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Important Dates:

September 24, 2013
Abstract Submission Opens

Conference Registration Opens

November 5, 2013
Deadline for Workshop Requests
December 9, 2013
Abstract Submission Deadline
December 22, 2013
Larry Sandler Award Submission Deadline
February 3, 2014
Deadline for Early (Discounted) Conference Registration
February 28, 2014
Deadline for Hotel Reservations


2014 Meeting Organizers:


Daniela Drummond-Barbosa
Elissa Lei
Mihaela Serpe
Mark Van Doren

Plenary & Platform Session Listing




Wednesday, March 26   7:00 PM–9:15 PM

Opening General Session

Co-Moderators: Mark Van Doren, Johns Hopkins University, Baltimore, Maryland and Elissa Lei, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland

Room: Atlas Ballroom


7:00 pm   Welcome and Opening Remarks. Mark Van Doren. Johns Hopkins University, Baltimore, Maryland.

7:10 pm   GSA Welcome and Update. Adam Fagen. Genetics Society of America, Bethesda, Maryland.

7:20 pm   Welcome and Opening Remarks. Mark Van Doren. Johns Hopkins University, Baltimore, Maryland.

7:25 pm   Larry Sandler Lecture.

7:55 pm   Keynote Introduction. Elissa Lei. NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.

8:00 pm   Science, Biology, and the World’s Future. Bruce Alberts. UCSF, San Francisco, CA.

9:00 pm   Presentation of George W. Beadle Award to Hugo Bellen, Baylor College of Medicine/HHMI.

Thursday, March 27   8:30 AM–12:00 NOON

Plenary Session I

Moderator: Daniela Drummond-Barbosa, Johns Hopkins University, Baltimore, Maryland

Room: Atlas Ballroom


8:30 am   Image Award Presentation. David Bilder. University of California, Berkeley.

8:35 am   Controlling Morphogen Gradients. Arthur D. Lander. Dept Dev Cell Biol and Dept of Biomedical Engineering, Univ California, Irvine, Irvine, CA.

9:05 am   Fat cadherins in growth, planar polarity and mitochondrial activity. Helen McNeill1,2. Lunenfeld-Tanenbaum Institute, Mt Sinai Hospital rm881, Toronto, ON, Canada; Dept. Molecular Genetics, University of Toronto Toronto, Canada.

9:35 am   Epigenetic Regulation of Drosophila Male Germ Cell Differentiation. Xin Chen. Dept Biol, Johns Hopkins Univ, Baltimore, MD.

10:05 am - Break

10:30 am   X marks the spot: Targeting the X chromosome during dosage compensation. Erica N. Larschan. Molec Biol, Cellular Biol & Biochem, Brown Univ, Providence, RI.

11:00 am   Circuit Mechanisms Underlying Behavioral Decisions and Motor Program Sequencing in Ecdysis. Benjamin H. White. Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD.

11:30 am   The molecular evolution of morphology and behavior. David L. Stern. Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA.

Thursday, March 27   4:30 PM–6:30 PM

Cell Division and Growth Control

Co-Moderators: Laura Buttitta, University of Michigan, Ann Arbor and Alex Gould, MRC National Institute for Medical Research, London, UK

Room: Town & Country

1 - 4:30
Re-replication during Follicle Cell Gene Amplification causes replication fork instability and requires double-strand break repair. Jessica L. Alexander, Terry L. Orr-Weaver. Whitehead Institute for Biomedical Research, and Dept. of Biology, MIT, Cambridge, MA 02142.

2 - 4:45
Regulation of cilium and centrosome function by rootletin. Jieyan Chen, Timothy Megraw. Biomedical Sciences, Florida State University, Tallahassee, FL.

3 - 5:00
The Drosophila orthologue of human GOLPH3 is required for contractile ring formation and membrane trafficking during cytokinesis. Maria Grazia Giansanti1, Giorgio Belloni2, Gianni Colotti1, Vincenzo Mattei3, Anna Frappaolo1, Grazia Daniela Raffa2, Margaret T. Fuller4, Stefano Sechi1. 1) IBPM, Consiglio Nazionale delle Ricerche, Rome, Italy; 2) Dipartimento di Biologia e Biotecnologie, Università Sapienza, Rome, Italy; 3) Laboratory of Experimental and Environmental Pathology, Sabina Universitas, Rieti, Italy; 4) Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, USA.

4 - 5:15
Adenosine is a paracrine homeostatic signal affecting growth of wts tumor clones. Michal Zurovec, Roman Sidorov, Lucie Kucerova. Biology Centre CAS, Ceske Budejovice, Czech Republic.

5 - 5:30
Growth control by the conserved Aac11/Api5 anti-apoptotic protein. Can Zhang1, Wenjian Xu2, Alexey Veraksa2, Kenneth Moberg1. 1) Department of Cell Biology, Emory University, Atlanta, GA; 2) Department of Biology, University of Massachusetts Boston, Boston, MA.

6 - 5:45
The Drosophila TNF receptor Grindelwald couples loss of cell polarity with neoplastic growth. Julien Colombani1, Ditte Andersen1, Krittalak Chakrabandhu1, Michael Röthlisberger2, Anne-Odile Hueber1, Konrad Basler2, Pierre Leopold1. 1) University of Nice Sophia Antipolis, CNRS UMR7277, INSERM U1091, Intitute of Biology Valrose, Nice, France; 2) Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

7 - 6:00
An evolutionarily conserved role for plexins during epithelial wound repair in Drosophila and zebrafish. Sa Kan Yoo1,2, Iswar Hariharan1. 1) UC-Berkeley, Berkeley, CA; 2) Miller institute, UC-Berkeley, Berkeley, CA.

8 - 6:15
Src64 generates a gradient of tyrosine phosphorylation and controls actin dynamics during incomplete cytokinesis in the Drosophila male germline. Asmund H. Eikenes1,2, Catherine Sem Wegner1,2, Lene Malerød1,2, Andreas Brech1,2, Knut Liestøl2, Harald Stenmark1,2, Kaisa Haglund1,2. 1) Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway; 2) Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway.

Thursday, March 27   4:30 PM–6:30 PM

Neural Development

Co-Moderators: Robin Hiesinger, UT Southwestern, Dallas, Texas and James Posakony, University of California, San Diego

Room: Golden West

9 - 4:30
Chromatin modulation in structural and functional refinement of fru+ ORN circuits in Drosophila. Pelin C. Volkan1,2,3, Doug Olsen1, Catherine Hueston2, Qingyun Li1, Jianni Wu4. 1) Duke University, Department of Biology, Durham, NC; 2) Duke University, Department of Neurobiology, Durham, NC; 3) Duke Institute of Brain Sciences; 4) Duke Univeristy, Undergraduate Program in Neuroscience, Durham, NC.

10 - 4:45
Intravital 2-photon imaging and computational modeling reveal simple pattern formation rules underlying neural superposition. Egemen Agi1,5, Marion Langen2,5, Dylan Altschuler2,3, Lani Wu2,4, Steven Altschuler2,4, Peter Robin Hiesinger1,2,4. 1) Department of Physiology, University of Texas Southwestern Medical Center, Dallas; 2) Green Center for Systems Biology, Department of Pharmacology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas; 3) STARS program, University of Texas Southwestern Medical Center, Dallas; 4) Co-corresponding; 5) Equal contribution.

11 - 5:00
Role of microRNA machinery in dendrite patterning. Marvin Nayan1, Charlie Kim2, Jay Parrish1. 1) Dept. of Biology, University of Washington, Seattle, WA; 2) Division of Experimental Medicine, University of California San Francisco, San Francisco, CA.

12 - 5:15
Drosophila Mitofusin affects mitochondrial trafficking, steroid-hormone production and NMJ maturation. Hector Sandoval1, Chi-Kuang Yao1,4, Kuchuan Chen2, Taraka Donti1, Manish Jaiswal3, Yong-Qi Lin3,5, Shinya Yamamoto1,2, Brett Graham1, Hugo Bellen1,2,3. 1) Human and Molecular Genetics; 2) Program in Development Biology; 3) Howard Hughes Medical Institute, BCM, Houston, TX; 4) Academia Sinica, Institute Institute of Biological Chemistry, Taipei, Taiwan; 5) Garvan Institute of Medical Research, Neuroscience Program, Sidney, Australia.

13 - 5:30
Crimpy enables discrimination of pre and postsynaptic pools of a BMP at the NMJ. Rebecca James1, Kendall Hoover1, Chris Wilson1, Kristi Wharton2, Ed Levitan3, Heather Broihier1. 1) Neurosciences, Case Western Reserve University, Cleveland, OH; 2) Molecular Biology, Cell Biology, and Biochemistry, Providence, Brown University, RI; 3) Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA.

14 - 5:45
Local BMP signaling sculpts synapse development at the Drosophila neuromuscular junction. Mikolaj J. SUlkowski, Mihaela Serpe. NICHD, National Institutes of Health, Bethesda, MD.

15 - 6:00
Xbp1-Independent Ire1 Signaling Is Required for Photoreceptor Differentiation and Rhabdomere Morphogenesis in Drosophila. Dina S. Coelho1, Fátima Cairrão1, Xiaomei Zeng2, Elisabete Pires1, Ana V. Coelho1, David Ron3, Hyung Don Ryoo2, Pedro M. Domingos1. 1) Instituto de Tecnologia Química e Biológica, 2780-157 Oeiras, Oeiras, Portugal; 2) Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA; 3) Metabolic Research Laboratory and NIHR Cambridge Biomedical Research Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

16 - 6:15
An E3 ubiquitin ligase regulates neural-specific glycosylation in the Drosophila embryo. Nickita Mehta, Mary Sharrow, Katherine Tiemeyer, Toshiko Katoh, Michael Tiemeyer. Biochemistry and Mol. Biology, Complex Carbohydrate Research Center, UGA, Athens, GA.

Thursday, March 27   4:30 PM–6:30 PM

Organogenesis and Gametogenesis

Co-Moderators: Rachel Cox, Uniformed Services University of the Health Sciences, Bethesda, Maryland and Amin Ghabrial, University of Pennsylvania, Philadelphia

Room: California

17 - 4:30
Alien, a highly conserved COP9 Signalosome (CSN) subunit, maintains the cellular microenvironment for germline cells in testes of Drosophila melanogaster. Yue Qian, Chun Ng, Cordula Schulz. Cellular Biology, University of Georgia, Athens, GA.

18 - 4:45
Loss of the nuclear envelope protein Otefin causes germline stem cell death due to activation of Checkpoint kinase 2. Lacy J. Barton, Kaylee E. Lovander, Melinda J. Martin, Pamela K. Geyer. Dept Biochemistry, Univ Iowa, Iowa City, IA.

19 - 5:00
Steroid Signaling and SREBP coordinate germline lipid accumulation with dietary nutrients in Drosophila. Matt Sieber1,2, Allan Spradling1,2. 1) Emrbyology, Carnegie Institution for Science, Baltimore, MD; 2) HHMI.

20 - 5:15
A secretion-based mechanism for basement membrane remodeling during egg chamber elongation. Adam J. Isabella1,2, Sally Horne-Badovinac1,2. 1) Committee on Development, Regeneration, and Stem Cell Biology; 2) Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL.

21 - 5:30
Sunday Driver (Syd/JIP3) and JNK Signaling are Required for Myogenesis and Muscle Function. Victoria K. Schulman1,2, Eric S. Folker2, Mary K. Baylies1,2. 1) Weill Cornell Graduate School of Medical Sciences, New York, NY; 2) Sloan-Kettering Institute, New York, NY.

22 - 5:45
Org-1-Tup expressing alary muscles and "new" related muscles in the thorax connect different internal organs in the developing embryo. Laetitia Bataillé1, Hadi Boukhatmi1, Christoph Schaub2, Ingolf Reim2, Jean-Louis Frendo1, Manfred Frasch2, Alain Vincent1. 1) Developmental Biology Center, CNRS/Université de Toulouse, Toulouse, France; 2) Dept of Biology, University of Erlangen-Nuremberg, Erlangen Germany.

23 - 6:00
Mipp1 (Multiple Inositol Polyphosphate Phosphatase) dephosphorylates Inositol polyphosphates extracellularly to facilitate filopodia formation. Yim Ling Cheng, Deborah Andrew. Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.

24 - 6:15
Caudal visceral mesoderm (CVM) cell migration is regulated by sphingolipids. Angelike M. Stathopoulos, Young-Kyung Bae. Div Biol, MC 114-96, Caltech, Pasadena, CA.

Friday, March 28   8:30 AM–10:15 AM

Cell Cycle and Cell Death

Co-Moderators: Nathalie Franc, The Scripps Institute, La Jolla, California and Terry Orr-Weaver, Whitehead Institute/Massachusetts Institute of Technology, Cambridge

Room: Town & Country

25 - 8:30
Protein phosphatase 2A promotes cell cycle exit. Dan Sun, Laura Buttitta. Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI.

26 - 8:45
Coordination of Zygotic Genome Activation and the DNA Damage Response at the MBT. Shelby A. Blythe, Eric F. Wieschaus. Molecular Biology, Princeton University, Princeton, NJ.

27 - 9:00
Widespeard post-transcriptional changes control cell cycle alteration at the oocyte-to-embryo transition in Drosophila. Iva Kronja1, Bingbing Yuan1, Stephen Eichhorn1,2, Kristina Dzeyk3, Jeroen Krijgsveld3, David Bartel1,2, Terry Orr-Weaver1,2. 1) Whitehead Institute for Biomedical Research, Cambridge, MA; 2) Department of Biology, MIT, Cambridge, MA; 3) European Molecular Biology Laboratory, Heidelberg, Germany.

28 - 9:15
Dying cells protect survivors from radiation-induced cell death. TinTin Su, Amber Bilak, Lyle Uyetake. MCD Biology, University of Colorado, Boulder, CO.

29 - 9:30
A steroid-controlled global switch in sensitivity to apoptosis during Drosophila development. Yunsik Kang1, Arash Bashirullah2. 1) Lab Genetics, Univ Wisconsin-Madison, Madison, WI; 2) Sch Pharmacy, Univ Wisconsi-Madison, Madison, WI.

30 - 9:45
The follicle cells non-autonomously contribute to the developmental programmed cell death of the nurse cells during Drosophila oogenesis. Allison K. Timmons, Albert A. Mondragon, Claire E. Schenkel, Jon Iker Etchegarary, Jeffrey Taylor, Olivia Rudnicki, Kim McCall. Boston University, Boston, MA.

31 - 10:00
Starvation-induced Sbf/MTMR13 and Rab21 activity promotes VAMP8 autophagosome-lysosome fusion. Steve Jean, Sarah Cox, Amy Kiger. Division of Biological Sciences, University of California San Diego, San Diego, CA.

Friday, March 28   8:30 AM–10:15 AM

Evolution and Quantitative Genetics I

Co-Moderators: Susan Harbison, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland and Martin Kreitman, University of Chicago, Illinois

Room: Golden West

32 - 8:30
Frequent sex chromosome transitions in Dipterans. Beatriz Vicoso, Doris Bachtrog. UC Berkeley, Berkeley, CA.

33 - 8:45
Female-expressed de novo genes in Drosophila. Li Zhao, David J. Begun. Department of Evolution and Ecology, University of California Davis, Davis, CA.

34 - 9:00
Evolution of H3K27me3-marked chromatin in Drosophila is linked to patterns of gene duplication and diversification. Robert Arthur1,2, Lijia Ma2,3, Matthew Slattery2,3,4, Rebecca Spokony2,3, Alexander Ostapenko2,3, Nicholas Negre2,3,5, Kevin White1,2,3. 1) Ecology and Evolution, University of Chicago, Chicago, IL; 2) 2. Institute for Genomics and Systems Biology, University of Chicago and Argonne National Laboratory, Chicago, Illinois, United States of America; 3) 3. Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America; 4) 4. Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, Minnesota, Unites States of America; 5) 5. Université de Montpellier 2 and INRA, UMR1333 DGIMI, F-34095 Montpellier, France.

35 - 9:15
Unusual Haplotype Structure and Reduced Recombination in Chromosomal Rearrangements in Populations of Drosophila pseudoobscura. Zach Fuller1, Gwilym Haynes1, Shannon Duggan2, Dianhuiz Zhu2, Stephen Richards2, Stephen Schaeffer1. 1) The Pennsylvania State University, University Park, PA; 2) Baylor College of Medicine, Houston, TX.

36 - 9:30
A novel cysteine-clamp gene establishes head-to-tail polarity in the midge Chironomus riparius. Jeff Klomp1, Derek Athy1, Chun Wai Kwan1, Natasha Bloch2, Thomas Sandmann3, Steffen Lemke4, Urs Schmidt-Ott1. 1) Dept. of Organismal Biology and Anatomy, University of Chicago, Chicago, IL; 2) Dept. of Ecology and Evolution, University of Chicago, Chicago, IL; 3) German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany; 4) Centre for Organismal Studies, Im Neuenheimer Feld 230, Heidelberg, Germany.

37 - 9:45
Signatures of polygenic adaptation from common natural variants in egg size evolution in experimentally evolved Drosophila melanogaster. Aashish R. Jha1,2,3, Cecelia M. Miles4, Nodia Lippert4, Christopher D. Brown5, Kevin P. White1,2,3, Martin Kreitman1,3. 1) Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL; 2) Department of Ecology and Evolution, The University of Chicago, Chicago, IL; 3) Department of Human Genetics, The University of Chicago, Chicago, IL; 4) Department of Biology, Augustana College, Sioux Falls, SD; 5) Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

38 - 10:00
Genomics and the molecular basis of hybrid incompatibilities. Nitin Phadnis1, Emily Baker2, Jacob Kitzman3, Kimberly Frizzell1, Emily Hsieh4, Jay Shendure3, Harmit Malik4,5. 1) Department of Biology, University of Utah, Salt Lake City; 2) University of Wisconsin, Madison; 3) University of Washington, Seattle; 4) Fred Hutchinson Cancer Research Center, Seattle; 5) Howard Hughes Medical Institute.

Friday, March 28   8:30 AM–10:15 AM

Pattern Formation

Co-Moderators: Thomas Kornberg, University of California, San Francisco and Amanda Simcox, Ohio State University, Columbus

Room: California

39 - 8:30
Trunk cleavage is essential for Drosophila terminal patterning and occurs independently of Torso-like. Michelle A. Henstridge1, Travis K. Johnson1,2, James C. Whisstock2, Coral G. Warr1. 1) School of Biological Sciences, Monash University, Clayton VIC 3800 Australia; 2) Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800 Australia.

40 - 8:45
Myosin ID controls Planar Cell Polarity for proper Left/Right asymmetry. Nicanor Gonzalez-Morales, Jean-Baptiste Coutelis, Charles Géminard, Delphine Cérézo, Stephane Noselli. Institut de Biologie Valrose, iBV, University of Nice, CNRS, Inserm, NICE Cedex 2, France.

41 - 9:00
Dispersion via cytonemes: how the Hedgehog gradient forms in the Drosophila wing imaginal disc. Weitao Chen, Thomas Kornberg. Cardiovascular Research Institute, UCSF, San Francisco, CA.

42 - 9:15
A wing margin enhancer at nab is limited by dorsal-ventral, anterior-posterior, and distal-proximal signals in Drosophila wing imaginal discs. Albert Erives, Elizabeth Stroebele. Biology, University of Iowa, Iowa City, IA.

43 - 9:30
Using a Synthetic Gene Network to Model and Understand the Effects of Shuttling on Gene Expression Patterns. Ashley Ann Jermusyk, Gregory T. Reeves. North Carolina State University, Raleigh, NC.

44 - 9:45
Dynamic aspects of Bcd gradient formation contributing to scaling and robustness. Alexander V. Spirov1,2, David M. Holloway3. 1) Computer Science and CEWIT, Stony Brook University, NY, USA; 2) The Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, St-Petersburg, Russia; 3) Mathematics, British Columbia Institute of Technology, Burnaby, BC, Canada.

45 - 10:00
Hedgehog signaling regulates mechanical tension along the Drosophila anteroposterior compartment boundary. Katrin Rudolf1, Maryam Aliee2, Frank Jülicher2, Christian Dahmann1. 1) Technische Universität Dresden, Institute of Genetics, 01062 Dresden, Germany; 2) Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.

Friday, March 28   10:45 AM–12:30 PM

Cell Biology and Cytoskeleton

Moderator: Michelle Starz-Gaiano, University of Maryland, Baltimore County

Room: Town & Country

46 - 10:45
Mechanical force induced adherens junctions remodeling. Mo Weng1, Eric Wieschaus1,2. 1) Howard Hughes Medical Institute; 2) Molecular Biology, Princeton University, Princeton, NJ.

47 - 11:00
Cellular and molecular mechanisms of epithelial organization in the Drosophila embryo. Masako Tamada, Jennifer Zallen. Howard Hughes Medical Institute and Developmental Biology Program, Sloan-Kettering Institute, NY.

48 - 11:15
Prickle/Spiny-legs isoforms control the polarity of the apical microtubule network in PCP. Katherine Sharp1,2, Jessica Olofsson1, Maja Matis1, Bomsoo Cho1, Jeffrey Axelrod1. 1) Pathology, Stanford University School of Medicine, Stanford, CA; 2) Genetics, Stanford University School of Medicine, Stanford, CA.

49 - 11:30
Myonuclear shape and architecture is maintained by cooperative activities between Spectraplakin-EB1 and Nesprin that link the microtubule network to the nuclear cytoskeleton. Shuoshuo Wang, Talila Volk. Weizmann Institute of Science, Rehovot, Israel.

50 - 11:45
Myosin II-mediated mechanosensory response generates cortical resistance to podosome invasion in Drosophila myoblat fusion. Ji Hoon Kim1, Yixin Ren2, Shuo Li1, Yee Kee2, Douglas Robinson2, Elizabeth Chen1. 1) Molecular Biology and Genetics, Johns Hopkins University , Baltimore, MD; 2) Cell Biology, Johns Hopkins University, Baltimore, MD.

51 - 12:00
Clueless/dGRASP dependent unconventional protein secretion differentiates the delivery of αPS2 integrin from that of βPS integrin in the Drosophila muscle. Zongheng Wang1, Ze Liu1, Nicole Green2, Catherine Rabouille3, Erika Geisbrecht1,2. 1) School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO; 2) Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS; 3) Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands.

52 - 12:15
Prostaglandins temporally regulate actin remodeling during Drosophila oogenesis. Andrew Spracklen1, Daniel Kelpsch1, Xiang Chen1, Cassandra Spracklen2, Tina Tootle1. 1) Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA; 2) Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA.

Friday, March 28   10:45 AM–12:30 PM

Evolution and Quantitative Genetics II

Co-Moderators: Cassandra Extavour, Harvard University, Cambridge, Massachusetts and Charles Langley, University of California, Davis

Room: Golden West

53 - 10:45
Genetic architecture of foraging behavior in natural Drosophila melanogaster population. Grace Y. C. Lee1, Wanhao Chi2, Qian Yang1, Wei Du3, Susie A. Turkson2, Nicholas VanKuren1, Xiaoxi Zhuang2, Manyuan Long1. 1) Department Ecology and Evolution, University of Chicago, Chicago, IL; 2) Department of Neurobiology, University of Chicago, Chicago, IL; 3) Department of Biology, Wayne State University.

54 - 11:00
Quantitative genetics of caffeine resistance in Drosophila melanogaster. Chad A. Highfill, Michael A. Najarro, Stuart J. Macdonald. Department of Molecular Biosciences, University of Kansas, Lawrence, KS. 66045.

55 - 11:15
Using engineered deletions in the study of behavioral evolution between Drosophila species. Wesley G. Cochrane, Veronica A. Cochrane, Thomas L. Turner. EEMB, UCSB, Santa Barbara, CA.

56 - 11:30
Genome-wide association of Drosophila melanogaster nutritional responses to gut microbiota. John Chaston, Adam Dobson, Peter Newell, Chun-nin Wong, David Sannino, Sara Ali, Angela Douglas. Cornell University - Entomology, Ithaca, NY.

57 - 11:45
Quantitative Characterization of Natural Variation in Heterochromatin of Drosophila melanogaster. Kevin H.-C. Wei, Daniel A. Barbash, Andrew G. Clark. Molecular Biology and Genetics, Cornell, Ithaca, NY.

58 - 12:00
Selective and demographic determinants of latitudinal variation in allele frequency in North American Drosophila melanogaster. Alan O. Bergland1, Ray Tobler3, Emily Behrman2, Katherine O'Brien2, Josefa Gonzales4, Paul Schmidt2, Dmitri Petrov1. 1) Stanford, Stanford, CA; 2) University of Pennsylvania, Philadelphia, PA; 3) Institut de Biologia Evolutiva, Barcelona, Spain; 4) Institute for Population Genetics, Vienna, Austria.

59 - 12:15
Convergent balancing selection on an antimicrobial peptide in Drosophila. Robert L. Unckless, Virginia1 M. Howick, Brian P. Lazzaro. Entomology, Cornell University, Ithaca, NY.

Friday, March 28   10:45 AM–12:30 PM

Chromatin and Epigenetics

Moderator: Vincenzo Pirrotta, Rutgers University, Piscataway, New Jersey

Room: California

60 - 10:45
Identification of new regulators of three dimensional Polycomb organization by a microscopy-based genome-wide RNAi screen. Giacomo Cavalli, Inmaculada Gonzalez, Julio Mateos, Aubin Thomas. Institute of Human Genetics, CNRS, Montpellier, France.

61 - 11:00
Spatial and Temporal Dynamics of Heterochromatin DSB Repair: Novel Role of Nuclear Pores. Taeyun Ryu1, Hannah Hopp1, Ryan Kunitake1, Kate Bowlin1, Preethi V. Palagani1, Lars Israel2, Alex Imhof2, Gary H. Karpen3, Irene Chiolo1. 1) Molecular and Computational Biology Department, University of Southern California, Los Angeles, CA; 2) Ludwig Maximilian University of Munich, Germany; 3) Genome Dynamics Department, Lawrence Berkeley National Laboratory, Berkeley, CA.

62 - 11:15
Targeting Heterochromatin Formation in Drosophila. Sarah C. R. Elgin, Monica Sentmanat, Kiri Ulmschneider, Tingting Gu. Dept Biology, Washington Univ, St Louis, MO.

63 - 11:30
The role of Drosophila chromatin remodeling factor CHD1 in replication-independent chromatin assembly and in chromosome organization. Alexander Y. Konev, Anna A. Makase, Natalia V. Belyakova, Natalia L. Ronzhina, Maria A. Ignatyeva. Department of Radiation and Molecular Biophysics, St. Petersburg Nuclear Physics Institute, Gatchina, Leningrad District, Russian Federation.

64 - 11:45
The SUUR Chromatin Protein Promotes Underreplication Through Inhibition of Replication Fork Progression. Jared T. Nordman1, Elena Kozhevnikova2, Peter Verrijzer2, Alexey Pindyurin3, Evgeniya Andreyeva4, Victor Shloma4, Igor Zhimulev4, Terry L. Orr-Weaver1,5. 1) Orr-Weaver Lab, Whitehead Inst, Cambridge, MA; 2) Erasmus Univ. Med. Center, Rotterdam, Netherlands; 3) Netherlands Cancer Institute, Amsterdam, Netherlands; 4) Russian Acad. Sciences, Novosibirsk, Russia; 5) Dept. of Biology, Massachusetts Institute of Technology, Cambridge, MA.

65 - 12:00
Transgenerational inheritance of nutrition-induced genome rearrangements. John C. Aldrich, Keith A. Maggert. Department of Biology, Texas A&M University, College Station, TX.

66 - 12:15
Maternal Haploid, the Drosophila ortholog of human Spartan, is required for the integrity of paternal chromosomes at fertilization. Laetitia Delabaere, Guillermo Orsi, Laure Sapey-Triomphe, Béatrice Horard, Pierre Couble, Benjamin Loppin. CGphiMC, CNRS UMR5534, Université Claude Bernard Lyon1, Villeurbanne, France.

Friday, March 28   4:30 PM–6:30 PM

Physiology, Organismal Growth and Aging

Co-Moderators: Pierre Leopold, Universite Nice Sophia Antipolis, France and Carl Thummel, University of Utah, Salt Lake City

Room: Town & Country

67 - 4:30
The Drosophila fat body controls nutrient flux via transcriptional mechanisms. Laura Palanker Musselman1, Jill Fink1, Zeke Maier2, Michael Brent2, Thomas Baranski1. 1) Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO; 2) Department of Computer Science, Washington University School of Medicine.

68 - 4:45
Suppression of insulin secretion by the decretin hormone Limostatin. Ronald Wakim Alfa1,2, Sangbin Park1, Kathleen-Rose Skelly1, Lutz Kockel1, Seung K. Kim1,3,4. 1) Developmental Biology, Stanford University School of Medicine, Stanford, CA; 2) Neuroscience Program, Stanford University School of Medicine, Stanford, CA; 3) Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA; 4) Department of Medicine (Oncology), Stanford University School of Medicine, Stanford, CA.

69 - 5:00
Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-mediated obesity model. Wei Song, Xiaochun Ni, Yanhui Hu, Edward Owusu-Ansah, Jonathan Zirin, Norbert Perrimon. Genetics Dept, Harvard Medical School, Boston, MA.

70 - 5:15
An organismal role of Dp53 in metabolic adaptation to nutrient deprivation. Lara Barrio, Andrés Dekanty, Marco Milán. Institute for Research in Biomedicine, Barcelona, Spain.

71 - 5:30
Innate immune signaling in the Drosophila fat body blocks DILP signaling by uncoupling PI(3,4,5)P3 production and Akt activation. Michelle L. Bland1, Moshe D. Bitterman2, Morris J. Birnbaum2. 1) Department of Pharmacology, University of Pennsylvania, Charlottesville, VA; 2) Department of Medicine, University of Pennsylvania, Philadelphia, PA.

72 - 5:45
Feeding and fasting signals converge on LKB1 and SIK3 pathway to regulate lipid homeostasis in Drosophila. Sekyu Choi1, Jongkyeong Chung1,2,3. 1) National Creative Research Initiatives Center for Energy Homeostasis Regulation, Seoul, South Korea; 2) Institute of Molecular Biology and Genetics, Seoul, South Korea; 3) School of Biological Sciences, Seoul National University, Seoul, South Korea.

73 - 6:00
Metabolic pathways contributing to increased longevity in Drosophila. Lauren A. Reynolds, Kimberly A. Hughes. Biology, Florida State University, Tallahassee, FL.

74 - 6:15
Or22a and Or22b Are Both Involved in the Regulation of Fruit Fly Longevity. Ceyda Bilgir1, Xiowen Chu2, Scott Pletcher1. 1) Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI; 2) Huffington Center on Aging, Baylor College of Medicine, Houston, TX.

Friday, March 28   4:30 PM–6:30 PM

Techniques and Resources

Co-Moderators: Kent Golic, University of Utah, Salt Lake City and Kevin White, University of Chicago, Illinois

Room: Golden West

75 - 4:30
CRISPR/Cas9-catalyzed homology-directed repair for complex genome engineering in Drosophila. Kate M. O'Connor-Giles1,2, Scott J. Gratz1, Fiona P. Ukken2, C. Dustin Rubinstein2. 1) Laboratory of Genetics, University of Wisconsin, Madison, WI; 2) Laboratory of Cell and Molecular Biology, University of Wisconsin, Madison, WI.

76 - 4:45
Expanding applications of CRISPR/Cas9 technology. Shu Kondo, Ryu Ueda. National Institute of Genetics, Mishima, Japan.

77 - 5:00
A highly efficient and specific gene mutagenesis technology for Drosophila melanogaster. Jiang Xu1,2, Xingjie Ren1, Lu-Ping Liu1,2, Jian-Quan Ni1. 1) Gene Regulatory Laboratory, School of Medicine, Tsinghua University, Beijing 100084, China; 2) Tsinghua Fly Center, Tsinghua University, Beijing 100084, China.

78 - 5:15
Golic+: Gene targeting during Oogenesis with Lethality Inhibitor and CRISPR/Cas9. Hui-Min Chen1,2, Tzumin Lee1. 1) HHMI: Janelia Farm, Ashburn, VA; 2) Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA.

79 - 5:30
The Genome Disruption Project: Protein tagging and gene inactivation using MiMIC. Sonal Nagarkar Jaiswal1, Paolo Mangahas1, Koen Venken1,6, Stephanie Anguiano-Zarate1, Theodore Busby III1, Yuchun He3, Benjamin Booth5, Karen Schulze3, Robert Levis4, Allan Spradling3,4, Roger Hoskin5, Hugo Bellen1,2,3. 1) Molecular and Human Genetics, Baylor college of medicine, Houston, TX; 2) Program in Developmental Biology,BCM, Houston, TX; 3) Howard Hughes Medical Institute; 4) Department of Embryology, Carnegie Institution for Science, Baltimore, MD; 5) Life Sciences Division, LBNL, Berkeley, CA; 6) Verna and Marrs McLean Department of Biochemistry and Molecular Biology,BCM, Houston, TX.

80 - 5:45
An efficient and inexpensive method to generate customized phiC31 landing sites. Jon-Michael Knapp, Phuong M. Chung, Julie H. Simpson. HHMI/Janelia Farm Research Campus, Ashburn, VA.

81 - 6:00
Quantitative phenotyping of Drosophila larvae crawling with predictive power. Maximilian N. Guenther, George T. Shubeita. Center for Nonlinear Dynamics and Department of Physics, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Tx 78712.

82 - 6:15
Light-induced elimination of protein function in vivo. Dave Stein. Department of Molecular Biosciences, University of Texas, Austin, TX.

Friday, March 28   4:30 PM–6:30 PM

RNA Biology

Co-Moderators: Susan Celniker, Lawrence Berkeley National Laboratory, California and Paul Lasko, McGill University, Montreal, Canada

Room: California

83 - 4:30
Diversity and Dynamics of the Drosophila Transcriptome. James B. Brown, The Celniker modENCODE Transcription Consortium. Genome Dynamics, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA.

84 - 4:45
Suppressor of sable [Su(s)] and its partner Wdr82 promote the production of short unstable RNAs from Hsp70-αβ elements. Lillie L. Searles1,2, Paul Brewer-Jensen1, Lonna Mollison2, Carrie B. Wilson1, John Abernethy1, Samantha Card1. 1) Dept Biol, Univ North Carolina, Chapel Hill, NC; 2) Curriculum in Genetics and Mol Biol, Univ North Carolina, Chapel Hill, NC.

85 - 5:00
Smg5 is critical for multiple NMD pathways. Jonathan O. Nelson1, Dominique Förster2, Stefan Luschnig2, Mark M. Metzstein1. 1) Human Genetics, University of Utah, Salt Lake City, UT; 2) IMLS, University of Zurich, Zurich, Switzerland.

86 - 5:15
Unusual origin of Drosophila RNase P RNA from the intron of a pol II-regulated transcript. Sathiya Narayanan Manivannan1, Lien Lai2, Venkat Gopalan1,2,3, Amanda Simcox1,3. 1) Molecular Cellular Developmental Biology program, The Ohio State University, Columbus, OH; 2) The Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH; 3) The Department of Molecular Genetics, The Ohio State University, Columbus, OH.

87 - 5:30
Regulated stop codon readthrough yields C-terminal protein extensions in Drosophila melanogaster. Joshua G. Dunn1,2,3,4, Catherine K. Foo1,2,3, Nicolette G. Belletier5, Elizabeth R. Gavis5, Jonathan S. Weissman1,2,3,4. 1) Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA; 2) California Institute of Quantitative Biosciences, San Francisco, CA; 3) Howard Hughes Medical Institute, UCSF; 4) Center for RNA Systems Biology, UCSF and University of California, Berkeley, CA; 5) Department of Molecular Biology, Princeton University, NJ.

88 - 5:45
IRES-Mediated Translation of grk mRNA During Drosophila Oogenesis. Jacob A. Merle, Danielle E. Hindes, Malachi A, Blundon, Maya D. Mills, Matthew A. Fountain, Scott B. Ferguson. Departments of Biology, Chemistry and Biochemistry, SUNY Fredonia, Fredonia, NY.

89 - 6:00
piRNAs and epigenetic conversion in Drosophila . Catherine Hermant, Antoine Boivin, Laure Teysset, Augustin de Vanssay, Valérie Delmarre, Christophe Antoniewski, Stephane Ronsseray. Laboratoire de Biologie du Développement- UMR7622-CNRS-Université Pierre Marie Curie, Paris.

90 - 6:15
Ribosomal protein RACK1 is a specific host factor required for IRES-mediated translation of fly and human viruses. Carine Meignin1, Karim Majzoub1, Mohamed Lamine Hafirassou2, Stefano Marzi3, Franck Martin3, Thomas Baumert2, Catherine Schuster2, Jean-Luc Imler1. 1) IBMC UPR9022, University of Strasbourg, Strasbourg, France; 2) UMR 1110, University of Strasbourg, Strasbourg, France Institut de Virologie; 3) IBMC UPR9002, University of Strasbourg, Strasbourg, France.

Saturday, March 29   8:30 AM–10:15 AM

Cell Biology and Signal Transduction

Co-Moderators: Christian Böekel, Technische Universitat, Dresden, Germany and Esther Verheyen, Simon Fraser University, Burnaby, Canada

Room: Town & Country

91 - 8:30
Calpain A regulates NFkappaB function during embryogenesis and the immune response by limited Cactus proteolysis. Marcio Fonetenele1,2, Maira Cardoso1, Bomyi Lim4, Daniela Oliveira1, David Perlman3, Trudi Schupbach3,5, Helena Araujo1,2. 1) Institute for Biomedical Sciences, Fed Univ Rio de Janeiro, Rio de Janeiro, Brazil; 2) National Institute for Molecular Entomology - INCT/INEM, Brazil; 3) Molecular Biology Department, Princeton University; 4) Lewis Sigler Institute for Integrative Genomics, Princeton University; 5) Howard Hughes Medical Institute.

92 - 8:45
GTPase Regulatory Proteins control Organ Size through Hippo Signalling. Lucas G. Dent1,2, Kieran F. Harvey1. 1) Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; 2) Pathology, University Of Melbourne, Melbourne, VIC, Australia.

93 - 9:00
Cytoneme-mediated contact-dependent transport of the Drosophila Decapentaplegic signaling protein. Sougata Roy, Hai Huang, Thomas B. Kornberg. Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA.

94 - 9:15
ERK interactome perturbations induced by mutations of docking domains. Liu Yang1, Alan Futran2, A. James LInk2, Stanislav Y. Shvartsman2, Alexey Veraksa1. 1) Biology, UMass Boston, Boston, MA; 2) Chemical and Biological Engineering, Princeton University, Princeton, NJ.

95 - 9:30
A novel Talin-dependent mechanism mediates clustering of integrin adhesion receptors to reinforce tissue architecture. Emily E. Lostchuck1, Stephanie J. Ellis1, Benjamin T. Goult2, Mohamed Bouaouina3, Michael J. Fairchild1, David A. Calderwood3, Guy Tanentzapf3. 1) Cell and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2) Dept. of Biochemistry, University of Leicester; 3) Dept. of Pharmacology, Yale University School of Medicine.

96 - 9:45
The surprising case of Wingless or how not to be a morphogen. Luis Alberto Baena-Lopez, Cyrille Alexandre, Jean-Paul Vincent. Developmental Biology, NIMR. MRC. London, United Kingdom.

97 - 10:00
Mechanisms of Notch-Src synergy in Drosophila. Diana M. Ho, S. K. Pallavi, Spyros Artavanis-Tsakonas. Dept. of Cell Biology, Harvard Medical School, Boston, MA.

Saturday, March 29   8:30 AM–10:15 AM

Drosophila Models of Human Disease I

Co-Moderators: Tian Xu, Yale University, New Haven, Connecticut and Bing Zhang, University of Missouri, Columbia

Room: Golden West

98 - 8:30
Role of the microbiota in a Drosophila model of intestinal barrier dysfunction. Rebecca Clark, David Walker. Dept. of Integrative Biology and Physiology, UCLA, Los Angeles, CA.

99 - 8:45
The formation of Hopscotch-induced hemocyte tumors requires the JAK/STAT transcriptional target Gα73B. Martin P. Zeidler, Nina Bausek. Biomedical Science, The University of Sheffield, Sheffield, United Kingdom.

100 - 9:00
The Transposon Storm Hypothesis of Neurodegeneration. Joshua T. Dubnau1, Nabanita Chatterjee1, Rebeca Borges1,2, Lisa Krug1,3, Lisa Prazak1, Will Donovan1,3, Anais Julien1,4. 1) Cold Spring Harbor Lab, Cold Spring Harbr, NY; 2) The Undergraduate Program on Genomic Sciences of the Nacional Autonomous University of Mexico; 3) Watson School of Biological Sciences, Cold Spring Harbor Laboratory; 4) Magistère de Génétique Graduate Program at Université Paris Diderot, Sorbonne Paris Cité, France.

101 - 9:15
Regulatory Network in Diet-induced Obesity and Lipotoxic Cardiomyopathy. Soda Diop, Rolf Bodmer. Development and Aging Program, Sanford Burnham Medical Research Institute, La Jolla, CA.

102 - 9:30
TDP-43 neurotoxicity is modulated by Fragile X Protein and Futsch in a Drosophila model of Amyotrophic Lateral Sclerosis. Alyssa Coyne1,2,3, Shizuka Yamada1,2,3, Patricia Estes1,2,3, Donovan Lockwood1,2,3, Michael Hart4, Brian Freibaum5, Joel Cassel6, Allen Reitz6, J. Paul Taylor5, Aaron Gitler4, Daniela Zarnescu1,2,3. 1) Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ; 2) Department of Neuroscience, University of Arizona, Tucson, AZ; 3) Department of Neurology, University of Arizona, Tucson, AZ; 4) Department of Genetics, Stanford University, Stanford, CA; 5) Department of Neurobiology, St. Jude Children's Research Hospital, Memphis, TN; 6) ALS Biopharma LLC, Philadelphia, PA.

103 - 9:45
Investigating Resistance and Tolerance to Cancer. Adler R. Dillman, David S. Schneider. Microbiology and Immunology, Stanford, Stanford, CA.

104 - 10:00
Flies and humans with prickle mutations exhibit similar epilepsy syndromes. Salleh Ehaideb1,2, Atulya Iyengar2, Katie Cranston2, Alexander G. Bassuk3, David Gubb4, Chun-Fang Wu2, J. Robert Manak1,2,3. 1) Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA; 2) Department of Biology, University of Iowa, Iowa City, IA; 3) Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA; 4) Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, Strasbourg Cedex, France.

Saturday, March 29   8:30 AM–10:15 AM

Regulation of Gene Expression I

Co-Moderators: Michael Levine, University of California, Berkeley and Lori Pile, Wayne State University, Detroit, Michigan

Room: California

105 - 8:30
Genome-wide binding of K50 family transcription factors. Rhea R. Datta1, Jia Ling1, Leila Shokri2, Anastasia Vedenko2, Martha L. Bulyk2, Steve Small1. 1) Department of Biology, New York University, 100 Washington Square East, 100 Silver Center, New York, NY 10003; 2) Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115.

106 - 8:45
Co-option of a Hox-regulated network underlies a morphological novelty in Drosophila melanogaster. Mark Rebeiz, William Glassford, Chas Elliot, Winslow Johnson. Biological Sciences, University of Pittsburgh, PIttsburgh, PA.

107 - 9:00
A simple model of gradient interpretation can explain the precise pattern of even skipped in the Drosophila embryo. Garth R. Ilsley1, Jasmin Fisher2,3, Rolf Apweiler4, Angela H. DePace5, Nicholas M. Luscombe1,6,7. 1) Okinawa Institute of Science and Technology Graduate University, Japan; 2) Microsoft Research Cambridge, United Kingdom; 3) Department of Biochemistry, University of Cambridge, United Kingdom; 4) European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, United Kingdom; 5) Department of Systems Biology, Harvard Medical School, Boston, MA; 6) UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, United Kingdom; 7) London Research Institute, Cancer Research UK, United Kingdom.

108 - 9:15
Zelda potentiates morphogen binding in the early embryo. Sun Melody Foo1, Yujia Sun1, Bomyi Lim2,3, Kai Chen4, Ruta Ziukaite1, Julia Zeitlinger4, Stanislav Shvartsman2,3, Christine Rushlow1. 1) Department of Biology, New York University, New York, NY; 2) Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ; 3) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ; 4) Stowers Institute for Medical Research, Kansas City, MO.

109 - 9:30
Spatial expression of a comprehensive set of Drosophila transcription factors reveals novel insights into regulatory networks. Erwin Frise1, Ann Hammonds1, Siqi Wu1,2, Antony Joseph1,2, Richard Weiszmann1, William Fisher1, Bin Yu2, Susan Celniker1. 1) BDGP/Genome Dynamics, Lawrence Berkeley National Labs, Berkeley, CA; 2) Dept. of Statistics, UCB, Berkeley, CA.

110 - 9:45
Direct Quantification of Transcriptional Regulation at an Endogenous Gene Locus. Heng Xu1,3, Anna Sokac1, Ido Golding1,2,3. 1) Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX; 2) Center for Theoretical Biological Physics, Rice University, Houston, TX; 3) Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL.

111 - 10:00
Characterizing the dynamics of Yan polymerization, DNA binding and transcriptional repression during RTK-regulated cell fate transitions. Jean-Francois Boisclair Lachance1,3, Nicolás Peláez2,3, Arnau Gavalda2,3, Luís Amaral2,3, Richard Carthew2,3, Ilaria Rebay1,3. 1) University of Chicago, Chicago, IL; 2) Northwestern University, Evanston, IL; 3) Chicago Center for Systems Biology (CCSB).

Saturday, March 29   10:45 AM–12:30 PM

Organelles and Trafficking

Moderator: Tina Tootle, University of Iowa, Iowa City

Room: Town & Country

112 - 10:45
Abl/Enabled signaling regulates Golgi architecture in vivo. Ramakrishnan Kannan, Irina Kuzina, Joy Gu, Edward Giniger. National Inst of Neurological Disorder and Stroke, National Institute of Health, Bethesda, MD.

113 - 11:00
Clathrin-mediated endocytosis promotes embryonic wound repair in Drosophila. Miranda V. Hunter1, Rodrigo Fernandez-Gonzalez1,2,3. 1) Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada; 2) Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; 3) Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

114 - 11:15
Kelch functions as a ubiquitin E3 ligase required for ovarian ring canal growth. Andrew Hudson, Lynn Cooley. Dept Genetics, Yale Univ Sch Medicine, New Haven, CT.

115 - 11:30
An AP-1-dependent E-Cadherin recycling defect reveals a role for E-Cadherin in ring canals anchoring in Drosophila germline cysts. Nicolas Loyer, Irina Kolotuev, Roland Le Borgne. IGDR, Rennes, France.

116 - 11:45
Mitotic Spatial Organization and Structural Morphology of the Endoplasmic Reticulum are Independently Regulated. Zane J. Bergman, Justin D. Mclaurin, Blake Riggs. Biology, San Francisco State University, San Francisco, CA.

117 - 12:00
Rab GTPases and BMP signalling regulate exosome secretion by controlling distinct endolysosomal trafficking events in Drosophila secondary cells. Siamak Redhai, Laura Corrigan, Aaron Leiblich, Shih-Jung Fan, Mark Wainwright, Carina Gandy, Sumeth Perera, Deborah Goberdhan, Clive Wilson. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

118 - 12:15
Fbxl7 is an F-box protein that functions with the atypical cadherin Fat to control tissue size and shape. Justin A. Bosch, Taryn Sumabat, Kevin Gandhi, Iswar K. Hariharan. Molecular and Cell Biology, University of California - Berkeley, Berkeley, CA.

Saturday, March 29   10:45 AM–12:30 PM

Drosophila Models of Human Disease II

Co-Moderators: Gabrielle Boulianne, Hospital for Sick Children, Toronto, Canada and John Manak, University of Iowa, Iowa City

Room: Golden West

119 - 10:45
A novel gene, SAD, is required for axonal integrity in aging - a discovery from an unbiased genetic screen using the Drosophila wing as a model. Yanshan Fang1, Xu Cao1, Xiuyin Teng2, Qinqin Li1, Yongqing Zhu2, Nancy Bonini2. 1) SIOC, IRCBC, Chinese Academy of Sciences, Shanghai, China; 2) HHMI, Univ of Pennsylvania, Philadelphia, PA.

120 - 11:00
Quantification of Drosophila insulin reveals genetic mechanisms of human diabetes risk. Sangbin Park, Ronald W. Alfa, Sydni M. Topper, Grace E. S. Kim, Lutz Kockel, Seung K. Kim. Developmental Biology, Stanford University School of Medicine, Standford, CA.

121 - 11:15
Common responses of Drosophila and mammalian cells to novel lipid-lowering drugs. Kseniya Golovnina1, Kirsten Tschapalda2,3, Zhuyin Li4, Min Shen4, Matthew Boxer4, Brian Oliver1, Mathias Beller2. 1) NIH/NIDDK, Bethesda, MD; 2) Institute for Mathematical Modeling of Biological Systems, Heinrich Heine University, Düsseldorf, Germany; 3) Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany; 4) NIH/NCATS, Rockville, MD.

122 - 11:30
Exploiting Drosophila as a platform to develop anti-amyloid strategies. Pedro Fernandez-Funez1,2, Jonantan Sanchez-Garcia1, Swati Khare1, Alfonso Martin-Peña1, Diego Rincon-Limas1,2. 1) Dept Neurology, Univ Florida, Gainesville, FL; 2) McKnight Brain Institute, Genetics Institute, and Center for Translational Research on Neurodegenerative Disorders.

123 - 11:45
H+ Efflux Enables Cancer Cell Behaviors. Bree K. Grillo-Hill, Mario Esquivel, Diane L. Barber. Cell and Tissue Biology, Univ California, San Francisco, San Francisco, CA.

124 - 12:00
Characterization of the leukemogenesis activity of the human Nup98-HoxA9 oncoprotein using Drosophila as a model system. Gwenaelle Gavory, Caroline Baril, Gawa Bidla, Marc Therrien. IRIC, University of Montreal, Montreal, Quebec, Canada.

125 - 12:15
Mitochondrial i-AAA protease deficiency leads to neuromuscular degeneration through apoptotic cell death. Yun Qi, Hong Xu. GDBC, NHLBI, bethesda, MD.

Saturday, March 29   10:45 AM–12:30 PM

Gene Expression and Chromatin II

Moderator: Maya Capelson, University of Pennsylvania, Philadelphia

Room: California

126 - 10:45
A new paternal effect lethal is required to prime paternal chromatin for embryonic mitosis. Mia T. Levine1, Helen M. Vander Wende1, Harmit S. Malik1,2. 1) Division of Basic Sciences, Fred Hutchinson Cancer Research Center Seattle, WA; 2) HHMI.

127 - 11:00
The Epigenome of Evolving Drosophila Neo-Sex Chromosomes: Dosage Compensation and Heterochromatin Formation. Qi Zhou1, Chris Ellison1, Vera Kaiser1, Artyom Alekseyenko2, Andrey Gorchakov2,3, Doris Bachtrog1. 1) Integrative Biology, University of California, Berkeley, Berkeley, CA; 2) Department of Genetics, Harvard Medical School; 3) Institute of Molecular and Cellular Biology, Novosibirsk, Russia.

128 - 11:15
The weak shall lead the strong: Low-affinity transcription factor binding sites in morphogen gradient responses and enhancer evolution. David Lorberbaum1,2, Andrea Ramos1,2, Victoria Blake1, Charles Katzman1, David Parker1, Christina Swanson1,3, Scott Barolo1,2. 1) Dept. of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI; 2) Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI; 3) Current address: Dept. of Biology, UNC Chapel Hill, NC.

129 - 11:30
Analysis of transcription factors binding footprints at developmental enhancers using ChIP-nexus, a novel ChIP-exo protocol. Qiye He1, Jeff Johnston1, Julia Zeitlinger1,2. 1) Stowers Institute for Medical Research, Kansas City, MO; 2) The University of Kansas School of Medicine, Department of Pathology and Laboratory Medicine, Kansas City, KS.

130 - 11:45
K27me3 and CTCF demarcate cis-regulatory domains in the Drosophila bithorax complex. Sarah K. Bowman1,2, Aimee M. Deaton1,2, Peggy Wang1, Heber Domingues3, Robert E. Kingston1,2, Welcome Bender3. 1) Massachusetts General Hospital, Dept. of Molecular Biology, Boston, MA; 2) Harvard Medical School, Dept. of Genetics, Boston, MA; 3) Harvard Medical School, Dept. of Biological Chemistry and Molecular Pharmacology, Boston, MA.

131 - 12:00
Intrinsically random decisions and interchromosomal communication control stochastic expression in the fly eye. Robert J. Johnston. Department of Biology, Johns Hopkins University, Baltimore, MD.

132 - 12:15
The function of Zelda in establishing early embryonic genome organization. Katharine N. Schulz1, Daniel J. McKay2, Danielle C. Hamm1, Jason D. Lieb3, Melissa M. Harrison1. 1) Dept. of Biomolecular Chemistry, University of Wisconsin, Madison, WI; 2) Dept. of Biology, The University of North Carolina, Chapel Hill, NC; 3) Dept. of Molecular Biology, Princeton University, Princeton, NJ.

Saturday, March 29   4:00 PM–6:00 PM

Immunity and Pathogenesis

Co-Moderators: Sara Cherry, University of Pennsylvania, Philadelphia and Rui Zhou, Sanford-Burnham Medical Research Institute, San Diego, California

Room: Town & Country

133 - 4:00
PVR controls the antiviral ERK pathway in the Drosophila gut. Christine L. Sansone, Jie Xu, Ari Yasunaga, Beth Gordesky-Gold, Sara Cherry. Microbiology, University of Pennsylvania, Philadelphia, PA.

134 - 4:15
Epigenetic regulation of the antiviral Jak-Stat pathway by the histone methyltransferase G9a in Drosophila. Sarah Merkling, Walter Bronkhorst, Gijs Overheul, Jamie Kramer, Annette Schenck, Ronald van Rij. Radboud University Nijmegen Medical Center, Nijmegen Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

135 - 4:30
Extracellular adenosine regulates complex host-pathogen interactions through the energy release for the immune response. Tomas Dolezal1,2, Adam Bajgar2, Katerina Kucerova2, Lucie Jonatova2, David Schneider1. 1) Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA; 2) Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic.

136 - 4:45
Drosophila-associated microbes promote host protein metabolism to rescue lifespan and development during malnutrition. Ryuichi Yamada, William Ja. Metabolism and Aging, The Scripps Research Institute, Jupiter, FL.

137 - 5:00
The serine protease homolog novi is involved in sensing of pathogenic Gram positive bacteria. Jelena Patrnogic, Vincent Leclerc, Jean-Marc Reichhart. Institut de Biologie Moléculaire et Cellulaire, CNRS UPR9022, 15 rue René Descartes, Strasbourg, France.

138 - 5:15
Origin, anatomy and proliferative capacity of adult hemocytes in Drosophila. Kalpana Makhijani1, Brandy Alexander1, Christa Rhiner4, Eduardo Moreno4, Katja Brückner1,2,3. 1) Dept. Cell and Tissue Biology; 2) Broad Center of Regeneration Medicine and Stem Cell Research; 3) CVRI; University of California San Francisco, CA; 4) University of Bern, Switzerland.

139 - 5:30
Protein restriction enhances anti-bacterial immunity through Target of Rapamycin and posttranslational regulation of Myc by protein phosphatase 2A. Jung-Eun Lee, Scott Pletcher. University of Michigan, Ann Arbor, MI.

140 - 5:45
Cholera toxin disrupts intestinal epithelial integrity by inhibiting junctional transport. Annabel E. Guichard1, Beatriz Cruz Moreno1, Berenice Aguilar2, Nina van Sorge2, Jennifer Kuang1, Adrianne Kurkciyan1, Zhipeng Wang4, Saiyu Hang4, Guillaume Pineton de Chambrun3, Declan McCole3, Paula Watnick4, Victor Nizet2, Ethan Bier1. 1) Dept Biology, Univ California, San Diego, La Jolla, CA; 2) Dept Pediatrics, Univ California, San Diego, La Jolla, CA; 3) Dept Medicine, Univ California, San Diego, La Jolla, CA; 4) Children's Hospital, Boston, MA 02115.

Saturday, March 29   4:00 PM–6:00 PM

Neurophysiology and Behavior

Co-Moderators: Chi-Hon Lee, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland and Noreen Reist, Colorado State University, Fort Collins

Room: Golden West

141 - 4:00
Taste of fatty acids - a new modality in Drosophila. Pavel Masek, Alex Keene. Biology Department, University of Nevada Reno, Reno, NV.

142 - 4:15
Acoustic Duetting During Courtship in Drosophila virilis. Kelly M. LaRue1,2, Gordon J. Berman1,3, Tristan Perez1,2, Georgia Guan1,2, David L. Stern4, Mala Murthy1,2. 1) Molecular Biology, Princeton University, Princeton, NJ; 2) Princeton Neuroscience Institute, Princeton University, Princeton, NJ; 3) Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ; 4) Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA.

143 - 4:30
Genetic and molecular bases of noxious cold detection in Drosophila larvae. Kevin Armengol1, Heather Turner2, Srividya C. Iyer1, Luis Sullivan1, Eswar P. R. Iyer1, Christian Landry2, Michael J. Galko2, Daniel N. Cox1. 1) Krasnow Institute, School of Systems Biology, George Mason University, Fairfax, VA; 2) Dept. of Biochemistry & Molecular Biol, Dept. of Genetics, UT MD Anderson Cancer Center, Houston, TX.

144 - 4:45
Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Yanmei Huang, Joshua Ainsley, Leon Reijmers, F. Rob Jackson. Department of Neuroscience, Tufts University School of Medicine, Boston, MA.

145 - 5:00
Synaptic microcircuits control Drosophila sleep and arousal. Divya Sitaraman1,2, Yoshinori Aso2, Gerald Rubin2, Michael Nitabach1,2. 1) Yale University School of Medicine, New Haven, CT; 2) Janelia Farm Research Campus, HHMI Ashburn, VA.

146 - 5:15
Serotonin motivates feeding behavior and appetitive memory performance in Drosophila. Stephanie D. Albin1, Karla R. Kaun1,2, Phuong Chung1, Jon-Michael Knapp1, Ulrike Heberlein1, Julie H. Simpson1. 1) HHMI Janelia Farm, Ashburn, VA; 2) Brown University, Providence, RI.

147 - 5:30
A novel high-throughput mechanical nociception paradigm suggests a role for neuropeptides in nociception behavior. W. D. Tracey, Melissa Gottron, Ken Honjo. Dept Anesthesiology, Duke Univ Med Ctr, Durham, NC.

148 - 5:45
Drosophila larvae establish a radish-dependent anesthesia resistent memory after aversive olfactory conditioning. Annekathrin Widmann, Andreas Thum. Biology, University, Konstanz, Germany.

Saturday, March 29   4:00 PM–6:00 PM

Stem Cells

Co-Moderators: Michael Buszczak, UT Southwestern, Dallas, Texas and Volker Hartenstein, University of California, Los Angeles

Room: California

149 - 4:00
dFezf/Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors. Derek Janssens1, Hideyuki Komori2, Daniel Grbac2, Cheng-Yu Lee2,3,4. 1) Program in Cellular and Molecular Biology; 2) Life Sciences Institute; 3) Department of Internal Medicine; 4) Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

150 - 4:15
Neuroblasts transiently express differentiation factor Prospero in nucleus during entry into quiescence. Sen-Lin Lai1,3, Chris Q. Doe1,2,3. 1) HHMI; 2) Institute of Molecular Biology; 3) Institute of Neuroscience, University of Oregon, Eugene, OR 97403.

151 - 4:30
Notch signaling and FoxA collaborate to maintain intestinal stem cells in Drosophila adult midgut. Qing Lan, Min Cao, Huaqi Jiang. Developmental Biology, UT Southwestern Medical Center, Dallas, TX.

152 - 4:45
Somatic mutation drives genetic heterogeneity and spontaneous neoplasia in the aging intestine. Katarzyna Siudeja, Patricia Skorski, Allison Bardin. Genetics and Developmental Biology Unit, Institut Curie, Paris, France.

153 - 5:00
Muscle niche ensures survival and reactivation of dormant Adult Muscle Precursors in Drosophila. Krzysztof Jagla, Rajaguru Aradhya. GReD, INSERM U1103, CNRS UMR6293, Clermont-Ferrand, France.

154 - 5:15
EGFR Regulates Epithelial Follicle Stem Cell Polarity to Facilitate Asymmetric Division. Angela Castanieto, Todd Nystul. University of California San Francisco, San Francisco, CA.

155 - 5:30
Wnt signaling in escorts cells regulate germ cell differentiation in drosophila ovary. Su Wang1,2, Ting XIe1,2. 1) Xie's Lab, Stowers Inst Medical Research, Kansas City, MO; 2) University of Kansas Medical Center, Department of Anatomy and Cell biology, Kansas City, KS.

156 - 5:45
An insulin-independent requirement for the adiponectin receptor homolog in the maintenance of Drosophila melanogaster germline stem cells. Kaitlin Laws1, Leesa Sampson1, Daniela Drummond-Barbosa1. 1) Department of Biochemistry and Molecular Biology; Johns Hopkins Bloomberg School of Public Health; Baltimore, MD; .

Sunday, March 30   8:30 AM–12:00 NOON

Plenary Session II

Moderator: Mihaela Serpe, NIH/National Institute of Child Health and Human Development, Bethesda, Maryland

Room: Atlas Ballroom


8:30 am   Poster Award Presentation. Mihaela Serpe. NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

8:35 am   Charting the Genotype-Phenotype Map: Lessons from Drosophila. Trudy F. Mackay. Dept Biological Sciences, North Carolina State Univ, Raleigh, NC.

9:05 am   Walking the Highwire from Synaptic Growth to the Axon Injury Response Pathway. Aaron DiAntonio. Dept of Developmental Biology, Washington University School of Medicine, St. Louis, MO.

9:35 am   piRNAs function for the safeguard of germline genome. Toshie Kai. Temasek Lifesciences Laboratory/Dept. Biological Science, National University of Singapore, Singapore.

10:05 am - Break

10:30 am   Multiple layers of complexity in the regulation of the bithorax complex. Francois Karch. Dept Genetic and Evolution, Univ Geneva, Geneva, Switzerland.

11:00 am   Cardiomyopathy models. Rolf Bodmer. Development and Agi, Sanford-Burnham Medical Research Institute, La Jolla, CA.

11:30 am   The Conflicted Existence of the Mitochondrial Genome. Patrick H. O'Farrell1. Dept Biochemistry, Univ California, San Francisco, CA.