of Cell and Developmental Biology, University of Michigan Medical School; 5) Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.

275B
Quantitative Analysis of Drosophila Embryonic Epidermal Development. Cody E. Narciso1, Jessica Freeman1, Jochen Kurswe2, Alexander Fletcher2, Jeremiah Zartman1. 1) Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN; 2) Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.

276C
Dmp53 interacts with the Hippo pathway to regulate cell proliferation and apoptosis. Shilpi Verghese1, Amit Singh1,2,3, Madhuri Kango-Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Center for Tissue Regeneration and Engineering at Dayton (TREND); 3) Premedical Programs, University of Dayton, Dayton OH 45469.

277A
Cell death as a defence against cytosolic DNA in Drosophila. Nazarii Vitak1, Karyn Johnson2, David Sester1, Katryn Stacey1. 1) School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia; 2) School of Biological Sciences, University of Queensland, Brisbane, QLD, Australia.

Cell Division and Growth Control


278B
Examination of the ER-specific Rab10 GTPase on ER partitioning during mitosis. Elliott Holt, Zane Bergman, Blake Riggs. Biology, San Francisco State University, San Francisco, CA.

279C
Spindle Matrix Formation is Required for Cyclin B Localization, Nuclear Envelope Breakdown, and Cell Cycle Progression. Jorgen Johansen, Changfu Yao, Jack Girton, Kristen Johansen. Biochem, Biophys & Molec Biol, Iowa State Univ, Ames, IA.

280A
Drosophila cytokinesis proteins regulate meiotic spindle assembly and homologue bi-orientation in oocytes. Arunika Das, Kim McKim. Waksman Institute,Rutgers University, New Jersey.

281B
Proposed cohesin complexes in Drosophila meiosis. Mercedes R. Gyuricza, Kathryn B. Landy, Kim S. McKim. Waksman Institute, Rutgers University, Piscataway, NJ.

282C
Germline progenitors escape the widespread phenomenon of homolog pairing during Drosophila development. Eric Joyce, C.-ting (Ting) Wu. Department of Genetics, Harvard Medical School, Boston, MA.

283A
Analysis of Meiotic functions of Sisters Unbound Reveals Similarities to Drosophila Cohesion Proteins. Badri Krishnan1, Sharon Thomas1, Igor Zhulin2, Hirotsugu Yamada1, Rihui Yan1, Bruce McKee1. 1) BCMB , University of Tennessee Knoxville, Knoxville, TN; 2) Department of Microbiology, University of Tennessee, Knoxville.

284B
Synaptonemal Complex Protein c3G is required for regulating crossover frequency. John R. Merriam. Dept Molec/Cell/Dev Biol, Univ California, Los Angeles, CA.

285C
Effects of SMC3 RNAi knockdown in Drosophila male meiosis. Avik Mukherjee. Genome Science and Technology, University of Tennessee, Knoxville, TN.

286A
A splice variant of centrosomin (Cnn) converts mitochondria into MTOCs to facilitate sperm tail elongation. Jieyan Chen, Timothy Megraw. Biomedical Sciences, Florida State University, Tallahassee, FL.

287B
The PCL acts as a sperm centriolar precursor during fertilization. Atul Khire1, Stephanie Blachon2, Tomer Avidor-Reiss1. 1) Department Biological Sciences, The University of Toledo, Toledo, OH-43606; 2) Hybrigenics, 3-5 impasse Reille, 75014 PARIS.

288C
Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells. Kiichiro Taniguchi1, Akihiko Kokuryo2,3, Takao Imano2,3, Ryunosuke Minami4, Hideki Nakagoshi4, Takashi Adachi-Yamada1,2,3. 1) Dept. Life Sci., Fac. Sci., Gakushuin University, Tokyo, Japan; 2) Inst. Biomol. Sci., Gakushuin University, Tokyo, Japan; 3) Dept. Biol., Grad. Sch. Sci., Kobe University, Kobe, Japan; 4) Grad. Sch. Nat. Sci./Tech., Okayama University, Okayama, Japan.

289A
Small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines. Miranda Burnette1, Jonathan Chen1, Jun Li2, Jeremiah Zartman1. 1) Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN; 2) Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame IN.

290B
Troponin-I localizes cell polarity signals and is required for tumor growth. Sergio Casas-Tinto, Alberto Ferrus. Cajal Institute, Madrid, Spain.

291C
A screen for Tribbles interacting genes using FijiWings, a toolkit for semi-automated wing morphometric analysis. Leonard L. Dobens, Anna Shipman. Sch Biological Sci, Univ Missouri, Kansas City, Kansas City, MO.

292A
Healing a fly by increasing cell size through polyploidization and fusion. Vicki Losick1, Allan Spradling1,2. 1) Dept Embryology, Carnegie Institution for Science, Baltimore, MD; 2) Howard Hughes Medical Institute.

293B
CG10126 is a downstream target of EGFR signaling. Qian Nie, Susan Spencer. Department of Biology, Saint Louis, MO.

294C
Non-autonomous tissue growth by endocytic regulation of Eiger and Ras signaling. Kyoko Takino1,2, Shizue Ohsawa1, Tatsushi Igaki1,3. 1) Lab. of Genetics, Kyoto Univ. Grad. Sch. of Biostu, Kyoto, Kyoto, Japan; 2) Division of Genetics, Kobe Univ. Grad. Sch. of Med; 3) PRESTO, Japan Science and Technology Agency.

295A
Identification and study of new genes involved in epithelial growth and morphogenesis. Parvathy Venugopal, Vincent Mirouse. GReD, Clermont University, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France.

296B
Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins. Venu Reddy Bommireddy Venkata1,2, Ken Irvine2. 1) KS 338D, ACTREC, TMH, Navi Mumbai, Maharastra, India; 2) Waksman Institute, Rutgers University, Piscatway, NJ 08854.

297C
Nitric oxide signaling in the prothoracic gland regulates growth coordination during the regeneration checkpoint. Jacob Jaszczak, Jacob Wolpe, Anh Dao, Adrian Halme. Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA.

298A
Genetic control of tissue specific growth in the larval trachea of Drosophila. Paulo Leal, Brett Bohmann, Cyril Cook, Alex Matlock, Robert Ward. Dept. of Molecular Biosciences, University of Kansas Lawrence, KS.

299B
Non-cell autonomous tumor progression driven by cell cycle arrest. Nakamura Mai1, Ohsawa Shizue1, Igaki Tatsushi1,2. 1) Kyoto University, Kyoto, Sakyo-ku, Japan; 2) PRESTO, JST, Japan.

300C
Identification of new Fat-Dachsous signaling regulators in growth control. Yifei Zhang, Xing Wang, Seth Blair. Zoology Dept, UW Madison, Madison, WI.

301A
Dynein Light Chain 1 (DLC1) is required for normal growth in Drosophila Melanogaster. Daniel Allyn Barron, Kenneth Moberg. Dept Cell Biol, Emory Univ Sch Med, Atlanta, GA.

302B
Regenerative signals regulate the timing of epithelial tumor development through ecdysone signaling. Thu Tran, Rebecca Garrett, Rajan Bhandari, Adrian Halme. Cell Biology, University of Virginia, Charlottesville, VA.

303C
Disc overgrown (Dco) as a player in Drosophila haematopoiesis. Lucie Jonatova, Tomas Dolezal. University of South Bohemia, Ceske Budejovice, Czech Republic.

304A
d-Csk regulates growth via the Hippo signaling pathway. Hailey J. Kwon1, Indrayani Waghmare1, Shilpi Verghese1, Madhuri Kango-Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Center for Tissue Regeneration and Engineering at Dayton, Dayton, OH; 3) Premedical Programs, University of Dayton, Dayton, OH 45469.

305B
A role for Spaetzle in sensing and signaling during cell competition. Lale Alpar1, Cora Bergantiños2, Marc Amoyel2, Laura A. Johnston2. 1) Biological Sciences, Columbia University, New York, NY; 2) Genetics and Development, Columbia University, New York, NY.

306C
Mosaic Ribosomal protein S6 deficiency: a Minute mouse model for studying cell competition. Laina Freyer, Nicholas E. Baker, Bernice E. Morrow. Genetics, Albert Einstein College of Medicine, Bronx, NY.

307A
A Transcriptional profiling approach to identify genes defining the loser cell identity in cell competition. Iwo Kucinski, Eugenia Piddini. Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.

308B
Mechanical processing of differential cell division during epithelial cell competition. Alice Tsuboi1, Shizue Ohsawa2, Kenji Matsuno1, Tatsushi Igaki2, Koichi Fujimoto1. 1) Graduate School Of Science, Osaka Univ., toyonaka, Japan; 2) Graduate School Of Biostudies, Kyoto Univ., Sakyo-ku, Japan.

309C
A Drosophila model to study signaling and intercellular interactions that Promote Aggressive Tumorigenesis. Indrayani Waghmare1, Shilpi Verghese1, Austin Roebke3, Amit Singh1,2,3, Madhuri Kango-Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH; 3) Premedical Programs, University of Dayton, Dayton OH 45469.

310A
Identification of factors regulating regenerative growth in Drosophila imaginal discs. Syeda Nayab Fatima Abidi, Amanda Brock, Sumbul Jawed Khan, Rachel Smith-Bolton. CDB, UIUC, Urbana, IL.

311B
Pattern reorganization occurs independently of cell division during Drosophila wing disc regeneration in situ. Sandra Diaz-Garcia1, Antonio Baonza2. 1) Division of Biological Sciences, University of California, San Diego, San Diego, CA; 2) Centro de Biología Molecular Severo Ochoa, Universidad Autonoma de Madrid. Madrid, Spain.

312C
Control of cell division during epithelial repair. Telmo Pereira, Marco Antunes, Antonio Jacinto. CEDOC - Centre for Studies in Chronic Diseases, Lisboa, Portugal.

313A
Nucleoporin Nup98 is required for normal tissue growth and cell cycle regulation. Kiriaki Kanakousaki, Olga Grushko, Laura Buttitta. Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI.

314B
Uncovering the principles of organ regeneration in Drosophila using whole-genome transcription profiling. Sumbul Jawed Khan, Syeda Nayab Fatima Abidi, Yuan Tian, Rachel K. Smith-Bolton. Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL.

315C
Chameleon: a mutant with an increased frequency of notum-to-wing transdetermination. Melanie I. Worley, Iswar K. Hariharan. Molec & Cell Biol, Univ California, Berkeley, Berkeley, CA.

316A
Zonda: a novel gene involved in autophagy and growth control. Mariana Melani1, Nuria Romero1, Julieta Acevedo1, Joel Perez Perri1, Eleonora Sorianello1, Ayelen Valko1, Milton Aguilera2, Maria Colombo2, Pablo Wappner1. 1) Fundacion Instituto Leloir-CONICET, Buenos Aires, Argentina; 2) Instituto de Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo-CONICET, Mendoza, Argentina.

317B
Muscle organizer cells regulate myoblast proliferation during adult myogenesis in Drosophila. Kumar Vishal, Mary Turvy, Kevin Venczel, Lindsay Grainger, Joyce Fernandes. Department of Zoology, Maimi University, Oxford, OH.

Physiology, Organismal Growth, and Aging


318C
Mating-Reward Reverses the Effects of Pheromone Perception in Drosophila. Zachary M. Harvanek1,2, Christi M. Gendron1, Brian Y. Chung1, Scott D. Pletcher1. 1) Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI; 2) Medical Scientist Training Program, University of Michigan, Ann Arbor, MI.

319A
Drosophila embryogenesis scales uniformly across temperature in diverse species. Steven G. Kuntz1,2, Michael B. Eisen1,2,3. 1) QB3, UC Berkeley, Berkeley, CA; 2) Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA; 3) Howard Hughes Medical Institute, UC Berkeley, Berkeley, CA.

320B
Role of ADI1 in regulation of ER stress. Wei-Cheng Lin, Li-Mei Pai. Chang-Gung University, Tao-Yuan, Taiwan.

321C
Heat stress disrupts key events in early embryonic development. Brent L. Lockwood, Kristi L. Montooth. Biology, Indiana University, Bloomington, IN.

322A
Oxidative stress and the fly metabolome. Thomas JS Merritt, Jose M. Knee. Chemistry & Biochemistry, Laurentian University, Sudbury, Ontario, Canada.

323B
The Fruit Fly: A Tractable System to Study Cold Tolerance. Daniel Ricketti1, David Luor1, Kosha Parikh1, Nuray Sariaydin1, Mohammad Khan1, Alessio Russomanno1, Daniel Shain1,2, Nir Yakoby1,2. 1) Biology Department, Rutgers, The State University of New Jersey, Camden, NJ; 2) Center for Computational and Integrative Biology, Rutgers, The State University of New Jersey, Camden, NJ.

324C
A Role for Drosophila p38 MAP Kinase in Protein Homeostasis. Sarah Ryan1, Amelia M. Burch2, Subhabrata Sanyal3, Alysia D. Vrailas-Mortimer1. 1) Biological Sciences, University of Denver, Denver, CO; 2) Department of Cell Biology, Emory University, Atlanta, GA; 3) BiogenIdec, Boston, MA.

325A
Hypoxia-induced insulin resistance and associated lipid metabolism defects in Drosophila melanogaster. Daniel Wong, Julian Martinez-Agosto. Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA.

326B
Desiccation regulates innate immunity via ecdysone signaling in Drosophila Malpighian tubules. Wenjing Zheng1, Ana Hernandez1, Florintina Rus2, Neal Silverman2, Marc Tatar1. 1) Ecology and Evolutionary Biology Department, Brown University, Providence, RI, USA; 2) Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical, Worcester, MA, USA.

327C
Seipin promotes adipose tissue fat storage through the ER Ca2+-ATPase SERCA. Junfeng Bi, Wei Wang, Zhonghua Liu, Xun Huang. Institute of Genetics and Developmental Biology, CAS, Beijing, China.

328A
The Roles of Endocannabinoids and Their Chemical Relatives in Regulating Drosophila melanogaster Metabolism. Ruth A. Bishop. Biology, The University of Alabama, Shreveport, LA.

329B
Metabolism and Locomotion in Anoxic Drosophila. Viviane Callier1, Steven C. Hand2, Jacob B. Campbell1, Jon F. Harrison1. 1) Arizona State University, Tempe, AZ; 2) Louisiana State University, Baton Rouge, LA.

330C
Dietary and Genetic Regulation of Longevity and Neuronal Function in Drosophila. Eric Ratliff1,2,3, Madhulika Achal1, Roxanne Kotzebue1,2, Arysa Gonzalez1,2,3, Ruth Mauntz1,3, Kim Finley1,3. 1) Shiley BioScience Center, San Diego State University, San Diego, CA; 2) Dept. Biology, SDSU; 3) Expression Drug Designs, LLC., SDSU, San Diego, CA.

331A
Genetic and metabolic bases of thermal plasticity in Drosophila. Luke A. Hoekstra, Kristi L. Montooth. Dept Biol, Indiana Univ, Bloomington, IN.

332B
Lost in translation: a mitonuclear interaction affecting metabolism, stress resistance and aging associated with mitochondrial tRNA mutations. Marissa A. Holmbeck1, David M. Rand2. 1) Bio-Med, Brown University, Providence, RI; 2) Ecology and Evolutionary Biology, Brown University, Providence RI, USA.

333C
Regulation of energy metabolism by the nuclear receptor DHR78. Stefanie M. Marxreiter, Carl S. Thummel. Human Genetics, University of Utah, Salt Lake City, UT.

334A
Regulation of glucose homeostasis by dsir2 in Drosophila melanogaster. Rebecca A. Somer, Carl S. Thummel. Human Genetics, University of Utah, Salt Lake City, UT.

335B
Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila. Eugenia Villa-Cuesta1, Marissa Holmbeck2, David Rand2. 1) BIOLOGY, DEPARTMENT OF, Adelphi University, Garden City, NY; 2) Department of Ecology and Evolutionary Biology, Brown University, RI, USA.

336C
Comparing Nutrient Restrictions and its Effects on Metabolic Output in Drosophila melanogaster. Rebecca A. Vaders1, Alexis A. Nagengast1,2. 1) Chemistry, Widener University, Chester, PA; 2) Biochemistry, Widener University, Chester, PA.

337A
Mio and bigmax act in the brain to control feeding and metabolism in Drosophila. James E. Docherty, Sarah M. Rosenheck, Joseph E. Manno, Jacqueline E. McDermott, Justin R. DiAngelo. Biology, Hofstra University, Hempstead, NY.

338B
The Role of dTORC1 on Muscle Development, Function and Longevity in Drosophila. Isabelle Hatfield1, Erika Yates1, Lawrence Reiter2,3, Dave Bridges1,3. 1) Department of Physiology, University of Tennessee Health Science Center, Memphis, TN; 2) Department of Neurology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163; 3) Children's Foundation Research Institute, Le Bonheur Children's Hospital, Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, Memphis, TN 38103.

339C
The Effect of Bacteria on Oviposition Preference of Drosophila melanogaster. Geon Ho Kim, Peter Newell, Angela Douglas. Entomology, Cornell University, Ithaca, NY.

340A
The Modified Effects of Bisphenol A (BPA) in Response to Dietary Composition. Ashley L. Parker, Trisha M. Zintel, Amber K. Weiner, AnnJosette Ramirez, Sheryl T. Smith. Biology, Arcadia University, Glenside, PA.

341B
Identification of Neurosensory Mechanism for Dietary Protein by Drosophila melanogaster. Jennifer Ro1, Gloria Pak2, Scott D. Pletcher3. 1) Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI; 2) College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI; 3) Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.

342C
Rapamycin reduces Drosophila longevity under low nutrition. Eugenia Villa-Cuesta1, Rand David2. 1) BIOLOGY, DEPARTMENT OF, Adelphi University, Garden City, NY; 2) Department of Ecology and Evolutionary Biology, Brown University, Providence, RI , USA.

343A
Influence of gene duplication on a critical hormone signaling pathway in Drosophila. Aaron Baumann, Raechel Warner, Michael Texada, Hui-Min Chen, James Truman, Lynn Riddiford. Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA.

344B
The Drosophila Neuropeptide F Circuit Integrates Sleep and Feeding Behavior to Regulate Aging. Brian Y. Chung1, Jenny Ro2, Kylie Miller3, Scott D. Pletcher1. 1) Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI; 2) Cellular and Molecular Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI; 3) College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI.

345C
The steroid deficiency protein Ecdysoneless is a pre-mRNA splicing factor. Ann-Katrin Claudius1, Patrizia Romani2, Tobias Lamkemeyer3, Marek Jindra4, Mirka Uhlirova1. 1) Institute for Genetics, CECAD Cologne, University of Cologne, Cologne, Germany; 2) Dipartimento di Biologia Evoluzionistica Sperimentale, Università di Bologna, Bologna, Italy; 3) Proteomics Facility, CECAD, University of Cologne, Cologne, Germany; 4) Biology Center, Academy of Sciences of the Czech Republic, Ceske Budejovice, Czech Republic.

346A
Met/Gce is a bona fide juvenile hormone receptor. Marek Jindra1,2, Jean-Philippe Charles3, Vlastimil Smykal1, Mirka Uhlirova4, Ron Hill2. 1) Dept Gen, Biol Ctr ASCR, Ceske Budejovice, Czech Republic; 2) Animal, Food and Health Sciences, CSIRO, North Ryde NSW, Australia; 3) Université de Bourgogne, Dijon, France; 4) Institute for Genetics, CECAD Cologne, University of Cologne, Cologne, Germany.

347B
Drosophila neurotrophin Spätzle5 is required for ecdysone synthesis. Qiuxiang Ou, Brian Phelps, Kirst King-Jones. Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.

348C
The effects of Bisphenol A (BPA) and Bisphenol S (BPS) on growth and development in Drosophila: A comparative study. Amber K. Weiner, Trisha M. Zintel, Ashley L. Parker, AnnJosette Ramirez, Sheryl T. Smith. Biology, Arcadia University, Glenside, PA.

349A
Nocturnin (curled) is involved in the regulation of ecdysone production via interaction with Drosophila Hormone Receptor 4. Jie Zeng, Qiuxiang Ou, Kirst King-Jones. Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.

350B
Exposure of D. melanogaster larvae to BDE-47 is associated with altered larval growth and delayed pupal development. Trisha M. Zintel, Ashley L. Parker, Amber K. Weiner, AnnJosette Ramirez, Shane A. Harris, Sheryl T. Smith. Biology Dept, Arcadia University, Glenside, PA.

351C
Does Rapamycin improve lifespan and healthspan? A test with multiple mitonuclear genotpyes and dietary treatments. James A. Mossman, Julia Donner, Denise Croote, Russyan Mark Mabeza, Matthew Min, Michele Koh, Neha Mehta, Emma Blake, Eugenia Villa Cuesta, David Rand. Ecology and Evolutionary Biology, Brown University, Providence, RI.

352A
The Role of miR-310s in ovarian soma in response to dietary conditions. Omer Cicek, Halyna Shcherbata. MPRG of Gene Expression and Signaling, Max Planck Institute, Goettingen, Germany.

353B
A proteomic screen towards identifying fat body factors transmitting nutritional status to stem cell lineages in the Drosophila ovary. Shinya Matsuoka1,3, Alissa Armstrong1,3, Leesa Sampson1, Kaitlin Laws1, Robert Cole2, Daniela Drummond-Barbosa1. 1) Biochemistry and Molecular Biology, JHU Bloomberg School of Public Health, Baltimore, MD; 2) Mass Spectrometry and Proteomics Facility, JHU School of Medicine, Baltimore, MD; 3) These authors contributed equally.

354C
The regulation of muscle function by Mio in Drosophila. Grzegorz Polak, Justin R. DiAngelo. Department of Biology, Hofstra Univ, Hempstead, NY.

355A
Analysis of βν integrin mutant showing a premature aging phenotype in Drosophila adult midgut. Takashi Okumura1,2, Koji Takeda1, Kiichiro Taniguchi1, Takashi Adachi-Yamada1. 1) Department of Life Science, Gakushuin University; 2) Department of Physics, Faculty of Science and Engineering, Waseda University.

356B
Salivary gland subcellular organization and regulatory conservation in Anopheles mosquitoes. Michael B. Wells, Deborah J. Andrew. Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD.

357C
Insulin signaling related function of Tribbles during Drosophila development. Rahul Das, Zach Sebo, Leonard Dobens. Cell & Molecular Biology, University of Missouri-Kansas City, Kansas City, MO 64110.

358A
Effect of insulin signaling on sexual attractiveness and performance. Tatyana Y. Fedina, Scott D. Pletcher. Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.

359B
Quantitative Analysis of the Effects of Insulin and Tor Signalling on Ageing in Drosophla. Corinna Hopfen1, Nicole Philippi1, Linda Partridge1,2. 1) Max-Planck Institut for Biology of Ageing, Joseph-Stelzmann-Straβe 9b, 50931, Cologne, NRW, Germany; 2) Institute of Healthy Ageing, and G.E.E., UCL, Gower Street, London, WC1E 6BT, UK.

360C
Regulatory mechanism of the nutrient-dependent expression of Drosophila insulin-like peptide gene. Naoki Okamoto, Takashi Nishimura. Center for Developmental Biology (CDB), RIKEN, Kobe, Hyogo, Japan.

361A
The nutritional geometry of insulin shapes the landscape of aging. Stephanie Post1, Marc Tatar1,2. 1) Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI; 2) Ecology and Evolutionary Biology, Brown University, Providence, RI.

362B
Exploring the interface of endoplasmic reticulum stress and insulin signal transduction. Zachary Sebo, Rahul Das, Leonard Dobens. Division of Molecular Biology and Biochemistry, UMKC, Kansas City, MO.

363C
Genetic regulation of regeneration. Robin Harris, Joshua Saul, Iswar Hariharan. MCB, University of California, Berkeley, Berkeley, CA.

364A
Interaction proteomics identify a novel translational repressor complex involved in p38MAPK-mediated control of myoproteostasis. Vladimir Belozerov1, Helen McNeill2, Arthur Hilliker1, John McDermott1. 1) Biology, York University, Toronto, ON, Canada; 2) Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

365B
Genetic and Morphological Characterization of Male Reproductive Senescence. Michelle Giedt, Douglas Harrison. Biology Department, University of Kentucky, Lexington, KY.

366C
Hypoxia effects on survival, fecundity and media of Drosophila. Jon F. Harrison, Saundra Schlessinger, Taylor Biddulph, Stephanie Heinrich, Nicole Holden, Katrina Ramsey. School of Life Sciences, Arizona State University, Tempe, AZ.

367A
A DGRP screen to identify host response factors to growth promotion effect mediated by Lactobacillus plantarum. Dali Ma, Claire-Emmanuelle Indelicato, François Leulier. Institut de Genomique Fonctionnelle de Lyon, ENS de Lyon, Lyon, France.

368B
Characterization of Bacterial factors underlying Drosophila - Lactobacilli mutualistic interactions. Gilles Storelli1, Jumamurat Bayjan2, Roland Siezen2, Sacha Van Hijum2, François Leulier1. 1) Institute of Functional Genomics Lyon (IGFL), CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France; 2) Nijmegen Centre for Molecular Life Sciences, CMBI, Nijmegen, The Netherlands.

369C
Transcription factors FTZ-F1 and Blimp-1 in fat body control the pupal development and eclosion timing in Drosophila. Hitoshi Ueda1,2, Abdel-Rahman Sultan2. 1) Dept Biol, Okayama Univ, Okayama, Japan; 2) The Grad. Sch. Nat. Sci. and Tech. Okayama Univ. Okayama, Japan.

Gametogenesis and Organogenesis


370A
Histone H1 Linker-Like and Transition Proteins involved in chromatin condensation in Drosophila. Zain A. Alvi, Tin-Chun Chu, Angela V. Klaus. Department of Biological Sciences, Seton Hall University, South Orange, NJ 07079.

371B
Genetic analysis of the spermeye region. Stephen Anderson, Steven Hernandez, Ujwala Gosavi, Chris Bazinet. Biological Sciences, St. John's University, Queens, NY.

372C
Nuclear and chromatin remodeling events during spermiogenesis are modulated by phosphoinositide levels. Lacramioara Fabian1, Julie Brill1,2. 1) Program in Cell Biology, Hospital for Sick Children, Toronto, Canada; 2) Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada.

373A
Essential roles for Profilin in the soma of the fly testes. Michael Fairchild, Guy Tanentzapf. Cell and Developmental Biology, University of British Columbia, Vancouver, British Columbia, Canada.

374B
Probing glycine metabolism in Drosophila. Ujwala Ashok Gosavi, Christopher Bazinet. St Johns University, Jamaica, Queens, NY.

375C
Identification of genes involved in spermatid morphogenesis. Dorota B. Grabowska, Arshag Mooradian, Kaushik Roychoudhury, Kathryn G. Miller. Department of Biology, Washington University, 1Brookings Drive St.Louis, MO 63130.

376A
Phosphatidylinositol 4,5-bisphosphate is required for axoneme assembly in Drosophila melanogaster spermatids. Alind Gupta1, Lacramioara Fabian2, Julie Brill1,2. 1) Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada; 2) Program in Cell Biology, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.

377B
Tudor-SN interacts with Piwi in regulating spermatogenesis in Drosophila. Hsueh-Yen Ku1, Vamsi Gangaraju1,2, Na Liu1, Haifan Lin1. 1) Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT; 2) Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC.

378C
Ectopic expression of male germline-specific RpL22e-like in RpL22e-depleted flies rescues embryonic lethality but causes reduced longevity and fertility. Catherine Mageeney, Michael Kearse, Jennifer Colquhoun, Vassie Ware. Dept. of Biological Sciences, Lehigh University, Bethlehem, PA 18015.

379A
Lipid signaling in spermatogenesis. Eli Miller, Geulah Ben-David, Josefa Steinhauer. Department of Biology, Yeshiva University, New York, NY.

380B
Analyzing the critical role of Pskl, a sperm protein, in Drosophila fertilization. Trung Phan, Barbara Wakimoto. Biology, University of Washington, Seattle, WA.

381C
The testis-enriched ATP synthase subunit d paralog Ms(2)1400 is required for Nebenkern organization and elongation in Drosophila spermatogenesis. Eric M. Sawyer, Lindsay Regruto, Olivia Brown, Yihharn Hwang, Lauren Ivey, Karen G. Hales. Department of Biology, Davidson College, Davidson, NC.

382A
Functional analysis of novel dual localization AAA proteins Nmd and CG4701 in mitochondrial, microtubule, and contractile ring dynamics in Drosophila spermatogenesis. Bethany L. Wagner, Devon E. Harris, Sarah C. Pyfrom, Jessica L. Gerard, Melissa E. Lorenzo, James J. Winkle, Karen G. Hales. Department of Biology, Davidson College, Davidson, NC.

383B
Roles of individual subunits of the testis meiotic arrest complex in transcriptional control. Simona Caporilli, Robert Pickering, Daphne Davies, Helen White-Cooper. Sch Biosci, Cardiff Univ, Cardiff, United Kingdom.

384C
Nuclear hormone receptor Eip78C controls ovarian germline stem cell niche formation and follicle growth and survival. Elizabeth T. Ables1,2, Kelly E. Bois2, Caroline A. Garcia1, Daniela Drummond-Barbosa2. 1) Dept. of Biology, East Carolina University, Greenville, NC; 2) Dept. of Biochemistry and Molecular Biology, Johns Hopkins University School of Public Health, Baltimore, MD.

385A
The roles of Cyclins A, B and B3 in Drosophila female meiosis. Mohammed R. Bourouh, Zhihao Guo, Rajdeep Dhaliwal, Sucheta Sinha. Biological Sciences, University of Windsor, Windsor, Ontario, Canada.

386B
Sea2, a conserved SEA/GATOR2 complex component, is required for oogenesis in Drosophila. Weili Cai, Youheng Wei, John Reich, Mary Lilly. NICHD, National Institutes of Health, Besthesda, MD.

387C
Purity of essence: a new E3 ubiquitin ligase family member in Drosophila oogenesis. Paromita Gupta1, Christopher Bazinet1, Janet Rollins2. 1) Biological Sciences, St John's University, New York, NY; 2) College of Mount Saint Vincent, New York, NY.

388A
Finding Novel “expressways” for gurken Translation. John W. Hasper, Austie F. Lawrence, Scott B. Ferguson. Biology, SUNY Fredonia, Fredonia, NY.

389B
Direct regulation of broad by the Notch pathway affects timing of follicle cell development during Drosophila oogenesis. Dongyu Jia, Wu-Min Deng. Department of Biological Science, Florida State University, Tallahassee, FL.

390C
Investigating Function and Composition of Follicle Cell Ring Canals in Drosophila. Ronit Kaufman1, Peter McLean1, Lynn Cooley1,2,3. 1) Department of Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520; 2) Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520; 3) Department of Molecular, Cellular, and Developmental Biology (MCDB), Yale University, 260 Whitney Avenue, New Haven, CT 06510.

391A
asteroid is required for oocyte determination and DNA repair. Julie A. Merkle, Trudi Schüpbach. HHMI/Molecular Biology, Princeton University, Princeton, NJ.

392B
The effects of mad2 deficiency on Drosophila female meiosis. David M. Osiecki, William D. Gilliland. Department of Biological Sciences, DePaul University, Chicago, IL.

393C
Cbl regulates endoreplication by controlling cytoophidia. Li-Mei Pai, Pei-Yu Wang. Dept Biochem & Molec Biol, Chang-Gung Univ, Tao-Yuan, Taiwan.

394A
Deciphering Thioredoxin function during Drosophila oogenesis. Boryana Petrova1, Zachary Whitfield1,2, Terry Orr-Weaver1,2. 1) Whitehead Institute, Cambridge, MA 02142; 2) Dept. of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.

395B
Ectopic expression of caspase-resistant B-type lamin in the germline results in aberrant nuclear architecture and morphology of mature oocytes. Alla Yalonetskaya, Elizabeth Tanner, Margaret Barkett, Jeanne Peterson, Kimberly McCall. Department of Biology, Boston University, Boston, MA.

396C
Investigation of the Roles of Proteins that Alter Phosphorylation State upon Egg Activation in Drosophila melanogaster. Zijing Zhang, Amber Krauchunas, Carolyn Milano, Mariana Wolfner. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

397A
The functional and structural analysis of germline Tudor protein complex. Ming Gao, Patrick McCluskey, Yanyan Lin, Alexey Arkov. Murray State University, Murray, KY.

398B
A genomic analysis of doublesex (dsx) targets and function in sex determination. E. Jimenez1, E. Clough2, C. Whitworth1,2, Y. Kim3, M. Goodwin4, L. Hempel2, H. Pavlou4, Z. Chen2, D. Sturgill2, R. Dale5, H. Smith6, T. Przytycka3, S. Goodwin4, M. Van Doren1, B. Oliver2. 1) JHU, Baltimore, MD; 2) Sect. Dev. Gen., Lab. Cell. Dev. Bio., NIDDK, NIH, Bethesda, MD; 3) Comp. Biol. Branch, NCBI, NLM, NIH, Bethesda, MD; 4) Dep. Phys., Anat. Gen., U Oxford, UK; 5) Lab. Cell. Dev. Bio., NIDDK, NIH, Bethesda, MD; 6) Gen. Core, NIH, Bethesda, MD.

399C
The grappa gene is target of the Doublesex transcription factors and is required for sex differentiation and gonad development. Satish Kumar, Emily Clough, Cale Whitworth, Brian Oliver, Doublesex Consortium. Section of Developmental Genomics, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

400A
Investigating the role of Sex Lethal in the germline of Drosophila Melanogaster. Shekerah Primus, Mark Van Doren. Department of Biology, Johns Hopkins University, Baltimore, MD.

401B
Mechanism and targets of a seminal protein proteolysis cascade in Drosophila. Frank W. Avila, Brooke A. LaFlamme, Kevin Michalski, Mariana F. Wolfner. Dept Mol Biol & Gen, Cornell Univ, Ithaca, NY.

402C
Nup50 is a lineage-specific nucleoporin required for germ cell differentiation. Jonah Cool1, Leanne Jones2, Martin Hetzer1. 1) MCBL, Salk Institute, La Jolla, CA; 2) MCDB, UCLA, Los Angeles, CA.

403A
Identification of novel Akirin-interacting factors during embryonic myogenesis. Austin Howard, Katharine Majeski, Shelby Johnston, Aayushi Bhagwanji, Scott Nowak. Dept. of Biology and Physics, Kennesaw State University, Kennesaw, GA.

404B
Non-canonical roles for Yorkie, Drosophila Inhibitor of Apoptosis 1, and DrICE in epithelial tube size control. Renee M. Robbins, Samantha C. Gbur, Greg J. Beitel. Molecular Biosciences, Northwestern Univ, Evanston, IL.

405C
Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification. S. M. Ahmad1,3, B. W. Busser1,3, D. Huang2,3, E. J. Cozart1, S. Michaud1, X. Zhu1, N. Jeffries1, I. Ovcharenko2, A. M. Michelson1. 1) NHLBI, NIH, Bethesda, MD; 2) NLM, NIH, Bethesda, MD; 3) Equally contributing authors.

406A
Characterization of the Role of BTB Family Proteins in Embryonic Gonad Formation. Jennifer C. Jemc, Andrew Droste, Diane Silva, Christopher Lenkeit. Dept. of Biology, Loyola University Chicago, Chicago, IL.

407B
Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation. Se-Yeon Chung, Deborah Andrew. Dept Cell Biol, Johns Hopkins Univ, Baltimore, MD.

408C
The Role of tbc-1 in Drosophila Salivary Gland Development. Dorothy M. Johnson, Deborah J. Andrew. Cell Biology, Johns Hopkins School Medicine, Baltimore, MD.

409A
Phantom and Shade, two enzymes essential for ecdysone biosynthesis, play a critical role in the control of border cell migration in Drosophila. Lauren Anllo, Elena Domanitskaya, Trudi Schüpbach. HHMI/Dept. of Molecular Biology, PRINCETON UNIVERSITY, PRINCETON, NJ.

410B
The role of Fd64a in salivary gland migration and muscle organization. Caitlin D. Hanlon. Cell Biol, Johns Hopkins Med Inst, Baltimore, MD.

411C
Live imaging of muscle development in akirin mutants. Katharine Majeski, Fatima Ali, Scott Nowak. Dept. of Biology and Physics, Kennesaw State University, Kennesaw, GA.

412A
Traffic Jam controls the architecture of the ovarian germline stem cell niche. Xi Chen, Trupti Panchal, Dorothea Godt. Dept. of Cell and System Biology, University of Toronto, Toronto, Canada.

413B
Snapshots of gene expression during pupal wing development lead to insights about cuticle and chitin deposition. Lukasz F. Sobala1,2, Paul N. Adler1. 1) University of Virginia, Charlottesville, VA; 2) Lodz University of Technology, Lodz, PL.

414C
Matrix metalloproteinase is required for ovulation and corpus luteum formation in Drosophila. Jianjun Sun1, Lylah Deady1, Sarah Mosure1, Allan Spradling2. 1) Department of Physiology & Neurobiology, University of Connecticut, Storrs, CT; 2) Department of Embryology, Carnegie Institution for Science/ HHMI, Baltimore, MD.

Stem Cells


415A
The Hippo pathway controls follicle stem cell maintenance in the Drosophila ovary. Ta-Hsing Hsu1, Jenn-Yah Yu1,2. 1) Department of Life Sciences, Institute of Genomic Sciences, National Yang-Ming University, Taipei, Taiwan; 2) Brain Research Center, National Yang-Ming University, Taipei, Taiwan.

416B
Function of Perlecan in the Drosophila Ovary. Alfonsa Diaz Torres, John Pearson, Acaimo Gonzalez Reyes. Centro Andaluz de Biologia del Desarrollo, Sevilla, Spain.

417C
Piwi is a key regulator of the testicular stem cell niche in Drosophila . Jacob M. Gonzalez, Haifan Lin. Yale Stem Cell Center, Yale University, New Haven, CT.

418A
Snail is required for maintenance of male germline stem cells. Gary R. Hime1, Aviv Gafni1, Arjun Chahal1, Agnes Gany1, Franca Casagranda1, Kate L. Loveland2, Helen E. Abud2. 1) Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia; 2) Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.

419B
A novel DnaJ domain protein activates integrin signaling to maintain stem cell niche in Drosophila. Joo-Yeun Lee. University of Southern California.

420C
DNA damage disrupts stem cell-niche interaction and differentiation program in the Drosophila ovary. Xing Ma1,2, Xiaoqing Song1, Trieu Do1, Ting Xie1,2. 1) Stowers Institute for Medical Research, Kansas city, MO; 2) University of Kansas Medical Center Kansas City, KS.

421A
Aging-induced Notch signaling suppresses adhesiveness of germline stem cells to the niche via E-cadherin. Chen-Yuan Tseng1,2, Shih-Han Kao1, Chih-Ling Wan1, Yueh Cho1, Shu-Yun Tung3, Hwei-Jan Hsu1. 1) Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan; 2) Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan; 3) Genomic Core Facility, Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.

422B
Cellular and molecular regulation of stem cell niche quiescence. Leah J. Greenspan, Phylis Hetie, Erika Matunis. Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.

423C
The receptor tyrosine kinase Pvr in the Drosophila testis stem cell niche. Kenneth Hammer, Judith Leatherman. Biological Sciences, University of Northern Colorado, Greeley, CO.

424A
Niche signaling regulates stem cell survival under stress-induced conditions in the Drosophila testis niche. Salman Hasan, Phylis Hétié, Erika Matunis. Johns Hopkins Medical Institute, Baltimore, MD.

425B
The Jak-STAT target Chinmo prevents sex transdifferentiation of adult stem cells in the Drosophila testis. Qing Ma1, Matthew Wawersik2, Erika Matunis1. 1) Cell Biology, Johns Hopkins Univ, Baltimore, MD; 2) Biology Dept, The Col of William & Mary, Williamsburg, VA.

426C
BMP signaling is required in the Drosophila testis cyst stem cells. James Major, Judith Leatherman. School of Biological Sciences, University of Northern Colorado, Greeley, CO.

427A
Apontic Functions as a Feedback Inhibitor of STAT to Maintain Niche Integrity and Limit Stem Cell Populations. Amanda J. Monahan, Michelle Starz-Gaiano. Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD.

428B
Role of Notch Signaling in Stem Cell Lineages of Testes. Chun Leung Ng, Cordula Schulz. Department of Cellular Biology, University of Georgia, Athens, GA.

429C
The Wnt signaling and cytoskeletal regulator APC2 controls stem cell niche size, architecture, and stem cell number in the Drosophila ovary. Stacie L. Oliver, Brooke M. McCartney. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.

430A
Ecdysone Regulation of Stem Cell Maintenance in the Drosophila Testis Niche. Yijie Li, Qing Ma, Erika Matunis. Johns Hopkins Medical Inst, Baltimore, MD.

431B
Stem cell division in the testis is affected by environmental rhythms and sleep duration. Natalia M. Tulina1, Jung Hsuan Chen1, Wen-Feng Chen2, Amita Sehgal2. 1) Fox Chase Cancer Center, Philadelphia, PA; 2) HHMI, Unviversity of Pennsylvania, Philadelphia.

432C
The Trithorax (Trx) histone methyl transferase complex maintains neural stem cell heterogeneity in Drosophila larval brain. Hideyuki Komori1, Qi Xiao2, Cheng-Yu Lee1,2,3. 1) Center for Stem Cell Biology, Life Sciences Institute,; 2) Depertment of Cell and Developmental Biology,; 3) Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.

433A
Role of p21-activated kinase Mbt in proliferation of central brain neuroblasts with special focus on the mushroom body neuroblasts. Juliane Melzer2, Karoline F. Kraft1, Rolf Urbach1, Thomas Raabe2. 1) Institute of Genetics, University of Mainz, Mainz, Germany; 2) Institute for Medical Radiation and Cell Research, University of Würzburg, Würzburg, Germany.

434B
Drosophila Phosphotyrosyl Phosphatase Activator (PTPA) Facilitates Miranda dephosphorylation in Early Mitosis and Regulates its Asymmetric Localization in Dividing Neuroblasts. Fan Zhang1, Zhenxing Huang2, Hongcun Bao1, Huashan Wang3, Yu Cai4,5, Xiaohang Yang1. 1) College of Life Sciences, Zhejiang University, Hang Zhou, China; 2) Yong Loo Lin School of Medicine, National University of Singapore; 3) National Neuroscience Institute, Singapore; 4) Temasek Life Sciences Laboratory, Singapore; 5) Department of Biological Sciences, National University of Singapore, Singapore.

435C
split-ends : a novel regulator of adult stem cells in Drosophila intestine. Maheva Andriatsilavo1, Carolina N. Perdigoto1,2, François Schweisguth2, Allison Bardin1. 1) Genetic and Developmental Biology unit, Institut Curie, PARIS, France; 2) GDD unit, Institut Pasteur, Paris France.

436A
Plasticity in Stem Cell Division Pattern and a Negative Feedback Slit-Robo2 Signaling Determine the Secretory EE Cell Fate in the Adult Drosophila Posterior Midgut. Xiankun Zeng, Steven Hou. Stem Cell Regulation and Animal Aging Section, NCI, NIH, Frederick National Laboratory, Frederick, MD.

437B
EGFR Signaling Mediates Intestinal Stem Cell Proliferation via Capicua Regulated Genes in Drosophila. Yinhua Jin, Bruce Edgar. ZMBH-DKFZ, Heidelberg, Germany, Germany.

438C
dWDR40a regulates the mitosis-to-endoreplication transition in the intestinal stem cell lineage. Jihyun Kim1, Dae-sung Hwangbo2, Heinrich Jasper1,2. 1) The Buck Institute for Research on Aging; 2) University of Rochester.

439A
Regulation of pH homeostasis in the Drosophila gastrointestinal tract. Hongjie Li1,2, Yanyan Qi1, Heinrich Jasper1,2. 1) Buck Institute for Research on Aging, Novato, CA, USA; 2) Department of Biology, University of Rochester, Rochester, NY, USA.

440B
Regulation of intestinal stem cells by the Snail family transcriptional repressor Escargot. Mariano A. Loza-Coll1,2, Sharsti S. Sandall2, Tony Southall3,4, Andrea Brand3,4, D. Leanne Jones1,2. 1) Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA; 2) The Salk Institute for Biological Studies, La Jolla, CA; 3) The Gurdon Institue, Cambridge, UK; 4) The University of Cambridge, Cambridge, UK.

441C
Targeted control of mRNA stability reestablishes quiescence in Drosophila intestinal stem cells. Lindy McClelland1,2, Heinrich Jasper1, Benoît Biteau2. 1) The Buck Institute for Research on Aging, Novato, CA; 2) University of Rochester Medical Center, Rochester, NY.

442A
Expression and Function of Group B Sox gene function in adult intestinal stem cells. Joanna Taborda, John Nambu. Biology, Florida Atlantic Univeristy, Jupiter, Fl.

443B
Regulation of String during Drosophila intestinal stem cell proliferation. Jinyi Xiang, Bruce Edgar. Cell growth and proliferation, DKFZ-ZMBH Alliance, Heidelberg, Germany.

444C
Adaptation of Drosophila hematopoiesis through sensory neuron stimulation. Kalpana Makhijani1, Brandy Alexander1, Sophia Petraki1, Stephanie Wachner1,4, Michael O’Connor5, Katja Brückner1,2,3. 1) Dept. Cell & Tissue Biol; 2) Broad Center of Regeneration Medicine and Stem Cell Research; 3) CVRI; University of California San Francisco, CA; 4) University of Heidelberg, Germany; 5) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN.

445A
Cell competition leads to active selection of fitter stem cells and their progeny in adult homeostatic tissues. Golnar Kolahgar, Saskia Suijkerbuijk, Enzo Poirier, Sarah Mansour, Benjamin Simons, Eugenia Piddini. Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.

446B
Novel genes involved in the maintenance of hematopoietic progenitors. Bama Charan Mondal, Cory Evans, Utpal Banerjee. Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA.

447C
Investigating the role of cell competition in Wnt-induced tumorigenesis. Saskia JE Suijkerbuijk, Golnar Kolahgar, Eugenia Piddini. The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, United Kingdom.

Immunity and Pathogenesis


448A
Flow cytometry in detecting blood cell populations during an immune challenge. Laura Vesala1, Ines Anderl1, Dan Hultmark1,2. 1) Institute of Biomedical Technology,University of Tampere, Tampere, Finland; 2) Department of Molecular Biology, University of Umeå, Umeå, Sweden.

449B
The Pallbearer-SCF complex degrades RpS6 and regulates actin to promote apoptotic cell clearance. Hui Xiao1, James Thompson2, John R. Yates Jr. III2, Nathalie C. Franc1. 1) The Department of Immunology & Microbial Science, The Scripps Research Institute, La Jolla, CA; 2) Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA.

450C
JAK/STAT signaling in Drosophila somatic muscles is involved in cellular immune response against parasitoid wasp infection. Hairu Yang, Jesper Kronhamn, Dan Hultmark. Umeå University, Umeå, Sweden.

451A
Damage induced expression of antimicrobial peptides via the Imd pathway in Drosophila larvae. Takayuki Kuraishi1,2, Aki Hori1, Shoichiro Kurata1. 1) Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; 2) PRESTO, Japan Science and Technology (JST).

452B
Spatial and temporal variation in innate immunity. Emily Louise Behrman1, Virgina Howick2, Brian Lazzaro2, Paul Schmidt1. 1) University of Pennsylvania, Philadelphia, PA; 2) Cornell University, Ithaca, NY.

453C
Innate Immune Memory Increases Drosophila melanogaster Resistance to the Lethal Insect Pathogen Xenorhabdus nematophila. Adler R. Dillman1, Marta Andres-Terre2, Brittney Nguyen1, David S. Schneider1. 1) Department of Microbiology and Immunology, Stanford, Stanford, CA; 2) Department of Immunology, Stanford, Stanford, CA.

454A
Sting Governs An Evolutionarily Conserved Innate Immune Pathway. Alan G. Goodman, Brandon M. Kitay, Keiko Konno, Hiroyasu Konno, R. Grace Zhai, Glen N. Barber. University of Miami School of Medicine, Miami, FL.

455B
Lifespan extension by promoting immune homeostasis and limiting commensal dysbiosis in the Drosophila intestine. Linlin Guo1,2, Jason Karpac1, Susan Tran3, Heinrich Jasper1,2,3. 1) Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945- 1400, USA; 2) Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA; 3) Department of Biology, University of Rochester, River Campus Box 270211, Rochester, NY, 14627, USA.

456C
Low Doses of Iron-Oxide Nanoparticles have a Detrimental Effect on Reproduction and Development. Benjamin W. Henderson1, Hunter Dean2, Rami R. Ajjuri1, Yuping Bao2, Janis M. O'Donnell1. 1) Department of Biological Sciences, Box 870344, University of Alabama, Tuscaloosa, AL 35487; 2) Department of Chemical and Biological Engineering The University of Alabama Box 870203 Tuscaloosa, AL 35487-0203.

457A
Gut immune response against Gram-positive bacteria. Aki Hori1, Takayuki Kuraishi1,2, Shoichiro Kurata1. 1) Tohoku University, Sendai, Japan; 2) PRESTO, Japan Science and Technology (JST).

458B
A Drosophila immune response against RasV12-induced altered self. Robert Krautz1, Thomas Hauling2, Robert Markus1, Anne Volkenhoff3, Ulrich Theopold1. 1) Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; 2) Karolinska Institute Science Park, SciLifeLab, Solna, Sweden; 3) Institute of Neuro- and Behavioral Biology, University of Münster, Münster, Germany.

459C
A novel dual role for Notch signaling in maintenance of lamellocyte progenitors and innate immunity to parasitoid wasps in Drosophila. Chiyedza Small1,2,3, Johnny Ramroop2,3, Maria Otazo2, Lawrence Huang2, Shireen Saleque2,3, Shubha Govind2,3. 1) Dept. of Biology, Medgar Evers College, CUNY, 1638 Bedford Ave, Brooklyn, NY, 11225; 2) Dept. of Biology, City College of New York, CUNY, 160 Convent Avenue, NY, NY 10031; 3) The Graduate Center, CUNY.

460A
Impact of prolonged hypergravity on the immune response of Drosophila melanogaster. William D. Wade, Sharmila Bhattacharya. NASA Ames, Moffett Field, CA.

461B
Physiological trade-offs during chronic infection. Moria C. Chambers, Sarah Khalil, Brian P. Lazzaro. Entomology, Cornell University, Ithaca, NY.

462C
Natural Variation Among Drosophila Melanogaster Populations in Response to Beauveria bassiana Exposure. Jessica Y. Chen, Jessica I. Gabrielian, Vivian Lu, Ju-Yin Hsu, Mishan D. Rambukwella, Matthew Salomon, Daniel Campo. Molecular and Computational Biology, University of Southern California, Los Angeles, CA.

463A
Effects of Metabolism and Stress on Immune Defense: Investigating the Molecular Crosstalk between Metabolism, Stress, and the Immune System. Katia Sotelo-Troha1, Nicolas Buchon2, Brian Lazzaro2. 1) Department of Biological & Biomedical Sciences, Cornell University, Ithaca, NY; 2) Department of Entomology, Cornell University, Ithaca, NY.

464B
Factors that influence Wolbachia titer in Drosophila simulans and Drosophila melanogaster. Marissa Cloutier, Jack Manquen, Roger Albertson. Biology Dept, Albion College, Albion, MI.

465C
The impact of nutrients on intracellular Wolbachia titer. Laura R. Serbus1, Pamela White2, Roger Albertson3, Amanda Rabe2, William Sullivan2. 1) Biological Sciences, OE210, Florida International University, Miami, FL; 2) MCD Biology, Sinsheimer 319, University of California, Santa Cruz, CA; 3) Biology Department, Putnam 262, Albion College, Albion, MI.

466A
Genome-wide RNAi screen for host factors that regulate Wolbachia titer. Pamela M. White1, Laura R. Serbus2, William Sullivan1. 1) Molecular, Cell, and Developmental Biology University of California, Santa Cruz 1156 High Street Santa Cruz, CA 95064; 2) Department of Biological Sciences, OE210 Florida International University 11200 SW 8th St Miami, FL 33199.

Neural Development


467B
An RNAi screen identifies a new determinant of R7 photoreceptor axon targeting. Jessica Douthit, Sergio Astigarraga, Jessica Treisman. Department of Cell Biology and Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY.

468C
Slit/Robo-mediated axon guidance in Tribolium and Drosophila. Tim Evans. Biological Sciences, University of Arkansas, Fayetteville, AR.

469A
The Drosophila formin dDAAM is required for axon growth in the developing mushroom body. Rita Gombos, József Mihály. Biological Research Centre, Hungarian Academy of Sciences, Szeged, Csondrad, Hungary.

470B
An RNAi screen to identify extracellular signals required in axonal targeting in the visual system. Justine Oyallon, Sergio Astigarraga, Gina Lee, Brie Wamsley, Felix Simon, Vincent Parillaud, Jessica Treisman. New York University School of Medicine, Skirball Institute of Biomolecular Medicine, New York, NY.

471C
Nejire/CBP regulates dendritic complexity by modulating the localization of Dar1. Sarah G. Clark, Myurajan Rubaharan, M. Jennifer Van, Srividya C. Iyer, Daniel N. Cox. Krasnow Institute, School of Systems Biology, George Mason University, Fairfax, VA.

472A
Dissecting the role of autophagy in mediating sensory neuron dendrite homeostasis. Lacey Graybeal, Srividya C. Iyer, Eswar P. R. Iyer, Caroline Thomas, Myurajan Rubaharan, Daniel N. Cox. Krasnow Institute, School of Systems Biology, George Mason University, Fairfax, VA.

473B
Silencing of the Drosophila ortholog of SOX5 in neurons leads to impaired dendrite differentiation and olfactory perception. Airong Li, Adele Bubnys, Rebecca Tate, Rudolph Tanzi. Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA.

474C
FoxO regulates dendritic morphology and MT organization. James Sears, Heather Broihier. Neurosciences, Case Western Reserve University, Cleveland, OH.

475A
Balancing dendrite-epidermis and dendrite-ECM interactions for dendrite morphogenesis. Conrad M. Tenenbaum, Mala Misra, Elizabeth Gavis. Molecular Biology, Princeton University, Princeton, NJ.

476B
Sexual identity affects the development and mature function of a defined neural circuit in Drosophila melanogaster. Parag Bhatt, Harsha Swamy, Selma Avdagic, Wendi Neckameyer. Pharmcological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO.

477C
Collapsin response mediator protein (CRMP) is required for presynaptic development in R7 photoreceptor neurons. Sarah Casper, Tory Herman. Institute of Molecular Biology, University of Oregon, Eugene, OR.

478A
The transmembrane domain of Neto engages the glutamate receptors and enables their clustering at the Drosophila NMJ. Qi Wang, Young-Jun Kim, Oghomwen Igiesuorobo, Mihaela Serpe. NICHD/NIH,Bethesda,MD.

479B
Expression profiling of R7 and R8 photoreceptors during development of the D. melanogaster eye. Stefan A. Koestler, Arzu Celik-Fuss. Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey.

480C
Studying the eye differentiation in the Drosophila transcriptome. Manon Quiquand1, Nicholas E. Baker1, Dachuan Zhang1, Jackie Han2, Shengbao Suo2, Nan Qiao2, Matthew Slattery3, Kevin White3. 1) Albert Einstein College of Medicine, Bronx, NY; 2) Institute for Computational Biology, Shanghai; 3) Institute for Genomics and System Biology, Chicago, IL.

481A
Combinatorial rules of precursor specification underlying olfactory neuron diversity. Pelin C. Volkan1,2,3, Qingyun Li1, Tal Soo HA4, Sumie Okuwa1, Yiping Wang1, Qian Wang5, S. Sean Millard6. 1) Department of Biology, Duke University, Durham, NC; 2) Department of Neurobiology, Duke University, Durham, NC; 3) Duke Institute of Brain Sciences; 4) Department of Biomedical Science, College of Natural Science, Daegu University, 15 Naeri, Jillyang, Gyeongsan, Gyeongbuk 712-714, South Korea; 5) The Pratt School of Engineering, Duke University, Durham, NC; 6) School of Biomedical Sciences, The University of Queensland, BNE, QUEENSLAND.

482B
Genetic interaction of alan shepard (shep) in neuronal remodeling during metamorphosis. Dahong Chen, Randall Hewes. Department of Biology, University of Oklahoma, Norman, OK.

483C
Lineage-related neuronal wiring properties of the Drosophila brain. Volker Hartenstein1, Jennifer Lovick1, Stephan Saalfeld2, Pavel Tomancak2, Albert Cardona3. 1) MCDB, UCLA, Los Angeles, CA; 2) Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; 3) Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.

484A
Linking cell surface receptor to microtubule: Tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis. Misako Okumura1, Chisako Sakuma1, Masayuki Miura1,2, Takahiro Chihara1,2. 1) Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo; 2) Core Research for Evolutional Science and Technology, Japan Science and Technology Agency.

485B
Analysis of Retinal Basal Glial cell Drivers from Janelia Gal4 Lines in Drosophila Melanogaster. Yen-Ching Chang1,2, Y. Henry Sun1,2. 1) Instituition of Moleuclar biology, Sinica, Taipei, Taipei, Taiwan; 2) Department of Life sciences and Institute of Genome sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China.

486C
RNAi screening for investigation of retinal basal glia development. Tsao Chia-Kang1,2, Sun Y. Henry1,2. 1) Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China; 2) Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China.

487A
Remodeling of peripheral glial ensheathment during metamorphosis - a role for the EGF signaling pathway. Matthew Siefert, Soumya Banerjee, Hayley Gibson, Tara Fallah, Joyce Fernandes. Department of Zoology, Miami University, Oxford, OH.

488B
A Comparison of Midline and Tracheal Gene Regulation during Drosophila Development. Patricia A. Estes1, Sarah K. R. Long1, Eric Fulkerson1, Rebecca Breese1, Giovanna Hernandez1, Cara Davis1, Mark A. Melton2, Rachana R. Chandran3, Napoleon Butler1, Lan Jiang3. 1) Dept of Biological Sciences, North Carolina State Univ, Raleigh, NC; 2) Dept of Biological and Physical Sciences, Saint Augustine's Univ, Raleigh, NC; 3) Dept of Biological Sciences, Oakland University, Rochester, MI.

489C
Investigating the effect of Odd-skipped (Odd) loss-of-function on neuronal specification in Drosophila melanogaster. Mena Farag, Camilla Larsen, Peter Levy. MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom.

490A
Investigating the molecular mechanism of Crimpy-mediated presynaptic Gbb signaling at the NMJ. Kendall Hoover, Rebecca James, Heather Broihier. Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

491B
Characterizing a novel FoxO-dependent neurotrophic pathway. Colleen McLaughlin, Heather Broihier. Neurosciences, Case Western Reserve University , Cleveland , OH.

492C
Connecting dCORL CNS expression and behavioral defects in dCORL mutants. Norma Takaesu1, Agapi Dimitriadou2, Janine Quijano1, Estela Arciniega1, Nancy Tran1, Carsten Duch3, Christos Consoulas2, Stuart Newfeld1. 1) Sch Life Sci, Arizona State Univ, Tempe, AZ; 2) Lab Experimental Physiology, Univ. Athens Medical School, Athens, Greece; 3) Inst. Neurobiology, Johannes Gutenberg Univ. Mainz, Germany.

493A
Characterizing the Role of E-cadherin in Neuroblast Maintenance. Alexis A. Reyes. Vanguard University, Costa Mesa, CA.

494B
Characterization of Group B Sox genes in Development of Adult Nervous System. Shweta Singh, John Nambu. Biology, Florida Atlantic University, Jupiter, FL.

495C
Multi-potent Intermediate Progenitor Cells Are Present Throughout All Pupa Stage In Drosophila melanogaster. Elizabeth R. Swezey. Vanguard University, Costa Mesa, CA.

Neurophysiology and Behavior


496A
Dopamine homeostasis is essential for daily activity and movement behavior in Drosophila melanogaster - a model system to study neurological disorders. Anathbandhu Chaudhuri1, Courtney Cunningham1, Mary Jane Krotzer1, Janis O'Donnell2, Natraj Krishnan3. 1) Department of Natural Sciences, Stillman College, Tuscaloosa, AL; 2) Biological Sciences, University of Alabama, Tuscaloosa, 35487, AL; 3) Department of Biochemistry, Mississippi State University, MS 39762.

497B
Changes in Acetylcholine Release Alter Locomotion and Touch Response Timing in Drosophila. Gabriel Gutierrez1, David Krantz1, Natalie Kendall2, Toshi Kitamoto3, Hakeem Lawal1,2. 1) Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles CA; 2) Neuroscience Program, Department of Biology, Delaware State University, Dover, DE; 3) Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA.

498C
The endosomal Hook protein is required for histamine recycling in the Drosophila visual system. Mokhlasur Rahman, Helmut Kramer. Department of Neuroscience, UT Southwestern Medical Center at Dallas, Dallas, TX.

499A
Control of Body Size by TGF-Beta Signaling. Lindsay Moss-Taylor1, Michael O'Connor2. 1) Molecular, Cellular, Developmental Biology and Genetics Program, University of Minnesota, Minneapolis, MN; 2) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN.

500B
Determination of the location of action of isoflurane in the Drosophila brain. Christina M. Colosimo1, Anna James1, Krista Pearman1, Michelle Peters2, Michael J. Murray3, Gerald B. Call1. 1) Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ; 2) Glendale Community College, Glendale, AZ; 3) Dept of Anesthesiology, Scottsdale, AZ.

501C
Photoreceptor neuron function requires a conserved Ncc69-activating kinase cascade specifically in glia. Drew Stenesen1, Jeffrey Schellinger2, Aylin Rodan2, Helmut Krämer1. 1) Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas; 2) Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.

502A
Minibrain kinase promotes efficient synaptic vesicle recycling. Chun-Kan Chen1,2, Catherine Bregere1, Jeremy Paluch3, Dion Dickman3, Karen Chang1,4. 1) Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA; 2) Dept. Biochemistry & Molecular Biology, University of Southern California, Los Angeles, CA; 3) Dept. of Neurobiology, University of Southern California, Los Angeles, CA; 4) Dept. Cell & Neurobiology, University of Southern California, Los Angeles, CA.

503B
An EP Overexpression Screen for Genetic Modifiers of rab7-Dependent Neurodegeneration in Drosophila Nervous System. Wei-Hung Jung1, Smita Cherry2, Jennifer Jin2, Robin Hiesinger2, Chih-Chiang Chan1. 1) Department of Physiology, National Taiwan University, Taipei, Taiwan; 2) Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

504C
The domain of synaptotagmin implicated in autoimmunity is not required for synaptic function. Michael D. Getzy1, Carin A. Loewen2, Laurie M. Biela1, Noreen E. Reist1. 1) Biomedical Sciences, Colorado State University, Fort Collins, CO; 2) Genetics, University of Wisconsin, Madison, WI.

505A
Functional Role of Mushroom Body Neurons in Courtship Conditioning. Shelby A. Montague, Yoshinori Aso, Gerald M. Rubin, Bruce S. Baker. HHMI Janelia Farm Research Campus, Ashburn, VA.

506B
A novel role for Notch signaling in alcohol reward memory. Arjun Ray1, Reza Azanchi2, Yoshi Aso3, Gerry Rubin3, Ulrike Heberlein3, Karla Kaun2. 1) Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI; 2) Neuroscience , Brown University, Providence, RI; 3) HHMI Janelia Farm Research Campus, Ashburn, VA.

507C
Localization of aversive gustatory memory. Kurtresha Worden1, Yoshi Aso2, Gerald Rubin2, Alex Keene1, Pavel Masek1. 1) University of Nevada, Reno, Sparks, NV; 2) HHMI JFRC, Ashburn, VA.

508A
Male-Specific Fruitless Isoforms Target Neurodevelopmental Genes to Specify a Sexually Dimorphic Nervous System. Megan C. Neville1, Tetsuya Nojima1, Elizabeth Ashley1, Darren Parker2, Tony Southall3, Andrea Brand3, Steven Russell4, Michael Ritchie2, Stein Aerts5, Stephen Goodwin1. 1) Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; 2) Centre for Biological Diversity, University of St Andrews, St Andrews; 3) The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge; 4) Department of Genetics, University of Cambridge, Downing Street, Cambridge; 5) Laboratory of Computational Biology, Department of Human Genetics, University of Leuven.

509B
Investigation into the molecular-genetic basis of Drosophila melanogaster female post-mating behaviors. Nicole R. Newell1, Joyce L. Kao2, Kjong-Van Lehmann2, Karrie D. Dudek1, Christopher L. Souders1, Peter Poon2, Daniel Campo2, Matthew Salomon2, Peter L. Chang2, Tevfik Hamdi Kitapci2, Justin M. Fear3, Justin E. Dalton1, Alison M. Morse3, Simon Tavaré2, Lauren McIntyre3, Sergey Nuzhdin2, Michelle N. Arbeitman1. 1) Department of Biomedical Sciences, Florida State University, Tallahassee, FL; 2) Molecular and Computational Biology, University of Southern California, Los Angeles, CA; 3) Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL.

510C
Modeling the circadian oscillator protein network in Drosophila melanogaster. Vu Lam, Ying Li, Jonathan Diehl, Joanna Chiu. Entomology and Nematology, UC Davis, Davis, CA.

511A
A novel Bayesian approach to social structure uncovers cryptic regulation of group dynamics. Brad R. Foley1, Julia B. Salz1, Sergey V. Nuzhdin1, Paul Marjoram2. 1) Molecular and Computational Biology, University of Southern California, Los Angeles, CA; 2) Keck School of Preventative Medicine, University of Southern California, Los Angeles, CA.

512B
The blood-brain barrier regulates ecdysone signalling in the CNS, affecting neurophysiology and behaviour. Samantha Hindle1, Souvinh Orng1, Michael DeSalvo1, Elena Dolgikh2, Hiroshi Ishimoto3, Fahima Mayer1, Toshihiro Kitamoto3, Matt Jacobson2, Roland Bainton1. 1) Department of Anesthesia, University of California San Francisco, CA; 2) Department of Pharmaceutical Chemistry, University of California San Francisco, CA; 3) Department of Anesthesia, University of Iowa, IA.

513C
Screening for a receptor for the Drosophila seminal fluid protein, ovulin. Jennifer Apger McGlaughon, Brooke A. LaFlamme, Mariana F. Wolfner. Cornell University, Ithaca, NY.

514A
Steroid signaling modulates nociception in Drosophila melanogaster. Aidan L. McParland, Mona Roesler, Geoffrey K. Ganter. Biology, University of New England, Biddeford, ME.

515B
Ecdysis Triggering Hormone acts on neurons to both positively and negatively regulate wing expansion. Rebecca Vaadia, Feici Diao, Benjamin H. White. Laboratory of Molecular Biology, NIMH, Bethesda, MD.

516C
Ecdysteroid plays a role in Drosophila nociception. Gwendolyn Davis Vesenka, Geoffrey K. Ganter. Biology Department, University of New England, Biddeford, ME.

517A
Behavioral Analysis of the Pruritus Response in Drosophila melanogaster. Ciny John, Edward Kempf, John Nambu. Department of Biological Sciences, Charles E. Schmidt College of Science, Florida Atlantic University, Jupiter, FL.

518B
Roles for jim lovell in larval feeding behavior and embryonic development. Kathleen M. Beckingham, Fanli Zhou, Cheng Wang. Dept Biochem & Cell Biol, Rice Univ, Houston, TX.

519C
Quantitative Genetics of Food Intake in Drosophila melanogaster. Megan Garlapow1, David Threadgill2, Trudy Mackay1. 1) Program in Genetics, Department of Biological Sciences, College of Science, North Carolina State University, Raleigh, NC; 2) Department of Veterinary Pathobiology, Texas A&M University, College Station, TX.

520A
The Anatomy and Function of Enteric Neurons. Marion Hartl, Dafni Hadjieconomou, Irene Miguel-Aliaga. Gut Signalling and Metabolism, MRC Hammersmith Campus, London, United Kingdom.

521B
Selection for starvation resistance promotes sleep and inhibits foraging behaviors in Drosophila. Pavel Masek1, Lauren Reynolds2, Wesley Bollinger1, Catriona Moody1, Aradhana Mehta1, Allen Gibbs2, Alex Keene1. 1) Dept of Biology, University of Nevada, Reno, NV; 2) School of Life Sciences, University of Nevada, Las Vegas, NV, 89154.

522C
Neural translin Regulates Metabolic Control of Sleep. Maria E. Yurgel1, Kaz Murakami1, Aradhna Mehta1, Justin DiAngelo2, Pavel Masek1, Alex C. Keene1. 1) University of Nevada, Reno, 1664 N. Virginia Street, Reno, NV 89557; 2) Hofstra University, 900 Fulton Avenue, Hempstead, NY, 11549.

523A
Acute hypergravity alters locomotor behavior and causes physiological stress in Drosophila melanogaster. Ravikumar Hosamani1, Jarret Weinrich2, Curran Reddy1, Sharmila Bhattacharya1. 1) NASA Ames Research Center, Mountain View, CA; 2) Weill Medical College of Cornell University, NY.

524B
Intracellular calcium signaling specifies dopaminergic neurons required for wing coordination during Drosophila flight. Sufia Sadaf, Sanjay Sane, Gaiti Hasan. National Centre for Biological Sciences, TIFR, Bangalore-560065, India.

525C
stallone and balboa are DEG/ENaC genes required for mechanical nociception in Drosophila larvae. Stephanie Mauthner1, Richard Hwang2, Qi Xiao2, W. Daniel Tracey1,2,3. 1) Univ Prog Genetics and Genomics, Duke University, Durham, NC; 2) Department of Neurobiology, Duke University, Durham, NC; 3) Department of Anesthesiology, Duke University Medical Center, Durham, NC.

526A
Dopaminergic pathways innervating Mushroom Bodies are involved in olfactory responses in Drosophila melanogaster. Nicolás Fuenzalida-Uribe, Jorge M. Campusano. Departamento de Biología Celular y Molecular, Universidad Católica de Chile, Santiago, Chile.

527B
Genome-wide Association Mapping of Natural Variation in Odor-guided Behavior in Drosophila. Elizabeth B. Brown1, John E. Layne1, Cheng Zhu2, Anil G. Jegga3,4, Stephanie M. Rollmann1. 1) Department of Biological Sciences, University of Cincinnati, Cincinnati, OH; 2) Department of Computer Science, University of Cincinnati, OH; 3) Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 4) Department of Pediatrics, University of Cincinnati, Cincinnati, OH.

528C
Molecular and Physiological Characterization of Drosophila melanogaster 4th Order Olfactory Neurons. Amanda J. Crocker1,2, Coleen Murphy2,3, Mala Murthy1,2. 1) Princeton Neuroscience Institute, Princeton University, Princeton, NJ; 2) Molecular Biology, Princeton University, Princeton, NJ; 3) Lewis Sigler Institute, Princeton University, Princeton, NJ.

529A
Variation in epistatic interactions that modify olfactory behavior in the Drosophila melanogaster Genetic Reference Panel. Xiaofang He1,2, Shanshan Zhou1, Genevieve E. Evans1, Trudy F. C. Mackay1, Robert R. H. Anholt1. 1) Biological Sciences, North Carolina State University, Raleigh, NC; 2) Department of Entomology, South China Agricultural University, Guangzhou 510642, China.

530B
Inhibition and activation of key olfactory pathways promotes both attraction and avoidance. Dyan MacWilliam, Anandasankar Ray. Dept. of Entomology, University of California, Riverside, CA.

531C
Conservation of innate olfactory avoidance pathways across Drosophila species. Christine K. Pham1, Anandasankar Ray2. 1) Interdepartmental Neuroscience Program, University of California, Riverside, Riverside, CA; 2) Entomology Department, University of California, Riverside, Riverside, CA.

532A
Acids modulate bitter and sweet taste in Drosophila. Yan Chen, Hubert Amrein. Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX.

533B
Molecular Basis of Sugar Sensing in Drosophila. Ahmet E. Yavuz1, Shinsuke Fujii1, Christopher Jagge1, Jesse Slone2, Xiangyu Song3, Hubert Amrein1. 1) Molecular & Cellular Medicine, Texas A&M HSC, College Station, TX; 2) Department of Biology, Vanderbilt University, Nashville, TN; 3) P&G BJTC, Beijing, China.

534C
Distinct neuronal circuits regulate sleep and wake within Drosophila mushroom body. Nan Chen1, Divya Sitaraman1,2, Yoshinori Aso1, Wyatt Korff1, Michael Nitabach1,2, Gerald Rubin1. 1) Howard Hughes Medical Institute Janelia Farm Research Campus, Ashburn, VA; 2) Yale University School of Medicine, Dept. of Cellular and Molecular Physiology, New Haven, CT 06511.

535A
A Hard-wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in Drosophila. Thangavel Karuppudurai1, Tzu-Yang Lin1, Benjamin White2, Marco Gallio3, Thomas Pohida4, Chi-Hon Lee1. 1) NIH/NICHD, Bethesda, MD; 2) NIH/NIMH, Bethesda, MD; 3) Northwestern University, Evanston, IL; 4) NIH/CIT, Bethesda, MD.

536B
CO2 Effects on Subsequent Anesthesia. Nathan R. Bartholomew1, Gerald B. Call2. 1) Biomedical Sciences, Midwestern University, Glendale, AZ; 2) Dept of Pharmacology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ.

537C
Sucrose-only diets suppress seizure-like activity (SLA) and shorten recovery time following SLA in the Bang-sensitive (BS) paralytic mutants easily-shocked and technical knockout. Kris Burner, Daniel Kuebler. Biology, Franciscan University, Steubenville, OH.

538A
Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays. Robin Chan1,2, Jacquie Delohyt2,3, Lara Lewellyn2, Matt Hewitt2, Kristyn Sennett2, Scarlett Coffman2, Jill Bettinger4,5, John Warrick6, Mike Grotewiel1,2,3,5. 1) Molecular Biology and Genetics Program; 2) Human and Molecular Genetics; 3) Neuroscience Program; 4) Pharmacology and Toxicology; 5) Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA; 6) Department of Biology, University of Richmond, Richmond, VA.

539B
Directional Preference in Drosophila. Taylor A. James, Eli D. Zachary, Spicie M. Davis, Michael J. Baltzley, Kristin L. Latham. Western Oregon University, Monmouth, OR.

540C
Systematic Profiling and Functional Characterization of rab GTPases in Drosophila Brain and Malpighian Tubules. Cheng-Wen Hsieh1, Chung-Chih Liu1, Smita Cherry3, Jennifer Jin3, June-Tai Wu2, Robin Hiesinger3, Chih-Chiang Chan1. 1) Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan; 2) Graduate Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan; 3) Department of Physiology, UT Southwestern Medical Center, Dallas, Texas, USA.

Drosophila Models of Human Diseases


541A
The JAK-STAT signaling pathway mediates the effects of ethanol on development and adult behavior. Kimberly D. McClure, Gina Trotto, Gabriella Ceresa, Maria Barajas, Joseph Skopek. Department of Biology, Elmhurst College, Elmhurst, IL.

542B
Targeting the Spindle Assembly Checkpoint gene, Mad2, and small molecule inhibitors using synthetic lethality. Shamim A. Butt, Blake Riggs. San Francisco State University, 1600 Holloway Ave, San Francisco, CA.

543C
Cachexia-like Wasting Induced by Malignant Tumors in Drosophila. Alejandra Figueroa-Clarevega, David Bilder. Molecular and Cell Biology, UC Berkeley, Berkeley, CA.

544A
A Drosophila Brain Tumor Model to Study Interclonal Interactions. Austin Roebke3, Indrayani Waghmare1, Madhuri Kango-Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH 45469; 2) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH 45469; 3) Premedical Programs, University of Dayton, Dayton, OH 45469.

545B
Dm-Myb regulation of cell cycle genes is independent of NURF. Juan Santana1, Mrutyunjaya Parida2, Abby Long3, Jonathan Birdsall3, Kealie Rogers3, Martin Aguilera3, Kar Men Mah3, Scott McDermott3, J. Robert Manak1,2,3,4. 1) Interdisc Grad Program in Genetics, University of Iowa, Iowa City, IA; 2) Interdisc Grad Program in Informatics; 3) Dept Biology; 4) Dept Pediatrics, Carver College of Medicine.

546C
Screening of medicinal plant extracts from Nepal, in cancer models of Drosophila. Bhupal G. Shrestha1,2, Parthiv H. Patel2, Bruce Edgar2. 1) Biotechnology, Kathmandu University, Dhulikhel, Kathmandu, Nepal; 2) DKFZ-ZMBH Alliance, University of Heidelberg, Germany.

547A
Identification and characterization of cancer-relevant genes in a Drosophila tumor model. Janine Toggweiler, Maria Willecke, Konrad Basler. Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

548B
Size and Growth Regulation in Development and Cancer. Tian Xu, Chiswili Chabu, Sangil Lee. Dept Gen, HHMI, Yale Univ, New Haven, CT.

549C
Diverse transcriptional cardiac aging profiles lead to similar decline in heart function. Leah Cannon1, Anthony Cammarato1, Sanford Bernstein2, Alexander Zambon2, Rolf Bodmer1. 1) Development and Aging, Sanford-Burnham Medical Research Institute, La Jolla, CA; 2) University of California, San Diego 9500 Gilman Drive San Diego, CA 92093.

550A
Tau-induced mitochondrial dysfunction mediates cardiomyopathy in Drosophila model. Sreehari Kalvakuri1, Adriana Trujillo2, Sanford I. Bernstein2, Rolf Bodmer1, Girish C. Melkani2. 1) Aging and Development Program, Sanford Burnham Medical Research Institute, San Diego, CA 92037; 2) Department of Biology, Molecular Biology and SDSU Heart Institutes, San Diego State University San Diego, CA 92182.

551B
Cardiac Remodeling Mechanisms. Karen Ocorr. Dept Neuroscience & Aging, Burnham Inst Medical Research, La Jolla, CA.

552C
Drosophila heart model to study the genetic basis underlying Ischemia/Reperfusion-induced cardiac injury: Combinatorial function of Hif1α and Hsp23. Sarah Piloto, Rolf Bodmer. Development and Aging, Sanford-Burnham Medical Research Institute, La Jolla, CA.

553A
Methylene blue as a therapeutic compound in Drosophila models of Huntington’s disease. Herve Tricoire, Raheleh Heidari, Elodie Martin, Veronique Monnier, Amandine Palandri. Unité de Biologie Fonctionnelle et Adaptative (BFA, Univ Paris Diderot, Sorbonne Paris Cité, PARIS, France.

554B
Modeling Ceramide-Induced Lipotoxic Cardiomyopathy. Stanley M. Walls1, Greg L. Harris2, Rolf Bodmer1. 1) Development, Aging and Regeneration Program, Sanford-Burnham Med. Res. Institute, San Diego, CA; 2) Department of Biology, San Diego State University, San Diego CA.

555C
Characterization of sialic acid synthase mutants rescued by a transgene expressed in the insulin producing cells: loss of sialic acid in IPC cells is a model for Type II diabetes. Aiden Nguyen, Ilhan Akan, John Nguyen, Karen Palter. Biology, Temple University, Philadelphia, PA.

556A
Phytochemical Withanolide A (WL-A) : A potent suppressor of Huntington's disease in transgenic Drosophila model. Namita Agrawal, Chongtham Anjalika. Dept of Zoology, University of Delhi, Delhi, India.

557B
Juvenile Exposure to the Herbicide Paraquat Result in Long-Term Consequences in Parkinson's Disease. Rami R. Ajjuri, James Anderson, De'Anna Trunnell, Ryan Colaianni, Janis O'Donnell. Biological Sciences, University of Alabama, Tuscaloosa, AL.

558C
PI3K-induced Synaptogenesis Prevents β-Amyloid Neurotoxicity. Mercedes Arnés1, Sergio Casas-Tintó1, Ángel Acebes1,2, Alberto Ferrús1. 1) Cajal Institute, Madrid, Spain; 2) Centro de Investigaciones Biomédicas de Canarias (CIBICAN) La Laguna, Tenerife, Spain.

559A
Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington’s disease. Megha Maheshwari1, Supriya Bhutani1, Aniruddha Das1, Rajarshi Mukherjee1, Ankit Sharma1, Yoshihiro Kino2, Nobuyuki Nukina2, Nihar Jana1. 1) National Brain Research Centre, Gurgaon, Haryana, India; 2) Structural Neuropathology Laboratory, Riken Brain Science Institute, Wako-shi, Saitama-351-0198, Japan.

560B
Characterization of dnr1 in Drosophila: linking innate immune response to neurodegeneration. Yang Cao1, Stanislava Chtarbanova-Rudlof1, Andrew Petersen2, Barry Ganetzky1. 1) Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI; 2) Molecular and Cellular Pharmacology Program, University of Wisconsin-Madison, Madison, WI.

561C
Role of Transcriptional Co-Activator CREB Binding Protein in Amyloid Beta 42 Mediated Neurodegeneration. Timothy L. Cutler1,2, Oorvashi Roy Puli3, Meghana Tare3, Michael T. Moran3, Greg Mancini3, Madhuri Kango-Singh1,3,4, Amit Singh1,3,4. 1) Premedical Programs, University of Dayton, 300 College Park Drive, Dayton, OH; 2) University Honors Program, University of Dayton, 300 College Park Drive, Dayton, OH; 3) Department of Biology, University of Dayton, 300 College Park Drive, Dayton, OH; 4) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, 300 College Park Drive, Dayton, OH.

562A
Aneuploidy by Mitotic Spindle Defects Drives Tau-mediated Neurodegeneration in Drosophila. Bart Dermaut1, Marc Gistelinck2, Nicolas Malmanche1, Pierre Dourlen1, Cloé Dupont1, Dieder Moechars3, Patrick Callaerts2. 1) Institut Pasteur de Lille, Inserm U744, University of Lille 2, Lille, France; 2) Laboratory of Behavioral and Developmental Genetics, VIB Center for the Biology of Disease, University of Leuven, Leuven, Belgium; 3) Neuroscience Department, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium.

563B
A Drosophila model of neurometabolic disease yields insights into therapeutic treatments for Adrenoleukodystropy. Hannah B. Gordon, Anthea Letsou. Department of Human Genetics, University of Utah, Salt Lake City, UT.

564C
Proteotoxicity in Drosophila: Relevance of the Drosophila Tau Protein. Marianna K. Gorsky1,2, Sylvie Burnouf1, Sebastian Grönke1, Jacqueline Dols1, Linda Partridge1,2. 1) Max Planck Institute for Biology of Ageing, Cologne, NRW, Germany; 2) Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

565A
Investigating genetic interactions between proteins in the PI3K-AKT signaling pathway and molecular motors. Timothy Hansen, Shermali Gunawardena. Biological Sciences, University at Buffalo, Buffalo, NY.

566B
Role of Calcium channels in fungal volatile organic compound-mediated neurotoxicity. Arati A. Inamdar, Joan W. Bennett. Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, NJ.

567C
Drosophila eye model to understand role of signaling pathways in Aβ42 mediated neurodegeneration. Madison N. Irwin1, Kristine Garcia1, Madhuri Kango-Singh1,2,3, Amit Singh1,2,3. 1) Department of Biology, University of Dayton, 300 College Park Drive, Dayton, OH; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton, OH; 3) Center for Tissue Regeneration and Engineering at Dayton (TREND), University ofDayton, Dayton, OH.

568A
MULAN E3 ligase interacts with PINK1 in regulating mitochondrial dynamics and mitophagy in a Drosophila Parkinson’s disease model. Sreehari Kalvakuri1, Ryo Yonashiro2, Zhihao Wu3, Bingwei Lu3, Claudio Joazeiro2, Rolf Bodmer1. 1) Development and aging program, Sanford Burnham Medicalsearch Institute, San Diego, CA; 2) Department of Cell Biology, The Scripps Research Institute, CB168, 10550 North Torrey Pines Road, La Jolla, California 92037, USA; 3) Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.

569B
A non-neural Drosophila model for NMDA receptor-mediated excitotoxic cell death. Michael Lehmann, Brandy Ree. Dept Biological Sci, Univ Arkansas, Fayetteville, AR.

570C
Mitochondrial induced oxidative damage in neurons activates JNK and SREBP, induces lipid droplet accumulation in neuronal support cells, and promotes neurodegeneration. Lucy Liu1, Ke Zhang2, Hector Sandoval3, Vafa Bayat4, Zhihong Li3, Shinya Yamamoto3,4, Manish Jaiswal3, Richard Palmiter5,6, Albert Quintana5,6, Brett Graham3, Hugo Bellen6,7. 1) Department of Neuroscience, Baylor College of Medicine, Houston, TX; 2) Structural and Computational Biology & Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX; 3) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 4) Program in Developmental Biology, Baylor College of Medicine, Houston, TX; 5) Department of Biochemistry, University of Washington, Seattle, WA; 6) Howard Hughes Medical Institute; 7) Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, TX.

571A
Locating E-cadherin and Glial Cells in the Brain of the Drosophila melanogaster During the Pupal Stage. Michael J. Lum. Vanguard University of Southern California, Costa Mesa, CA.

572B
Insights into Alzheimer’s disease from NMR metabolomics of Aβ-expressing Drosophila. Anders Malmendal1, Stanislav Ott2, Damian Crowther2. 1) Department of Biomedical Science, University of Copenhagen, Denmark; 2) Department of Genetics, University of Cambridge, United Kingdom.

573C
FoxO modulates neurotoxicity in a Drosophila model of ALS. Andrés A. Morera1, Daniela Zarnescu1,2,3. 1) Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ; 2) Department of Neuroscience, University of Arizona, Tucson, AZ; 3) Department of Neurology, University of Arizona, Tucson, AZ.

574A
Structural and functional organization of a nucleus under stress in Drosophila melanogaster: the role of the limk1 gene. Ekatherina Nikitina1,2, Anna Medvedeva1,3, Vladimir Pronikov2, Elena Savvateeva-Popova1,3. 1) Pavlov Institute of Physiology, St Petersburg, Russian Federation; 2) Herzen State Pedagogical University, St Petersburg, Russian Federation; 3) St Petersburg State University, St Petersburg, Russian Federation.

575B
Mitochondrial abnormalities and nicotine treatment in a familial model of Parkinson's disease. Morolake Odumosu1, Gerald Call2, Lori Buhlman1. 1) Biomedical Science, Midwestern University, Glendale, AZ; 2) Arizona College of Osteopathic Medicine, Glendale, AZ.

576C
Glial function of pak3 and draper show overlapping but distinct regulation of spastin neuronal synaptic bouton formation. Emily F. Ozdowski, Nina T. Sherwood. Dept Biol, Duke Univ, Durham, NC.

577A
Using an Androgen Receptor-Humanized-Drosophila to Study the Molecular Pathology of Spinal Bulbar Muscular Atrophy. Conor Barker2, Stephanie Yee3, Paul Lasko3, Mark Trifiro1, Miltiadis Paliouras1. 1) Medicine, Lady Davis Institute for Medical Research - Jewish General Hospital, Montreal, QC, Canada; 2) Department of Cell Biology and Anatomy McGill University Montreal, QC, Canada; 3) Department of Biology McGill University Montreal, QC, Canada.

578B
Implication of mutant Huntingtin protein (mHtt) in Huntington’s disease pathogenesis in transgenic Drosophila. Nidhi Paliwal, Namita Agrawal. Department of Zoology, University of Delhi, Delhi, India.

579C
The Effects of Genetic Manipulation of Synaptotagmin 1 in a Drosophila model of Machado-Joseph Disease. Rachel Pearcy, John Warrick. University of Richmond, Richmond, VA.

580A
A genetic screen for identifying novel genes involved in neurodegeneration. Amy Pribadi, Shizuka Yamada, Megan Huynh, Michael Chen, Ashley Boehringer, Daniela Zarnescu. University of Arizona, Tucson, AZ.

581B
The influence of mis-regulating dJNK in a Drosophila model of Machado-Joseph Disease. Catherine Romberger, John Warrick. University of Richmond, Richmond, VA.

582C
Uncovering Prion Protein Stability. Jonatan Sanchez-Garcia, Diego Rincon-Limas, Pedro Fernandez-Funez. Univ of Florida, Gainesville, FL.

583A
Role of Signaling Pathways in Aβ42 mediated neurodegeneration. Ankita Sarkar1, Amit Singh1,2,3. 1) Department of Biology, University of Dayton, 300 College Park Drive,Dayton, OH; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton,OH; 3) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

584B
Aggregate formation in the central nervous system of drosophila after a brief reduction in proteasome activity. Thomas Schmidt-Glenewinkel, Marlon Jansen, Chun-Hung Yeh, Annie Cheng, Jie Gao, Eugene Lempert, Karina Perlaza. Dept Biological Sci, Hunter Col & Grad Ctr., City Univ New York, New York, NY.

585C
Probing integrin signaling in neuronal maintenance in flies. Mumine Senturk1, Shinya Yamamoto2, Manish Jaiswal3, Nele Haelterman1, Hugo Bellen1,2,3,4. 1) Program in Developmental Biology, Baylor College of Medicine, Houston, TX; 2) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 3) HHMI; 4) Department of Neuroscience; Neurological Research Institute at Baylor College of Medicine, Houston, TX.

586A
Nebula/DSCR1 Ameliorates APP-Induced Learning and Memory Impairments. Jillian L. Shaw, Karen T. Chang. Zilkha Neurogenetic Institute, University of Southern California, Neuroscience Graduate Program, 1501 San Pablo St, Los Angeles CA 90033.

587B
Investigating initiation of Cdk5-associated neurodegeneration. Joshua Spurrier1,2, Kristina McLinden1, Edward Giniger1. 1) NINDS, National Institutes of Health, Bethesda, MD; 2) CMDB, Johns Hopkins University, Baltimore, MD.

588C
Role of Isocitrate Dehydrogenase in retinal degeneration in Drosophila melanogaster. Berrak A. Ugur1, Manish Jaiswal2,3, Shinya Yamamoto2, Nele Haelterman1, Hector Sandoval2, Hugo Bellen1,2,3,4,5. 1) Developmental Biology, Baylor College of Medicine, Houston, TX; 2) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 3) Howard Hughes Medical Institute; 4) Department of Neuroscience, Baylor College of Medicine, Houston, TX; 5) Jan and Dan Duncan Neurological Institute at Baylor College of Medicine, Houston, Texas.

589A
FoxO Mediates APP-Induced AICD-Dependent Cell Death. Lei Xue, Xingjun Wang, Zhiqiang Wang. Tongji University, Shanghai, China.

590B
Investigation of the Role of Endoplasmic Reticulum in Motor Neuron Axons. Belgin Yalcin, Niamh O'Sullivan, Martin Stofanko, Cahir O'Kane. Department of Genetics, University of Cambridge, Cambridge, United Kingdom.

591C
A screen for RNA Binding Proteins as Modulators of TDP-43 toxicity in a Drosophila Model of ALS. Shizuka B. Yamada1, Amy Pribadi1, Megan Huynh1, Michael Chen1, Nakia Keita1, Linh Pham1, Ashley Boehringer1, Daniela C. Zarnescu1,2. 1) MCB, University of Arizona, Tucson, AZ; 2) Neuroscience, University of Arizona, Tucson, AZ.

592A
Defining Spinal Muscular Atrophy Gene Networks in Drosophila. Takakazu Yokokura1, Elizabeth McNeill2, Andreia Fonseca3, Maureen Lynes4, Seiko Yoshikawa1, Tamar Chobanyan1,2, Howard Chang2, Douglas Dimlich2, Anindua Sen2, Spyros Artavanis-Tsakonas2, Lee Rubin4, Margarida Gama Carvalho3, David Van Vactor1,2. 1) Okinawa Institute of Science and Technology, Okinawa, Japan; 2) Dept Cell Biology, Harvard Medical School, Boston, MA; 3) Bio-FIG, Faculty of Science, University of Lisbon, Lisbon, Portugal; 4) Harvard University, Dept Stem Cell and Regenerative Biology, Cambridge, MA.

593B
Proteomic Analysis of Huntingtin Interacting Network Using Drosophila. Zhen Xu1,4, Dongsheng Chen1,4, Zhihua Chen1,4, Yanning Rui1,4, Antonio Tito1,3,4, Sheng Zhang1,2,3,4. 1) Center for Metabolic & Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine; 2) Department of Neurobiology and Anatomy; 3) The Graduate School of Biomedical Sciences (GSBS); 4) The University of Texas Health Science Center at Houston (UTHEALTH), 1825 Pressler Street, Houston, TX 77030.

594C
Transgenerational effect of diet on metabolic phenotypes. Kelly Dew-Budd, Laura Reed. Department of Biological Sciences, University of Alabama, Tuscaloosa, AL.

595A
Modulation of lipid droplet accumulation in the larval midgut of Drosophila. Ron Dubreuil, Bianca Diaconeasa. Dept Biological Sci, Univ Illinois at Chicago, Chicago, IL.

596B
The Effects of Laminin A Mutation on Metabolic Syndrome in Drosophila melanogaster. Matthew B. Kieffer, Joana Hubickey, Laura K. Reed. University of Alabama, Tuscaloosa, AL.

597C
The influence of gene Cam on life span, moving activity and Ca2+ concentration in dystrophy mutants of Drosophila melanogaster.. Natalia Holub, Vasylyna Borutska, Chrystyna Dronska, Yaroslava Chernyk. Departament of Genetics and Biotechnology, Ivan Franko National University, Lviv, Ukraine.

598A
A whole genome enhancer/suppressor screen for Dube3a interacting genes involved in autism. Addison E. Jezek1, Lawrence T. Reiter2. 1) Rhodes College, Memphis, TN; 2) Department of Neurology, UTHSC, Memphis, TN.

599B
Modeling aberrant behavior of autism spectrum disorders in UBE3A mutations. Matthew Lollar1, Rami Ajjuri1, Larry Reiter2, Janis O'Donnell1. 1) Biological Sciences, University of Alabama, Tuscaloosa, AL; 2) Department of Neurology, University of Tennessee Health Science Center, Memphis, TN.

600C
pointed and vap Mediate Ethanol-Related Mortality in a Drosophila melanogaster Model of Fetal Alcohol Syndrome. Peter Luu. biology, San Jose State University, San Jose, CA.

601A
Defining the phenotypic specificity of Schimke immuno-osseous dysplasia. Marie Morimoto1, Clara Myung1, Kimberly Beirnes1, Andrew Gormley2, Christy Mayfield3, Behzad Najafian4, David Parham5, Zhongxin Yu6, Kunho Choi1, Yan Huang1, Kyoung Sang Cho7, Thomas Lücke8, Cornelius Boerkoel1. 1) Department of Medical Genetics, UBC, Vancouver, BC, Canada; 2) Department of Pediatrics, UOHSC, Oklahoma City, OK; 3) Warren Clinic, Tulsa, OK; 4) Department of Pathology, UW, Seattle, WA; 5) Department of Pathology, Children’s Hospital Los Angeles and Keck School of Medicine, USC, Los Angeles, CA; 6) Department of Pathology, UOHSC, Oklahoma City, OK; 7) Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea; 8) Department of Neuropediatrics, University Children's Hospital, Ruhr-University, Bochum, Germany.

602B
Exposure of larvae to Perfluorooctanoic acid (PFOA) causes dysregulation of the dTOR signaling pathway in Drosophila melanogaster. AnnJosette Ramirez1, Edward Wolff2, Trisha Zintel1, Amber Weiner1, Ashley Parker1, Kristin Johndreau1, Kara Bennett1, Caroline Rachfalski1, Sheryl T. Smith1. 1) Biology, Arcadia University, Glenside, PA; 2) Math and Computer Science, Arcadia University, Glenside, PA.

603C
Dube3a expression levels affect motor neuron axonal propagation and resting potential. Lawrence T. Reiter1,2, Colleen Valdez1, Reese Scroggs2. 1) Neurology, UTHSC, Memphis, TN; 2) Anatomy and Neurobiology, UTHSC, Memphis, TN.

604A
Drosophila as a Simple Model to Test Dark Toxicity and Tolerance of Potential Photodynamic Therapy Agents. Joshua Yoho1,4, Colette Stroh4, Shawn Swavey4, Madhuri Kango-Singh1,2,3. 1) Biology, University of Dayton, Dayton, OH; 2) Center for Tissue Regeneration and Engineering at Dayton (TREND); 3) Premedical Programs, University of Dayton, Dayton; 4) Chemistry, University of Dayton, Dayton, OH.

605B
Role of miRNAs in Drosophila model for Muscular Dystrophy. Evgeniia V. Edeleva, April K. Marrone, Halyna R. Shcherbata. Max Planck Insitute for Biophysical Chemistry, Goettingen, Germany.

606C
Epigenetic regulation of lipase activity establishes a postnatal protection from high-fat diet induced obesity and heart dysfunction. Ryan Tyge Birse1, Fabian Filipp1,2, Rolf Bodmer1. 1) Program of Development and Aging, Sanford-Burnham Medical Research Institute, La Jolla, CA; 2) School of Natural Sciences, University of California Merced, Merced, CA.

607A
A Drosophila Model of Wolfram Syndrome Disease. Chan Hsiao-Yen1,2, Chen Yi-Chun1, Kuo Tzer-Min2, Lin Wan-Hsuan2, Li Jian-Chiuan2, Wang Horng-Dar1, Chen Chun-Hong2. 1) Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan; 2) Institute of Molecular and Genomic Medicine,National Health Research Institutes, Zhunan, Miaoli, Taiwan.

608B
Analysis of transgenerational effects of Bisphenol A (BPA) in Drosophila melanogaster. Ashley M. Labdik, Amber K. Weiner, Trisha M. Zintel, AnnJosette Ramirez, Sheryl T. Smith. Arcadia University, Glenside, PA.

609C
Effects of the Mediterranean Diet on Metabolic Phenotypes. Jordyn Lee Merriam, Laura Reed. Department of Biological Sciences, University of Alabama, Tuscaloosa, AL.

610A
Cytoplasmic Protein Aggregation as a Trigger For LMNA Associated Muscle Dystrophy. Jessica Ponce1, Dylan Thiemann2, Grant Young2, George Dialynas3, Lori Wallrath1,2. 1) Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA; 2) Department of Biochemistry, University of Iowa, Iowa City, IA; 3) Stowers Institute for Medical Research, Kansas City, MO.

611B
Genetic Basis of Genotype-by-Environment (GxE) Interactions for weight in Drosophila melanogaster. A. Cigdem Tunckanat, Leah Leonard, Julie Jarnigan, Andrea Davidson, Laura Reed. Department of Biological Sciences, University of Alabama, Tuscaloosa, AL.

612C
Drosophila Mitochondrial Pyruvate Carrier mutants display defects in carbohydrate homeostasis and hallmarks of diabetes. Dona Roonalika Wisidagama, Daniel K. Bricker, Carl S. Thummel. Department of Human Genetics, University of Utah, Salt Lake city, UT.

613A
Oxidative stress as a consequence of ethanol exposure in developing Drosophila. Anthony J. Bortolazzo, Jodie Wu, Naomi Fieger, David Do, Theresa Logan-Garbisch, Audrey Ford, Hilal Jarrar, Rachael French. Biological Sciences, San Jose State University , San Jose , CA.

614B
Rapamycin as a potential treatment for succinate dehydrogenase mutants in Drosophila melanogaster. Frances Fan, Eugenia Villa-Cuesta. Biology Department, Adelphi University, Garden City, NY.

615C
Determinants of Frailty in Drosophila. Mariann M. Gabrawy1,2, Mehnaz A. Khan1, Peter M. Abadir2, Jeff Leips1. 1) Biological Sciences, UMBC, Baltimore, MD; 2) Division of Geriatric Medicine, Johns Hopkins Medical Institute, Baltimore, MD.

616A
Mutations in von Hippel Lindau Enhances Susceptibility to Paraquat and Exarcebates Neuroinflammatory and Hypoxia Responses. Marleshia Dorcell Hall, Anna Moyer, Erin Mcminn, Emily Peel, Janis O'Donnell. Department of Biological Sciences, University of Alabama, Tuscaloosa, AL.

617B
Nephrocyte as a model to identify and study renal disease genes. Fujian Zhang1, Tiffany Chang1, Ying Zhao1, Katherine Muir1, Zhe Han1,2. 1) Internal Med, Univ Michigan, Ann Arbor, MI; 2) Sanford Burnham Medical Research Institute, La Jolla, CA.

618C
CYFIP1 functions in brain: insights into Autism and Intellectual Disabilities. Alexandros Kanellopoulos1, Lysimachos Zografos2, Douglas Armstrong2, Patrick Callaerts3, Claudia Bagni1. 1) Laboratory of Molecular Neurobiology, K.U. Leuven/VIB Center for the Biology of Disease, Leuven, Belgium; 2) Brainwave Ltd, University of Edinburgh, UK; 3) Laboratory of Behavioral and Developmental Genetics, K.U. Leuven/VIB Center for the Biology of Disease, Leuven, Belgium.

619A
dPKD2 trafficking in Drosophila sperm. Weizhe Li, Stacey Bridges, Terry Watnick. Department of Medicine, University of Maryland, Baltimore, MD.

620B
Suppression of TOR pathway ameliorates skeletal muscle defects in a Drosophila model of Huttingtons disease. Jennifer A. Suggs, Samvel Avagyan, Raul Ramos, Anju Melkani, Sanford I. Bernstein, Girish C. Melkani. Department of Biology, Molecular Biology and Heart Institutes, San Diego State University San Diego, CA 92182.

621C
Modeling nerve injury in a long-lived Drosophila larval system. Daniel L. Miller, Barry Ganetzky. Department of Genetics University of Wisconsin Madison 425 Henry Mall Madison, WI 53706.

622A
Behavioral models analogous to rodent depressive-like behaviors. Wendi S. Neckameyer, Selma Avdagic, Andres Nieto, Kelly Hainz, Anisa Tabtiang, Sarah Chan. Dept Pharmac & Physiol Sci, St Louis Univ School Med, St Louis, MO.

623B
Effects of ethanol exposure on developmental time and survival in Drosophila. Victoria A. Pray1,2, Rachel A. Lyman1,2, Raveena M. Chhabria2, Lenovia J. McCoy1, Tatiana V. Morozova1,2, Robert R. H. Anholt1,2, Trudy F. C. Mackay1,2. 1) Biological Sciences, NCSU, Raleigh, NC; 2) W.M. Keck Center for Behavioral Biology, NCSU, Raleigh, NC.

624C
Functional Modeling of Human Muscle Tauopathies in Drosophila. Eric Ratliff2, Jennifer A. Suggs1, Kim D. Finley2, Sanford I. Bernstein1, Girish C. Melkani1. 1) Department of Biology, Molecular Biology and Heart Institutes, San Diego State University San Diego, CA 92182; 2) Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA 92182.

625A
Expression of polyQ aggregates in non neuronal cells leads to developmental anomalies in Drosophila melanogaster. Suman Yadav, Madhu G. Tapadia. CYTOGENETICS LABORATORY, ZOOLOGY, BANARAS HINDU UNIVERSITY, VARANASI, 221005, UTTAR PRADESH, India.

Evolution and Quantitative Genetics


626B
Multiple DNA motifs contribute to variation in recombination localization across the Drosophila genome. Andrew Adrian1,2, Josep Comeron1,3. 1) Department of Biology, University of Iowa, Iowa City, IA; 2) Interdisciplinary Program in Bioinformatics, University of Iowa; 3) Interdisciplinary Program in Genetics, University of Iowa.

627C
Nucleotide Polymorfism of Enhancer Region of DRAS1 Gene in The Drosophila Virilis Sibling Species Group. Sivoplyas Ekaterina2, Chekunova Anna1, Proshakov Prokhor1, Barsukov Maxim2, Sorokina Svetlana1, Mitrofanov Vladimir1, Kutuzova Nina2. 1) Russian Academy of Sciences Koltzov Institute of Developmental Biology; 2) FSFEI of HPE Moscow State Pedagogical University (MSPU).

628A
Muller F elements maintain a distinctive pattern of gene structure over 40 million years of evolution. Wilson Leung1, Christopher Shaffer1, Jeremy Buhler2, Sarah Elgin1, Faculty & Students of the Genomics Education Partnership. 1) Dept Biology, Washington Univ, St Louis, MO; 2) Dept Computer Science & Engineering, Washington Univ, St. Louis, MO.

629B
Genome-wide effect of 785 generations of parallel adaptation in replicate populations of Drosophila melanogaster. Mark A. Phillips1, Anthony D. Long1,2, Lee F. Greer1,2, Laurance D. Mueller1,2, Michael R. Rose1. 1) Ecology and Evolutionary Biology, University of California, Irvine, CA; 2) Genescient Corporation, Fountain Valley, CA 92708.

630C
Domesticated genes from PIF transposable elements in Drosophila melanogaster. Diwash Jangam1, Cedric Feschotte2, Esther Betrán1. 1) Biology, University of Texas at Arlington, Arlington, TX; 2) Human Genetics, University of Utah, Salt Lake City, UT.

631A
Genome of Scaptomyza flava, a leaf mining drosophilid. Richard Lapoint, Noah Whiteman. Dept of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ.

632B
Regulatory impacts of tandem duplications in Drosophila yakuba. Rebekah L. Rogers, Ling Shao, Kevin Thornton. Ecology and Evolutionary Biology, Thornton Lab, Irvine, CA.

633C
A Novel Dataset for Identifying Sex-Biased Genes in Drosophila. Nicholas VanKuren1,2, Maria Vibranovski2,3. 1) Committee on Genetics, Genomics, and Systems Biology, The University of Chicago, Chicago, IL, USA; 2) Department of Ecology and Evolution, The University of Chicago, Chicago, IL, USA; 3) Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.

634A
Drosophila simulans wRi Wolbachia variants differ by multi-gene duplications in a natural population. Chenling Xu, Chris Smith. Evolution and Ecology, UC Davis, Davis, CA.

635B
Directional asymmetry of the Drosophila wing as a target of evolution of bilateral traits. Denis Anisiforov, Alexey Kulikov, Oleg Lasebny. Russian Academy of Sciences, Koltzov INSTITUTE of DEVELOPMENTAL BIOLOGY , Moscow, Russian Federation.

636C
Genomic basis of parallel evolution of dark pigmentation in high-altitude populations of Drosophila melanogaster in Africa. Héloïse Bastide, Amir Yassin, Justin Lack, Evan Johanning, John Pool. Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI.

637A
Evolution of Germline Stem Cell Regulating Genes in Drosophila ananassae: Testing the Wolbachia pipientis conflict hypothesis. Jae Young Choi, Charles Aquadro. Dept of Molecular Biology and Genetics, Cornell University, Ithaca, NY.

638B
Life History Determinants: Physiological Mechanisms of Egg Dumping in Drosophila melanogaster Using Extreme Phenotypes and Genetic Mapping. Ashley A. Gilchrist1, Laura Reed2, Trish Moore3. 1) Ashley Gilchrist Biological Sciences, University of Alabama, Tuscaloosa, AL; 2) Laura Reed PhD, Dept. Biology, UA; 3) Trish Moore PhD, Department of Entomology, University of Georgia.

639C
Differences in regulatory variability between sexes and ’X’s, in D. simulans. Rita M. Graze1,6, Lauren M. McIntyre1,2, Alison M. Morse1, Brett M. Boyd5, Sergey V. Nuzhdin3, Marta L. Wayne4. 1) Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL; 2) Department of Statistics, University of Florida, Gainesville, FL; 3) Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA; 4) Department of Biology, University of Florida, Gainesville, FL; 5) Florida Museum of Natural History, University of Florida, Gainesville, FL; 6) Biological Sciences, Auburn University, Auburn, AL.

640A
Whole genome sequencing of Drosophila melanogaster from the southeast United States and Caribbean Islands to investigate admixture in North America. Joyce Y. Kao, Matt P. Salomon, Asif Zubair, Daniel Campo. Biological Sciences, University of Southern California, Los Angeles, CA.

641B
The genetic basis of high-altitude adaptation in Drosophila melanogaster. Justin B. Lack, John Pool. Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI.

642C
Clinal patterns of genomic variation and their demographic implications in D. melanogaster and D. simulans. Heather Machado1, Alan Bergland1, Katherine O'Brien2, Emily Behrman2, Paul Schmidt2, Dmitri Petrov1. 1) Biology, Stanford University, Palo Alto, CA; 2) Department of Biology, University of Pennsylvania, Philadelphia, PA.

643A
Recent colonization history of the invasive drosophilid Zaprionus indianus in Mexico and Central America. Therese Ann Markow1,2, Giovanni Hanna2, Juan R. Riesgo-Escovar3, Maxi Polihronakis Richmond2, Nestor Octavio Nazario-Yepiz1, Mariana Ramírez-Loustalot-Laclette1, Javier Carpinteyro-Ponce1, Edward Pfeiler4. 1) Laboratorio Nacional de Genómica para la Biodiversidad, CINVESTAV Irapuato, Irapuato, Guanajuato, C.P. 36821 Mexico; 2) Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; 3) Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, C.P. 76230, México; 4) Centro de Investigación en Alimentación y Desarrollo, A.C., Unidad Guaymas, Apartado Postal 284, Guaymas, Sonora, 85480, México.

644B
Identifying functional elements and species-specific gain and loss of function from population genomic data. Daniel R. Schrider, Andrew D. Kern. Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ.

645C
“Molecular fossils” and genetic diversity of ancestral population of D.virilis. Svetlana Y. Sorokina1, Sergej V. Bukhanov1, Denis A. Romanov2, Boris V. Andrianov2. 1) Genetics, Koltzov INSTITUTE of DEVELOPMENTAL BIOLOGY RAS, Moscow, Russian Federation; 2) Vavilov INSTITUTE of GENERAL GENETICS RAS, Moscow, Russian Federation.

646A
Regulation of developmental timing in the Drosophila embryo. Cynthia Staber, Axel Shum, Samuel Meier, Julia Zeitlinger. Stowers Institute for Medical Research, Kansas City, MO.

647B
Latitudinal variation in sleep in Drosophila melanogaster. Nicolas Svetec1, Perot Saelao1, Joanna Chiu2, David Begun1. 1) Department of Evolution & Ecology, UC Davis, Davis, CA; 2) Department of Entomology and Nematology, UC Davis, CA.

648C
What gene expression can tell us about selective forces driving chromosome evolution. Gwilym Haynes1, Zachary Fuller1, Shannon Duggan2, Stephen Richards2,3, Stephen Schaeffer1. 1) Biology, Pennsylvania State University, State College, PA; 2) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030; 3) Chevron, 1500 Louisiana St, Houston, Texas, 77002.

649A
DNA copy number evolution in Drosophila modENCODE cell lines. Hangnoh Lee, Brian Oliver, modENCODE. National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD.

650B
The Evolution of Breakpoint Sequences in Drosophila pseudoobscura. Haley E. Randolph1, Megan E. Lee1, Geovanny C. Montoya1, Atousa Jahanshahi1, Shannon Duggan2, Dianhuiz Zhu2,3, Stephen Richards2, Stephen W. Schaeffer1. 1) Biology, The Pennsylvania State University, University Park, PA; 2) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston TX; 3) Chevron, 1500 Louisiana St, Houston, Texas.

651C
The ovipositor of an invasive pest, Drosophila suzukii, provides insight into the evolution of an adaptive novelty. Joel Atallah, Raul Salazar, Lisa Teixeira, George Zaragoza, Artyom Kopp. Evolution & Ecology, University of California - Davis, Davis, CA.

652A
Microsatellite repeat instability fuels evolution of embryonic enhancers in Hawaiian Drosophila. Andrew S. Brittain, Elizabeth Stroebele, Albert Erives. University of Iowa, Dept. of Biology, Iowa City, IA 52242, USA.

653B
Dorsocross is a putative target for morphological divergence in fly embryos. Francesca Caroti, Steffen Lemke. Molecular Developmental Biology & Physiology, Center for Organismal Studies (COS), Heidelberg, Baden-Württemberg, Germany.

654C
Genome of Drosophila arizonae and its divergence from D. mojavensis. Javier Carpinteyro Ponce1, Fernando Peñaloza2, Alejandro Sanchez2, Cei Abreu-Goodger1, Therese Markow1,3. 1) LANGEBIO, CINVESTAV Irapuato, Irapuato, Guanajuato, Mexico; 2) Unidad Universitaria de Apoyo Bioinformático, Instituto de Biotecnología, UNAM, Cuernavaca, Morelos. México; 3) Division of Biological Sciences, UCSD, La Jolla, CA.

655A
Study of function of two young nuclear transport retrogenes (Dntf-2r and Ran-like). Susana Domingues, Erica Eckstrand, Esther Betrán. The University of Texas at Arlington, Arlington, TX.

656B
Molecular evolution of the proteins comprising the synaptonemal complex in the Drosophila genus. Lucas Hemmer, Justin Blumenstiel. Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS.

657C
The insect order Diptera as framework to assess the genetics of morphological divergence. Steffen Lemke, Silvia Urbansky, Francesca Caroti, Lucas Schütz. Centre for Organismal Studies, Universität Heidelberg, Heidelberg, Germany.

658A
Evolution of the maternally deposited mRNA pool in the Drosophila egg. Susan E. Lott. Department of Evolution and Ecology, University of California, Davis, Davis, CA.

659B
Evolution of shape and sense in male Drosophila prolongata. David Luecke, Artyom Kopp. Center for Population Biology, University of California - Davis, Davis, CA.

660C
Coordinated cis- and trans-regulatory changes along the dpp pathway correlate with a derived wing phenotype in D. sechellia. Richard W. Lusk1, Nuala Bobowski2, Alberto Civetta2, Cassandra Kirkland1, Emily Valice1, Patricia Wittkopp1, Ian Dworkin3. 1) Ecology & Evolutionary Biology, University of Michigan, Ann Arbor, MI; 2) Dept. of Biology, University of Winnipeg, Winnipeg, MB, Canada; 3) Dept. of Zoology, Michigan State University, East Lansing, MI.

661A
Conservation of long intergenic noncoding RNAs (lincRNAs) between D. pseudoobscura and D. melanogaster: expression is key. Kevin G. Nyberg, Carlos A. Machado. Biology Department, University of Maryland, College Park, MD.

662B
Molecular mechanism behind the evolution of a novel sex-specific trait. Gavin R. Rice1, Olga Barmina1, Michelle Arbeitman2, Daniel Friedman1, Artyom Kopp1. 1) Evolution and Ecology, University of California at Davis, Davis, CA; 2) College of Medicine, Florida State University, Tallahassee, FL.

663C
What does it take to evolve an enhancer? Saurabh Sinha1,2, Thyago S. P. C. Duque1. 1) Department of Computer Science, University of Illinois, Urbana, IL; 2) Institute for Genomic Biology, University of Illinois, Urbana, IL.

664A
Gene expression profiling of Drosophila testis. Toshiyuki Takano-Shimizu, Masatoshi Tomaru, Masahide Watanabe. Drosophila Genetic Resource Center, Kyoto Institute of Technology, Kyoto.

665B
Comparative transcriptomics of X chromosome meiotic drive in Drosophila simulans. Shu Fang1, Wei-Chung Yu1, David Ogereau2, Ching-Ho Chang3, Quentin Helleu2, Chau-Ti Ting3, Catherine Montchamp-Moreau2. 1) Biodiversity Research Center, Academia Sinica, Taiwan, ROC; 2) Laboratoire Evolution, Génomes & Spéciation, UPR9034 - CNRS, France; 3) Department of Life Science, National Taiwan University, Taipei, Taiwan, ROC.

666C
Study of segmentation using Dermestes maculatus as a non-model organism. Jie Xiang1,2, Leslie Pick1,2. 1) Dept of Entomology, Univ. of Maryland-College Park, College Park, MD; 2) Program in Molecular & Cell Biology, Univ. of Maryland-College Park, College Park, MD.

667A
How does selection at tyrosine hydroxylase (pale) drive melanism in high-altitude Ethiopian Drosophila melanogaster? Amir Yassin, Héloïse Bastide, John Pool. Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI.

668B
QTL affecting genotype-by-diet interactions of larval triglyceride levels. Alison F. Adams, Kelly J. Dew-Budd, Laura K. Reed. Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL.

669C
Genomic basis of parallel seasonal variation in stress tolerance traits in Drosophila melanogaster and D. simulans. Alan O. Bergland1, David Enard1, Felicia King1, Jamilla Akhund-Zade1,2, Dmitri Petrov1. 1) Stanford University, Stanford, CA; 2) Cornell University, Ithica, NY.

670A
Climatic adaptations of life-history traits in outdoor field cage and laboratory populations of Drosophila melanogaster. Veer Bhan. Department of Biotechnology, UIET, M D University, Rohtak, Haryana, India.

671B
Naturally Occurring Variations in Food Intake in Drosophila melanogaster. Matthew John Eveland, Hayley Leuch, Maria De Luca. Nutrition Sciences, University of Alabama, Birmingham, Birmingham, AL.

672C
Bayesian multi-phenotype genome-wide association methods for experimental designs of arbitrary complexity. Anthony Greenberg1,2, Jason Mezey1, Susan McCouch1,2, Jean-Luc Yannink3. 1) Biostatistics and Computational Biology, Cornell University, Ithaca, NY; 2) Plant Breeding and Genetics, Cornell University, Ithaca, NY; 3) USDA-ARS, Robert W. Holley Center, Ithaca, NY.

673A
The relationship between sleep and evolutionary fitness in Drosophila melanogaster . Amanda Lobell, Susan Harbison. Laboratory of Systems Genetics, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD.

674B
What is the best design to understand gene regulatory networks? Lauren M. McIntyre1, Sergey Nuzhdin2. 1) Dept Molec Gen & Micro, Univ Florida, Gainesville, FL; 2) University of Southern California, Los Angeles CA.

675C
Mapping divergent pupation behavior between Drosophila melanogaster and D. simulans. Alison Pischedda, Michael Shahandeh, Thomas Turner. Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, Santa Barbara, CA.

676A
Genes of Attraction: Mapping male preference for a species-specific female pheromone in Drosophila. Michael Shahandeh, Alison Pischedda, Thomas Turner. Ecology, Evolution and Marine Biology, University of California, Santa Barbara, Santa Barbara, CA.

677B
The genetics of convergent evolution. Sarah A. Signor1, Artyom Kopp2. 1) University of Southern California, Los Angeles, CA; 2) University of California, Davis, Davis, CA.

678C
Divergence of water balance mechanisms in two sibling species (Drosophila simulans and D. melanogaster ): effects of growth temperatures. Divya Singh, Ravi Parkash. M.D.UNIVERSITY, ROHTAK, HARYANA, India.

679A
Mapping natural variation in courtship song to the gene level using the Drosophila Synthetic Population Resource. Thomas L. Turner, Alison Pischedda, Wes G. Cochrane, Veronica A. Cochrane. Ecology Evolution and Marine Biology Dept, University of California, Santa Barbara.

680B
Reproductive barriers in a hybrid zone of Drosophila melanogaster. Joyce Y. Kao, Sergey V. Nuzhdin. Biological Sciences, University of Southern California, Los Angeles, CA.

681C
Investigating genomic divergence in the Asian fruit fly Drosophila nasuta complex. Wynn K. Meyer, Doris Bachtrog. Integrative Biology, University of California, Berkeley, Berkeley, CA.

682A
Genome-wide scans reveal a young candidate speciation gene in Drosophila athabasca. Karen M. Wong Miller1, Michael Eisen1,2,3, Doris Bachtrog1. 1) Integrative Biology, University of California, Berkeley, Berkeley, CA; 2) Department of Molecular and Cell Biology, University of California, Berkeley, CA; 3) Howard Hughes Medical Institute, University of California, Berkeley, CA.

683B
The role of fungal interactions in the host-plant specialization of Hawaiian Drosophila. Allison Quan1, Patrick O'Grady2, Michael Eisen1. 1) Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA; 2) Department of Environmental Science, Policy & Management, UC Berkeley, Berkeley, CA.

684C
Radiation of the Drosophila nannoptera species group in Mexico. Michael Lang1, Maxi Polihronakis Richmond2, Andrea E. Acurio3, Therese A. Markow2,4, Virginie Orgogozo1. 1) CNRS UMR7592, Institut Jacques Monod, Paris, France; 2) University of California, San Diego, USA; 3) Universitat Autònoma de Barcelona, Barcelona, Spain; 4) Laboratorio Nacional de Genomica de la Biodiversidad, CINVESTAV, Irapuato, Mexico.

685A
Bioinformatic Analysis of Odorant-Binding Proteins from an Emerging Agricultural Pest, Drosophila suzukii. Herbert Lee, Jessica Wu-Woods, Daniel Woods. Inscent, Inc., Irvine, CA.

686B
The transposable element Bari-Jheh mediates oxidative stress response in Drosophila. Josefa Gonzalez, Lain Guio, Lidia Mateo, Anna Ullastres, Maite Barron. Institute of Evolutionary Biology, Barcelona, Barcelona, Spain.

687C
Genome-wide analysis of positive selection in an herbivorous drosophilid. Andrew Gloss, Richard Lapoint, Noah Whiteman. University of Arizona, Tucson, AZ.

688A
Soft shoulders ahead: on the problem of differentiating between hard and soft sweeps. Andrew D. Kern1, Daniel R. Schrider1, Fabio Mendes2, Matthew Hahn2. 1) Dept of Genetics, Rutgers University, Piscataway, NJ; 2) Dept of Biology, Indiana University, Bloomington, IN.

689B
Transmission of mitochondrial mutations and action of purifying selection in Drosophila. Hansong Ma1, Hong Xu2, Patrick O'Farrell1. 1) Department of Biochemistry & Biophysics, UCSF, San Francisco, CA; 2) National Heart, Lung, and Blood Institute, Molecular Genetics Lab, Bethesda, MD 20892.

690C
Direct and correlated responses to laboratory selection for body melanisation in Drosophila melanogaster: support for the melanisation-desiccation resistance hypothesis. Seema Ramniwas, Ravi Parkash. GENETICS, M. D.UNIVERSITY, ROHTAK, India.

691A
The effect of linked selection on Approximate Bayesian estimation of demographic parameters. Alexander G. Shanku, Andrew D. Kern. Department of Genetics, Rutgers University, Piscataway, NJ.

692B
The contributions of epistasis and biochemical plasticity to ethanol tolerance across life stages. Brandon S. Cooper, P. Signe White, Kristi L. Montooth. Biology, Indiana University, Bloomington, IN.

693C
Understanding the influence of diet and gut microflora on host behavior and mate preferences in Drosophila melanogaster. Michael A. Najarro, Thomas L. Turner. Dept. of Ecology, Evolution, and Marine Biology, University California Santa Barbara, Santa Barbara, CA.

694A
Genetic and plastic effects on body melanisation in a cold adapted drosophilid -Drosophila takahashii. Shama Singh. ZOOLOGY, UNIVERSITY OF DELHI, DELHI, India.

695B
Mitonuclear epistasis and the transcriptional response to hypoxia. David M. Rand, Yawei Ge, Nicholas Jourjine, James Mossman. Ecology & Evolutionary Biol, Brown Univ, Providence, RI.

696C
Yeast metabolic state mediates attraction of wild Drosophila melanogaster to suitable breeding sites. Kelly M. Schiabor1, Michael B. Eisen1,2. 1) Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA; 2) Howard Hughes Medical Institute, Bethesda, MD.

697A
Robust genome-wide analysis of metabolic phenotypes in Drosophila melanogaster using a panel of hybrid genotypes containing a common haplotype. Kjong-Van Lehmann1, Peter Poon2, Daniel Campo2, Matthew Salomon2, Peter Chang2, Tevik Hamdi Kitapci2, Justin Fear3, Alison Morse3, Michelle Arbeitman4, Lauren McIntyre3, Simon Tavare5, Sergey Nuzhdin2, John Tower2. 1) Memorial Sloan Kettering Cancer, New York, NY; 2) University of Southern California, Los Angeles, CA; 3) University of Florida, Gainesville, FL; 4) Florida State University, Tallahassee, FL; 5) Cancer Research, Cambridge, UK.

698B
Pathogen pressures increase the rate of meiotic recombination in Drosophila. Dallas Criscoe1, Erin Keebaugh2, Shelly Skolfield2, Todd Schlenke2, Nadia Singh1. 1) Department of Biological Sciences, North Carolina State University, Raleigh, NC; 2) Department of Biology, Emory University, Atlanta, GA.

699C
Sexual dimorphism in extent and mechanisms of resistance to infections shows that the Bateman principle does not apply to Drosophila immunity. David Duneau, Brian Lazzaro. Entomology, Cornell University, Ithaca, NY.

700A
Divergence of desiccation-related traits in two Drosophila species of the takahashii subgroup from the western Himalayas. Babita Kajla, Ravi Parkash. Department of Genetics, M. D.UNIVERSITY, ROHTAK, Haryana, India.

701B
Divergence of water balance mechanisms and acclimation potential in body color morphs of a tropical rainforest Drosophila species. Chanderkala Lambhod, Ravi Parkash. M.D.UNIVERSITY, ROHTAK, haryana, India.

702C
Seasonal changes in humidity impact drought resistance in tropical Drosophila leontia: testing developmental effects of thermal versus humidity changes. Poonam Ranga, Ravi Parkash. GENETICS, MAHARSHI DAYANAND UNIVERSITY, ROHTAK, India.

703A
MiRNA transcriptome follows different evolutionary trajectories at the onset of Drosophila metamorphosis. Shu-Dan Yeh1, Marcin von Grotthuss1, Vivek Jayaswal2, José Ranz1. 1) Ecology and Evolutionary Biology, UC Irvine, Irvine, CA; 2) School of Mathematics and Statistics, The University of Sydney, Sydney, Australia.

Pattern Formation


704B
Novel Interactions between the NF-κB and BMP Signaling Pathways in the D. melanogaster Embryo. Sophia Carrell, Alexander Thomas, Jeramey Friedman, Gregory Reeves. Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC.

705C
Differential cell response to Epidermal Growth Factor Receptor (EGFR) signalling in the ovary. Scott De Vito1, Jean François Boisclair Lachance2, Mariana Fregoso Lomas1, Laura Nilson1. 1) Deparment of Biology, McGill University, Montreal, QC, Canada; 2) Ben May Department for Cancer Research, University of Chicago, Chicago, Il.

706A
A role for ABCF2 in early morphogenetic patterning. Rachel Harney1, Byron Williams2, Mike Hayes3, Arida Dhanaswar1, Danielle Beekman1, Clinton Rice1, Karla Daniels4, David Soll4, Daniel Weeks3, Jan Fassler1, Albert Erives1. 1) Dept. of Biology, University of Iowa, Iowa City, IA; 2) Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA; 3) Dept. of Biochemistry, University of Iowa, Iowa City, IA; 4) Developmental Studies Hybridoma Bank, University of Iowa, Iowa City, IA.

707B
Self-organized shuttling: generating sharp dosro-ventral polarity in the early Drosophila embryo. Michal Haskel-Ittah, Danny Ben-Zvi, Merav Branski-Arieli, Eyal Schejter, Naama Barkai, Benny Shilo. molecular genetics, weizmann institute, Rehovot, Israel.

708C
Maternal Torso-like functions post terminal patterning to control Drosophila gastrulation. Travis K. Johnson1,2, James C. Whisstock1, Coral G. Warr2. 1) Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia; 2) School of Biological Sciences, Monash University, Clayton, Victoria, Australia.

709A
Role of BMP signaling in serosa and amnion development of the phorid fly Megaselia abdita. Chun Wai Kwan, Urs Schmidt-Ott. Dept. of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637.

710B
The Regulation of Dorsoventral Patterning in the Early Drosophila Embryo. Ruta Ziukaite. New York University, New York, NY.

711C
Compartments in the second tracheal metamere of Drosophila larva. Prashanth Rao, Li Lin, Sougata Roy, Thomas Kornberg. CVRI, UCSF, San Francisco, CA.

712A
The Drosophila T-box Transcription Factor Midline Functions within the Notch-Delta Signaling Pathway to Specify Sensory Organ Precursor Cell Fates and Regulates Cell Survival within the Eye Imaginal Disc. Sandra M. Leal, Sudeshna Das, Qichuan Chen, Joseph Saucier, Brandon Drescher, Sarah Morgan, John Forstall, Andrew Meriwether, Randy Toranzo. Dept Biological Sci, Univ Southern Mississippi, Hattiesburg, MS.

713B
defective proventriculus (dve), a new member of DV patterning in the eye. Oorvashi Roy G. Puli1, Takeshi Yorimitsu3, Madhuri Kango-Singh1,2,4, Hideki Nakagoshi3, Amit Singh1,2,4. 1) Department of Biology, University of Dayton, 300 College Park Drive, Dayton, OH; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton, OH; 3) School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan; 4) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

714C
Role of growth regulatory pathway in eye development and differentiation. Erika L. Wittkorn1, Kristine Garcia1, Madhuri Kango-Singh1,2,3, Amit Singh1,2,3. 1) Department of Biology, University of Dayton, 300 College Park Drive, Dayton, OH; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton, OH; 3) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

715A
A genetic screen in wing imaginal discs for regeneration mutants. Amanda R. Brock, Rachel K. Smith-Bolton. Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL.

716B
Evolution of dipteran wing vein patterning. Valentino M. Gantz, Xiang-Ru Xu, Ethan Bier. Biological Sciences, University of California San Diego, La Jolla, CA.

717C
Cytoneme-mediated Notch signaling between wing disc myoblasts and trachea. Hai Huang, Sougata Roy, Thomas Kornberg. Cardiovascular Research Institute, UCSF, San Francisco, CA.

718A
Dual role for Dpp in early wing disc development in regulating EGFR and Wg signaling. Sathiya Narayanan Manivannan1, Amanda Simcox1,2. 1) Molecular Cellular Developmental Biology, The Ohio State University, Columbus, OH; 2) The Department of Molecular Genetics, The Ohio State University, Columbus, OH.

719B
Pan-leg developmental regulators control pro-thoracic leg specific Scr expression. Christopher L. McCallough, Ece Eksi, Emily R. Wyskiel, Teresa V. Orenic. Dept Biological Sci, Univ Illinois at Chicago, Chicago, IL.

720C
Modeling dorsoventral patterning of the Drosophila embryo in silico reveals critical details overlooked by fluorescence imaging studies. Michael D. O'Connell, Gregory T. Reeves. Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC.

721A
Lethal (2) Essential for Life Gene Regulates Lateral Muscle Shapes During Embryonic Development. Teresa Jagla, Inga Wojtowicz, Krzysztof Jagla. GReD, INSERM U1103, CNRS UMR6293, Clermont, FD, France.

722B
Gene regulatory domains controlling eggshell patterning are enriched within the first intron. Nicole Pope1, Maira Farhat2, Robert Marmion1, Nir Yakoby1,2. 1) CCIB Rutgers University- Camden, Camden, NJ; 2) Biology Rutgers University-Camden, Camden, NJ.

Regulation of Gene Expression


723C
The tfiia-s-2 gene is a germline-specific homolog of the small subunit of the General Transcription Factor TFIIA. Maura Coughlin, Kevin Wons, Leah Hirschman, Cynthia Cain, Mark Hiller. Biological Sciences, Goucher College, Baltimore, MD.

724A
Identification of phosphorylation sites of the transcription factor MEF2 in vivo. Ashley A. DeAguero, Melanie Adams, Marilyn Cisneros, Richard M. Cripps. Biology, University of New Mexico, Albuquerque, NM.

725B
Determining general and male-specific functions of the essential protein CLAMP in Drosophila Melanogaster. Jennifer Johnson, Erica Larschan. Brown University, Providence, RI.

726C
Regulation of a conserved Class I/ Class V Helix-Loop-Helix (HLH) Gene Regulatory Network. Ke Li, Nicholas Baker. Genetics, Albert Einstein College of Medicine, Bronx, NY.

727A
The molecular basis of enhancer-promoter choice. Jia Ling, Theresa Apoznanski, Jinshuai Cao, Stephen Small. Department of Biology, New York University, New York, NY.

728B
KDM5 interacts with Foxo to modulate cellular levels of oxidative stress. Xingyin Liu, Christina Greer, Julie Secombe. Genetics, Albert Einstein Med College, Bronx, NY.

729C
Genome-wide analysis of tissue-specific effector genes in the Drosophila embryo. Malini Natarajan, Samuel Meier, Jeff Johnston, Julia Zeitlinger. Stowers Institute for Medical Research, Kansas City, MO.

730A
Identification of New Wingless Targets in Drosophila via ChIP-seq. Claudia Rockel, Konrad Basler. University of Zürich, Zürich, Switzerland.

731B
Differential utilization of TATA Box-Binding Protein (TBP) and TBP-related Factor 1 (TRF1) at different classes of RNA polymerase III promoters. Neha Verma1, Ko-Hsuan Hung2, Jin Joo Kang2, William Stumph2. 1) Dept. of Biology, San Diego State University, San Diego, CA 92182; 2) Dept. of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182.

732C
Measuring polymerase dynamics with multi-color fluorescent in situ hybridization. Shawn C. Little1, Mikhail Tikhonov2, Eric F. Wieschaus1, Thomas Gregor2. 1) Department of Molecular Biology / HHMI, Princeton University, Princeton, NJ; 2) Joseph Henry Laboratories of Physics / Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.

733A
Dual roles of TAK1 in the important dengue vector Aedes aegypti. Shin-Hong Shiao. Department of Parasitology, National Taiwan University, Taipei, Taipei, Taiwan.

734B
A Targeted RNAi Screen of Maternally Deposited Cofactors in the Drosophila Embryo. Adam N. Carte1,2, Max V. Staller2, Meghan D. Bragdon2, Ben Vincent2, Zeba B. Wunderlich2, Angela H. DePace2. 1) West Virginia University, Morgantown, WV; 2) Department of Systems Biology, Harvard Medical School, Boston, MA.

735C
The bromodomain protein tBRD-1 interacts with two new members of the BET family and is required for gene activation in male germ cells. Ina Theofel, Tim Hundertmark, Renate Renkawitz-Pohl, Christina Rathke. Developmental Biology, Philipps Universität Marburg, Marburg, Hessen, Germany.

736A
Dissecting the mechanism of Capicua- and Groucho-mediated repression in the terminal patterning system. Marta Forés1, Leiore Ajuria1, Núria Samper1, Sergio González-Crespo1, Rona Grossman2, Ze'ev Paroush2, Gerardo Jiménez1,3. 1) IBMB-CSIC, Parc Cientific de Barcelona, Barcelona, Spain; 2) Dept. of Developmental Biology and Cancer Research, IMRIC, The Hebrew University, Jerusalem, Israel; 3) ICREA, Barcelona, Spain.

737B
INO80-dependent regression of transcriptional responses regulates developmental timing in Drosophila. Sarah Neuman, Robert Ihry, Arash Bashirullah. University of Wisconsin-Madison, Madison, WI.

738C
Novel Gli-independent regulation of Hedgehog target enhancers via Gli binding sites. Andrea Isabel Ramos1, Scott Barolo1,2. 1) Program in Cellular and Molecular Biology,; 2) Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI.

739A
Identification of novel STAT92E target genes in hematopoiesis using in silico methods. Aditi Vyas1, Rami Al-Ouran2, Lonnie Welch2, Soichi Tanda1. 1) Dept. of Biological Sciences, Ohio University, Athens, OH; 2) School of Electrical Engineering and Computer Science, Ohio University, Athens, OH.

740B
The Mechanistic Basis for the Conservation of Enhancer Grammar Elements. Jenny E. Atanasov, James W. Posakony. Division of Biological Sciences-CDB, UCSD, La Jolla, CA.

741C
The Effects of Poly-Glutamine Tract Variation on Protein-Protein Interactions in Enhanceosomes. Danielle Beekman, Clinton Rice, Megan Bowman, Rachel Harney, Albert Erives. Dept. of Biology, University of Iowa, Iowa City, IA, 52242, USA.

742A
Non-additive cis-regulatory interactions underlie pair-rule regulation of Drosophila wingless at the blastoderm stage. Kimberly Bell1,2, Kevin Chen1, Jinelle Wint1,3, J. Peter Gergen1. 1) Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY; 2) Graduate Program in Genetics, Stony Brook University, Stony Brook, NY; 3) Graduate Program in Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY.

743B
Identification and analysis of regulatory elements at the endogenous apterous locus. Dimitri Bieli1, Oguz Kanca1, Fisun Hamaratoglu-Dion2, Daryl Gohl3, Paul Schedl3, Martin Müller1, Markus Affolter1. 1) University of Basel, Biozentrum, Basel, Switzerland; 2) University of Lausanne, Switzerland; 3) Princeton University, NJ.

744C
Cis-regulatory elements controlling fiber-specific expression of muscle structural gene Troponin C at 41C. Maria Chechenova, Sara Maes, Richard Cripps. Biol, Univ New Mexico, Albuquerque, NM.

745A
The activity of the en/inv imaginal disc enhancer depends on the genomic neighborhood. Yuzhong Cheng, Judith Kassis. Program in Genomics of Differentiation, NICHD, NIH, Bethesda MD 20892.

746B
Tunable Control of Transcriptional Enhancers Using TAL-Effectors: Computing Back the Magic. Justin Crocker1, Garth Ilsley2,3, David Stern1. 1) HHMI Janelia Farm, Ashburn, VA; 2) European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; 3) Okinawa Institute of Science and Technology Graduate University, Japan.

747C
Global analysis of early nervous system specification. Lea Daempfling, Robert P. Zinzen. BIMSB, MDC Berlin, Berlin, Berlin, Germany.

748A
Decoding the regulatory grammar at homeotic gene enhancers. Robert Drewell1,3,4, Lauren Winkler4, Jessica Kurata4, Michael Nevarez4, Lily Li4, Jacqueline Dresch2. 1) Department of Biology, Amherst College, Amherst, MA; 2) Department of Mathematics, Amherst College, Amherst, MA, 01002; 3) Department of Biological Sciences, Mount Holyoke College, South Hadley, MA, 01075; 4) Biology Department, Harvey Mudd College, Claremont, CA, 91711.

749B
Identifying the enhancer region for singles bar expression in Drosophila melanogaster myoblasts. Brayon Fremin, Tonya Brunetti, Richard Cripps. Biology Dept, UNM, Albuquerque, NM.

750C
Evolution of sex comb enhancers in the HOX gene Scr. Daniel Friedman, Olga Barmina, Artyom Kopp. Department of Evolution and Ecology, University of California, Davis, Davis, CA.

751A
The Abdominal-A Hox factor acts in the EGF signal receiving cell to promote oenocyte formation. Lisa M. Gutzwiller, David Li-Kroeger, Brian Gebelein. Dev Biol, Cincinnati Children's Hosp, Cincinnati, OH.

752B
Do regulatory interactions that result in repression of transcription elongation dominantly interfere with activation by other enhancers at the same promoter? Michael L. Higgins1, Lisa Prazak2, Haiyue Zhang3, John Peter Gergen4. 1) Graduate Program in Biochemistry and Structural Biology, Stony Brook University, Stony Brook, NY; 2) Cold Spring Harbor Laboratory, Cold Spring Harbor, Stony Brook NY; 3) Nanjing University, Nanjing, China; 4) Department of Biochemistry and Cell Biology and the Center for Developmental Genetics.

753C
Tissue-specific cis-regulatory interactions in early Drosophila development. Sabrina Krueger, Robert P. Zinzen. BIMSB, MDC Berlin, Berlin, Germany.

754A
Establishment of chromatin states during maternal to zygotic transition in Drosophila embryos. Xiao-Yong Li1, Melissa Harrison2, Tommy Kaplan3, Michael Eisen1,4. 1) Howard Hughes Medical Institute, University of California, Berkeley, CA; 2) Dept of Biomolecular Chemistry, University of Wisconsin, Madison, WI; 3) School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; 4) Dept of Molecular and Cell Biology, Dept of Integrative Biology, QB3 Institute, University of California, Berkeley, CA.

755B
Tinman and Pannier Regulate a Mef2 Shadow Enhancer in the Drosophila Heart. TyAnna L. Lovato, Cheryl A. Sensibaugh, Kirstie L. Swingle, Melody M. Martinez, Richard M. Cripps. Biol, Univ New Mexico, Albuquerque, NM.

756C
Complex Cis-Regulation of the Drosophila Genome: Insights from the modENCODE Project. Steve W. Miller1, Nicholas Negre2, Matthew Slattery2, Chris Bristow3, Jia Chen2, Rachel Selfon3, Lijia Ma2, Manolis Kellis3, Kevin P. White2, James W. Posakony1. 1) Div of Bio/CDB, UCSD, San Diego, CA; 2) Institute for Genomics & Systems Biology, Dept of Human Genetics, Univ of Chicago, Chicago, IL; 3) Comp Sci and Artificial Intelligence Lab, Broad Inst of MIT and Harvard, Cambridge MA.

757A
Dissecting the cis-regulatory DNA that controls the POU-domain transcription factor genes, pdm-1 and pdm-2. Jermaine Ross1,2, Kuzin Alexander1, Thomas Brody1, Ward F. Odenwald1. 1) NIH, Bethesda, MD; 2) Brown University, Providence, RI.

758B
Spalt major directly regulates seven-up expression in Drosophila oenocytes. Kathryn M. Ryan, Richard M. Cripps. Dept Biol, Univ New Mexico, Albuquerque, NM.

759C
Deciphering the logic of Su(H)-dependent Notch-target enhancers. Elizabeth Stroebele, Xin Yuan, Christian Noblett, Andrew Brittain, Albert Erives. Dept. of Biology, University of Iowa, Iowa City, IA 52242, USA.

760A
Multiple cis-regulatory elements regulate eyes absent expression in the developing retina. Bonnie Weasner, Justin Kumar. Department of Biology, Indiana University, Bloomington, IN.

761B
The Regulation and origin of sexually dimorphic segment number in Drosophila abdomen. Shun Yan, Wei Wang, John Yoder. University of Alabama, Tuscaloosa, AL.

762C
The Chromatin Regulator Sin3A Buffers Transcriptional Changes in the Somatic Musculature. Krista C. Dobi1, Marc S. Halfon2, Mary K. Baylies1. 1) Dept Dev Biol, Sloan-Kettering Inst, New York, NY; 2) Dept Biochemistry, SUNY Buffalo, Buffalo, NY.

763A
Krüppel regulation of hunchback increases reliability of mid-embryo expression patterning. David M. Holloway1, Alexander V. Spirov2,3. 1) Dept Mathematics, British Col Inst Tech, Burnaby, BC, Canada; 2) CEWIT and Computer Science, Stony Brook University, New York, USA; 3) Sechenov Institute of Evolutionary Physiology and Biochemistry St. Petersburg, Russia.

764B
Natural variation on the expression of developmentally essential gene even-skipped in Drosophila melaogaster. Pengyao Jiang1, Michael Ludwig1, Martin Kreitman1,2, John Reinitz1,3. 1) Ecology & Evolution, University of Chicago, Chicago, IL; 2) Committee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, IL; 3) Molecular Genetics & Cell Biology, The University of Chicago, Chicago, IL.

765C
In vivo interpretation of morphogen gradients in neural development. Agnieszka Klawiter, Robert P. Zinzen. BIMSB, MDC Berlin, Berlin, Germany.

766A
Regulation of ligand transcription mediates signaling pathway crosstalk. Noemie Ammeux1, Ben Housden1, Norbert Perrimon1,2. 1) Department of Genetics, Harvard Medical School, Boston, MA; 2) Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA.

767B
FlyBase Gene Model Annotations: The Rule-Benders. Madeline Crosby, Gil dos Santos, Sian Gramates, Beverley Matthews, Susan E. St. Pierre, David Emmert, Pinglei Zhou, Andrew Schroeder, Kathleen Falls, Susan Russo, William Gelbart, FlyBase Consortium. FlyBase, Harvard University, Cambridge, MA.

768C
Expression of the RpL22e family: Evidence for tissue-specific post-translational modification of RpL22e-like in the fly eye. Brett W. Gershman, Michael G. Kearse, Vassie C. Ware. Biological Sciences, Lehigh University, Bethlehem, PA.

769A
An editing-independent function for the Drosophila dADAR mRNA truncated isoform during rnp-4f 5’-UTR intron splicing regulation. Sushmita Ghosh, Yaqi Wang, John Cook, Lea Chhiba, Jack Vaughn. Biology, Miami University, Oxford, OH.

770B
Allele spesific expression in heterozygous D. melanogaster embryos. Tevfik H. Kitapci, Srna Vlaho, Jessica Gabrielian, Daniel Campo, Sergey Nuzhdin. Molecular and Computational Biology, USC, Los Angeles, CA.

771C
Is there evidence for Dosage Compensation in Strepsiptera? Shivani Mahajan, Doris Bachtrog. Integrative Biology, University of California , Berkeley, US.

772A
Role of regulatory small peptides in the control of gene expression during cell morphogenesis. Emilie Benrabah1,2, Jennifer Zanet1,2, Tongchao Li3, Hugo Bellen3, Francois Payre1,2, Serge Plaza1,2. 1) Centre de Biologie du development, Universite Paul Sabatier, Toulouse, France; 2) CNRS UMR5547, Toulouse, France; 3) Baylor College of Medicine, Houston, Texas, USA.

773B
Alternative splicing of Drosophila nmnat functions as a switch between NAD synthetic and neuroprotective functions. Kai Ruan, Chong Li, Shaoyun Zang, R.Grace Zhai. MCP, Miller School of Medicine, University of Miami, Miami, FL.

774C
FlyBase Gene Model Annotations: Impact of High Throughput Data. Susan E. St. Pierre, Beverley Matthews, Madeline Crosby, Gil dos Santos, Sian Gramates, David Emmert, Pinglei Zhou, Andrew Schroeder, Kathleen Falls, Susan Russo, William Gelbart, FlyBase Consortium. FlyBase, Harvard University, Cambridge, MA.

Chromatin and Epigenetics


775A
The chromatin landscape of Drosophila: comparisons between sexes, species, and chromosomes. Emily Brown, Doris Bachtrog. Department of Integrative Biology, University of California, Berkeley, Berkeley, CA.

776B
How does Ago2 contribute to dosage compensation in Drosophila melanogaster? Nikita Deshpande, Victoria Meller. Department of Biological Sciences, Wayne State University, Detroit, MI.

777C
The Genetic Basis of Paris Sex-Ratio Drive in Drosophila simulans. Quentin Helleu1,2, Pierre Gérard1, David Ogereau1, Benjamin Prud'homme3, Catherine Montchamp-Moreau1. 1) Laboratoire Evolution Génomes & Spéciation, CNRS, Gif sur Yvette, France; 2) Université Paris XI, Orsay, France; 3) Institut de Biologie du Developpement de Marseille-Luminy, Aix-Marseille Université, Marseille, France.

778A
Nucleosomes shape DNA polymorphism and divergence. Sasha A. Langley1, Charles H. Langley2, Gary H. Karpen1,3. 1) Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA; 2) University of California, Davis, Department of Evolution and Ecology, Davis, CA; 3) University of California, Berkeley, Department of Molecular and Cellular Biology, Berkeley, CA.

779B
The Influence of the Chd1 on puffing pattern in polytene chromosomes during drosophila development. Anna Makase, Alexander Konev. St. Petersburg Nuclear Physics Institute, Gatchina, Russian Federation.

780C
HP1B’s role in gene regulation and chromatin structure. Louis Watanabe, Nicole Riddle. Biology, University of Alabama at Birmingham, Birmingham, AL.

781A
Structure-Function Studies of Drosophila Myb-Interacting Protein Mip120. MeiHsin Cheng1, Laura Andrejka2, Joseph Lipsick1,2,3. 1) Genetics, Stanford University , Stanford, CA; 2) Pathology, Stanford University , Stanford, CA; 3) Biology, Stanford University , Stanford, CA.

782B
Neocentromere formation in Drosophila. Jason T. Palladino, Barbara Mellone. Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT.

783C
Analyzing the co-evolution of CENP-A, CAL1, and centromeric DNA in Drosophila. Leah Rosin, Barbara Mellone. Molecular and Cell Biology, University Of Connecticut, Storrs, CT.

784A
Monitoring the influence of CHD1 on histone dynamics in Drosophila melanogaster. Michael A. Erb, Jennifer A. Armstrong. W.M. Keck Science Department, Claremont McKenna College, Claremont, CA.

785B
A candidate screen to identify factors important for CHD1 in Drosophila melanogaster. Sharon Kim, Jennifer Armstrong. W.M. Keck Science Department, Scripps College, Claremont, CA.

786C
The role of centromeric protein misregulation in aneuploidy and cancer. Nicole L. Beier1,2, Gary H. Karpen1,2. 1) Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA; 2) Department of Genome Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA.

787A
Understanding the regulation of expression and stability of the SIN3 isoforms. Ashlesha M. Chaubal, Ambikai Gajan, Lori Pile. Biological Sciences, Wayne State University, Detroit, MI.

788B
The signature of repressed enhancers during Drosophila pattern formation. Nina Koenecke1,2, Samuel Meier1, Jeffrey Johnston1, Julia Zeitlinger1,3. 1) Stowers Institute for Medical Research, Kansas City, MO, USA; 2) The Open University, UK; 3) University of Kansas Medical Center, Department of Pathology and Cell Biology, Kansas City, KS, USA.

789C
Histone H3S10 Phosphorylation by the JIL-1 Kinase in Pericentric Heterochromatin and on the 4th Chromosome Creates a Composite H3S10phK9me2 Epigenetic Mark. Chao Wang, Yeran Li, Weili Cai, Xiaomin Bao, Jack Girton, Jorgen Johansen, Kristen Johansen. Biochemistry, Biophysics & Mol Biol, Iowa State University, Ames, IA.

790A
Drosophila Rm62 and SU(VAR)3-9 complex targeted by a 5’ non coding midsized RNA for Heterochromatin assembly. Indira Bag1, Manika Pal-Bhadra1, J. Boeke3, Axel Imhof3, Utpal Bhadra2. 1) Centre for Chemical Biology, Indian Institute of Chemical Technology, Tarnaka, Uppal road, Hyderabad 500007, Andhra Pradesh, India; 2) Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Hyderabad-500007, India; 3) 3Munich Center of Integrated Protein Science and Adolf-Butenandt Institute, Ludwig Maximilians University of Munich, Munich, Germany.

791B
Understanding Heterochromatin: Determination of DNA Elements That Influence Gene Expression. April Bauer, Sarah Elgin. Department of Biology, Washington University, St. Louis, MO.

792C
Heterochromatin Function and Dynamics by the KDM4A Demethylase. Serafin U. Colmenares1, Sasha Langley1, Cameron Kennedy1, Irene Chiolo2, Joel Swenson1, Axel Imhof3, Gary Karpen1. 1) Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, CA; 2) Dept of Biological Sciences, University of Southern California, Los Angeles, CA; 3) Adolf Butenandt Institut, University of Munich, Germany.

793A Unprogrammed presentation number

794B
Development of a single break system to study DNA damage repair in heterochromatin. Aniek Janssen1,2, Jan LaRocque3, Gary Karpen1,2. 1) Genome Dynamics, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA; 2) Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA; 3) Department of Human Science, School of Nursing & Health Studies, Georgetown University, Washington DC, USA.

795C
Centromeric variation in natural populations of Drosophila melanogaster. Charles H. Langley1, Gary H. Karpen2,3, Sasha A, Langley2. 1) Dept, of Evolution and Ecology, Univ California - Davis, Davis, CA; 2) Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA; 3) University of California, Berkeley, Department of Molecular and Cellular Biology, Berkeley, CA.

796A
Ator, a Novel AT-hook Protein Co-purifies with Chromator and Localizes to the Chromocenter and Interband Regions of Polytene Chromosomes. Yeran Li1, Peng Wang2, Changfu Yao1, Jack Girton1, Vincent Archambault2, Kristen Johansen1, Jorgen Johansen1. 1) Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, IA; 2) Institut de Recherche en Immunologie et en Cancérologie, Montreal, Canada.

797B
Novel Roles of Helicases in Preventing Aberrant Recombination Repair in Heterochromatin. Taehyun Ryu, Kate Bowlin, Devika Das, Irene Chiolo. Molecular and Computational Biology Department, University of Southern California, Los Angeles, CA.

798C
Identification and Characterization of Novel Regulators of Heterochromatin Structure and Function. Joel Swenson1,2, Serafin Colmenares2, Sylvain Costes3, Gary Karpen1,2. 1) Molec & Cell Biol, Univ California-Berkeley, Berkeley, CA; 2) Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, CA; 3) Department of Cancer and DNA Damage Response, Lawrence Berkeley National Laboratory, Berkeley, CA.

799A
Illuminating the onset of late replication and heterochromatinization of particular repetitive sequences during Drosophila embryogenesis using TALE-lights. Kai Yuan, Tony Shermoen, Patrick O'Farrell. Biochemistry & Biophysics, UCSF, San Francisco, CA.

800B
Dissection of a domain border in the bithorax complex. Welcome Bender. BCMP Dept, Harvard Medical Sch, Boston, MA.

801C
Mechanism of Homie insulator-mediated long-range interaction. Miki Fujioka, James B. Jaynes. Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA.

802A
The RNA-binding protein CIP3 antagonizes gypsy chromatin insulator function in a tissue-specific manner. Matthew R. King, Leah H. Matzat, Ryan K. Dale, Su Jun Lim, Elissa P. Lei. Laboratory of Cellular and Developmental Biology, NIDDK, NIH, Bethesda, MD.

803B
The chromatin state-dependent TRL binding conservation in Drosophila species. Lijia Ma1, Matthew Slattery2, Nicolas Negre3, Robert Arthur1, Rebecca Spokony1, Sasha Ostapenko1, Ryan Ptashkin1, Jennifer Zieba1, Kevin White1. 1) University of Chicago, Chicago, IL., US; 2) University of Minnesota, Duluth, MN., US; 3) University of Montpellier, Montpellier, France.

804C
Cis-elements mediating epigenetic regulation of eyeless locus in Drosophila melanogaster. Shreekant Verma, Rashmi U. Pathak, Rakesh K. Mishra. Centre for Cellular and Molecular Biology - CSIR, Hyderabad-07, India.

805A
De novo establishment of PcG-mediated repression. Jumana S. AlHaj Abed, Rick Jones. Southern Methodist University, Dallas, TX.

806B
Cyclin G, a link between epigenetic regulation of gene expression and developmental stability? Camille Dupont1, Delphine Dardhalon-Cuménal1, Valérie Ribeiro1, Vincent Debat2, Frédérique Peronnet1, Neel B. Randsholt1. 1) UMR7622 - Developmental Biology, CNRS-UPMC, Paris, France; 2) UMR7205 - OSEB, Systematic and Evolution, CNRS-MNHN, Paris, France.

807C
Deciphering the functions of Ino80, a chromatin remodeling protein, in Drosophila development. Mohsen Ghasemi1, Vasanthi Dasari2, Shruti Jain1, Narendra Pratap Singh2, Rakesh K. Mishra2, Vani Brahmachari1. 1) Dr. B. R. Ambedkar Center for Biomedical Research, Delhi University, Delhi, India; 2) Centre for Cellular and Molecular Biology, Hyderabad, India.

808A
Polycomb group regulation of engrailed and invected. Judith A. Kassis, Sandip De, Yuzhong Cheng. NICHD/NIH, Bethesda, MD.

809B
Identifying new Polycomb group genes by screening for mutations that disrupt pairing-sensitive silencing. James A. Kennison. Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD.

810C
Genome-wide functions for Polycomb complexes. Hun-Goo Lee1, Yuri Schwartz2, Tatyana Kahn2, Amanda Simcox3, Vincenzo Pirrotta1. 1) Molecular Biology and Biochemistry Dept, Rutgers University, Piscataway, NJ; 2) Molecular Biology Dept, Umeå University, Umeå, Sweden; 3) Molecular Genetics Dept, Ohio State University, Columbus, OH.

811A
Dynamic and differential targeting of Polycomb complexes during Drosophila development. Anne-Marie Martinez, Anna Delest, Aubin Thomas, Bernd Schuttengruber, Samy Sakr, Giacomo Cavalli. Institute of Human Genetics, CNRS, Montpellier, Languedoc-Roussillon, France.

812B
Polycomb/ Trithorax group proteins collaborate with Heterochromatin protein 1 to regulate Drosophila gene expression. Janel Rodriguez, Jamila Horabin. Biomedical Science, Florida State University, Tallahassee, FL.

813C
A screen of chromatin modifier mutants in Drosophila wing disc regeneration using a non-surgical ablation system. Yuan Tian, Rachel Smith-Bolton. Cell & Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL.

814A
What makes the X unique: an X-clusive sequence story. Sonal S. Joshi, Victoria H. Meller. Department of Biological Sciences, Wayne State University, Detroit, MI.

815B
The function of the dosage compensation protein, CLAMP, at the histone locus body. Leila E. Rieder, Anna Zeidman, Erica Larschan. Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI.

816C
Cohesin-independent connections between sister chromatids and their relationship to homolog pairing. Tharanga Niroshini Senaratne, Eric Joyce, Chao-ting Wu. Genetics, Harvard Medical School, Boston, MA.

817A
Investigating the role of chromatin remodeler CHD1 in the nucleolus of D. melanogaster. Lauren S. Siems, Jennifer Armstrong. Biology, Scripps College, Claremont, CA.

818B
Trans--Activation: A New Epigenetic Phenomenon Responsible for Transcriptional Memory. Davide Corona, Maria Cristina Onorati, Walter Arancio. STEBICEF, Universita di Palermo, Palermo, Italy.

819C
Presence of assymetic CpC methylation in Drosophila melanogaster. Deepti D. Deobagkar1,2, Chitra Pannikar1, Abhyankar Varada1, Deshmukh Saniya1. 1) Zoology, University of Pune, Pune, India, 411007; 2) Bioinformatics center, University of Pune, Pune, India, 411007.

820A
Identifying the Genetic Components of Hybrid Sterility in Drosophila virilis. Mauricio Galdos1,2, Alex Erwin1, Chris Harrison1, Justin Blumenstiel1. 1) Ecology and Evolutionary Biology, The University of Kansas, Lawrence, KS; 2) Molecular Biosciences, The University of Kansas, Lawrence, KS.

821B
Defining the roles of chromatin environment in DNA replication origin activation. Brian Hua1,2, Terry Orr-Weaver1,2. 1) Whitehead Institute, Cambridge, MA; 2) MIT Biology, Cambridge, MA.

822C
Evaluation of genes required for cell survival after telomere loss. Rebeccah Kurzhals1, Cory Parks1, Hailey Lowery1, Jenny Atanasov2, Zachary Lee3. 1) Department of Biology, Southeast Missouri State University, Cape Girardeau, MO; 2) University of California San Diego, California 92093; 3) University of Utah, Salt Lake City, UT 84112.

823A Unprogrammed presentation number

824B
Faithful Transmission of Paternal Telomeres Ensured by a Sperm-Specific Chromosomal Protein. Takuo Yamaki1, Glenn Yasuda2, Barbara Wakimoto1. 1) Department of Biology, University of Washington, Seattle, WA 98195; 2) Department of Biology, Seattle University, Seattle, WA 98122.

RNA Biology


825C
MicroRNA-mediated Regulation of Apoptosis in Drosophila. Chao-Yi Chen1,2, Jian-Chiuan Li2, Kun-Nan Tsai2,4, Chi-Chuan Li2,5, Hsi-Ju Chen2, Haixia Huang3, Wan-Hsuan Lin2, Bruce A. Hay3, Chun-Hong Chen2,3. 1) Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan; 2) Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan Mioali, Taiwan, Taiwan; 3) Division Of Biology, Mc 156-29, California Institute Of Technology, Pasadena, CA. USA; 4) Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan; 5) Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.

826A
MicroRNAs regulates the neuronal and developmental timing. Chu-Ya Cheng1, Kun-Nan Tsai1,2, Jian-Chiuan Li1, Hung-Hsiang Yu3, Chun-Hong Chen1. 1) Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan; 2) Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan; 3) Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.

827B
Unbiased screening by conditional competitive inhibition reveals novel functions of conserved Drosophila miRNAs during development and adult behavior. Elizabeth M. McNeill1, Tudor A. Fulga1,6, Richard Binari2, Julia Yelick1, Alexandra Blanche1, Matthew Booker2, Michael Schnall-Levin2, Yong Zhao2, Todd DeLuca3, Fernando Bejarano4, Zhe Han5, Eric C. Lai4, Dennis Wall3, Norbert Perrimon2, David Van Vactor1. 1) Cell Biology, Harvard Medical School, Boston, MA; 2) Genetics, Harvard Medical School, Boston, MA; 3) Systems Biology, Harvard Medical School, Boston, MA; 4) Developmental Biology, Sloan-Kettering Institute, New York, NY; 5) Internal Medicine-Molecular Medicine, Genetics and Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI; 6) Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

828C
Sexual divergence by global and coordinated reductions in microRNA abundance and 3'UTR length in spermatogenesis. Yang Shen1, Bitao Qiu1, Chung-I Wu1,2,3. 1) State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guang Zhou, P.R. China; 2) Department of Ecology and Evolution, Univeristy of Chicago, Chicago, USA; 3) Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P.R. China.

829A
Genome-wide microRNA screening reveals that the evolutionary conserved microRNA-9a regulates body growth by targeting sNPFR1/NPYR. Yoon Seok Suh1,2, Kweon Yu1,2. 1) Bionano Research Center, KRIBB, Daejeon, South Korea; 2) Department of Functional Genomics, KUST, Daejeon, South Korea.

830B
Characterization of subtelomeric regions involved in transposable element repression in Drosophila melanogaster. Amna Asif-Laidin. Université Pierre et Marie Curie, Paris, France.

831C
Primary processing and Aub homotypic ping-pong cycle are acting in Drosophila primary spermatocytes to produce piRNAs. Emilie Quenerch'du1,2, Amit Anand1, Toshie Kai1,2. 1) Temasek Life Sciences Laboratory, Singapore; 2) National University of Singapore, Department of Biological Sciences, Singapore.

832A
Cosuppression of Adh gene in Drosophila melanogaster by insertion of inducible transgene follows typical RNAi pathway. Debabani Roy Chowdhury, Utpal Bhadra. Functional Genomics Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500007, INDIA.

833B
Dietary Restriction and the effects of the Syndecan gene on life span in Drosophila. Thanhlong G. Tran1, Maria De Luca2, Jeff Leips1. 1) Dept of Biological Science, UMBC, Baltimore, MD; 2) Dept of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL.

834C
Core snRNP splicing factor SmD1 modulates RNA interference in Drosophila. Xiao-Peng Xiong1, Krishna Kurthkoti1, Kung-Yen Chang1, Gianluigi Lichinchi1, Nabanita De2, Anette Schneemann3, Ian J. MacRae2, Tariq M. Rana1, Norbert Perrimon4, Rui Zhou1. 1) Program for RNA Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA; 2) Department of Integrative Structural and Computational Biology; 3) Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA; 4) Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA.

835A
Circular RNA transcripts in Drosophila melanogaster development. Shannon Hateley1, Lior Pachter1,2, Michael Eisen1,3. 1) Department of Molecular and Cell Biology, University of California, Berkeley, CA; 2) Department of Mathematics, University of California, Berkeley, CA; 3) Howard Hughes Medical Institute, University of California, Berkeley, CA.

836B
Acal, a long non-coding RNA that collaborates with Raw to downregulate JNK signaling during dorsal closure. Luis Daniel Ríos-Barrera, Juan Riesgo-Escovar. Dev Biology., Neurobiology Inst, Univ Nacional Autónoma de México, Querétaro, Juriquilla, Mexico.

837C
Tropomyosin protein expression is regulated by a novel coding region determinant. Nathan Boin, Jessica Williams, Aaron N. Johnson. Dept of Integrative Biology, University of Colorado Denver, Denver, CO.

838A
Analysis of the nuclear localisation of castor-mRNA in Drosophila melanogaster. Antje Juengling1, Melanie Homberg2, Kathrin Fischer1, Joachim Urban1. 1) Institute of Genetics, University of Mainz, Mainz, Germany; 2) TRM Leipzig, Dpt. for Cell and Development Biology, Leipzig, Germany.

839B
Identification of a conserved motif in mRNAs that localize to RNA islands during Drosophila embryogenesis. Stephanie Yee1, Michelle Kowanda1, Xiao Li2, Quaid Morris3, Howard Lipshitz2, Eric Lecuyer4, Paul Lasko1. 1) Biology, McGill University, Montreal, Quebec, Canada; 2) Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; 3) Computer Science, University of Toronto, Toronto, Ontario, Canada; 4) RNA Biology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada.

840C
Distinct neural mRNA decay kinetics in Drosophila embryogenesis. Dana A. Burow, Maxine Umeh, Michael Cleary. Quantitative and Systems Biology, University of California, Merced, Merced, CA.

841A
Stable intronic sequence RNAs (sisRNAs) in Drosophila melanogaster. Jun Wei Pek, Eugene Gardner, Joseph Gall. Embryology, Carnegie Institution, Baltimore, MD.

842B
New RNA-seq and RNAi data on the function of alternatively spliced exons in the complex Drosophila dumpy gene. Amber Carmon, Ross MacIntyre. Dept Molec Biol & Genetics, Cornell Univ, Ithaca, NY.

843C
Analysis of alternative splicing in Drosophila using RNA-sequence data. Lauren Gibilisco, Qi Zhou, Shivani Mahajan, Doris Bachtrog. University of California, Berkeley, Berkeley, CA.

844A
Decreased expression of 9G8 and sex determination genes alter lipid droplet morphology and triglyceride levels in larvae. Bijal C. Kakrecha1, Robert M. Gingras3, Spencer Ng2, Justin R. DiAngelo3, Alexis Nagengast2. 1) Biology, Widener Univ, Chester, PA; 2) Biochemistry and Chemistry, Widener Univ, Chester, PA; 3) Biology, Hofstra Univ, Hempstead, NY.

845B
A phylogenetic study of Drosophila splicing assembly chaperone RNP-4F associated U4-/U6-snRNA: a revised secondary structure. Jack C. Vaughn, Sushmita Ghosh, Jing Chen. Dept Biology, Miami Univ, Oxford, OH.

846C
A new non-spliceosomal nuclear intron class in Drosophila rnp-4f. Yaqi Wang, Sushmita Ghosh, Angila Simone, Amy Feiber, Jack Vaughn. Biology, Miami University, Oxford, OH.

847A
The effect of ALS-associated TDP-43 mutations on active translation of specific RNAs using polysome profiling and RNA-seq. Scott G. Daniel1, Antony Pearson1, Daniela C. Zarnescu1,2,3. 1) Molecular and Cellular Biology Dept, University of Arizona, Tucson, AZ; 2) Neuroscience Dept, University of Arizona, Tucson, AZ; 3) Neurology Dept, University of Arizona, Tucson, AZ.

848B
Orb and Wispy cooperate in the cytoplasmic polyadenylation of grk mRNA during oogenesis. Amanda Norvell, Lauren Langbein, Kristen Randolph, Letitia Thompson. Dept Biol, Col of New Jersey, Ewing, NJ.

849C
gurken (grk) mRNA is alternatively polyadenylated. Letitia Thompson, Amanda Norvell. Biology, The College of New Jersey, Ewing, NJ.

850A
The RNA export pathway and regulation of tissue specific gene expression. Simona Caporilli, Yachuan Yu, Jianqiao Jiang, Helen White-Cooper. Sch Biosci, Cardiff Univ, Cardiff, United Kingdom.

Techniques and Resources


851B
Three-dimension magnetic resonance microscopy of the Drosophila brain at 10 micron isotropic resolution. Pedro Fernandez-Funez1,2, Choong Lee2, Steve Blackband2,3. 1) Dept Neurology, Univ Florida, Gainesville, FL; 2) Dept. Neuroscience, Univ. of Florida, Gainesville, FL; 3) National High Magnetic Field Laboratory.

852C
Computational tissue labeling: Tissue and Cellular Recognition in Developing Drosophila Embryos. Soile V. E. Keränen1, Jonathan T. Barron2, Pablo Arbeláez2, Mark D. Biggin1, Jitendra Malik2, David W. Knowles1. 1) Lawrence Berkeley National Laboratory, Berkeley, CA; 2) University of California Berkeley, Berkeley, CA.

853A
Ultrastructural characterization of cytokinesis and abscission in polarized epithelia cells using advanced TEM approaches. Irina Kolotueva, Emeline Daniel, Roland Le Borgne. IGDR, Rennes, France.

854B
Microfluidic culturing for studying morphogenesis and gastrulation in live Drosophila embryos. Thomas J. Levario1, Bomyi Lim2, Jiyuan Ding1, Stanislav Y. Shvartsman2, Hang Lu1. 1) School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA; 2) School of Chemical and Biological Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.

855C
The Transgenic RNAi Project (TRiP): new resources, online tools and validation data. Ian T. Flockhart1, Yanhui Hu1, Charles Roesel1,3, Richelle Sopko1, Marianna Foos1, Colleen Kelley1, Noemie Ammeux1, Norbert Perrimon1,2, Stephanie E. Mohr1, Lizabeth Perkins1. 1) Harvard Med Sch, Boston, MA; 2) HHMI, Boston, MA; 3) Northeastern U, Boston MA.

856A
Development of novel CRISPR tools for genome editing in Drosophila. Benjamin E. Housden1, Yanhui Hu1, Charles Roesel3, Ian Flockhart1, Shuailiang Lin1, Colleen Kelley1, Rong Tao1, Michael Buckner1, Laura Holderbaum1, Stephanie Mohr1, Norbert Perrimon1,2. 1) Department of Genetics, Harvard Medical School, Boston, MA; 2) Howard Hughes Medical Institute, Harvard Medical School, Boston, MA; 3) Northeastern University, Boston, MA.

857B
Genome engineering and RNAi resources at the Drosophila RNAi Screening Center. Stephanie E. Mohr1, Yanhui Hu1, Ian T. Flockhart1, Quentin Gilly1, Michael Buckner1, Benjamin E. Housden1, Gerald Marsischky1, Charles Roesel1,2, Shuailiang Lin1, Bahar Yilmazel1, Kirstin Rudd1, Norbert Perrimon1,3. 1) Dept Gen, Harvard Med Sch, Boston, MA; 2) Northeastern University, Boston, MA; 3) Howard Hughes Medical Institute, Boston, MA.

858C
A versatile toolbox for CRISPR/Cas-mediated engineering of the Drosophila genome. Fillip Port1, Hui-Min Chen2, Tzumin Lee2, Simon Bullock1. 1) MRC Laboratory of Molecular Biology, Cambridge, United Kingdom; 2) Janelia Farm Research Campus, HHMI, Ashburn, VA.

859A
High performance gene expression profiling of D melanogaster, and host-parasite interactions. MM Kańdula1, S. Shridhar1, N. Stralis-Pavese1, DP Kreil1,2. 1) Chair of Bioinformatics, BOKU University, Vienna, Austria; 2) School of Life Sciences, University of Warwick, U.K.

860B
New methods for translational profiling of sensory neurons of Drosophila larvae. Andrew Bellemer1, Sherry Tang2, W. Daniel Tracey1,3,4. 1) Department of Anesthesiology, Duke University, Durham, NC; 2) Department of Biology, Duke University, Durham, NC; 3) Department of Neurobiology, Duke University, Durham, NC; 4) Department of Cell Biology, Duke University, Durham, NC.

861C
A Synthetic Non-amplyfing RNAseq Carrier. Peter A. Combs1, Michael B. Eisen2,3. 1) Biophysics Grad Group, UC Berkeley, CA; 2) Molecular and Cell Biology, UC Berkeley, CA; 3) HHMI, UC Berkeley, CA.

862A
Large-scale identification of chemically induced mutations in Drosophila melanogaster . Nele A. Haelterman1, Lichun Jiang2, Yumei Li2, Vafa Bayat1,3, Berrak Ugur1, Kai Li Tan1, Ke Zhang4, Danqing Bei2, Bo Xiong1, Wu-Lin Charng1, Hector Sandoval2, Shinya Yamamoto1,2, Manish Jaiswal2,5, Koen J. T. Venken1,6, Rui Chen1,2, Hugo J. Bellen1,2,4,5. 1) Developmental Biology Program, Baylor College of Medicine, Houston, TX; 2) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tx; 3) Medical Scientist Training Program, Baylor College of Medicine, Houston, Tx; 4) Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Tx; 5) Howard Hughes Medical Institute; 6) Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Tx.

863B
Prediction of genetic interactions from high-throughput RNA-Seq of Drosophila deletion collections. Hangnoh Lee1, Dong-Yeon Cho2, Steven Russell3, Teresa Przytycka2, Brian Oliver1. 1) National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD; 2) National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD; 3) Department of Genetics, University of Cambridge, Cambridge, United Kingdom.

864C
High-speed robotic system for handling live non-anesthetized adult Drosophila melanogaster for biological research. Joan Savall1,2, Eric Tatt Wei Ho1,3, Mark Schnitzer1,2. 1) James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA; 2) Howard Hughes Medical Institute, Stanford University, Stanford, CA; 3) University Teknologi PETRONAS, Malaysia.

865A
Modeling a gene's expression from its intergenic sequence. Md A. Hassan Samee1, Tara Lydiard-Martin3, Angela DePace3, Saurabh Sinha1,2. 1) Dept of Comp Sci, Univ of Illinois, Urbana, IL; 2) Institute for Genomic Biology, Univ of Illinois, Urbana, IL; 3) Dept of Systems Biology, Harvard Med School, Boston, MA.

866B
Automated Image Annotation of Drosophila Embryos. Qian Sun1,2, Stuart Newfeld3, Sudhir Kumar1,3,4, Jieping Ye1,2. 1) Center for Evolutionary Medicine and Informatics, Biodesign Institute, Arizona State University, Tempe, AZ; 2) School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ; 3) School of Life Sciences, Arizona State University, Tempe, AZ; 4) Center of Excellence in Genomic Medicine Research, King Abdulaziz Univ, Jeddah, Saudi Arabia.

867C
Annotation of genes on the Drosophila biarmipes dot chromosome using comparative genomics. Alison Dubé, Benjamin Reid, Genevieve St. Martin, Tiffany Turner, James E. J. Bedard. Department of Biology, University of the Fraser Valley, Abbotsford, BC, Canada.

868A
GeneSeer Aids Drug Discovery by Exploring Evolutionary Relationships Between Genes Across Genomes. Douglas D. Fenger, Matthew Shaw, Philip Cheung, Tim Tully. Bioinformatics Department, Dart NeuroScience, San Diego, CA.

869B
FlyExpress 6: Discovering cis-regulatory motifs by integrative analysis of sequence and spatiotemporal patterns of expression. Charlotte E. Konikoff1, Bremen Braun1, Maxwell Sanderford1, Qian Sun1,2, Thomas Brody3, Jieping Ye1,2, Sudhir Kumar1,4. 1) Center for Evolutionary Medicine and Informatics, Biodesign Institute, Arizona State University, Tempe, AZ; 2) School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ; 3) National Institutes of Health, Neural Cell-Fate Determinants Section, Bethesda, MD; 4) School of Life Sciences, Arizona State University, Tempe, AZ.

870C
A website consolidating multiple Drosophila species genome data. Virginie Orgogozo. Institut Jacques Monod, CNRS UMR7592, Paris, France.

871A
A proposed standardized Drosophila thoracico-abdominal ganglion nomenclature. Douglas Armstrong2, Jana Börner4, Gwyneth Card1, Robert Court2,3, Marta Costa5, Michael Dickinson6, Carsten Duch7, Wyatt Korff1, Richard Mann8, David Merritt9, Rod Murphey4, Shigehiro Namiki1, Andrew Seeds1, David Shepherd3, Troy Shirangi1, John Tuthill10, James Truman1, Darren Williams11. 1) HHMI- Janelia Farm; 2) School of Informatics, U. of Edinburgh; 3) School of Biol. Sci, Bangor University; 4) Biological Sciences, Florida Atlantic University; 5) Dept. of Genetics, U. of Cambridge; 6) Dept. of Biology, U. of Washington; 7) Univ. of Mainz; 8) Biochemistry and Molecular Biophysics, Columbia University; 9) School of Biological Sciences, The University of Queensland; 10) Department of Neurobiology, Harvard Medical School; 11) MRC Centre for Developmental Neurobiology, King's College London.

872B
High rates of background mutagenesis induced by the hsFLP-FRT targeted deletion method. David R. Andrew1,2, Robert Kraft2, Alvin J. Clark2, Judith Tello2, Monica Chaung2, Elise Blackmore2, Frank Valdes2, Linda L. Restifo1,2. 1) Center for Insect Science, University of Arizona, Tucson, AZ; 2) Department of Neuroscience, University of Arizona, Tucson, AZ.

873C
Regulated, inducible Cre for spatio-temporal mosaic analysis in Drosophila. Sougata Roy, Songmei Liu, Frank Hsiung, Thomas B. Kornberg. Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA.

874A
RMCE in Drosophila tissue-culture cells. Amanda Simcox, Thomas Jacobsen, Sathiya Manivannan, Bhavani Selvaraj. Dept Molec Gen, Ohio State Univ, Columbus, OH.

875B
Visualization of Sqd-grk Interactions in Live Drosophila Oocytes Using Tri-molecular Fluorescence Complementation. Nancy J. Levensailor, Steven J. Gangloff, Alicia R. Watson, Dane M. Buenton, Nathanael R. Terwilliger, Scott B. Ferguson. Department of Biology, SUNY Fredonia, Fredonia, NY.

876C
Analysis of temperature sensitivity of nine Rho1 alleles. Nicole K. Barnette1, Lauren Stone2, Laurence von Kalm1. 1) Biology, University of Central Florida, Orlando, FL; 2) Rollins College, Winter Park, FL.

877A
Drosophila Habitat Developed to Support Research on the International Space Station. Sharmila Bhattacharya, Matthew Lera, Ravikumar Hosamani. Space Biosciences Division, NASA Ames Res Ctr, Mail stop 236-5. Moffett Field, CA 94035.

878B
Characterization of histidine decarboxylase bearing an internal FLAG epitope in Drosophila melanogaster . Anthony Hage1, Maxwell Mianecke2, Andra Trapp1, Deb Burg1, Martin G. Burg1,2. 1) Biomedical Sciences, Grand Valley State Univ., Allendale, MI; 2) Cell and Molecular Biology, Grand Valley State Univ., Allendale, MI.

879C
Survey or Drosophila species on Santa Catalina Island. Joyce Y. Kao, Sergey V. Nuzhdin. Biological Sciences, University of Southern California, Los Angeles, CA.

880A
Novel vectors for tracking multiple transgenes within a single Drosophila strain. David Li-Kroeger1, Hugo Bellen1,2,3. 1) Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 2) Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX; 3) Howard Hughes Medical Institue, Baylor College of Medicine, Houston, TX.

881B
New stocks at the Bloomington Drosophila Stock Center. Annette L. Parks, Kevin R. Cook, Thom C. Kaufman, Kathy A. Matthews. Bloomington Drosophila Stock Center, Dept. of Biology, Indiana University, Bloomington, IN.

882C
Geometric morphometric analysis reveals opposing effects of PVR and JNK signaling on thorax morphology. Lewis Baker1, Rebecca Garlena1, Trish Parsons2, Seth Weinberg2, Beth Stronach1. 1) Dept Micro & Mol Genetics, Univ Pittsburgh Sch Medicine, Pittsburgh, PA; 2) Dept Oral Biology, Univ Pittsburgh Sch Dental Medicine, Pittsburgh, PA.

883A
An intersectional genetic approach that is interoperable with existing GAL4 lines. Shamprasad Varija Raghu1, Claudia Barros1, Farhan Mohammad1, Joanne Lam1, Sadhna Sahani1, Adam Claridge-Chang1,2. 1) Program in Neuroscience and Behavior, Duke-NUS Graduate Medical School, Singapore; 2) Institute for Molecular and Cell Biology, Singapore.

884B
Weak imaginal disc GAL4 drivers can be used to express toxic UAS responder constructs throughout development. Minpei Wang, Mariah Pero, Laurence von Kalm. Department of Biology, University of Central Florida, Orlando, FL.

885C
National BioResource Project “Drosophila” --- Fly Stock Centers Consortium in Japan. Masayoshi Watada1, Toshiyuki Takano2, Muneo Matsuda3, Ryo Akashi4, Ryu Ueda5. 1) Dept Biol, Fac Sci, Ehime Univ, Matsuyama, Ehiem, Japan; 2) Drosophila Genetic Resource Center, Kyoto Institute of Technology, Japan; 3) School of Medicine, Kyorin University, Japan; 4) Frontier Science Research Center, University of Miyazaki, Japan; 5) Genetic Resource Center, National Institute of Genetics, Japan.

Educational Initiatives


886A
Melanogaster...Catch the fly! The video game. Josefa Gonzalez1, Roberto Torres2. 1) Institute of Evolutionary Biology, Barcelona, Barcelona, Spain; 2) Torresdecomunicacion, Barcelona, Spain.

887B
An interdisciplinary project-based approach using Drosophila genetics and cell biology to improve reasoning, problem solving and foundational knowledge in high school students. Sonia Hall1, Camden Hanzlick-Burton2. 1) Molecular Biosciences, University of Kansas, Lawrence, KS; 2) Olathe Northwest High School, Olathe, KS.

888C
A genetic screen for new dis3 alleles in Drosophila. Hemlata Mistry1, Mark Snee2, James Skeath2. 1) Dept of Biology, Widener University, Chester, PA; 2) Dept of Genetics, Washington University Medical School, St Louis, MO.

889A
Using an undergraduate course to map and clone adult visible mutations. Eric P. Spana. Department of Biology, Duke University, Durham, NC.

890B
The Genomics Education Partnership: Implementing a Research-Based Genomics Project for Undergraduates. S. Elgin1, C. Bazinet2, J. Bedard3, M. Burg4, J. DiAngelo5, C. Jones6, L. Kadlec7, J. Leatherman8, H. Mistry9, A. Nagengast9, L. Reed10, NL Reeves11, J. Sanford12, C. Small13, S. Smith14, L. Zhou15, C. Shaffer1, W. Leung1, D. Lopatto16. 1) Washington U St Louis, MO; 2) St John's U, NY; 3) U Fraser Valley, BC; 4) Grand Valley St U, MI; 5) Hofstra U, NY; 6) Moravian Col, PA; 7) Wilkes U, PA; 8) U Northern Colorado, CO; 9) Widener U, PA; 10) U Alabama-Tusc, AL; 11) Mt San Jacinto Col, CA; 12) Ohio Northern U, OH; 13) Medgar Evers Col, NY; 14) Arcadia U, PA; 15) U Pittsburg, PA; 16) Grinnell Col, IA.

891C
Implementation of the Genomics Education Partnership (GEP) Project at a Community College. Nick L. Reeves1, Céline Gerber1, Astrid Russell1, Gabriel A. Sanchez1, Ursula Simonoski1, Curtis C. Smith1, Robert Haywood1, Maureen Njuguna1, Wilson Leung2, Christopher D. Shaffer2, Sarah C. R. Elgin2. 1) Biological Sciences, Mt. San Jacinto College, Menifee, CA; 2) Biology Department, Washington University, St Louis, MO.