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Important Dates:

 
September 24, 2013
Abstract Submission Opens

Conference Registration Opens

 
November 5, 2013
Deadline for Workshop Requests
 
December 9, 2013
Abstract Submission Deadline
 
December 22, 2013
Larry Sandler Award Submission Deadline
 
February 3, 2014
Deadline for Early (Discounted) Conference Registration
 
February 28, 2014
Deadline for Hotel Reservations
 

 

2014 Meeting Organizers:

 

Daniela Drummond-Barbosa
Elissa Lei
Mihaela Serpe
Mark Van Doren
 

Workshop Listing

 

WORKSHOPS LISTING

 


Wednesday, March 26   12:00 NOON–6:00 PM
Ecdysone Workshop


Room:

Pacific Ballroom Salon 3

Organizers:

Ginger Carney, Texas A & M University, and
Laurie von Kalm, University of Central Florida

The Ecdysone Workshop welcomes all those interested in insect endocrinology. Importantly, this workshop is a forum to discuss the role of different hormones (e.g., 20-hydroxyecdysone, juvenile hormone, peptide hormones, insulin) and the crosstalk between their signaling pathways. The topics covered include, but are not limited to, hormone synthesis and secretion, and hormonal control of transcription, differentiation, morphogenesis, growth, metabolism, timing and behavior. Platform talks of 15 minutes will be selected from interested applicants and grouped into sessions, with each session highlighted by an invited speaker. To apply and/or receive the final program, please email the organizers (gcarney@bio.tamu.edu or lvonkalm@ucf.edu).

Keynote Address:
Fred Nijhout, Duke University: Ecdysone has multiple and diverse roles in the regulation of growth and size

Invited Speakers:
Nicholas Sokol, Indiana University: Ecdysone induced let-7-C microRNAs regulate BTB-ZFs to control neuronal morphology and cell fate

Toshi Kitamoto, University of Iowa: Behavioral abnormalities displayed by mutants for Drosophila DopEcR, a dual receptor for dopamine and ecdysteroids

Travis Johnson, Monash University: The maternal patterning gene Torso-like has a second role in regulating larval growth and developmental timing




Friday, March 28   1:30 PM–4:00 PM
Undergraduate Plenary Session and Workshop


Room:

Royal Palm Ballroom 5-6

Organizers:

Alexis Nagengast, Widener University, and
Beth Ruedi, Genetics Society of America, Bethesda, Maryland

Undergraduate conference attendees will attend an "Undergraduate Plenary Session" from 1:30-2:45 pm, with two talks presented at a level appropriate for an undergraduate audience. From 3:00-4:00 pm, undergraduates will have a chance to talk to a panel of graduate students about applications, interviewing, admission, choosing a lab, and quality of life in graduate school.


Friday, March 28   1:45 PM–3:45 PM
Flies on Drugs - Screening for Therapeutics in Drosophila


Room:

Pacific Ballroom Salons 4-5

Organizers:

Daniela Zarnescu, University of Arizona, Tucson, and
Tin Tin Su, University of Colorado, Boulder

Recent successes using Drosophila for drug screening have brought attention to the fly as an emerging model that holds great promise for the rapid discovery of high quality therapeutic leads. Talks from expert speakers will focus on the challenges and opportunities of screening for therapeutics in the fly. Topics will include screening approaches using various paradigms ranging from behavior to cancer to neurodegeneration models. A summary discussion will focus on identifying opportunities and challenges associated with using Drosophila for drug discovery, and strategies for increasing its visibility with funding agencies and pharmaceutical companies.

Tin Tin Su, U Colorado: Using Drosophila to identify small molecule radiation modulators

Anandasankar Ray, U California Riverside: Using Drosophila to develop odor-based mosquito control strategies to prevent malaria transmission

Larry Marsh, U California Irvine: Preclinical screening of pharmacologic agents for the treatment of Huntington's disease in Drosophila

Daniela Zarnescu, U Arizona: Drug screening in a Drosophila model of ALS based on TDP-43


Friday, March 28   1:45 PM–3:45 PM
Developmental Mechanics


Room:

Pacific Ballroom Salon 3

Organizers:

Guy Tanentzapf, University of British Columbia, Vancouver Canada, and
Rodrigo Fernandez-Gonzalez, University of Toronto, Canada

D'Arcy Thompson, in his seminal book on growth and form, proposed that physical forces play a central role in animal development. Over the last twenty years, the establishment of tools to measure and manipulate mechanical forces in living organisms has demonstrated that indeed mechanical forces influence molecular dynamics and cell behaviors during tissue morphogenesis. In this workshop, we will review the most recent technical advances to visualize and quantify force generation during Drosophila development, and we will discuss the latest results demonstrating the interplay between physical forces, molecular dynamics and tissue morphogenesis.

Todd Blankenship, Denver University: Unexpected node behaviors during Drosophila germband extension

Glenn Edwards, Duke University: Biophysical insights into tissue mechanics during Drosophila development

Rodrigo Fernandez-Gonzalez, University of Toronto: Force generation and cytoskeletal dynamics in embryonic wound repair

Shane Hutson, Vanderbilt University: Cellular mechanics of germband retraction

Ken Irvine, Rutgers University: Regulation of Hippo signaling by cytoskeletal tension

Guy Tanentzapf, University of British Columbia:Cell-ECM adhesion regulates cell behaviour during dorsal closure

Shicong Xie, Massachusetts Institute of Technology: Coordinating pulsed and ratcheted contractions in the Drosophila ventral furrow


Friday, March 28   1:45 PM–3:45 PM
Drosophila Male Fertility as a Cell Biological Model


Room:

Pacific Ballroom Salon 7

Organizers:

Julie Brill, The Hospital for Sick Children, Toronto, Canada, and
Mariana Wolfner, Cornell University, Ithaca, New York

This workshop will showcase the exciting progress in Drosophila male fertility research, and at the same time highlight how the special features of the Drosophila male reproductive system provide a powerful way to dissect cell biological processes of general importance. After a brief historical overview, the workshop will feature talks that focus on novel cellular mechanisms that underlie Drosophila spermatogenesis and male fertility. Topics will include recent advances in understanding the biogenesis and function of sperm and accessory gland organelles, mitochondrial morphogenesis, microtubule organization, individualization, exosome biology, and paternal contributions to embryogenesis.

Julie Brill, Hospital for Sick Children and University of Toronto, and Mariana Wolfner, Cornell University: Overview: Drosophila male fertility as a cell biological model

Karen Hales, Davidson College: Genetic control of mitochondrial morphogenesis during Drosophila spermatogenesis

Jieyen Chen, Florida State University: A splice variant of Centrosomin converts mitochondria to MTOCs to facilitate sperm tail elongation

Eli Arama, Weizmann University: The mitochondria as rate-limiting factors for caspase activation during spermatid individualization

Lacramioara (Lala) Fabian, Hospital for Sick Children: Phosphoinositide levels modulate nuclear and chromatin remodeling events during spermiogenesis

Takuo Yamaki, University of Washington: Paternal effect mutations reveal diverse roles of sperm specific chromosomal proteins

Frank W. Avila, Cornell University: Seminal proteins as a model for the mechanism and control of extracellular proteolysis cascades

Clive Wilson, Oxford University: Probing the regulation and function of exosomes in the male accessory gland

Special talk by Dan Lindsley, University of California at San Diego: Model for chemical mutagenesis


Friday, March 28   1:45 PM–3:45 PM
The Practice and Promise of CRISPR/Cas9-mediated Genome Engineering


Room:

Pacific Ballroom Salon 1

Organizers:

Melissa Harrison, University of Wisconsin, Madison, and
Kate O'Connor-Giles, University of Wisconsin, Madison, and
Jill Wildonger, University of Wisconsin, Madison

The bacterial CRISPR/Cas9 system was recently adapted for genome editing in many organisms, including Drosophila. The workshop will highlight the rapid advances in how this exciting new system is being used for genome engineering and encourage discussion of methods for expanding the utility of this technology. Speakers will present their work on topics including optimizing the system in Drosophila, balancing efficiency and specificity, and expanding its application for generating a range of genome modifications. Following the talks, a question-and-answer discussion forum will promote a dynamic exchange of ideas on creative strategies for future applications.

Scott Gratz, University of Wisconsin Madison: CRISPR and the promise of genome engineering on demand

Fillip Port, MRC Cambridge: CRISPR fly design: An optimized toolbox for Drosophila genome engineering

Guanjun Gao, Tsinghua University: Transgenic Cas9/gRNA system mediates high efficient gene targeting in Drosophila

Andrew Bassett, University of Oxford: Genetic knockouts and homologous targeting in Drosophila cell lines with CRISPR/Cas9 - new tools to investigate gene function

Luis Alberto Baena-Lopez, MRC National Institute for Medical Research: Different cocktails for various flavours of genomic engineering

Kelly Beumer, University of Utah:Designer mutations with nucleases: Homologous recombination tips and tricks


Friday, March 28   1:45 PM–3:45 PM
Extracellular Epithelial Barriers


Room:

Pacific Salon 6

Organizers:

Edward Blumenthal, Marquette University, Milwaukee, Wisconsin, and
Bernard Moussian, University of Tuebingen, Germany

Tissues exposed to potentially hostile environments produce protective extracellular barriers such as the external and tracheal cuticle, the eggshell, and the midgut peritrophic matrix. In the past few years, using the fruit fly as a model organism, a growing body of research has examined the molecular and genetic mechanisms of barrier formation. This workshop will feature presentations and discussion covering the biochemistry, cell biology, and genetics of barrier synthesis and stabilization and techniques available for studying the properties of these structures.


Saturday, March 29   6:45 PM–8:45 PM
Drosophila Metabolomics Workshop


Room:

Golden Pacific Ballroom

Organizers:

Thomas Merritt, Laurentian University, Sudbury, Canada, and
Daniel Promislow, University of Washington, Seattle, and
Jason Tennessen, Indiana University, Bloomington

Metabolomics is emerging as a powerful arm of the 'omics' world, linking genetic and environmental factors with downstream phenotypes and metabolomic studies are becoming increasingly common in Drosophila research. The "Drosophila metabolomics workshop" seeks to promote a shared approach to developing new methods in Drosophila-focused metabolomics research. This workshop is an outgrowth of the recently created International Drosophila Metabolomics Curation Consortium, which aims to facilitate metabolomics research by promoting standardization and sharing of protocols, results and best practices. Workshop discussion topics will include: potential reference fly strains, standardized controls and conditions, data analysis and data storage, and current metabolomic studies.

Thomas Merritt, Laurentian University : Goals the International Drosophila Metabolomics Curation Consortium

Trudy Mackay, North Carolina State University: Drosophila melanogaster Genetics Reference Panel

Daniel Promislow, University of Washington : A metabolomic perspective on the diet restriction response in Drosophila

Anders Malmendal, University of Copenhagen: NMR metabolomics of Drosophila.

Brandon Cooper, Indiana University: Quantitative profiling of glycerophospholipids to understand cellular plasticity in response to the thermal environment.

Laura Reed, University of Alabama, Tuscaloosa: Genotype-by-Diet Interaction Effects on Metabolomic Profiles

Andy Clark, Cornell University: Natural variation in Drosophila energy metabolism

Dominika Korzekwa, University of Glasgow: FlyMet: a flyatlas for tissue metabolomes

Jason Tennessen, Indiana University : Coordinated metabolic transitions during Drosophila embryogenesis


Saturday, March 29   6:45 PM–8:45 PM
Wound Healing and Regeneration


Room:

Pacific Ballroom Salon 3

Organizers:

Adrian Halme, University of Virginia School of Medicine, Charlottesville, and
Rachel Smith-Bolton, University of Illinois, Urbana-Champaign

Drosophila has become an important model system for understanding both wound healing and regeneration of tissues and organs. The goal for this workshop is to bring together presentations of recent work from researchers studying tissue repair in diverse contexts. This workshop will highlight and encourage discussion of the themes in this field including, but not limited to: the roles of stem cells, cell biological and mechanical mechanisms, and inflammatory and innate immune systems in tissue repair and regeneration in different developmental and adult tissues.


Saturday, March 29   6:45 PM–8:45 PM
Data-driven Mathematical Modeling in Drosophila as a Tool for Discovery


Room:

Pacific Ballroom Salon 7

Organizer:

David M Umulis, Purdue University, West Lafayette, Indiana

The integration of mathematical modeling with diverse imaging strategies in Drosophila has led to a number of new discoveries in the areas of network inference, the mechanics of morphogenesis, spatial pattern formation, cell-fate determination, among many others. In this workshop we investigate how researchers are bridging the gaps between experimental data and mathematical models to inform our understanding of mechanism and drive discovery in Drosophila. Specific topics include Model-Based Optimal Design of Experiments (MB-ODE), the integration of data into model design and optimization, and the mathematical modeling of morphogenesis.

Jeremiah Zartman, University of Notre Dame: Quantitative analysis of EGFR signaling in the Drosophila epidermis

Michael Pargett, University of California, Davis: Connecting qualitative imaging data with quantitative modeling in the Drosophila germarium

Gregory T. Reeves, North Carolina State University: Using mathematical modeling to deconvolute fluorescence imaging data of morphogen gradients


Saturday, March 29   6:45 PM–8:45 PM
Drosophila Research and Pedagogy at Primarily Undergraduate Institutions (PUI)


Room:

Pacific Ballroom Salons 4-5

Organizers:

Scott Ferguson, SUNY, Fredonia, New York, and
Jennifer Kennell, Vassar College, Poughkeepsie, New York, and
David M Roberts, Franklin & Marshall College, Lancaster, PA, and
Josefa Steinhauer, Yeshiva University, New York

This workshop focuses on increasing the quality and visibility of Drosophila research performed at primarily undergraduate institutions (PUIs) and facilitating faculty and students in these endeavors. The goals include: 1) Encouraging undergraduate research by providing a forum for students to make oral presentations; 2) Connecting people interested in this career path with current PUI faculty; 3) Establishing a network among current PUI faculty to promote discussion and provide support on professional issues that differ from those at large institutions; 4) Sharing concepts and techniques that encourage the integration of Drosophila as a teaching tool in the classroom and laboratory.


Saturday, March 29   6:45 PM–8:45 PM
Genetic, Genomic and Informatic Resources for Non-melanogaster Drosophilidae


Room:

Pacific Ballroom Salon 1

Organizers:

William Gelbart, Harvard University, Cambridge, Massachusetts, and
Therese Markow, University of California, San Diego

Many species of the family Drosophilidae are actively used for studies of evolution, population variation and ecology and comparative functional analyses (as well as for many other purposes). Given limitations on available resources for reference strains and mutations at the Drosophila Species Stock Center and for informatics support at FlyBase, it is essential to develop a community-supported consensus on priorities for these resources and to think about other resources that may be needed. This workshop is intended to provide a forum for discussion of possible options and priorities at this critical juncture in our rapidly expanding assemblage of information.


Saturday, March 29   9:15 PM–11:15 PM
Everything You Ever Wanted to Know About Sex


Room:

Pacific Ballroom Salon 3

Organizers:

Artyom Kopp, University of California, Davis, and
Michelle Arbeitman, Florida State University, Tallahassee

The workshop will cover the molecular genetics, development, neurobiology, genomics, evolution, and population genetics of sexual dimorphism, with an emphasis on cross-disciplinary interactions. Presentations by invited speakers and selected abstracts from each discipline will be followed by moderated discussions. The speakers are encouraged to summarize the key ideas behind their research for people working in other fields, outline the main unsolved questions, offer their opinions about future directions, and suggest connections that could be built with other disciplines.


Saturday, March 29   9:15 PM–11:15 PM
Feeding Behavior, Nutrition and Metabolism


Room:

Golden Pacific Ballroom

Organizers:

Tânia Reis, University of Colorado School of Medicine, Aurora, and
William W Ja, The Scripps Research Institute, Jupiter, Florida

Drosophila has become as a powerful model system for studying how diet and nutrition can influence a wide range of metabolic processes. This workshop is designed to assemble a diverse group of presentations that highlight recent advances in the field of nutrition and metabolism. The goal of this workshop is to foster discussions and encourage collaborations among individuals interested in topics ranging from food intake as a fundamental parameter of metabolism to the effects of diet on energy storage and utilization.

William Ja, The Scripps Research Institute: Introduction/Food intake and prandial behavior in Drosophila

Scott Pletcher, University of Michigan: High-throughput, continuous analysis of Drosophila feeding behavior reveals novel preferences

Nilay Yapici, The Rockefeller University: An internal taste circuit promotes food intake

Stephanie Albin, HHMI Janelia Farm: Serotonin motivates feeding behavior and appetitive memory performance in Drosophila

Tânia Reis, University of Colorado Medical School: Neuronal regulation of organismal fat

Marko Brankatschk, Max Planck Institute of Molecular Cell Biology and Genetics: Delivery of circulating lipoproteins to specific neurons in the brain regulates systemic insulin signaling

Alex Gould, MRC National Institute for Medical Research: Metabolic crosstalk and signaling between neuroblasts and their glial niche

Alejandra Figueroa-Clarevega, University of California, Berkeley: Cachexia-like wasting induced by malignant tumors in Drosophila

Rebecca Somer, University of Utah: Regulation of glucose homeostasis by dSir2 in Drosophila melanogaster


Saturday, March 29   9:15 PM–11:15 PM
Centrosomes and Cilia in Cell Division and Disease


Room:

Pacific Ballroom Salon 7

Organizers:

Tim Megraw, Florida State University, Tallahassee, and
Tomer Avidor-Reiss, University of Toledo, Ohio, and
Nasser Rusan, NIH, Bethesda, Maryland

This workshop will unite the centrosome and cilium research community at a rare forum focused on the centrosome/cilium complex and its role in cell division, stem cell biology, development and disease.

John Poulton, University of North Carolina at Chapel Hill: Centrosomes are key components of mitotic spindle assembly and orientation in the symmetric divisions of epithelial cells

Oscar Cabrera, Florida State University: Proteomic and genetic screens reveal a novel requirement for cnn in neurological health

Brian Galletta, NIH: The centrosome interactome reveals novel roles for Asterless

Alain Debec, Paris Diderot University: New Drosophila acentriolar cell lines

Clemens Cabernard, University of Basel: Centrosome size asymmetry in Drosophila neuroblasts

Bénédicte Durand, Université Lyon: Chibby and transition zone assembly in Drosophila

Marcus L. Basiri , University of Toledo: The Cilium Transition Zone and Cep290 Form a Mobile Molecular Gate in Spermatids

Seok Jun Moon, Yonsei University: Trafficking of TRP channels to cilia