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Important Dates:

 
September 24, 2014
Abstract Submission Opens

Conference Registration Opens

 
November 5, 2014
Deadline for Workshop Requests
 
November 10, 2014
Abstract Submission Deadline
 
December 1, 2014
Larry Sandler Award Submission Deadline
 
January 16, 2015
Deadline for Early (Discounted) Conference Registration
 
February 6, 2015
Deadline for Hotel Reservations
 

 

2015 Meeting Organizers:

 

Greg Beitel
Michael Eisen
Marc Freeman
Ilaria Rebay
 

Poster Session Listing

 

POSTER SESSIONS LISTING

 

Cell Biology and Cytoskeleton


158A
Quantification of mechanical force driving left-right asymmetric morphogenesis of the embryonic gut in Drosophila. Mai Adachi1, Naotaka Nakazawa2, Shukei Sugita3, Takeo Matsumoto3, Kenji Matsuno1. 1) Osaka University, Osaka, Japan; 2) National University of Singapore, Lower Kent Ridge Road ,Singapore; 3) Nagoya Inst. of Tech, Aichi, Japan.

159B
Differential roles of the unconventional Dock family members Myoblast city and Sponge in Drosophila development. Bridget H. Biersmith1, Erika R. Geisbrecht2. 1) University of Missouri - Kansas City, Kansas City, Missouri, MO; 2) Kansas State University, Manhattan, KS.

160C
Defining the role of CG1674 in adult muscle development. Marilyn Cisneros, Richard Cripps. Biology, University of New Mexico, Albuquerque, NM.

161A
Compound Heterozygosity of Meckel-Gruber Syndrome Proteins. Nicole M. Clark, Marcus L. Basiri, Andrew Ha, Avidor-Reiss Tomer. Biological Sciences, University of Toledo, Toledo, OH.

162B
Pavarotti/MKLP1 regulates microtubule sliding and neurite outgrowth in Drosophila neurons. U. del Castillo, W. Lu, M. Winding, M. Lakonishok, V. Gelfand. Feinberg School of Medicine, Cell and Molecular Biology Dept, Northwestern University, Chicago, IL.

163C
Branched F-actin dynamics regulate contact length during Drosophila eye morphogenesis. Steven Del Signore, Victor Hatini. Dev, Mol, & Chem Biology, Tufts Univ Sch Med, Boston, MA.

164A
Dynamic analysis of the function of the actin cable during Drosophila dorsal closure. Antoine Ducuing1, Maxime Dureau1, Charlotte Keeley2, Bertrand Mollereau1, Stéphane Vincent1. 1) Laboratory of Molecular Biology of the Cell, Ecole Normale Supérieure de Lyon, Lyon, France; 2) Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

165B
Integrins regulate apical constriction via microtubule stabilization in the Drosophila eye disc epithelium. Vilaiwan M. Fernandes1, Kasandra McCormack1, Lindsay Lewellyn2, Esther M. Verheyen1. 1) Simon Fraser University, Burnaby, BC, Canada; 2) Butler University, Indianapolis, Indiana, USA.

166C
Clic functions to regulate Moesin phosphorylation during Drosophila rhabdomere formation. Kara J. Finley1, Robert Hikida2, Mark Berryman2, Soichi Tanda1. 1) Department of Biological Sciences, Ohio University, Athens, OH; 2) Department of Biomedical Sciences, Ohio University, Athens, OH.

167A
Biochemical optimization of the purification of the C-terminal domains of ck/MyoVIIA. Thomas Halverson, Jennifer Sallee. Science, North Central College, Naperville, IL.

168B
F-actin turnover is essential for apical constriction and tissue morphogenesis. J. N. Jodoin1, M. Tworoger1, L. Perkins2, N. Perrimon2,3, A. C. Martin1. 1) Biology, MIT, Cambridge, MA; 2) Genetics, Harvard, Boston, MA; 3) HHMI, Harvard, Boston, MA.

169C
Identifying a Kelch-Cullin3 ubiquitin ligase substrate. Katelynn Mannix, Andrew Hudson, Lynn Cooley. Department of Genetics, Yale School of Medicine, New Haven, CT.

170A
Rho GAPs are required for proper organization of the apical actomyosin cortex and epithelial invagination. Frank Mason, Michael Tworoger, Adam Martin. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.

171B
Characterization of twinfilin mutants in denticle formation. Jane M. McCullough, Kayla Antle, Jennifer Sallee. North Central College, Naperville, IL.

172C
A coupled in vitro-in vivo approach to dissect APC-Diaphanous mediated actin assembly. Olivia Molinar1, Richa Jaiswal2, Ezgi Kunttas-Tatli1, Aneliya Rankova2, Vince Stepanik1, Bruce L. Goode2, Brooke M. McCartney1. 1) Biological Sciences, Carnegie Mellon University, Pittsburgh, PA; 2) Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA.

173A
Actomyosin network dynamics during epithelial cell alignment. Katy Ong, Stephen DiNardo. Cell and Developmental Biology Department, University of Pennsylvania, Philadelphia, PA.

174B
A novel concept of local homeostasis for the long-term maintenance of neuronal axons. Andreas Prokop1, Yue Qu1, Ines Hahn1, Meredith Lees1, Jill Parkin1, Zhen Zang2, Pakorn Tony Kanchanawong2. 1) Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom; 2) MBI, Singapore.

175C
Key features of the axon initial segment are present in Drosophila neurons. Melissa M. Rolls1, Michelle M. Nguyen1, Daniel J. Goetschius1, Timothy J. Jegla2. 1) Biochemistry and Molecular Biology, Penn State, University Park, PA; 2) Biology, Penn State, University Park, PA.

176A
Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis. Jennifer Sallee1,2, Janice Crawford2, Vinay Singh2, Daniel Kiehart2. 1) Biology, North Central College, Naperville, IL; 2) Department of Biology, Duke University, Durham, NC.

177B
Actin regulators are important for regeneration in Drosophila melanogaster wing imaginal discs. Mabel Seto, Amanda R. Brock, Rachel K. Smith-Bolton. Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL.

178C
An optogenetic approach to assess tissue mechanics in epithelial wound detection. Erica Shannon1, Monica Lacy2, M. Shane Hutson2, Andrea Page-McCaw1. 1) Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN; 2) Department of Physics, Vanderbilt University Collage of Arts and Sciences, Nashville, TN.

179A
Polarized cytoskeletal organization in the Drosophila embryo. Alison Spencer1, Shinya Yamamoto2, Vafa Bayat2, Manish Jaiswal2, Nele Haelterman2, Hugo J. Bellen2, Jennifer A. Zallen3. 1) Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY; 2) HHMI and Program in Developmental Biology, Baylor College of Medicine, Houston, TX; 3) HHMI and Developmental Biology Program, Sloan Kettering Institute, New York, NY.

180B
Apico-basal forces exerted by apoptotic cells drive epithelium folding. Bruno Monier1, Melanie Gettings1, Guillaume Gay2, Thomas Mangeat1, Sonia Schott1, Ana Guarner3, Magali Suzanne1. 1) LBCMCP, Toulouse University /CNRS, Toulouse, France; 2) DamCB company, Marseille, France; 3) Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, , Madrid, Spain.

181C
New cellular sites of prostaglandin regulated Fascin activity: the nucleus and nuclear periphery. Christopher Groen, Tina Tootle. Anatomy and Cell Biology, University of Iowa, Iowa City, IA.

182A
A composite scaffold provides structural integrity to myonuclei. Shuoshuo Wang, Talila Volk. Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

183B
Examining the regulation of Drosophila Rho kinase by phosphorylation. Y. Zhang, T. Jiang, T. Harris. University of Toronto, Toronto, Canada.

184C
Continuous ROCK activity sustains apical constriction in a folding epithelium through the maintenance of centripetal tension. Jonathan Coravos, Adam Martin. Biology, Massachusetts Institute of Technology, Cambridge, MA.

185A
Tuning of a Par-1-Par-3-centrosome pathway to couple epithelial cell polarity and adhesion. Tao Jiang, Andrew McKinley, Tony Harris. Cell & Systems Biology, University of Toronto, Toronto, ON, Canada.

186B
hosphorylation of DE-Cadherin Controls Adherens Junction Dynamics During Apical-Basal Polarization. Yang Hong, Yi-Jiun Chen, Juan Huang. Dept Cell Biol & Physiology, Univ Pittsburgh Med Sch, Pittsburgh, PA.

187C
The role of Moesin in specialized membrane domain formation during early Drosophila embryogenesis. Danielle Howell1, Michael Ludwig2, Xiao Sun3, Richard Fehon4. 1) Development, Regenerative and Stem Cells Biology, University of Chicago, Chicago, IL; 2) Department of Ecology and Evolution, University of Chicago, Chicago, IL; 3) Peking University, Beijing, China; 4) Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

188A
Intracellular mechanisms involving post-translational modifications of the PIP5K Skittles regulate PI(4,5)P2 associated cell polarity. Julie Jouette, Antoine Guichet, Sandra Claret. Institut Jacques Monod, Paris, France.

189B
Dachsous, Fat and actin modulators contribute to planar cell polarity in the Drosophila ventral epidermis. Gregory Osborn, Dan Ly, Kynan Lawlor, Stephen DiNardo. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA.

190C
Exploring the mechanism of Prickle/Spiny-legs isoforms’ control of microtubule polarity and symmetry breaking in planar cell polarity. Katherine Sharp1,2, Jessica Olofsson1,3, Jeffrey Axelrod1. 1) Department of Pathology, Stanford University School of Medicine, Stanford, CA; 2) Department of Genetics, Stanford University School of Medicine, Stanford, CA; 3) Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

191A
Planar polarity and oriented cell division generate an epithelial square grid in the Drosophila embryo. Masako Tamada1,2, Jennifer Zallen1,2. 1) Howard Hughes Medical Institute; 2) Dev Biol, Sloan Kettering Institution, New York, NY.

192B
Parkinson’s disease gene Vps35 regulates autophagy in Drosophila neurons. Y.-J. Ho, R. Linhart, D. Kaing, E. Hou, D. Sohal, R. Fedrizzi, A. Tsang, D. Fong, R. Eismati, J. Rosales, A. Dawson, J. Ly, C. Kim, K. Venderova. Physiology and Pharmacology, University of the Pacific, Stockton, CA.

193C
A rapid, membrane-dependent pathway directs furrow formation through RalA in the early Drosophila embryo. R. Holly, L. Mavor, Z. Zuo, T. Blankenship. University of Denver, Denver, CO.

194A
Rab8 directs tubulation and furrow ingression during epithelial formation in Drosophila melanogaster. L. M. Mavor, Z. Zuo, J. T. Blankenship. Biological Sciences, University of Denver, Denver, CO.

195B
Dynamin-mediated endocytosis promotes cell intercalation during epithelial tube morphogenesis in the Drosophila ovary. Nathaniel Peters, Kamsi Odinammadu, Celeste Berg. Department of Genome Sciences, University of Washington, Seattle, WA.

196C
The ArfGAP Asap is required for plasma membrane furrow formation in the syncytial Drosophila embryo. Francisco Rodrigues, Tony Harris. Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.

197A
Sequential trafficking events target White transporter to pigment granules. DS Chen1, J. Xiong1,3, YN Rui1, A. Tito1,3, Z. Chen1, Z. Xu1, L. Ye1, G. Jiang4, S. Zhang1,2,3. 1) Inst Mol Med; 2) Dept Neurobio Anatomy, UTHSC-H; 3) Programs in HMG and Neuroscience, University of Texas Graduate School of Biomedical Sciences, Houston, TX; 4) Shandong Univ, School of Medicine, China.

198B
Polarization of the epithelial layer is required for apical localization of the integrin heterodimer, αPS3βPS, to promote engulfment. Tracy Meehan1, Sarah Kleinsorge2, Allison Timmons1, Jeffrey Taylor1, Kimberly McCall1. 1) Department of Biology, Boston University, Boston, MA; 2) Graduate Program of Genetics and Genomics, Boston University Medical Center, Boston, MA.

199C
Polarized transport and selective retention localizes the signaling center for bristle cell elongation. T. Otani1, K. Oshima1, A. Kimpara1, M. Takeda1, U. Abdu2, S. Hayashi1. 1) Lab Morphogenetic Signaling, RIKEN Ctr Dev Biol, Kobe, Japan; 2) Dept of Life Sciences, Ben-Gurion Univ, Beer-Sheva, Israel.

200A
Novel smad protein dysmorphic regulates Drosophila tracheal tube size through luminal matrix maintenance. Rachana Radhamani Chandran, Lan Jiang. Department of Biological sciences, Oakland University, Rochester, MI.

201B
Dosage-sensitive interactions between Kinesin-1 and transiently expressed Halo regulate lipid-droplet transport. Michael Welte, Gurpreet Arora, Susan Tran, Nicholas Rizzo. Dept Biol, RC Box 270211, Univ Rochester, Rochester, NY.

202C
Content release from salivary-gland secretory vesicles is mediated by a dynamic acto-myosin network. Eyal Schejter, Tal Rousso, Ben-Zion Shilo. Dept Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

203A
Myosin activity at the periphery of the border cell cluster promotes its compact shape during migration between nurse cells. George Aranjuez1,2, Pralay Majumder1, Ashley Burtscher1, Jocelyn McDonald1,2. 1) Molecular Genetics, Cleveland Clinic Foundation, Cleveland, OH; 2) Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH.

204B
Tsp66E, the KAI1 homologue, functions in the border cell migration and maintaining the adhesion of premature border cells in Drosophila. Haemin Jeong, Seung Yeop Han, Minjung Lee, Soojin Lee, Myeong Cheol Shin, Young Jae Jeon, Kyoung Sang Cho. Department of biological sciences, Konkuk university, Seoul, South Korea.

205C
LAMININS ARE REQUIRED FOR PROPER MIGRATION OF EMBRYONIC HAEMOCYTES IN DROSOPHILA MELANOGASTER. Besaid J. Sánchez-Sánchez1, J. M. Urbano2, K. Comber3, W. Wood3, M. D. Martín-Bermudo1. 1) CABD, CSIC, Sevilla, Spain; 2) PDN Department, University of Cambridge, UK; 3) Department of Developmental Biology, University of Bristol, UK.

206A
Role of ADP ribosylation factors and their regulators in collective cell migration. Carlos Zeledon, Xiaojuan Sun, Gregory Emery. Université de Montréal, Montréal, Canada.

207B
A novel role for secreted hemolymph proteins in Drosophila muscle attachment. Nicole Green1, Nadia Odell2, Clara Bazjek3, Mitch Dushay3, Erika Geisbrecht1. 1) Bioch. & Mol. Biophysics Dept., Kansas State University, Manhattan, KS; 2) Cell Biol. & Biophysics Dept., University of Missouri-Kansas City, Kansas City, MO; 3) Biology Dept., Illinois Institute of Technology, Chicago, IL.

208C
A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and regulates tube morphogenesis in Drosophila. Shigeo Hayashi1,2, Dong Bo1, Guanxia Miao1,2. 1) Lab Morphogenetic Signaling, Riken Center Develop Biology, Kobe Hyogo, Japan; 2) Department of Biology, Kobe University Graduate School of Science, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8051, Japan.

209A
The Role of Mechanical Cross-linking in Basement Membrane Repair. Angela Howard1,2, Gautam Bhave1,3, Andrea Page-McCaw1,2,4. 1) Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee; 2) Program of Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee; 3) Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; 4) Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee.

210B
Identification and Analysis of Ras Pathway Candidate Genes. Peter Lyon, Sathiya Manivannan, Ashley Heinaman, Nanki Hura, Molly Josifov, Amanda Simcox. Department of Molecular Genetics, The Ohio State University, Columbus, OH.

211C
Defining the role of Canoe in apical-basal polarity establishment in early Drosophila embryogenesis. Teresa T. Bonello1, Kaelyn Sumigray2, Mark Peifer1. 1) Department of Biology, University of North Carolina, Chapel Hill, NC; 2) Department of Cell Biology, Duke University School of Medicine, NC.

212A
Continuous Talin function is required to maintain apposition of myofibrils between cardiomyocytes. Duygu Cevik1, Simina Bogatan1, Abdullah Panchbhaya1, Valentin Demidov2, Alex Vitkin2, J. Roger Jacobs1. 1) Biology, McMaster University, Hamilton, Ontario, Canada; 2) Medical Physics, University of Toronto, Ontario, Canada.

213B
Phenotypic Analysis of Genes in Retinal Basal Glial cells. Yen-Ching Chang1,2, Y. Henry Sun1,2. 1) Institute of Molecular biology, Academia sinica, Taipei, Taipei, Taiwan; 2) Department of Life sciences and Institute of Genome sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China.

214C
Biophysical approach to elucidate molecular links between PCP and adhesion/cytoskeleton dynamics. Nabila Founounou1, Reza Farhadifar2, Marek Mlodzik1. 1) Developmental and regenerative biology, Mt. Sinai School of Medicine , New York, NY; 2) Department of Applied Physics, Center for Systems Biology, Harvard University, Cambridge, MA,.

215A
Uncovering a fundamental requirement for septate junction genes during morphogenesis. Sonia Hall, Robert Ward. Molecular Biosciences, University of Kansas, Lawrence, KS.

216B
An E-Cadherin trafficking defect reveals its role in maintenance of intercellular bridges anchoring. Roland Le Borgne, Nicolas Loyer, Irina Kolotueva. Institut de Génétique et Développement de Rennes, CNRS UMR 6290, Rennes, France.

217C
The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated by Moesin, aPKC, the cortical cytoskeleton and endocytosis. Kristin Sherrard, Richard Fehon. Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

218A
Tracking vertices in epithelial tissues for the analysis of coordinated cell shape changes during epithelial morphogenesis. Rodrigo Cilla, Steven Del Signore, Victor Hatini. Tufts University, Boston, MA.

219B
Huntingtin (HTT) transports a novel class of synaptic vesicles during axonal transport: Identification of a moving HTT-Rab4 vesicle in Drosophila larval axons. Joseph A. White II1, Eric Anderson1, Katherine Zimmerman1, Kan Hong Zheng1, Harsh Saxena2, Ge Yang2, Shermali Gunawardena1. 1) Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY 14260,; 2) Lane Center for Computational Biology and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.

220C
Asymmetric mRNA segregation during neuroblast division. Jens Januschke, Anne Ramat. Cell & Developmental Biology, University of Dundee College of Life Sciences, Dundee, United Kingdom.

221A
Transmembrane and secreted MMPs are required for heart morphogenesis in Drosophila. Qanber S. Raza, Jessica Vanderploeg, Roger Jacobs. McMaster Univeristy, 1280 Main St West, Hamilton, ON,CA L8S4L8.

222B
Expression of the testis-specific paralog of ATP synthase subunit d in Drosophila flight muscle. Dennis Akrobetu, Brian Johnson, Lindsay Regruto, Eric Sawyer, Karen Hales. Department of Biology, Davidson College, Davidson, NC.

223C
F-box proteins in Drosophila muscle. C. Clark1, K. Bauman2, M. Kelly2, E. Geisbrecht1. 1) Dept. of Biochem. & Mol. Biophysics, Kansas State University, Manhattan, KS; 2) Cell Biology & Biophysics Dept., University of Missouri KC, Kansas City, Mo.

224A
The Role of Ubiquitin Specific Protease 5 in Drosophila melanogaster. Gorica Ristic, Sokol Todi. Pharmacology, Wayne State University School of Medicine, Detroit, MI.

Cell Biology and Signal Transduction


225B
Characterization of a novel Wnt signaling factor regulating tissue homeostasis and regeneration in the aging Drosophila intestine. Anna-Lisa Boettcher, Teresa Eichenlaub, Claudia Strein, Michael Boutros. German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics and Heidelberg University, D-69120 Heidelberg, Germany.

226C
Ras activated Dsor1 promotes Wg signaling in Drosophila development. Eric T. Hall, Esther M. Verheyen. Simon Fraser University, 8888 University Dr. Burnaby, BC, Canada V5A 1S6.

227A
Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling. David Roberts, Robert Yamulla, Eric Kane, Alexandra Moody, Kristin Politi, Nicole Lock, Andrew Foley. Department of Biology, Franklin & Marshall College, Lancaster, PA.

228B
Characterization of a conserved, negative regulator of Wg/Wnt signaling in Drosophila melanogaster. Michael Suchanek, Varun Chaudhary, Gerrit Erdmann, Michael Boutros. German Cancer Research Center (DKFZ), Div. Signaling and Functional Genomics and University of Heidelberg, Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, D-69120 Heidelberg, Germany.

229C
Sol narae (Sona) is required for cleavage of exosomal Wingless and generation of a soluble Wingless fragment. Jong-Hoon Won1, Go-Woon Kim2, Ja-young Kim1, Ok-Kyung Lee1, Sang-Soo Lee1, Orkhon Tsogtbaatar1, Su-Jin Nam1, Yeon Kim1, Kyung-Ok Cho1, Go-Woon Kim. 1) Biological Science, KAIST, Daejeon, South Korea; 2) Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Korea.

230A
Latency of a Drosophila BMP-prodomain complex is prevented by proconvertase cleavage within the prodomain. Edward Anderson, Eric Tung, Kristi Wharton. MCB, Brown University, Providence, RI.

231B
A DPP-mediated Feed-Forward Loop canalizes morphogenesis during Drosophila dorsal closure. Antoine Ducuing1, Charlotte Keeley2, Bertrand Mollereau1, Stéphane Vincent1. 1) Laboratory of Molecular Biology of the Cell, Ecole Normale Supérieure de Lyon, Lyon, France; 2) Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

232C
Dpp signaling antagonism is mediated by the formation of a chondroitin sulfate sink. Matthew Moulton, Gregory Humphreys, Anthea Letsou. Human Genetics, University of Utah, Salt Lake City, UT.

233A
Uncovering a role for the TGF-β/Activin factor Myoglianin in regulating wing imaginal disc growth through analysis of dSmad2 protein null mutants. Ambuj Upadhyay, Aidan J. Peterson, Michael B. O'Connor. Dept. of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN.

234B
Dissecting the nuclear co-repressor complex(es) of Notch. Stephen Chan, Gustavo Cerda-Moya, Bettina Fischer, Robert Stojnic, Sarah Bray. Anatomy Building, Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, United Kingdom, CB2 3DY.

235C
The Ecdysone and Notch pathways regulate Cut via a shared cut enhancer region for proper dorsal-ventral (D/V) boundary formation in Drosophila wing disc. Allison Jevitt, Dongyu Jia, Jamal Bryant, Wu-Min Deng. Florida State University, Tallahassee, FL.

236A
Deciphering the Function of midline within Insulin/dAKT and c-Jun N-terminal Kinase Signaling Pathways during Larval CNS and Eye Development. Sandra Leal, Q. Brent Chen, Visic Petra, Buford Ken. Dept Biological Sci, Univ Southern Mississippi, Hattiesburg, MS.

237B
The Drosophila glucoside xylosyltransferase Shams is a novel ligand-specific regulator of Notch signaling. Tom Lee1, Hamed Jafar-Nejad1,2. 1) Molecular & Human Genetics, Baylor College of Medicine, Houston, TX; 2) Program in Developmental Biology, Baylor College of Medicine, Houston. TX.

238C
A screen for tyrosine phosphatases redundant with Eyes absent. Charlene Hoi, Trevor Davis, Ilaria Rebay. Ben May Department of Cancer Research, University of Chicago, Chicago, IL.

239A
Exploring the Relationship Between ETS-Family Transcription Factor Polymerization and RTK Signaling Output. Matthew Hope1, John Reinitz2, Ilaria Rebay2. 1) Department of Biochemistry and Molecular Biophysics; 2) Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

240B
Cellular and temporal dynamics of the Pointed-Yan network during cell fate specification in the Drosophila eye. Jean-Francois Boisclair Lachance1,3, Nicolás Peláez2,3, Luís Amaral2,3, Richard Carthew2,3, Ilaria Rebay1,3. 1) University of Chicago, Chicago, IL; 2) Northwestern University, Evanston, IL; 3) Chicago Center for Systems Biology (CCSB), Chicago, IL.

241C
In vivo screen for a novel small molecule inhibitor of PLCγ in Drosophila. Chitra Naidu, Claire Rosenwasser, Todd Rosenberg, Michelle Latino, Justin Thackeray. Biology, Clark University, Worcester, MA.

242A
Uncovering a novel interplay between the EGFR and JNK signaling pathways in Drosophila dorsal closure. Ze'ev Paroush, Tatyana Shestkin, Sharon Mezuman, Shaked Cohen, Ayala Smotrich, Aharon Helman. Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.

243B
Characterization of Dis3 in Drosophila melanogaster. Lindsay Petsch1, Danielle Bazelak1, Mark Snee2, Hemlata Mistry1, James Skeath2. 1) Dept. of Biology, Widener University, Chester, PA; 2) Dept. of Genetics, Washington University School of Medicine, St Louis, MO.

244C
Src42A Modulates Tumor Invasion and Cell Death via Ben/dUev1a-JNK Signaling in Drosophila. Xianjue Ma, Yingyao Shao, Hongyu Zheng, M. Li, Wenzhe Li, Lei Xue. Department of Interventional Radiology, Shanghai Key Laboratory of Signaling and Disease Research, Shanghai 10th People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.

245A
Investigation of novel epidermal growth factor receptor signaling target genes implicated in Drosophila development. Connor Zale, Sean Thomas, Jeffrey Perluke, Michael Warkala, Lisa Kadlec. Dept. of Biology, Wilkes University, Wilkes-Barre, PA.

246B
Invadolysin: a novel metalloprotease plays an important role in metabolism. Kanishk Abhinav, Margarete M. S. Heck. University of Edinburgh, Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

247C
Cdk8 and Sgg control the intensity and range of the BMP-activity gradient in developing Drosophila tissues. Abigail Aleman, Hugo Urrutia, Edward Eivers. California State University Los Angeles, Los Angeles , CA.

248A
Epithelia patterning and body plan mapping in the Drosophila egg chamber. Alexis L. Braun, Bhavna Chanana, Isabel M. Palacios. Zoology, University of Cambridge, Cambridge, United Kingdom.

249B
Spatiotemporal Patterning of Polyamine Metabolism during Drosophila Development. Miranda Burnette, Gabrielle Dohmen, Galvin Loughran, Steven Penny, Jeremiah Zartman. Chemical Engineering, University of Notre Dame, Notre Dame, IN.

250C
Exploring potential downstream targets of Atrophin in Fat/Dachsous PCP signaling using DamID. C. Kuok1,2, A. Soltyk3, M. Fanto4, T. Westwood3, H. McNeill1,2. 1) Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; 2) The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; 3) Department of Cell and Systems Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada; 4) MRC Centre for Developmental Neurobiology, King’s College London, London, UK.

251A
Poly: a novel protein with an essential role in metabolism and Type 2 Diabetes. Ioanna Panagakou, Margarete M. S. Heck. University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

252B
The role of G protein o alpha subunit in the eye development and aging in Drosophila. Silvia Plascencia Oliveros1,2, Marlène Cassar1, Doris Kretzschmar1. 1) Oregon Institute of Occupational Health Sciences, OHSU, Portland, OR; 2) Biology, University of Portland, Portland, OR.

253C
The Abelson kinase prevents photoreceptors from adopting pigment cell fate. Nicelio Sanchez-Luege1,2, Ilaria Rebay3. 1) Development, Regeneration, and Stem Cell Biology, University of Chicago, Chicago, IL; 2) Medical Scientist Training Program, University of Chicago, Chicago, IL; 3) Ben May Department for Cancer Research, University of Chicago, Chicago, IL.

254A
The phenotypic effects associated with loss of PKN function are manifest upon perturbation of cell death in Drosophila melanogaster. Georgette Sass, Jessica Schoenherr. Biology, Grand Valley State University, Allendale, MI.

255B
Coordinated regulation of tissue remodeling and insulin signaling during Drosophila metamorphosis. Craig Woodard, Giulia Notarangelo, Bezawit Woldemeskel, Hanna Cho, Yeonhee You, Efthymia Papalexi. Department of Biological Sciences, Mount Holyoke College, South Hadley, MA.

256C
Targeted mutagenesis and functional analysis of Drosophila adipokinetic hormone gene. M. Zurovec1, S. Sajwan1, R. Sidorov1, Y. Takasu2, T. Staskova1, A. Zaloudikova1, D. Kodrik1. 1) Biology Centre Czech Acad. Sci., Ceske Budejovice, Czech Republic; 2) 2National Institute of Agrobiological Sciences, 1-2 Owashi, Tsukuba, Ibaraki 305-8634, Japan.

257A
Multiple roles for the Netrin receptor, Frazzled, in EMT. S. Golenkina1, R. Manhire-Heath1, R. Saint2, M. J. Murray1. 1) The University of Melbourne, Australia; 2) The University of Adelaide, South Australia.

258B
Functional understanding of Ral signaling in Drosophila melanogaster. Helene Knaevelsrud1, Marc Therrien1,2. 1) IRIC, Universite de Montreal, Montreal, Quebec, Canada; 2) Département de pathologie et de biologie cellulaire, Université de Montréal.

259C
Nanobody-mediated morphogen trapping - Growth and patterning in the absence of a Dpp gradient. S. Harmansa, M. Affolter, E. Caussinus. Biozentrum, Universität Basel, Basel, Switzerland.

260A
Dissecting signaling crosstalk in the midgut with dynamic transcriptional reporters. David P. Doupé1, Benjamin E. Housden1, Li He1, Richard Binari1, Norbert Perrimon1,2. 1) Dept of Genetics, Harvard Medical School, Boston, MA; 2) Howard Hughes Medical Institute, Boston, MA.

261B
Computational modeling of transient EGFR signaling in the early embryo. Yogesh Goyal1,2, Bomyi Lim1,2, Andreas Raue3, Birgit Schoeberl3, Stanislav Shvartsman1,2. 1) Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ; 2) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ; 3) Merrimack Pharmaceuticals, 1 Kendall Square, Cambridge, MA.

262C
The Hippo Signaling Pathway Interactome. Young Kwon1, Arunachalam Vinayagam1, Xiaoyun Sun3, Noah Dephoure4, Steven Gygi4, Pengyu Hong3, Norbert Perrimon1,2. 1) Department of Genetics, Harvard Medical School, Boston, MA; 2) Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA; 3) Department of Computer Science, Volen Center for Complex Systems, Brandeis University, Waltham, MA; 4) Department of Cell Biology, Harvard Medical School, Boston, MA 02115.

263A
microRNA-9a canalizes myotendinous junction assembly via targeting of muscle-specific genes. Andriy Yatsenko, Halyna Shcherbata. Max Planck Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Goettingen, Germany.

264B
Proteomic discovery of a novel mechanism linking calcium signaling and p38MAPK pathway activation. Vladimir Belozerov, Lisa Shim, April Kong, Reza Amirzadeh, Arthur Hilliker, Spencer Mukai, John McDermott. Department of Biology, York University, Toronto, ON, Canada.

265C
Mitochondria are maintained by local fusion and mitophagy at neuromuscular junction synapses. Ryan Insolera1, Ruohan Wang1, Pushpanjali Soppina1, Grace Kim1, Eric Robertson1, Yih-Woei Fridell2, Catherine Collins1. 1) MCDB Department, University of Michigan, Ann Arbor, MI; 2) University of Connecticut, Allied Health Sciences, Storrs, CT.

266A
Chromatic Assembly Factor Complex Component p180 is a Potential Component of the Hippo Pathway. William B. Yee, Patrick Delaney, Pamela Vanderzalm, Richard Fehon. Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

Cell Cycle and Cell Death


267B
In vivo RNAi knockdown of the Drosophila N-acetyltransferase NatA causes cell death. Joseph Ahlander1, Kelsey Dozier2, Ethan Hayman2, Pamela Martin1, Amanda Scholes2. 1) Department of Natural Sciences, Northeastern State University, Tahlequah, OK; 2) Department of Biological Sciences, Univeristy of Arkansas, Fayetteville, AR.

268C
dCAF1 is required for the cell death sensitivity of rbf1 mutant cells. Heather Collins, Nam-Sung Moon. McGill University, Montreal, QC, Canada.

269A
Engulfment receptor, Draper, and its ligand for the clearance of dead cells in the developing Drosophila optic lobe. Ryosuke Nakano1, Masashi Iwamura1, Akiko Obikawa1, Ryo Iizuka1, Hiromi Akagawa1,2, Hidenobu Tsujimura1. 1) Developmental Biology, Tokyo University of Agriculture and Technology, Fuchushi, Tokyo, Japan; 2) Department of Biological Production Science, Tokyo University of Agriculture and Technology, Fuchushi, Tokyo, Japan.

270B
Sensitivity to apoptosis is differentially regulated by cell growth pathways. Sarah Neuman, Yunsik Kang, Arash Bashirullah. University of Wisconsin-Madison, Madison, WI.

271C
Non-autonomous protective effect of dying and undead cells. Tin Tin Su, Angela Delano, Annika Gustafson. MCD Biology, University of Colorado, Boulder, CO.

272A
Tousled-like kinase mediates a new type of apoptosis in Drosophila. Yu Zhang1, Lei Liu1,2. 1) College of Life Sciences,PKU, Beijing, Beijing, China; 2) Beijing Institute for Brain Disorder and Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, China.

273B
Non-autonomous control of nurse cell death by follicle cells in the Drosophila ovary. Albert Mondragon, Allison Timmons, Claire Schenkel, Jon Iker Etchegaray, Jeffrey Taylor, Kim McCall. Boston University, Boston, MA.

274C
Cell Survival in Muscle Development. Tatevik Sarkissian, Richa Arya, Kristin White. MGH/ Harvard Medical School, Boston, MA.

275A
A heat shock protein regulates caspase-mediated autophagy. Courtney Choutka1,2, Lindsay DeVorkin1,2, Nancy Erro Go1,2, Claire Hou1, Annie Moradian3, Gregg Morin1,3, Sharon Gorski1,2. 1) Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada; 2) The Genome Sciences Centre, BC Cancer Research Centre, Vancouver, British Columbia, Canada; 3) Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

276B
Investingating survival mechanisms in transformed Drosophila cells following oncogene withdrawal. Ashley Heinaman1,2, Sathiya Manivannan1,2, Nanki Hura1, Molly Josifov1, Amanda Simcox1. 1) Molecular Genetics, The Ohio State University, Columbus, OH; 2) Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, OH.

277C
The NF-kB factor Relish Controls Drosophila Salivary Gland Degradation During Metamorphosis. Anubhab Nandy, Lin Lin, Eric Baehrecke, Neal Silverman. University of Massachusetts Medical School, Worcester, MA.

278A
Mitochondrial fission plays a key role in neuronal necrosis downstream of the epigenetic alteration in Drosophila. Lianggong Ding1, Lei Liu1,2. 1) State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Peking University, Beijing 100871, China; 2) Beijing Institute for Brain Disorder and Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, China.

279B
Genetic screen to identify new mechanisms of spreading apoptosis induced by necrotic neurons in Drosophila. Lin Hou1, Rong Cai1, Lei Liu1,2. 1) State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Peking University, Beijing 100871, China; 2) Beijing Institute for Brain Disorder and Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, China.

280C
The Roles of Cyclins A, B, and B3 in Drosophila Female Meiosis. Mohammed Bourouh, Rajdeep Dhaliwal, Ketki Rana, Sucheta Sinha, Zhihao Guo, Andrew Swan. Biological Sciences, University of Windsor, Windsor, Ontario, Canada.

281A
The mitotic role of SCF-Skp2 in maintaining genome stability. Nilanjana Das, Biju Vasavan, Andrew Swan. Dept. of Biological Sciences, University of Windsor, Windsor, Ontario, Canada.

282B
Characterization of a Drosophila ortholog of the Cdc7 kinase: Differential requirement for Dbf4/Chiffon in distinct DNA replication programs within Drosophila. Robert Stephenson1, Marcus Hosler1, Navnath Gavande2, Arun Ghosh2,3, Vikki Weake1,3. 1) Department of Biochemistry, Purdue University, West Lafayette, IN; 2) Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN; 3) Center for Cancer Research, Purdue University, West Lafayette, IN.

283C
Drosophila RNase ZL links mitochondrial RNA processing and cell cycle progression. Xie Xie, Veronica Dubrovskaya, Edward Dubrovsky. Biological Sciences, Fordham University, Bronx, NY.

284A
Drosophila Mcm10 is required for female reproductive success. Michael C. Reubens, Sidney Bedsole, Megan Biller, Lucas Hopkins, Elizabeth T. Ables, Tim W. Christensen. Department of Biology, East Carolina University, Greenville, NC.

285B
Determining the role of FancM, Blm, and HelQ helicases in the repair of double strand breaks. Julie Cox, Adam Thomas, Mitch McVey. Tufts University, Medford, MA.

286C
The NuA4 complex coordinates proper cell cycle gene expression with phase, which impacts the transition to a post-mitotic state. Kerry Flegel, Olga Grushko, Kelsey Bolin, Ellen Griggs, Nicholas Rachmaninoff, Laura Buttitta. University of Michigan, Ann Arbor, MI.

287A
Using gene expression profiling and quantitative proteomics to study E2F/Dp function in Drosophila. Ana Guarner, Robert Morris, Michael Korenjak, Myriam Boukhali, Sridhar Ramaswamy, Wilhelm Haas, Nick Dyson. MGH Cancer Center (Massachusetts General Hospital / Harvard Medical School). 149 13th Street, 02129. Charlestown, MA. USA.

288B
The role of E2F in regulating muscle growth is necessary and sufficient for fly viability. Maria Paula Zappia, Maxim V. Frolov. Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL.

289C
Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissuge damage. J. H. Meserve1, R. J. Duronio1,2,3,4. 1) Curriculum in Genetics & Molecular Biology, UNC, Chapel Hill, NC; 2) Integrative Program for Biological and Genome Sciences, UNC, Chapel Hill, NC; 3) Departments of Biology and Genetics, UNC, Chapel Hill, NC; 4) Lineberger Comprehensive Cancer Center, Chapel Hill, NC.

Cell Division and Growth Control


290A
CG10126, a calcium-binding microtubule-associated protein, promotes mitosis during Drosophila development. Q. Nie, S. Spencer. Saint Louis University, Saint Louis, MO.

291B
Protein phosphatase 1 antagonizes Aurora B kinase in maintaining chromosome structure and cohesion in Drosophila oocytes. Arunika Das, Rachel A. Battaglia, Kim S. McKim. Waksman Institute, Rutgers University, Piscataway, NJ.

292C
Synaptonemal complex assembly is regulated by multiple cohesion complexes in Drosophila meiosis. Mercedes Gyuricza, Kathryn Landy, Vandana Apte, Kim McKim. Waskman Institute, Rutgers University, Piscataway, NJ.

293A
Increased Oxidative Stress in Drosophila Oocytes Leads to Loss of Meiotic Cohesion and Chromosome Segregation Errors. A. T. Perkins, E. M. Morse, T. M. Das, C. A. Jeffreys, B. A. Toffey, L. A. Oberg, S. E. Bickel. Dartmouth College, Hanover, NH.

294B
Organization of the dynamic centrosome structure in rapidly dividing embryos. Dorothy A. Lerit1, John S. Poulton2, Holly A. Jordan1, Carey J. Fagerstrom1, Brian J. Galletta1, Karen M. Plevock1,2, Mark Peifer2, Nasser M. Rusan1. 1) Cell Biology and Physiology Center. NHLBI, NIH. Bethesda, MD; 2) Department of Biology. University of North Carolina. Chapel Hill, NC.

295C
The microcephaly protein Wdr62/CG7337 is required to maintain centrosome asymmetry in Drosophila neuroblasts. Anjana Ramdas Nair1, Priyanka Singh1, David Rodriguez Crespo2, David Salvador1, Borris Egger2, Clemens Cabernard1. 1) Biozentrum,University of Basel,Klingelbergstrasse 50-70,4056 Basel,Switzerland; 2) Department of Biology,University of Fribourg,Chemin du Musée 10,CH-1700, Fribourg,Switzerland.

296A
3D-structured illumination microscopy of Centriolar and Centrosomal proteins in Drosophila melanogaster neuroblasts. Anjana Ramdas Nair, Priyanka Singh, Alexia Loynton-Ferrand, Clemens Cabernard. Biozentrum, University of Basel, Klingelbergstrasse 50-70, 4056 Basel, , Switzerland.

297B
Relationship between localization and function of the Chromosomal Passenger Complex in Drosophila melanogaster oocytes. Rachel A. Battaglia, Sarah J. Radford, Kim S. McKim. Waksman Institute of Microbiology, Rutgers University, Piscataway, NJ 08854.

298C
Spindle Matrix Formation is Required for Cell Cycle Progression. Jorgen Johansen, Changfu Yao, Chao Wang, Yeran Li, Jack Girton, Kristen Johansen. Biochem, Biophys & Molec Biol, Iowa State Univ, Ames, IA.

299A
Cooperation between the kinesin motors KLP61F, Subito, and NCD promotes spindle and chromosome organization in Drosophila oocytes. Sarah J. Radford1, Allysa Marie M. Go1,2, Kim S. McKim1,2. 1) Waksman Institute, Rutgers University, Piscataway, NJ; 2) Department of Genetics, Rutgers University, Piscataway, NJ.

300B
The roles of the Doublefault protein in chromosome segregation and cytokinesis. Stefano Sechi, Anna Frappaolo, Giorgio Belloni, Roberto Piergentili, Maria Grazia Giansanti. IBPM, Consiglio Nazionale delle Ricerche, Rome, Italy.

301C
Myosin dynamics during asymmetric stem cell division. Anna Tsankova, Clemens Cabernard. Biozentrum, University of Basel, Klingelbergstrasse 50-70, 4056 Basel, Switzerland.

302A
snoRNAs are a novel class of biologically relevant Myc targets. Peter Gallant1,2, Eva Herter1,2, Maria Stauch1,2, Maria Gallant1,2, Elmar Wolf1,2, Thomas Raabe3. 1) Biochemistry & Molecular Biology, University Wuerzburg, Wuerzburg, Germany; 2) Comprehensive Cancer Center Mainfranken, University Wuerzburg, Wuerzburg, Germany; 3) Institute for Medical Radiation and Cell Research, University Wuerzburg, Wuerzburg, Germany.

303B
Mitochondrial Growth & Dynamics During Drosophila melanogaster Oogenesis. Jasmin Imran Alsous1, Matheus Viana2, Susanne Rafelski2, Stanislav Shvartsman1. 1) Princeton University , Princeton , NJ; 2) University of California Irvine, Irvine, CA.

304C
Conditional screen for growth mutants identifies two negative regulators of Hedgehog signaling with distinct overgrowth phenotypes. Jacob Kagey, Frank Adamini, Erik Coopes, Shannon Moore, Jordan Stewart. Biology, University of Detroit Mercy, Detroit, MI.

305A
Context dependent regulation of proliferation and cellular growth by Hippo-Yorkie signaling. Zhiqiang Shu, Wu-Min Deng. Department of Biological Science, Florida State University, Tallahassee, FL 32306.

306B
Acinus Links Autophagy and Hippo Signaling. Lauren Tyra, Nilay Nandi, Helmut Krämer. Neuroscience, UT Southwestern Medical Center, Dallas, TX.

307C
Following dedifferentiation in cells with inactivated Rb and Hippo pathways. Battuya Bayarmagnai, Maxim V. Frolov. Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607.

308A
Quantitative analysis of EGFR-regulated size control in the Drosophila epidermis. Pavel A. Brodskiy1, Jochen Kursawe2, Cody Narciso1, Ruth Baker2, Alexander Fletcher2, Jeremiah J. Zartman1. 1) Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN; 2) Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.

309B
Motor neuron dependent regulation of myoblast proliferation uses the EGF signaling pathway. Joyce Fernandes, Kumar Vishal. Biology Dept, Miami Univ, Oxford, OH.

310C
Insulin signaling acts downstream of ecdysone to mediate intra-organ growth coordination in Drosophila larvae. Rewatee Gokhale1, Takashi Hayashi2, Christopher Mirque3, Alexander Shingleton3,4. 1) Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824; 2) Division of Developmental Genetics, National Institute of Genetics, Mishima, Shizouka 411-8540, Japan; 3) Department of Biology, Lake Forest College, Lake Forest, IL 60045; 4) Department of Zoology, Michigan State University, East Lansing, MI 48824.

311A
Junctional tumor suppressor Dlg interacts with 14-3-3 proteins to control planar alignment of the mitotic spindle in Drosophila epithelia. Yu-ichiro Nakajima1, Zachary Lee1, Matthew C. Gibson1,2. 1) Stowers Institute for Medical Research, Kansas City, MO; 2) Department of Anatomy & Cell Biology, University of Kansas Medical Center, Kansas City, KS.

312B
Non-cell autonomous tumor progression by cellular senescence. Mai Nakamura1, Shizue Ohsawa1, Tatsushi Igaki1,2. 1) Kyoto University, Kyoto, Japan; 2) PRESTO, JST, Japan.

313C
Genetic control of tissue specific growth in the larval trachea of Drosophila. Erin Suderman, Alex Matlock, Collin Clay, Robert Ward. Molecular Biosciences, Univ. Kansas, Lawrence, KS.

314A
The big bang gene: a novel interactor of crumbs. Giorgos Tsoumpekos, Linda Nementscke, Elisabeth Knust. Max Planck Institute (MPI-CBG) , Dresden, Germany.

315B
Functions of Yorkie and the polarity proteins at the cell cortex. Jiajie Xu1, Pamela Vanderzalm2, Richard Fehon1. 1) University of Chicago, Chicago, IL; 2) John Carroll University, University Heights, OH.

316C
The Drosophila tumor suppressor Tid glycosylates TNFR to control Hippo signaling. Geert de Vreede1,2, Holly Morrison1, Ditte Andersen3, Julien Colombani3, Pierre Leopold3, David Bilder1. 1) Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA; 2) Developmental Biology, Utrecht University, Utrecht, The Netherlands; 3) University of Nice-Sophia Antipolis, CNRS, INSERM, Institute of Biology Valrose, Parc Valrose, Nice, France.

317A
Time series Profiling identifies co-regulated genes involved in RasV12- immortalization of muscle precursors. Mary-Lee Dequeant1, D. Fagegaltier2, Y. Hu1, A. Simcox3, G. Hannon2, Norbert Perrimon1. 1) Harvard Medical School, Boston, MA; 2) Cold Spring Harbor Laboratory, NY; 3) Ohio State University, OH.

318B
Nucleoporins Nup98-96 are required for normal tissue growth and proper cell cycle regulation. Kiriaki Kanakousaki, Olga Grushko, Laura Buttitta. Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI.

319C
Drosophila C-terminal Src kinase regulates growth via Hippo signaling pathway. Hailey J. Kwon1, Indrayani Waghmare1, Shilpi Verghese1, Aditi Singh4, Amit Singh1,2,3, Madhuri Kango-Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Center for Tissue Regeneration and Engineering at Dayton, Dayton, OH; 3) Premedical Programs, University of Dayton, Dayton, OH; 4) Centerville High School, Centerville, OH.

320A
Impaired Hippo Signaling Promotes Rho1-JNK Dependent Growth. Xianjue Ma1,2, Yujun Chen2, Duojia Pan1, Lei Xue2. 1) Molecular Biology & Genetics, Johns Hopkins School of Medicine, Baltimore, MD; 2) School of Life Science and Technology, Tongji University, Shanghai, China.

321B
The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization. Hitoshi Matakatsu1,2, Seth Blair2, Richard Fehon1. 1) MGCB, The University of Chicago, Chicago, IL; 2) Dept. Zoology, Univ. Wisconsin-Madison, WI.

322C
Ras-ERK signaling controls growth in imaginal discs and intestinal stem cells via synthesis of rRNA and tRNA. Shrivani Pirahas, Savraj S. Grewal. Clark H. Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.

323A
Apical delamination of pro-tumor cells in intrinsic tumor hotspots initiates tumorigenesis. Yoichiro Tamori1, Emiko Suzuki1, Wu-Min Deng2. 1) Structural Biology Center, National Institute of Genetics, Mishima, Shizuoka, Japan; 2) Department of Biological Science, Florida State University, Tallahassee, FL.

324B
JNK-Yki mediated signal amplification loop promotes tumorigenesis in epithelial cells. Indrayani Waghmare1, Shilpi Verghese1, Austin Roebke1, Hailey Kwon1, Amit Singh1,2,3, Madhuri Kango-Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Premedical Programs, University of Dayton, Dayton OH 45469; 3) Center for Tissue Regeneration and Engineering at Dayton (TREND), Department of Biology SC333, University of Dayton, 300 College.

325C
Regulation of cell competition by the cytokine Spätzle. Lale Alpar1, Laura Johnston2. 1) Department of Biological Sciences, Columbia University, New York, NY; 2) Department of Genetics and Development, Columbia University 701 W168th Street, New York, NY.

326A
Analysis of Toll-related receptor function in triggering cell death during cell competition. C. Bergantinos, L. Johnston. Department of Genetics & Development, Columbia University Medical Center, 701 West 168th Street, HHSC 704, New York, NY, 10032.

327B
Defining the loser cell identity in cell competition. Iwo Kucinski, Eugenia Piddini. GURDON INSTITUTE, UNIVERSITY OF CAMBRIDGE, CAMBRIDGE, United Kingdom.

328C
Delineating the machanism of postmitotic cell competition. Sarayu Row, Pang-Kuo Lo, Dongyu Jia, Yoichiro Tamori, Wu-Min Deng. Department of Biological Science, Florida State University, Tallahassee, FL.

329A
Cell shape homeostasis against differential proliferation during epithelial cell competition. Alice Tsuboi1, Shizue Ohsawa2, Kenji Matsuno1, Tatsushi Igaki2, Koichi Fujimoto1. 1) Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Osaka, Osaka, Japan; 2) Grad. Sch. of Biostudies, Univ. of Kyoto, Kyoto, Japan.

330B
Pumilio regulates regenerative growth in Drosophila imaginal discs. Syeda Nayab Fatima Abidi, Amanda Brock, Rachel Smith-Bolton. Cell and Developmental Biology Dept, University of Illinois at Urbana-Champaign, Urbana, IL.

331C
A genetic screen in wing imaginal discs for regeneration genes. Amanda R. Brock, Mabel Seto, Rachel K. Smith-Bolton. Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL.

332A
Investigating the role of Extracellular Matrix (ECM) remodeling during wing disc regeneration in Drosophila. Amanda Sul, Sumbul Khan, Rachel Smith-Bolton. University of Illinois at Urbana-Champaign, Urbana, IL.

333B
Abscission is regulated by the ESCRT-III protein Shrub in Drosophila germline stem cells. Neuza Reis Matias1,2, Juliette Mathieu1,2, Jean-René Huynh1,2. 1) Department of Genetics and Developmental Biology, Institut Curie, Paris, France; 2) CNRS UMR3215; Inserm U934 F-75248 Paris, France.

334C
Deciphering the Functional Collaboration of Mid and Bric-a-Brac 2 as Potential Regulators of Cellular Proliferation within Adult Drosophila Ovaries. Petra Visic, Sandra Leal. Biological Sciences, University of Southern Mississippi, Hattiesburg, MS.

Physiology, Organismal Growth, and Aging


335A
Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Fabio Demontis1, Vishal K. Patel2, William R. Swindell3, Norbert Perrimon2. 1) Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; 2) Department of Genetics, Harvard Medical School/HHMI, Boston, MA 02115, USA; 3) Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

336B
Heart function, flight performance, and stress resistance in Drosophila. James N. Kezos, Larry G. Cabral, Laurence D. Mueller, Michael R. Rose. Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA.

337C
Drosophila p38 MAP Kinase Regulates Age-dependent Protein Homeostasis. Sarah M. Ryan1, Amelia M. Burch2, Subhabrata Sanyal2,3, Alysia D. Vrailas-Mortimer1,2. 1) Department of Biological Sciences, University of Denver, Denver, CO; 2) Department of Cell Biology, Emory University, Atlanta, GA; 3) BiogenIdec, Boston, MA.

338A
Fecundity vs. Starvation Resistance: Resource Allocation in Starvation-Selected Drosophila. Timothy J. Saitta, Allen G. Gibbs. Univesity of Nevada, Las Vegas School of Life Sciences 4505 Maryland Parkway Las Vegas, NV 89154.

339B
Innate immune aging mediated by ecdysone signaling in response to water stress. Wenjing Zheng2, Florentina Rus1, Marc Tatar2, Neal Silverman1. 1) Med/Div Infectious Dis, Univ Massachusetts Med Sch, Worcester, MA; 2) Dept. Ecology and Evol. Biology Brown University.

340C
Arginine methyltransferases regulate longevity and stress resistance in Drosophila melanogaster. Su Yeun Yu1, Gwang-Ic Son1, Bodokhsuren Tsogbadrakh2, Yunjeong Kim1, Joong-Jean Park3, Yongchul Lim4, Eunil Lee1. 1) Preventive medicine, College of Medicine, Korea University, Seoul, Korea; 2) Department of Internal medicine, Seoul National University Hospital, Seoul, Korea; 3) Department of Physiology, College of Medicine, Korea University, Seoul, Korea; 4) Department of Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.

341A Unprogrammed presentation number

342B
The biological roles of Iron-Sulfer protein in Drosophila. Kai-Ting Huang1,2, Jian-Chiuan Li1, Hsiao-Yen Chan1, Chu-Ya Cheng1, Po-Lin Chen1, Ya-Chen Lin1,2, Horng-Dar Wang2, Chun-Hong Chen1. 1) National Health Research Institutes, Miaoli, Taiwan; 2) National Tsing Hua University, Hsinchu, Taiwan.

343C
Signaling and starvation: effects of activity reduction of central metabolic pathway genes in AKH and dILP2 producing cells on starvation resistance. Erik Lavington1, Eugene Brud2, Matthew Talbert3, Walter Eanes2. 1) Graduate Program in Genetics, Stony Brook University, Stony Brook, NY; 2) Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY; 3) Department of Biology, University of Louisiana at Monroe, Monroe, LA.

344A
The Drosophila Lactate Dehydrogenase gene promotes production of the oncometabolite 2-hydroxyglutarate during normal juvenile growth. Hongde Li, Alexander Hurlburt, Jason Tennessen. Indiana University Bloomington, IN 47405.

345B
Regulation of lipid and energy homeostasis by the nuclear receptor DHR78. Stefanie Marxreiter, Carl S. Thummel. Human Genetics, University of Utah, Salt Lake City, UT.

346C
Metabolic studies and the insulin pathway in Drosophila species. María T. Peña-Rangel, Deyannira Otero-Moreno, Juan Manuel Murillo-Maldonado, Juan R. Riesgo-Escovar. Neurobiologia del Desarrollo y Neurofisiología, Universidad Nacional Autónoma de México, Querétaro, Querétaro, Mexico.

347A
dFatp Regulates Nutrient Distribution and Long-term Physiology in Drosophila. Chelsea R. Richardson, Alyson L. Sujkowski, Robert J. Wessells. Physiology, Wayne State University, Detroit, MI.

348B
Age and Gender Effects on Anoxia Tolerance in Drosophila melanogaster Mirror Patterns in Mammals. James C. Sargent, Jacob B. Campbell, Jon F. Harrison. School of Life Sciences, Arizona State University, Tempe, AZ 85287.

349C
Drosophila metabolic and transcriptomic responses to its gut symbiont Lactobacillus plantarum point enhancement of host dietary protein digestion and fatty acids beta-oxidation as key features of bacterial growth-promoting effect. Gilles Storelli, François Leulier. IGFL/ENS Lyon, Lyon Cedex 07, Lyon, France.

350A
Drosophila Mitochondrial Pyruvate Carrier mutants display defects in carbohydrate metabolism and hallmarks of diabetes. Dona Wisidagama, Daniel K. Bricker, Carl S. Thummel. Human Genetics, University of Utah, Salt Lake city, UT.

351B
Hsc70 regulates fat metabolism during Drosophila aging. Yan Yan1, Hao Wang2, Renjie Jiao1,3. 1) State Key Laboratory of Brain and Cognitive Scienc, Institute of Biophysics, the Chinese Academy of Sc, Beijing, China; 2) Department of Chemistry and Biology, National University of Defense Technology, Changsha 410072, China; 3) Guangzhou Hoffmann Institute of Immunology, School of Basic Sciences, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou 510182, China.

352C
Absence of a peritrophic matrix in drop-dead mutant flies. Sean Conway1, Christine L. Sansone1, Johan Billen2, Jozef Vanden Broeck2, Edward M. Blumenthal1,2. 1) Biological Sciences, Marquette University, Milwaukee, WI; 2) Zoological Institute, University of Leuven, Leuven, Belgium.

353A
Stunted is a fat body-derived factor that remotely couples insulin secretion with nutrient availability through its receptor Methuselah. Renald Delanoue, Neha Agrawal, Meschi Eleonore, Leopold Pierre. iBV, CNRS UMR 7277/INSERM UMR 1091/UNS, Nice, France.

354B
FLIC: High-throughput, continuous analysis of Drosophila feeding behaviors. Jennifer Ro1, Zachary Harvanek3, Scott Pletcher2. 1) Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan; 2) Department of Molecular and Integrative Physiology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan; 3) Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan.

355C
The importance of a balanced diet: The effect of protein-to-carbohydrate ratio on body and organ size in Drosophila. Yuqing Zhu1, Josephine R. Masandika1, Lily S. Thorsen1, Diego R. Rojas-Toledo1, Christen K. Mirth2, Alexander W. Shingleton1,3. 1) Department of Biology, Lake Forest College, Lake Forest, IL; 2) Instituto Gulbenkian de Ciencia, Oeiras, Portugal; 3) Department of Zoology, Michigan State University, East Lansing, MI 48824, USA.

356A
Reverse genetic screen for identification of non-autonomous growth signal(s) originating in the larval fat body. O. Carreño, M. Gallant, P. Gallant. Lehrstuhl für Biochemie and Molekularbiologie, University Würzburg, Germany.

357B
Functional significance of the enzymatic and transcriptional co-regulator activities of dLipin. Michael Lehmann, Sandra Schmitt, Qiuyu Chen. Dept Biological Sci, Univ Arkansas, Fayetteville, AR.

358C
A role for tyrosine in mediating progression through oogenesis in Drosophila. Danielle Scheunemann, Tyler J. Halicek, Edward M. Blumenthal. Biological Sciences, Marquette University, Milwaukee, WI.

359A
The Drosophila Estrogen-Related Receptor acts as a nutrient sensor to coordinate larval growth with nutrient availability. Maria C. Sterrett, Samantha L. St. Clair, Jason M. Tennessen. Indiana University, Bloomington, IN.

360B
Juvenile Hormone regulates body proportion in Drosophila. Christopher D. Mirque1, James J. Haney1, Lauren M. Lyon1, Thomas Flatt2, Christen K. Mirth3, Alexander W. Shingleton1,4. 1) Department of Biology, Lake Forest College, Lake Forest, IL 60045, USA; 2) Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Biophore, CH-1015, Switzerland; 3) Instituto Gulbenkian de Ciencia, Oeiras, Portugal; 4) Department of Zoology, Michigan State University, East Lansing, MI 48824, USA.

361C
A novel function of the hippo-pathway member, warts, in modulating organism size of drosophila. Morten E. Møller1, E. Thomas Danielsen1, Michael B. O'Connor2, Kim F. Rewitz1. 1) Department of Biology, University of Copenhagen, Copenhagen, Denmark; 2) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.

362A
Autophagy in prothoracic gland controls developmental timing in Drosophila melanogaster. Xueyang Pan1,2, Michael O'Connor1. 1) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN; 2) Molecular, Cellular, Developmental Biology and Genetics Program, University of Minnesota, Minneapolis, MN.

363B
A genome-wide in vivo RNAi screen in Drosophila identifies regulators of cholesterol-dependent steroid production. Morten Moeller1, E. Thomas Danielsen1, Naoki Yamanaka2, Kirst King-Jones3, Michael O'Connor4, Kim Rewitz1. 1) Biology, University of Copenhagen, Copenhagen, Copenhagen, Denmark; 2) Entomology, University of California, Riverside, USA; 3) Biological Sciences, University of Alberta, Alberta, Canada; 4) Genetics, Cell biology and Development, University of Minnesota, Minneapolis, USA.

364C
A novel ecdysteroidogenic gene noppera-bo encoding glutathione S-transferase regulates cholesterol behavior. Enya Sora1, Yuko Shimada-Niwa1, Fumihiko Igarashi2, Masatoshi Iga3, Hiroshi Kataoka3, Tetsuro Shinoda4, Ryusuke Niwa1,5. 1) Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, ibaraki, Japan; 2) Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan; 3) Graduate School of Frontier Sciences, University of Tokyo, Japan; 4) Division of Insect Science, National Institute of Agrobiological Sciences, Japan; 5) PRESTO, JST, Japan.

365A
Regulation of enterocyte cell death by dMyc modulates intestinal barrier function and lifespan in D. melanogaster. Kazutaka Akagi, Subhash Katewa, Kenneth Wilson, Subir Kapuria, Amit Sharma, Arshad Ayyaz, Heinrich Jasper, Pankaj Kapahi. Buck Inst Research Aging, Novato, CA.

366B
Lifespan extension by ginseng berry extract and its active component syringaresinol. Kyung-Jin Min1, Shin-Hae Lee1, Hye-Yeon Lee1, Si-Young Cho2, Ju-Won Kim2, Sang Joon Lee2. 1) Department of Biological Sciences, Inha University, Incheon, South Korea; 2) R&D Center, Amorepacific Corporation, Gyeonggi-do, South Korea.

367C
Mitonuclear AxGxE: Genetic and dietary interactions are as important as single factors in explaining Drosophila lifespan and healthspan. David Rand, C.-T. Zhu, J. Mossman, J. Santiago, A. Spierer, L. Biancani, T. Devlin, J. Dewey, B. Frankin, M. McAteer, Z. Pataki, C. HalE-Phillips, D. Yoon. Ecology & Evolutionary Biol, Brown Univ, Providence, RI.

368A
Analysis of the cSOD-Null Mutant Phenotypes of Drosophila melanogaster Across a Suite of Genetic Backgrounds. Courtney E. Lessel1, Thomas J. S. Merritt1, Tony L. Parkes2. 1) Biology Dept, Laurentian University, Sudbury ON; 2) Biology and Chemistry Dept, Nipissing University, North Bay ON.

369B
The Role of miR-310s in ovarian soma in response to dietary conditions. Ibrahim Omer Cicek, Halyna R. Shcherbata. Gene Expression and Signaling, Max Planck Institute, Goettingen, Germany.

370C
How does diet regulate lifespan? Organ-specific, Tor-dependent transcriptomic responses to essential amino acids. Adam Dobson1, Mingyao Yang1,2, Xiaoli He1, Eric Blanc3, Matthew Piper1. 1) Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK; 2) Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, China; 3) Medical Research Council (MRC) Centre for Developmental Neurobiology, King's College London, London, UK.

371A
Absence of mitochondrial SOD2 in Drosophila induces a novel peroxidase, which plays an essential role during adult wing maturation. Dondra Bailey, Sanjay Nag, Mohammed Basar, Atanu Duttaroy. Dept Biol, Howard Univ, Washington, DC.

372B
The FIT in fat: Mating behavior and metabolism are influenced by fat body FIT expression and secretion into hemolymph. Hina Iftikhar, Ginger Carney. Biology, Texas A&M University, College Station, TX.

373C
Mitochondrial knockdown using tissue specific expression of mitochondrially-targeted restriction enzymes against mtDNA as a model for the decline in organismal performance. Adam N. Spierer, A. Pascal, R. Mabeza, David M. Rand. Ecology and Evolutionary Biology, Brown University, Providence, RI.

374A
Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms. Alyson Sujkowski1, Brian Bazzell3, Kylie Carpenter3, Robert Arking2, Robert Wessells1. 1) Wayne State School of Medicine, Detroit, MI; 2) Wayne State University, Detroit, MI; 3) Univ of Michigan, Ann Arbor, MI.

375B
The nuclear receptor dHNF4 coordinates a transition towards oxidative phosphorylation and glucose-stimulated insulin secretion at the onset of adulthood. William E. Barry, Carl S. Thummel. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT.

376C
Elucidating the role of CyclinB3 in mediating lifespan extending effects of reduced insulin signaling in Drosophila. Ekin Bolukbasi1, Jennifer Regan1, Linda Partridge1,2. 1) Insitute of Healthy Ageing, UCL, London, United Kingdom; 2) Max Planck Institute for Biology of Ageing, Cologne Germany.

377A
Tissue-specific effects of insulin signaling on female attractiveness. Tatyana Fedina, Scott Pletcher. Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.

378B
The sex determination gene transformer controls male-female differences in growth. Elizabeth Rideout1,2, Savraj Grewal1. 1) Clark H. Smith Brain Tumour Center, Dept. Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada; 2) Dept. Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

379C
Connections between the effects of various chemicals on the development of Drosophila melanogaster and Homo sapiens. Amy Brenner. Biology Department, Olivet Nazarene University, Bourbonnais, IL.

380A
Metabolic and genetic implications of survival in anoxia. Jacob Campbell, Jon Harrison. Arizona State University, Tempe, AZ.

381B
Activation of Transposable Elements Across Multiple Tissues in Aging Drosophila. Brian C. Jones, Jason G. Wood, Cheng-yi Chan, Stephen L. Helfand. Molecular Biology, Cell Biology, Biochemistry, Brown University, Providence, RI.

382C
The Effects of Aging on DNA Double-Strand Break Repair. Faraz Sohail, Elisa Bienenstock, Jeannine LaRocque. Human Science, Georgetown University, Washington, DC.

383A
Control of pupation timing by transcription factors Blimp-1 and FTZ-F1 in fat body during prepupal period. Haruka Nishida, Abdel-Rahman Sultan, Kazutaka Akagi, Moustafa Sarhan, Azusa Koie, Takumi Nakayama, Hitoshi Ueda. Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.

384B
Evaluating toxicity of silver nanoparticles in Drosophila melanogaster. Ananya Sharma, Ajay Srivastava. Biology and Biotechnology Center, WKU and the Gatton Academy of Math and Science ,Western Kentucky University, Bowling Green, KY 42101.

385C
Identifying Novel UNC-45 Interacting Partners in Drosophila melanogaster. Daniel Smith1, Carmen Carland1, Majid Mekany1,2, Sanford Bernstein1. 1) Biology Department, San Diego State University, San Diego, CA; 2) Cell and Molecular Biology Joint Doctoral Program, San Diego State University and UC San Diego, San Diego, CA.

386A
The speck gene, discovered in 1910, is a mutation in a transcript of the Dopamine acetyltransferase (Dat) gene. Eric P. Spana, Amanda B. Abrams. Department of Biology, Duke University, Durham, NC.

387B
Microarray analysis of Drosophila Cdk5/p35 kinase mutants. J. Spurrier1,2, K. McLinden1, E. Giniger1. 1) NINDS, National Institutes of Health, Bethesda, MD; 2) CMDB, Johns Hopkins University, Baltimore, MD.

388C
Activation of innate immune response induces age-related caspase activation in Or42b neuron. Ken-ichi Takeuchi1, Takahiro Chihara1,2, Masayuki Miura1,2. 1) Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan; 2) CREST, Japan Science and Technology Agency (JST), Gobancho, Chiyoda-ku, Tokyo, Japan.

Gametogenesis and Organogenesis


389A
Nuclear Spermatid Transition Proteins involved in chromatin condensation in Drosophila. Zain Alvi, Angela Klaus, Tin-Chun Chu. Department of Biological Sciences, Seton Hall University, South Orange, NJ 07079.

390B
A function for Syncrip in the Drosophila male germline. Catherine Baker, Emily Taing, Margaret Fuller. Dept Developmental Biol, Stanford Univ Sch Medicine, Stanford, CA.

391C
Characterization of the function of AAA ATPase Nmd in Drosophila spermatogenesis and in vitro. Tucker Bates, James Winkle, Karen Hales. Department of Biology, Davidson College, Davidson, NC.

392A
The Role of Ribbon in the Drosophila Testis. Andrew P. Droste, Diane Silva, Jennifer Jemc. Biology, Loyola University Chicago, Chicago, IL.

393B
Dynamic expression of Suppressor of Hairy-wing [Su(Hw)] in spermatogenesis underlies a role in male fertility. Tingting Duan, Pamela Geyer. Department of Biochemistry, University of Iowa, Iowa City, IA.

394C
Phospholipid-derived signaling molecules in Drosophila spermatogenesis. Yosef Frenkel, Eli Miller, Josefa Steinhauer. Department of Biology, Yeshiva University, New York, NY.

395A
Characterization of age related effects on spermatogenesis in the DGRP. Michelle Giedt, Douglas Harrison. Biology, University of Kentucky, Lexington, KY.

396B
Characterization of AAA ATPase proteins Nmd and CG4701 through an analysis of mitochondrial dynamics, cytokinesis, and microtubule organizing centers during Drosophila melanogaster spermatogenesis. Devon Harris, Bethany Wagner, Sarah Pyfrom, Jessica Gerard, Melissa Lorenzo, James Winkle, Lindsay Regruto, Karen Hales. Davidson College Department of Biology, Davidson College, Davidson, NC.

397C
Snail is required for maintenance of male germline stem cells. Gary Hime1, Aviv Gafni1, Arjun Chahal1, Agnes Gany1, Franca Casagranda1, Nicole Siddall1, Kate Loveland2, Helen Abud2. 1) Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia; 2) Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.

398A
A Visual Screen for Centriolar Mutants. S. Hynek, T. Janowicz, S. Baghdy, K. Arum, A. Marcano, M. S. Choi, N. Scheanwald, T. Avidor-Reiss. Biological Sciences, University of Toledo, Toledo, OH.

399B
Overexpression of erpL22 leads to increased proliferation, decreased fertility, and a shortened lifespan. Catherine Mageeney, Alex Chen, Jennifer Colquhoun, Michael Kearse, Vassie Ware. Biological Sciences, Lehigh University, Bethlehem, PA.

400C
Notch Signaling is Active in Stem Cell Lineages of Testes. C. Ng, C. Schulz. Department of Cellular Biology, University of Georgia, Athens, Athens, GA.

401A
Differential gene expression associated with X-linked sex-ratio meiotic drive in Drosophila affinis. Robert Unckless, Andrew Clark. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

402B
Three RNA Binding Proteins Form a Complex to Promote Differentiation of Germline Stem Cell Lineage in Drosophila. Di Chen1,2, Chan Wu1,2, Shaowei Zhao1,2, Qing Geng1,2, Yu Gao1,2, Xin Li1,2, Yang Zhang1,2, Zhaohui Wang1,2. 1) State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; 2) The University of Chinese Academy of Sciences.

403C
Disrupting Laminin function reveals an unexpected role for an ovarian muscle tissue in shaping the Drosophila egg. Darcy Andersen, Sally Horne-Badovinac. Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637.

404A
Evidence that the planar polarized localization of Fat2 in Drosophila follicle cells depends on microtubule-based transport. F. Aurich, C. Dahmann. Technische Universität Dresden, Dresden, Germany.

405B
Evidence the dot chromosomes help organize chromosome movements during female meiotic prometaphase I in Drosophila melanogaster.. William Gilliland, Eileen Colwell, David Osiecki. Department of Biological Sciences, DePaul University, Chicago, IL.

406C
Blm and mei-MCM Complex Coordinately Regulate Crossover Control in Drosophila. Talia Hatkevich, Kathryn Kohl, Susan McMahan, Jeff Sekelsky. University of North Carolina Chapel Hill, Chapel Hill, NC.

407A
A tunable, secretion-based mechanism for basement membrane remodeling during egg chamber elongation. Adam Isabella1,2, Sally Horne-Badovinac1,2. 1) Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL; 2) Committee on Development, Regeneration, and Stem Cell Biology, University of Chicago, Chicago, IL.

408B
The Ecdysone and JAK/STAT pathways synergize to suppress Notch-induced Broad for proper morphogenetic movement in the follicular epithelium. Dongyu Jia, Jamal Bryant, Wu-Min Deng. Department of Biological Science, Florida State University, Tallahassee, FL.

409C
Characterizing a Role for the Misshapen Kinase in Growth of the Germline Ring Canals in the Developing Egg Chamber. Ashley Kline, Lindsay Lewellyn. Department of Biological Sciences, Butler University, Indianapolis, IN.

410A
Diversification and redundancy of Drosophila septins Sep2 and Sep5. Ryan O'Neill, Denise Clark. Department of Biology, University of New Brunswick, Fredericton, New Brunswick, Canada.

411B
Diversity of epithelial morphogenesis among drosophilid eggshells. Miriam Osterfield1, Trudi Schüpbach1, Eric Wieschaus1,2, Stanislav Shvartsman1. 1) Lewis-Sigler Inst, Princeton Univ, Princeton, NJ; 2) Howard Hughes Medical Institute (HHMI), USA.

412C
small ovaries (sov) is required for establishment and maintenance of the Drosophila melanogaster ovary. Cale Whitworth1, Kevin Cook2, Brian Oliver1. 1) National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA; 2) Bloomington Drosophila Stock Center, Dept. of Biology, Indiana University, Bloomington, IN, USA.

413A
Imaginal disc growth factors regulate dorsal-appendage tube morphogenesis. Sandra Zimmerman, Celeste Berg. Department of Genome Sciences, University of Washington, Seattle, WA.

414B
Studying the cis- and trans- regulation of Sex lethal in the germline. Raghav Goyal, Pradeep Bhaskar, Mark Van Doren. Biology Department, Johns Hopkins University, Baltimore, MD.

415C
Sexual differentiation of the Drosophila germline stem cell niche regulated by doublesex and fruitless. Hong Zhou, Cale Whitworth, Mark Van Doren. Department of Biology, Johns Hopkins University, Baltimore, MD.

416A
Transfer and processing of the seminal fluid protein Antares during and after mating in Drosophila melanogaster. Kaitlyn Baranowski1, Mariana Wolfner2, Geoffrey Findlay1,2. 1) Department of Biology, College of the Holy Cross, Worcester, MA; 2) Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.

417B
Interactions between akirin and pannier during embryonic myogenesis. Dyana C. Brooks, Emily R. Champion, Scott J. Nowak. Department of Biology and Physics, Kennesaw State University, Kennesaw, GA.

418C
Examination of the Roles of RhoGEF2 and Ribbon in Gonad Morphogenesis. Fatma B. Ciftci, Jennifer Jemc. Loyola University Chicago, Chicago, IL.

419A
The smooth muscles cells of the Drosophila testes arise by myoblast fusion. Katharina Fritzen, Jessica Kuckwa, Renate Renkawitz-Pohl. Philipps-University, Marburg, Hessen, Germany.

420B
Noncanonical roles for Tropomyosin during myogenesis. Jessica Williams, Nathan Boin, Juliana Valera, Aaron Johnson. Dept Integrative Biology, Univ Colorado, Denver, Denver, CO.

421C
The Role of the BTB Family Proteins Lola and Rib in Gonad Morphogenesis. Diane Silva, Christopher P. Lenkeit, Edwin Chaharbakhshi, Andrew Droste, Jennifer Jemc. Loyola University, Chicago, IL.

422A
Transcriptome analysis of embryonic tendon and muscle cells during myotube elongation. Juliana Valera, Aaron Johnson. Department of Integrative Biology, University of Colorado Denver, Denver, CO.

423B
Genetic Analysis of Conserved Eya Protein Domains in Drosophila. M. Jin, G. Mardon. Pathology Dept, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030.

424C
Signaling through Rickets, a G-protein-coupled receptor, is crucial for polarity and migration of the border cells in Drosophila. Lauren Anllo, Trudi Schupbach. Dept. of Molecular Biology, PRINCETON UNIVERSITY, PRINCETON, NJ.

425A
Exploring the Role of Raw in the Embryonic Nervous System. Emily R. Temple-Wood, Diane Silva, Jennifer Jemc. Department of Biology, Loyola University Chicago, Chicago, IL, IL.

426B
Dynamic protein modification: Variable tissue-specific modification and localization of eRpL22-like during fly eye development. Brett Gershman, Michael Kearse, Vassie Ware. Biological Sciences, Lehigh University, Bethlehem, PA.

427C
Kette and WASP act antagonistically during F-actin formation in fusion competent myoblasts. A. Loewer1, G. Schaefer2, J. Hamp3, S. Oenel1. 1) Entwicklungsbiologie, Philipps-Universitaet Marburg, Marburg, Germany; 2) Institute for Genetics, Marburg, Germany; 3) Fresenius Kabi GmbH, Bad Hersfeld, Germany.

428A
Loh: a matricellular protein required for cardiac function. Bárbara Rotstein1, Maik Drechsler2, Ariane Wilmes1, Achim Paululat1. 1) Osnabrueck University, Department of Developmental Biology, Osnabrueck, Germany; 2) University of Cambridge, Department of Zoology, Cambridge, England.

429B
Dynamic Notch signaling sequentially specifies cell fate in the secretory lineage of Drosophila spermathecae. Wei Shen1, Fabio Carvalho1, Jianjun Sun1,2. 1) Physiology and Neurobiology, University of Connecticut, Storrs, CT; 2) Institute for Systems Genomics, University of Connecticut, Storrs.

430C
Genes expressed in the secondary cells of the male accessory gland are essential for the female post mating response. Jessica Sitnik1, Dragan Gligorov2, Robert Maeda2, Fancois Karch2, Mariana Wolfner1. 1) Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY; 2) Department of Genetics and Evolution and NCCR Frontiers in Genetics, University of Geneva, Geneva, Switzerland.

431A
Investigatingon of the Roles of Mrityu in Egg Activation in Drosophila melanogaster. Zijing Zhang1, Amber Krauchunas2, Mariana Wolfner1. 1) Molecular Biology and Genetics, Cornell University, Ithaca, NY; 2) Waksman Institute of Microbiology, Rutgers University, New Brunswick, NJ.

Stem Cells


432B
Investigating the role of Hrb27C in the regulation of female germline stem cell activity. Danielle Finger, Elizabeth Ables. Dept. of Biology, East Carolina University, Greenville, NC.

433C
Identification of Germline sex defining signals in Drosophila melanogaster. Pradeep K. Bhaskar, Raghav Goyal, Kelly Baxter, Mark Van Doren. Department of Biology, Johns Hopkins University, Baltimore, MD.

434A
Niche signaling promotes stem cell survival in the Drosophila testis via the Jak-STAT target DIAP1. Salman Hasan1, Phylis Hetie1,2, Dr Erika Matunis1. 1) Johns Hopkins Medical Institute, Baltimore, MD; 2) Harvard University, Cambridge, MA.

435B
Aging delays the S phase progression of normal and tumorous germline stem cell division cycles distinct from the effect of diet. Shih-Han Kao1, Chen-Yuan Tseng1,2, Chih-Lin Wan1, Yu-Han Su1, Hwei-Jan Hsu1. 1) Insitute of Cellular and Organismic Biology, Academia Sinica 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan, R.O.C; 2) Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

436C
Heparan sulfate proteoglycans regulate germline stem cell behavior and niche organization in the Drosophila testis. Daniel C. Levings1, Hiroshi Nakato2. 1) Molecular, Cellular, Developmental Biology and Genetics Program, University of Minnesota-Twin Cities, Minneapolis, MN; 2) Department of Genetics, Cell Biology and Development, University of Minnesota-Twin Cities, Minneapolis, MN.

437A
Loss of the Nuclear Lamina protein Otefin reveals a novelgermline stem cell checkpoint . Kaylee E. Lovander, Lacy Barton, James Bullard, Pamela Geyer. Department of Biochemistry, University of Iowa, Iowa City, IA.

438B
Wnt signaling regulates escort cell-expressed Thickveins to constrain Dpp activity within the Drosophila ovarian stem cell niche. Lichao Luo1,2, Huashan Wang1, Chao Fan1. 1) Temasek Life Science Laboratory, Singapore, Singapore, 117604; 2) Department of Biological Sciences, National University of Singapore, Singapore, 117543.

439C
Up-regulation of germline stem cell division frequency in response to mating. Manashree Malpe, Karl Kudyba, Chun Ng, Cordula Schulz. Cellular Biology, University of Georgia, Athens, GA.

440A
Gap junction-mediated signalling regulates the proliferation and differentiation of somatic cyst cells in the Drosophila testis. Christopher M. Smendziuk, Fayeza Islam, Anat Messenberg, Guy Tanentzapf. Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

441B
Insulin Signaling-Mediated Control of the ‘Failed Axon Connections’ Protein in the Niche Maintains Germline Stem Cells in Response to Diet. Yu-Han Su, Hwei-Jan Hsu. Institute of Cellular and Organismic Biology, Academia Sinica 128 Academia R.d., Sec 2, ICOB R337, Nankang, Taipei 115, Taiwan, R.O.C.

442C
Uncovering the role of adipocyte-derived collagen type IV in regulating Drosophila oogenesis. Lesley Weaver, Daniela Drummond-Barbosa. Department of Biochemistry and Molecular Biology, Johns Hopkins University, Baltimore, MD.

443A
Rapid Evolution of a Germline Stem Cell Maintenance Factor. Daniel Zinshteyn, Michael McGurk, Aaron Chen, Daniel Barbash. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

444B
Regeneration in the adult Drosophila brain. Kassi L. Crocker1,2, Stacey Rimkus2, Grace Boekhoff-Falk1,2. 1) Genetics Training Program, University of Wisconsin-Madison, Madison, WI; 2) Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI.

445C
Induction of malignant neural stem cells through early evasion of temporal patterning in Drosophila. Cedric Maurange, Karine Narbonne-Reveau, Caroline Eple, Elodie Lanet, Sophie Foppolo. IBDM (Aix-Marseille University/CNRS), Marseille, France.

446A
Regulators of mushroom body neuroblast apoptosis. Matthew Pahl, Sarah Siegrist. Biology, University of Virginia, Charlottesville, VA.

447B
The Drosophila Sp8 Transcription Factor Buttonhead Prevents Premature Differentiation of Intermediate Neural Progenitors. Yonggang Xie1, Xiaosu Li1, Xian Zhang1, Shaolin Mei1, Hongyu Li1, Andreacarola Urso2, Sijun Zhu1. 1) Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY; 2) Department of Biology, Syracuse University, Syracuse, NY.

448C
dSox9 is required for intestinal stem cell proliferation and differentiation in the adult Drosophila midgut. Qing Lan, Min Cao, Huaqi Jiang. Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX.

449A
Cell fate determination in intestinal stem cell progeny. Jérémy Sallé, Allison Bardin. Institut Curie, Paris, France.

450B
Defining tissue injury responses at the midgut/hindgut boundary with single-cell resolution. Jessica Sawyer, Emily Bowie, Ruth Montague, Donald Fox. Pharmacology & Cancer Biology, Duke University, Durham, NC.

451C
Epithelial-derived BMPs are the niche signals for Drosophila intestine stem cell self-renewal. Ai-Guo Tian, Jin Jiang. Department of Developmental Biology, UT Southwestern Medical Center, Dallas, TX.

452A
"Receptome-wide" RNAi screen in vivo identifies novel regulators of ISC activity in Drosophila midgut. Charles Xu1, Claire Hu1, Junjie Luo2, Norbert Perrimon1. 1) Genetics Department, Harvard Medical School, Boston, MA; 2) Neurosciences Research Institute, University of California, Santa Barbara, CA.

453B
Sensory regulation of calcium signalling in hematopoiesis. Katrina Gold1, Kalpana Makhijani2, Brandy Alexander1, Jenny Kim1, Katja Brückner1,3,4. 1) Dept of Cell and Tissue Biology, UCSF, San Francisco, CA; 2) Dept of Pharmaceutical Chemistry, UCSF, San Francisco, CA; 3) Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA; 4) Cardiovascular Research Institute, UCSF, San Francisco, CA.

454C
Gal4 screening for introducing new insights into Drosophila hematopoiesis. T. Tokusumi, Y. Tokusumi, M. Brahier, V. Lam, J. Stoller-Conrad, P. Kroeger, R. Schulz. Biological Sci, Univ Notre Dame, Notre Dame, IN.

455A
Differential levels of PI3K/TOR signalling determine the outcome of competition between stem cells for differentiation. Marc Amoyel1,2, Kenzo-Hugo Hillion1, Shally Margolis1, Erika Bach1,2. 1) Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA; 2) The Helen L. and Martin S. Kimmel Center for Stem Cell Biology, New York University School of Medicine, New York, NY, USA.

456B
Quiescent cells in the adult Drosophila testis niche are not replenished after damage. P. Hétié, M. de Cuevas, E. Matunis. Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205.

457C
Investigating a Role for JAK/STAT Cytokine Signaling in Mushroom Body Neuroblast Apoptosis. Xin Yuan, Sarah Siegrist. Biology, University of Virginia, Charlottesville, VA.

458A
Ecdysteroids and miRNA cooperate in regulating differentiation of germline stem cell progeny. Annekatrin König, Andriy S. Yatsenko, Halyna R. Shcherbata. Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

Immunity and Pathogenesis


459B
Drosophila crystal cells undergo pyroptosis to release pro-phenoloxidase at wound sites. Robert Krautz1, Zhi Wang1, Robert Markus2, Ulrich Theopold1. 1) Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Stockholm, Sweden; 2) University of Nottingham School of Life Sciences E100, E Floor, Medical School, Queen's Medical Centre, Clifton Boulevard, Nottingham NG7 2UH.

460C
Belle is functionally required for the expression of transgenes and subsets of transposable elements. Pang-Kuo Lo, Yi-Chun Huang, William Palmer, Wu-Min Deng. Department of Biological Science, Florida State University, Tallahassee, FL.

461A
Role of a lysosomal chloride transporter in the phagocytic degradation of bacteria. Ching-On Wong, Hongxiang Hu, Yufang Chao, Meera Namireddy, Kartik Venkatachalam. Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX.

462B
Dual role of Beadex in Drosophila immunity. Arunita Chatterjee, Kumar Aavula, Esha Patnaik, Upendra Nongthomba. Dept of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.

463C
The microbiota induces Pvf2 to activate the antiviral ERK pathway in the Drosophila gut. Jonathan Cohen, Christine Sansone, Ari Yasunaga, Jie Xu, Beth Gordesky-Gold, Sara Cherry. Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA.

464A
zfh2 is an in vivo mediator of hypercapnic immune suppression. Ryan Haake, James Kwon, Greg Beitel. Dept. of Molecular Biosciences, Northwestern University, Evanston, IL.

465B
A chromatin remodeling factor contributes to innate immune homeostasis in intestine. Xiaomeng He, Lei Pan. Institute of Biophysics,CAS, Beijing, China.

466C
Molecular mechanisms of neuroinflammatory response in a Drosophila Parkinson’s model. Anna Moyer, Janis O'Donnell. Biological Sciences, University of Alabama, Tuscaloosa, AL.

467A
Investigating host-microbe interactions in Drosophila. Meera Namireddy1, Ching-On Wong2, Yufang Chao2, Hongxiang Hu2, Kartik Venkatachalam2. 1) Rice University, Houston, TX; 2) The University of Texas Health Sciences Center-Houston, Houston, TX.

468B
Post-mating reduction of immune defense in Drosophila melanogaster females: testing the hormonal pleiotropy hypothesis. Robin Schwenke, Brian Lazzaro. Cornell University, Ithaca, NY.

469C
Regulatory Roles of Bromodomain Containing Proteins (BCPs) and Jumonji Domain Containing Proteins (JDCPs) in Immunity and Inflammation. J. Sharrock, M. S. Dionne. Centre of Molecular and Cellular Biology of Inflammation (CMCBI), Kings College London.

470A
The physiological genetic basis of immune-energetic interactions in Drosophila. Justin Buchanan, Colin Meiklejohn, Kristi Montooth. Biological Science, University of NE - Lincoln, Lincoln, NE.

471B
Determinants of paralytic behavior after viral infection. Jonathan Chow, Jonathan Kagan. Harvard University and Boston Children's Hospital, Boston, MA.

472C
Production of Nora virus ORF1 monospecific antisera. Tad Fuchs, Kirsten Lipps, Brad Ericson, Darby Carlson, Kimberly Carlson. Biology, University of Nebraska at Kearney, Kearney, NE.

473A
Dissecting the mechanisms by which cAMP-producing toxins disrupt junctional trafficking. Annabel Guichard1, Stephen Chin1, Beatriz Cruz Moreno1, Janet Liu2, Lin Zhu1, Berenice Aguilar2, Victor Nizet2,3, Ethan Bier1. 1) Dept of Biology, Univ. California, San Diego, La Jolla, CA; 2) Dept of Pediatrics, Univ. California, San Diego, La Jolla, CA; 3) Skaggs School of Pharmacy , Univ. California, San Diego, La Jolla, CA.

474B
The genetic architecture of defense as tolerance and resistance. Virginia Howick, Brian Lazzaro. Entomology, Cornell University, Ithaca, NY.

475C
Production of Nora virus ORF2 monospecific antisera. Alexis Page, Brad Ericson, Darby Carlson, Kimberly Carlson. Biology, University of Nebraska at Kearney, Kearney, NE.

476A
Drosophila melanogaster Nora virus virus-like particles: in vitro assembly. Ryan Sowle, Kellie Licking-Murray, Brad Ericson, Darby Carlson, Kimberly Carlson. Biology, University of Nebraska at Kearney, Kearney, NE.

477B
The POU/Oct transcription factor nubbin (nub) is necessary for a beneficial gut microbiota and for normal adult life-span of Drosophila. Ylva Engström1, Widad Dantoft1, Daniel Lundin2. 1) Dept. of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden; 2) Bioinformatics Infrastructure for Life Sciences, Science for Life Laboratory, Box 1031, SE-171 21 Solna, Sweden.

Neural Development


478C
Study of the Brain Tumor protein role in the midline axon guidance during Drosophila neural development. Elise Arbeille, Melissa Hernandez, Jonathan Levin, Greg Bashaw. Department of Neuroscience, University of Pennsylvania, Philadelphia, PA.

479A
Functional requirements of Abelson tyrosine kinase in the nervous system. Han S. J. Cheong, Jessica C. Love, Mark F. A. VanBerkum. Biological Sciences, Wayne State University, Detroit, MI.

480B
A characterization of growth cone morphodynamics in a live-pathfinding axon. Akanni Clarke1,2, Ramakrishnan Kannan1, Irina Kuzina1, Edward Giniger1. 1) NINDS/NIH, Bethesda, MD; 2) The George Washington University.

481C
Axon targeting of Gr32a-expressing neurons is dependent on octopamine expression. David Hess-Homeier1, Gilia Patterson1, Jessica Bailey1, Sarah Certel1,2. 1) Department of Biological Sciences, University of Montana, Missoula, MT; 2) Neuroscience Graduate Program, University of Montana, Missoula, MT.

482A
The transmembrane protein Off-track 2 is implicated in the guidance of embryonic motor neurons. David J. Robinson, Samantha Alsbury. University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Kent. ME4 4TB. UK.

483B
Dissecting the roles of Homeodomain and Hox transcription factors in mediating dendritic development. Sarah G. Clark, Lacey Graybeal, Srividya C. Iyer, Myurajan Rubaharan, Eswar Prasad R. Iyer, Daniel N. Cox. Neuroscience Institute, Georgia State University, Atlanta, GA.

484C
HSPG-dependent Regulation of Dendrite Development. Amy R. Poe, Chun Han. Graduate Field of Genetics, Genomics, and Development, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.

485A
FOXO Regulates Dendrite Branching. J. Sears, H. Broihier. Neurosciences, Case Western Reserve University, Cleveland, OH.

486B
Short stop exerts differential effects on class-specific dendritic homeostasis. Sarah Trunnell, Shatabdi Bhattacharjee, Daniel N. Cox. Neuroscience Institute, Georgia State University, Atlanta, GA.

487C
Endocytic Pathways Downregulate the L1-type Cell Adhesion Molecule Neuroglian to Promote Dendrite Pruning in Drosophila. Heng Zhang1, Yan Wang1,2, Jack Jing Lin Wong1,2, Kah-Leong Lim3,4,5, Yih-Cherng Liou1, Hongyan Wang2,3,5, Fengwei Yu1,2,3. 1) 1Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, 1 Research Link, Singapore 117604, Singapore; 2) NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences, Singapore 117456, Singapore; 3) Neuroscience and Behavioural Disorders Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore; 4) National Neuroscience Institute, Singapore 308433, Singapore; 5) Department of Physiology, National University of Singapore, Singapore 117597, Singapore.

488A
Examining the Effects of Oxidative Stress on the Development of a Defined Neural Circuit in Drosophila melanogaster. Ryan Doan, Parag Bhatt, Wendi Neckameyer. Pharmacological & Physiological Science, Saint Louis University School of Medicine, Saint Louis, MO.

489B
Autophagy affects glutamate receptor localization at the Drosophila neuromuscular junction. Elizabeth Isbell, Faith Libel. Biological Sciences, Southern Illinois University-Edwardsville, Edwardsville, IL.

490C
TDRD3 works with an RNA topoisomerase and Fragile X mental retardation protein to promote synapse formation. S. Lee1, W. Shen1, Y. Xue1, D. Xu1,3, S. Zou2, W. Wang3. 1) Lab of Genetics, National Institute on Aging, National Institute of Health, Baltimore, MD 21224; 2) Translational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, MD 21224; 3) College of Life Sciences, Peking University, Beijing, China.

491A
Kismet affects synaptic transmission and endocytosis at the Drosophila Neuromuscular Junction. Carley Gridley, Taylor Delaney, Faith Liebl. Biological Sciences, Southern Illinois University Edwardsville, Edwardsville, IL.

492B
MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development. Cecilia Lu1,2, Bo Zhai2, Alex Mauss3,4, Matthias Landgraf3, Steve Gygi2, David Van Vactor1,2. 1) Okinawa Institute of Science and Technology, Onna-son, Okinawa, Japan; 2) Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; 3) Department of Zoology, University of Cambridge, Cambridge, UK; 4) Max Planck Institute of Neurobiology, Martinsried, Germany.

493C
Neto-mediated intracellular interactions shape postsynaptic structures at the Drosophila neuromuscular junction. Cathy Ramos, Oghomwen Igiesuorobo, Qi Wang, Mihaela Serpe. NICHD, NIH, Bethesda, MD.

494A
The Ig Transmembrane Protein Borderless Is Required for Synaptic Development and Function in the Drosophila Visual System. Hunter S. Shaw, Scott Cameron, Wen-Tzu Chang, Yong Rao. Centre for Research in Neuroscience, Department of Biology, Department of Neurology and Neurosurgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.

495B
Conserved interactions between Sorting nexins and Nervous wreck reveal a role for SH3PX1 at synapses. Fiona P. Ukken, Joseph J. Bruckner, Kate O'Connor-Giles. UW-Madison, Madison, WI.

496C
Separable intrinsic and extrinsic timers regulate terminal differentiation of a target-dependent gene in Drosophila neurons. Anthony Berndt1, Jonathan Tang2, Tianshun Lian1, Ridyard Marc1, Douglas Allan1. 1) Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2) Department of Genetics, Harvard Medical Schol, 77 Avenue Louis Pasteur, Boston, MA 02115.

497A
Antp controls the differential survival and morphology of adult-specific neurons in the thoracic vs. subesophageal ganglia. Kathleen Bell, Christine Murphy, Amy Patterson, Ginna Freehling, Alexandra Panzarino, Erin Schuler, Elizabeth Marin. Biology Department, Bucknell University, Lewisburg, PA.

498B
Genetic regulation of cell fate determination in the Drosophila ocelli. A. K. Mishra, S. G. Sprecher. Department of Biology, University of Fribourg, Fribourg, Switzerland.

499C
A temporal series of transcription factors in mushroom body precursors. Anthony M. Rossi, Claude Desplan. Biology, New York University, New York, NY.

500A
Investigating the Transcriptional Programs that specify Axon Targeting of Adult Leg MNs. Lalanti Venkatasubramanian, Jonathan Enriquez, Richard Mann. Columbia University Medical Center, New York, NY.

501B
RNA stability regulates balance between neuroblasts division and differentiation. Lu Yang1, Richard Parton1, Tomasz Dobrzycki1, Yoav Arava2, David Ish-Horowicz3, Ilan Davis1. 1) Biochemistry Dept., University of Oxford, Oxford, United Kingdom; 2) Department of Biology, Technion, Israel Institute of Technology, Haifa, Israel; 3) MRC for Molecular Cell Biology, University College London, London, United Kingdom.

502C
How does the misexpression of CHMP2B affect the wing development of Drosophila melanogaster? Pralaksha Gurung, Andrew Rhoads, S. Tariq Ahmad. Colby College, Waterville, ME.

503A
Drosophila miR-34 overexpression results in neural remodeling defect of mushroom body γ neurons. Yen-Wei Lai1,2, Hung-Hsiang Yu3, Chun-Hong Chen2. 1) Molecular and Cellular Biology, Taipei, Taiwan; 2) Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan; 3) 3.Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.

504B
Kinesin-1-powered microtubule sliding drives axonal regeneration in Drosophila cultured neurons. Wen Lu, Margot Lakonishok, Vladimir Gelfand. Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL.

505C
Gap junctions are required for glia-glia communication and survival in Drosophila PNS. M. Das, V. Auld, C. Rankin. University of British Columbia, Vancouver.

506A
An evolutionarily conserved gene function underlying the Glial Regenerative Response in the living injured larval CNS. Maria Losada-Perez, Neale Harrison, Alicia Hidalgo. Biosciences, University of Birmingham, Biermingham, Birmingham, United Kingdom.

507B
Role of integrins in glial phagocytosis of apoptotic cells during Drosophila embryogenesis. Boris Shklyar, Flonia Levy-Adam, Estee Kurant. Department of Genetics and Developmental Biology, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

508C
Ecdysone Receptor and Ultraspiracle Mediate Activation and Repression in Mushroom Body γ Neuron Pruning. Kathryn Lee, Rachael Wachter, Adam Windham, Alper Dincer, Christopher Dunne, Devin Gordon-Hamm, Elizabeth Marin. Biology Department, Bucknell University, Lewisburg, PA.

509A
Investigating the molecular mechanisms of Crimpy-Gbb signaling at the NMJ. Kendall Hoover, Rebecca James, Heather Broihier. Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

510B
Pak (p21-activated kinase) mutations cause defects in brain structure and neurite-arbor morphogenesis through regulation of non-muscle myosin. Sara A. Lewis1,2,3, Linda L. Restifo1,2,3. 1) Neuroscience Graduate Program, University of Arizona, Tucson, AZ; 2) UA Neuroscience; 3) UA Neurology.

511C
The role of sialic acid in Drosophila nervous system. H. Scott1, R. Islam1, C. Caster1, M. Zoran2, V. Panin1. 1) Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX; 2) Department of Biology, Texas A&M University, College Station, TX.

512A
Expression of Sox Neuro in development of adult nervous system. Shweta Singh, John Nambu. Florida Atlantic University, Biological Sciences, 5353 Parkside Drive, Jupiter FL-33458.

513B
Identification of a New Regulator of Neuron Glia Interaction during Development. Diana Luong, Roni Milgrom, Jennifer Jemc. Biology, Loyola University Chicago, Chicago, IL.

514C
Self-renewal capacity of sensory organ precursor cells. Joseph Ayeni1, Agnès Audibert2, Pierre Fichelson3, Martin Srayko1, Michel Gho2, Shelagh Campbell1. 1) Dept Biological Sci, University of Alberta, Edmonton, AB, Canada; 2) Laboratoire de Biologie du Développement (LBD-IBPS) Université Pierre et Marie Curie [UPMC] - Paris VI UPMC UMR 7622, Université Paris 06. 9, Quai St. Bernard 75005 Paris; 3) Health Interactions Admiral House, London, EC1V 9AZ.

515A
Autophagy serves as a backup cell-death mechanism to ensure the removal of unwanted cells in chordotonal organ development. Adel Dunayevskyy, Adi Salzberg. Department of Genetics, Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel.

Neurophysiology and Behavior


516B
Alcohol addiction affects stress tolerance, movement behavior and female reproductive ability in Drosophila melanogaster: A possible link to dopamine synthesis pathway. Anathbandhu Chaudhuri1, Karlson Udebuani1, Elizabeth Caver1, Mary , J. Krotzer1, Janis O’Donnel2. 1) Department of Natural Sciences, Stillman College, Tuscaloosa, AL; 2) Biological Sciences, University of Alabama, Tuscaloosa, 35487, AL.

517C
Ecdysone Receptor Modulates Nociception in Drosophila melanogaster. A. McParland, T. Follansbee, GK. Ganter. University of New England, Biddeford, ME.

518A
Ecdysis triggering hormone is necessary for fertilization of oocytes in Drosophila melanogaster. Matthew Meiselman, Michael Adams. University of California-Riverside, Riverside, CA.

519B
Differential Effects of Global Depletion of Ecdysteroid or its Receptor on Nociception. Gwendolyn Vesenka, Geoffrey Ganter. Biology Department, University of New England, Biddeford, ME.

520C
Suppression of GADD45 and stress-activated protein kinase pathways reduces severity of neurological phenotypes displayed by a voltage-gated sodium channel Drosophila mutant, Shudderer. H. Chen1, P. Landson1, J. Kasuya2, T. Kitamoto1,2. 1) Interdisciplinary Genetics Ph. D. Program, University of Iowa, Iowa City, IA; 2) Department of Anesthesia, University of Iowa, Iowa City, IA.

521A
Effects of diet on neurological phenotypes of a voltage-gated sodium channel mutant, Shudderrer. J. Kasuya1, P. Lansdon2, H.-L. Chen2, T. Kitamoto1,2. 1) Dept Anesthesia,; 2) Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA.

522B
Effects of diet on sleep of Shudderer, a Drosophila voltage-gated sodium channel mutant that displays seizure-like behaviors. Patrick Lansdon1, Emily Petruccelli1, Toshi Kitamoto1,2. 1) Interdisciplinary Ph.D. Program in Genetics, University of Iowa, Iowa City, IA; 2) Department of Anesthesia, University of Iowa, Iowa City, IA.

523C
Molecular characterization of noxious cold detection in Drosophila larvae. Benjamin Williamson1, Harold Burke1, Kevin Armengol2, Daniel Cox2, Susan Halsell1. 1) Biology, James Madison University, Harrisonburg, VA; 2) Neuroscience Institute, Georgia State University, Atlanta, GA.

524A
Neuronal insulin signaling negatively regulates SV release in response to high protein diet. Rebekah Mahoney, Jorge Azpurua, Benjamin Eaton. Physiology, UTHSCSA, San Antonio, TX.

525B
GLUTAMATE CLEARANCE BY ASTROCYTE-LIKE GLIA REGULATES NEURONAL EXCITABILITY AND SYNAPSE GROWTH IN DROSOPHILA LARVAL MOTONEURONS. Jhan-Jie Peng1,2, Shu-Hui Lin1, Tzu-Li Yen1, Chi-Kuang Yao1,2. 1) NPAS and Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan; 2) Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.

526C
The role of ER morphology in the control of synaptic transmission and locomotor behavior. James Summerville, Joseph Faust, Miguel Betancourt, Joseph Formella, James McNew, Michael Stern. BioSciences, Rice University, Houston, TX.

527A
Ca2+ influxes via Flower facilitate Clathrin-mediated and bulk endocytosis at the Drosophila neuromuscular junction. Chi-Kuang Yao1,2,3, Shu-Hui Lin1, Jing-Ming Chen1, Tzu-Li Yen1, Yu-Tzu Liu1. 1) Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan; 2) NPAS, Academia Sinica, Taipei, Taiwan; 3) Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.

528B
Unable to forget in mutants of homologs of autism susceptibility genes in Drosophila. Tao Dong1, Jing He1, Shiqing Wang1, Lianzhang Wang1, Yi Zhong1,2. 1) School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; 2) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

529C
Importin limits long-term memory consolidation in Drosophila. Qian Li1, Xuchen Zhang1, Xitong Liang1, Wantong Hu1, Fang Zhang1, Lianzhang Wang1, Yi Zhong1,2. 1) School of Life Sciences, Tsinghua University, Beijing 100084, PR China; 2) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

530A
A dopamine-modulated neural circuit regulating taste memory in Drosophila. P. Masek1, K. Worden1, Y. Aso2, G. Rubin2, A. Keene1. 1) Biology Department, University of Nevada Reno, Reno, NV; 2) 2. Janelia Farms Research Campus, 19700 Helix Drive, Ashburn, VA 20147.

531B
Effect of hsp83 on Drosophila melanogaster courtship behavior. Ekaterina Nikitina1,2, Marianna Shabanova2, Elena Savvateeva-Popova1. 1) neurogenetics, Pavlov Institute of Physiology RAS, St-Petersburg, Russian Federation; 2) Herzen State Pedagogical University, St-Petersburg, Russian Federation.

532C
The Genetic Basis of Learning and Thermotolerance in Drosophila Melanogaster. Anna M. Perinchery, James Mrkvicka, Elizabeth King, Troy Zars. University of Missouri, Columbia, MO.

533A
Neural pathways routing early memory decay in Drosophila. Yichun Shuai1, Areekul Hirokawa1, Yulian Ai1, Wanhe Li2, Yi Zhong1. 1) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; 2) Laboratory of Genetics, Rockefeller University, New York, NY.

534B
A new method for reliable scoring of olfactory preferences and learning in Drosophila melanogaster. Elisabetta Versace1,2, Julia Reisenberger1, Christian Schlötterer1. 1) Institut für Populationsgenetik, Vetmeduni Vienna, Wien, Austria; 2) Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy.

535C
Evidence for PKA Dependent Regulation of Tomosyn, a Syntaxin Binding Protein. Sarah J. Zinn1, Szi-Chieh Yu1, Martin Schwärzel2, Carolin Wichmann3, David E. Featherstone1, Janet E. Richmond1. 1) Biological Sciences, University of Illinois, Chicago, Chicago, , IL; 2) Institute for Biology/Genetics, Free University Berlin D-14195 Berlin, Germany; 3) Department of Otolaryngology, University of Göttingen, 37075 Göttingen,Germany.

536A
Study of the courtship behavior in some sibling species of the Drosophila virilis group. Elena G. Belkina1, Oleg E. Lazebny1, Varvara Yu. Vedenina2. 1) Russian Academy of Sciences, Koltzov INSTITUTE of DEVELOPMENTAL BIOLOGY, Moscow, Russian Federation; 2) Russian Academy of Sciences, Kharkevich Institute for Information Transmission Problems, Moscow, Russian Federation.

537B
Effect of Central Brain Histamine Deficiency on Courtship Behavior in Drosophila melanogaster. Tina Daniels1, Laura Schroeder1, Martin Burg1,2. 1) Biomedical Sciences, Grand Valley State University, Allendale, MI; 2) Cell & Molecular Biology, Grand Valley State University, Allendale, MI.

538C
Mating Success is Influenced by Multiple Signal Modalities in Drosophila saltans. Jennifer M. Gleason, Kaila Colyott, Cynthia Odu. Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS.

539A
Expression of the Female Specific Transformer Protein using the Trapped in endoderm-1 Promoter Decreases Wing Song Latency. P. Luu, D. Tran, R. French. Biological Sciences, San Jose State University, San Jose, CA.

540B
The transcription factor dati is required for female courtship acceptance. Joseph Schinaman1, Rachel Giesey1, Claudia Mizutani1, Tamas Lukacsovich2, Rui Sousa-Neves1. 1) Case Western Reserve University, Cleveland, OH; 2) University of California, Irvine, Irvine, California.

541C
Increased dietary macronutrients affect Drosophila melanogaster reproductive behavior. Janna Schultzhaus, Ginger Carney. Biology, Texas A&M, College Station, TX.

542A
Complex social behavior in Drosophila: ethanol and natural genetic variation in courtship and aggression. Sarah Signor1, Mohammad Abbasi1, Brad Foley1, Paul Marjoram1, Sergey Nuzhdin1, Lauren McIntyre2. 1) Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA; 2) Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL.

543B
Expression of a mutant form of human CHMP2B in the Drosophila CNS is capable of disrupting circadian rhythms. Christopher Krasniak, Joshua Kavaler, Tariq Ahmad. Department of Biology, Colby College, Waterville, ME.

544C
RNA-Seq Reveals Age-Induced Changes in Rhythmicity in the Drosophila Transcriptome. Rachael Kuintzle1, Eileen Chow2, Jadwiga Giebultowicz2, David Hendrix1,3. 1) Biochemistry & Biophysics, Oregon State University, Corvallis, OR; 2) Integrative Biology, Oregon State University, Corvallis, OR; 3) School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR.

545A
Analyses of alcohol induced behavior in Drosophila period mutants. Jennifer Liao, Tariq Ahmad. Colby College, Waterville, ME.

546B
Investigating the roles of glial cells in supporting circadian function and healthy aging. Dani Long, Jadwiga Giebultowicz. Integrative Biology, Oregon State University, Corvallis, OR.

547C
Sleep abnormalities in a Drosophila knock-in model of human generalized epilepsy with febrile seizures-plus (GEFS+). Emily Petruccelli, Patrick Lansdon, Toshihiro Kitamoto. University of Iowa, Iowa City, IA.

548A
Neurexin regulates sleep by modulating the Na+/K+ ATPase activity. Huawei Tong, Qian Li, Wei Xie, Junhai Han. Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.

549B
Circadian Translational Profiling Of The Drosophila Head Fat Body. Amy Marie Yu, Yanmei Huang, F. Rob Jackson. Neurobiology, Tufts University Medical School, Boston, MA.

550C
Genetic dissection of aggressive behavior in Drosophila melanogaster. Mahmoudreza Ramin, Claudiu Domocos, David Slawaska-Eng, Yong Rao. Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Quebec, Canada.

551A
Molecular and behavioral analysis of gustatory receptor neurons in pharyngeal organs as modulators of feeding in Drosophila larvae. Jaekyun Choi, Min Sung Choi, Jae Young Kwon. Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, South Korea.

552B
The regulation of feeding and metabolism by activating insulin signaling in DSK neurons in Drosophila. Justin Palermo, Justin R. DiAngelo. Department of Biology, Hofstra University, Hempstead, NY.

553C
The regulation of feeding and metabolism by the DSK receptor CCKLR-17D1 in Drosophila. Christopher Tenorio, Justin DiAngelo. Department of Biology, Hofstra University, Hempstead, NY.

554A
Impaired climbing and flight behavior in D. melanogaster following carbon dioxide anesthesia. Nathan R. Bartholmew1, Jacob Burdett1, John M. VandenBrooks2, Michael Quinlan2, Gerald B. Call3. 1) Arizona College of Osteopathic Medicine (AZCOM), Midwestern University, Glendale, AZ; 2) Dept of Physiology, AZCOM, Midwestern University, Glendale, AZ; 3) Dept of Pharmacology, AZCOM, Midwestern University, Glendale, AZ.

555B
Anxiolytic-like effects of an organic extract from the seaweed Sargassum platycarpum in anxiety-related behavior in Drosophila melanogaster. Zulmari Martínez, Jesica Vicente, Angeliz Rivas, Keysh Mejías, Jeslie Ramos, Grisel Robles, Valeria Pedraza, Claudia Ospina, Ricardo Chiesa. University of Puerto Rico at Cayey, NEC Building Cayey, PR 00736.

556C
Ethanol-Induced locomotion in Drosophila melanogaster is decreased by the administration of an organic extract of the seaweed Sargassum platycarpum. Adbiel Rodríguez, Noelia Acevedo, Karelis Pagán, Claudia Ospina, Ricardo Chiesa. University of Puerto Rico at Cayey Antonio R. Barcelo Avenue NEC Building Cayey, PR 00736.

557A
New genes required for mechanical nociception identified by a novel assay for mechanical pain sensitization. PJ Huang1,2, HT Turner2, SH Im2, MJ Galko2. 1) Department of Biochemistry & Cell Biology, Rice University, Houston, TX; 2) Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX.

558B
Sensory control of larval epithelial cell layer redox status through ROS-mediated avoidance of atmospheric oxygen to maintain foraging stage food immersion. Wayne Johnson, Carder Justin. Dept Molec Physiol/Biophysics, Univ Iowa, Iowa City, IA.

559C
Factors affecting the release of and response to the Stress Odourant (dSO) by Drosophila melanogaster. Ian S. McDonald, Selwyn Chui, Andrew F. Greco, Shirley Q. Long, Jeremy N. McNeil, Anne F. Simon. Department of Biology, Faculty of Science, Western Ontario University, Ontario, London, Canada.

560A
Reduced odor evoked neural responses during sleep and impaired response after prolonged waking in the Drosophila mushroom body (MB). Daniel B. Bushey, Giulio Tononi, Chiara Cirelli. Psychiatry, University of Wisconsin, Madison, WI.

561B
The Effect of Bacteria on Oviosition Preference of Drosophila melanogaster. Geon Ho Kim1, Peter Newell2, Angela Douglas1. 1) Entomology, Cornell University, Ithaca, NY; 2) Microbiology, State University of New York, Oswego, NY.

562C
Complex and non-redundant signals from individual odor receptors that underlie chemotaxis behavior in Drosophila melanogaster larvae. Jeewanjot Grewal, Christina Cho, Karolina Kir, Nicole Fledderman, Kathryn Swain, Scott A. Kreher. Department of Biological Sciences, Dominican University, River Forest, IL.

563A
Presynaptic gain control drives sweet and bitter taste integration. Bonnie Chu, Vincent Chui, Kevin Mann, Michael Gordon. Zoology, University of British Columbia, Vancouver, British Columbia, Canada.

564B
Identification and characterization of gustatory second-order interneurons. K. Shimizu1, T. Miyazaki1, T. Y. Lin1, K. Ito2, C. H. Lee1, M. Stopfer1. 1) NICHD/NIH, Bethesda, MD 20892, USA; 2) IMCB, Univ. of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo, 113-0032, Japan.

565C
Ecdysis Triggering Hormone Receptor Splice Isoforms Govern Distinct Aspects of Drosophila Ecdysis Sequences. Feici Diao1, Fengqiu Diao1, Wilson Mena2, Brandon Mark2, Jonathan Shi3, Dongkook Park3, Paul Taghert3, John Ewer2, Benjamin White1. 1) national institute of mental health, Bethesda, MD; 2) CINV, Universidad Valparaiso, Valparaiso, Chile; 3) Washington University, St Louis.

566A
Virtual Fly Brain - A Data Integration Hub for DrosophilaNeurobiology. David J. Osumi-Sutherland1, Marta Costa2, Robert Court3, Gregory S. X. E. Jefferis4, Helen Parkinson1, J. Douglas Armstrong3, Cahir J. O'Kane2. 1) EMBL-EBI, Cambridge, UK; 2) Dept of Genetics, University of Cambridge, Cambridge, UK; 3) School of Informatics, University of Edinburgh, Edinburgh, UK; 4) MRC Laboratory for Molecular Biology, Cambridge, UK.

567B
Failure to burrow while wandering: an indication of tracheal damage in mutants of the jim lovell (lov) gene. K. Beckingham, F. Zhou, K. Qiang, Y. Yuan, P. Yun, R. Dibbs, T. Ghanayem, R. Mohan, P. Frasse, N. Sankoorikkal. BioSciences, Rice University, Houston, TX.

568C
Differential regulation of Drosophila Glutamate receptor subunit production by optimus-prime, a novel mRNA associated gene. Dina M. Beeler1, Julie E. Karr (Minibiole)2, Subhashree Ganesan1, David E. Featherstone1. 1) Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL; 2) Department of Science and Mathematics Columbia College Chicago, Chicago, IL.

569A
Early life stress affects higher order procesisng in brain structures in Drosophila. Davinelle Daniels1, Andres Nieto2, Wendi Neckameyer2. 1) Academic Affairs, Harris-Stowe State University, St. Louis, MO; 2) Dept of Pharmacological & Physiological Science, Saint Louis University School of Medicine.

570B
The Role of the BMP signaling family in the Induction of Allodynia. Taylor Follansbee1, Kayla Gjelsvik1, Michael Galko2, Geoffrey Ganter1. 1) University of New England, Biddeford ME; 2) UT Southwestern MD Anderson, Houston TX.

571C
Sex peptide receptor and myoinhibitory peptide modulate mating state-dependent choice behavior of Drosophila females. Ilona C. Grunwald Kadow1, Ashiq Hussain1, Mo Zhang1, Habibe Ucpunar1, Thomas Svenson2, Elsa Quillery2, Rickard Ignell2. 1) Sensory Neurogenetics Research group, Max-Planck Institute of Neurobiology, Martinsried, Germany; 2) Swedish University of Agricultural Sciences, Department of Plant Protection Biology, Division of Chemical Ecology, Sundsvägen 14, 23053 Alnarp, Sweden.

572A
Beadex function in the motor neurons is essential for female reproduction in Drosophila melanogaster. Subhash Kairamkonda, Upendra Nongthomba. Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.

573B
Response to stress in Drosophila is mediated by the hormonal milieu of the brain. Wendi Neckameyer, Andres Nieto. Dept Pharmac & Physiol Sci, St Louis Univ School Med, St Louis, MO.

574C
princess glia, a novel gene required for neuronal and cellular homeostasis. Wendi Neckameyer1, Davinelle Daniels2, Andres Nieto1, Amer Avdagic1, Sarah Chan1, Anisha Chava1, Ryan Doan1. 1) Dept Pharmac & Physiol Sci, St Louis Univ School Med, St Louis, MO; 2) Academic Affairs, Harris-Stowe State University, St Louis MO.

575A
Transposable element misexpression and neuronal decline. L. Prazak1,2, W. Li2,3, N. Chatterjee2, S. Grüninger4,5, L. Krug5, D. Theodorou6, J. Dubnau2,5. 1) Farmingdale State College, Farmingdale, NY; 2) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; 3) Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY; 4) Institute of Neuroinformatics, University of Zurich, 8057 Zurich, Switzerland; 5) Watson School of Biological Sciences, Cold Spring Harbor Laboratory; 6) Magistère de Génétique Graduate Program at Université Paris Diderot, Sorbonne Paris Cité.

576B
Determination of environmental factors affecting social space in Drosophila melanogaster. Alison R. McNeil1, Nicholas Choi1, Adesanya A. Akinleye2, Sam N. Jolley1, Zulekha Rouzyi2, Anne F. Simon1. 1) Department of Biology, Faculty of Science, Western Ontario University, Ontario, London, Canada; 2) Department of Biology, York College of the City University of New York, Jamaica, NY, USA.

577C
Characterization of a novel bang-sensitive gene in Drosophila melanogaster. Ghazal Stity, Christopher J. Jones. Biological Sciences, Moravian College, Bethlehem, PA.

Drosophila Models of Human Diseases


578A
The JAK-STAT signaling pathway functions in GABAergic neurons to mediate the effects of ethanol on developmental and adult behavior. Kimberly McClure, Gabriella Ceresa, Amanda Menzie, Axel Munoz, Gina Trotto. Biology, Elmhurst College, Elmhurst, IL.

579B
Effects of Ethanol Exposure on Development Time and Survival in Drosophila. Yasmeen N. Hussain1,2, Victoria A. Pray1, Eugenea V. Zhirnov2, Morgan Davis1, Rachel A. Lyman1, Lenovia J. McCoy1, Tatiana V. Morozova1,2, Robert R. H. Anholt1,2, Trudy F. C. Mackay1,2. 1) Department of Biological Sciences, North Carolina State University, NC; 2) W.M. Keck Center for Behavioral Biology, North Carolina State University.

580C
Analysis of the Pruritic (Itch) Response in Drosophila melanogaster. Ciny John, John Nambu. Department of Biological Sciences, Charles E. Schmidt College of Science, Florida Atlantic University, Jupiter, FL.

581A
Effects of Lead Exposure on Development Time and Survival in Drosophila. Sarah E. McAdams1, Lenovia J. McCoy1, Yasmeen N. Hussain1,2, Shanshan Zhou1,2, Tatiana V. Morozova1,2, Trudy F. C. Mackay1,2, Robert R. H. Anholt1,2. 1) Department of Biological Sciences, North Carolina State University, Raleigh, NC; 2) W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC.

582B
Drosophila as a low complexity model for myeloproliferative neoplasms. Abigail M. Anderson, Elizabeth Rodkin, Erika Bach. Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY.

583C
Identifying new modulators of blood cell development using Drosophila as a low complexity model of human myeloproliferative neoplams. Alessandro A. Bailetti, Abigail Anderson, Erika Bach. Biochemistry and Molecular Pharmacology, New York University School of Medicine , New York, NY.

584A
The role of RecQ proteins, BLM and WRNexo, in DNA repair, aging, and tumorigenesis. Elyse Bolterstein1, Molly Ahern2, Rob Salomon3, Mitch McVey2. 1) Dept of Biology, Northeastern Illinois University, Chicago, IL; 2) Dept of Biology, Tufts University, Medford, MA; 3) Tufts University, School of Medicine, Boston, MA.

585B
Comparative genomics of Drosophila melanogaster and a butterfly, Cercyonis pegala, to model metastatic melanoma. Thomas Brown. Thomas M. Brown, Ph.D., President, Genectar Com LLC, 539 Kalispell Ave. Whitefish, MT 59937.

586C
Oncogene-specific effects of abnormal systemic metabolism on tumor growth and metastasis. Kiu Ming April Kong, Lisa Shim, Cemre Cetin, Arthur Hilliker, Spencer Mukai, Kyle Belozerov. Department of Biology, York University, Toronto, Canada.

587A
TRIM3, a human ortholog of Drosophila brat, maintains asymmetric cell division of glioma stem cells by regulating NOTCH1 transport. Subhas Mukherjee1, Jun Kong2, Gang Chen1, Daniel Brat1,2. 1) Pathology and Laboratory Medicine, Winship Cancer Institute of Emory University, Atlanta, GA; 2) Department of Bioinformatics, Emory University, Atlanta, GA.

588B
Role for SETDB1 in maintaining blood cell homeostasis in the Drosophila larvae. Indira Paddibhatla. Biol Dept, Center for Cellular and Molecular Biology, Hyderabad, India.

589C
JAK/STAT pathway control of cell competition during development. Poojitha Sitaram, Erika Bach. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY.

590A
Systemic Effects of Tissue Overgrowth on Hematopoiesis. Carrie Spratford, Banerjee Utpal. Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA.

591B
Studying a model of Autism Spectrum Disorder in Drosophila. Marlene Cassar, Doris Kretzschmar. Oregon Institute of Occupational Health Sciences, OHSU, Portland, OR.

592C
Developmental ethanol exposure disrupts lipid metabolism and causes oxidative stress in Drosophila larvae. Payam Khodabakhshi, Theresa Logan-Garbisch, Tony Bortolazzo, Peter Luu, David Do, Rachael French. San Jose State University, San Jose, CA.

593A
The ANKLE2 and VRK1 pathway: microcephaly in flies and humans. Nichole Link, Wu-Lin Charng, Jim Lupski, Hugo Bellen. Baylor College of Medicine, Houston, TX.

594B
Using Drosophila to characterise the human disease gene MEGF8. Deborah Lloyd, Andrew Wilkie, Tudor Fulga. Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom.

595C
Diminished MTORC1-Dependent JNK-Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Ching-On Wong1, Michela Palmieri2, Dmitry Akhmedov1, Jiaxing Li3, Yufang Chao1, Geoffrey Broadhead1, Catherine Collins3, Rebecca Berdeaux1, Marco Sardiello2, Kartik Venkatachalam1,4,5. 1) Integrative Biology and Pharmacology, University of Texas, School of Medicine, Houston, Houston, TX; 2) Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, TX 77030; 3) Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109; 4) Program in Cell and Regulatory Biology (CRB), Graduate School of Biomedical Sciences, University of Texas School of Medicine, Houston, TX 77030; 5) Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas School of Medicine, Houston, TX 77030.

596A
Characterization of the Drosophila insulin-signaling pathway. Laura Musselman1, Thomas Baranski2. 1) Biological Sciences, Binghamton University, State University of New York, Binghamton, NY; 2) Washington University School of Medicine, St. Louis, MO.

597B
QTL candidate gene expression correlation with diet-specific glucose levels. Jaron N. Nix, Laura K. Reed. The University of Alabama, Tuscaloosa, AL.

598C
Metabolic impact of maternal obesity on offspring. Rita Brookheart, Christina Collins, Laura Cline, Jennifer Duncan. Pediatrics, Washington University in St. Louis, St. Louis, MO.

599A
Lipid droplet flux in the larval midgut of Drosophila. Ron Dubreuil, Bianca Diaconeasa, Jamie Moy, Sneha Gummuluri. Dept Biological Sci, Univ Illinois, Chicago, IL.

600B
An investigation of the effects of HFD in the head of Drosophila melanogaster. Osvaldo Rivera, Jamon Harris, Silvienne Sint Jago, Siddhartha Dhakal, Matthew Talbert. Biology, University of Louisiana at Monroe, Monroe, LA.

601C
Metabolic Analysis of IDH Mutant Gliomas in Drosophila . M. Brown, J. Buccetti, J. Mills, M. Tipping. Biology, Providence College, Providence, RI.

602A
Effects of dim light at night through disruption of circadian rhythm on metabolism in Drosophila melanogester. Mary Kim1, Su-yeon Yu1, Yunjeong Kim1, Hyo Sun Lee1, Eunil Lee1, Joong-Jean Park2. 1) Department of Preventive Medicine,College of Medicine, Korea University, Seoul, Korea; 2) Department of Preventive Phyology, College of Medicine,Korea University, Seoul, Korea.

603B
Metabolomics approach to understand the effect of genotype and diet on metabolic profile of Drosophila. Vishal Oza, Laura Reed. Department of Biological Sciences, University of Alabama, Tuscaloosa, AL.

604C
Dietary effects on the association between metabolite and gene expression using eigenvector metabolite analysis. Clare Scott1, Ronglin Che2, David Reif3, Allison Montsinger-Reif4, Laura Reed1. 1) Biological Sciences, University of Alabama, Tuscaloosa, AL; 2) SAS, Raleigh-Durham, NC; 3) Genetics, NC State University, Raleigh, NC; 4) Bioinformatics Research Center, NC State University, Raleigh, NC.

605A
Altered dSERF gene expression impacts protein homeostasis during aging and in neurodegenerative disease models. Swagata Ghosh, Sarah Milian, Alice Bevins, Douglas Harrison, Brian Rymond. Biology Dept, University of Kentucky, Lexington, KY.

606B
The effect of long-term selection on Drosophila melanogaster in a high-fat environment. Tanner L. Hallman, Laura K. Reed. University of Alabama, Dept. of Biological Sciences, Box 870344, Tuscaloosa, AL 35487.

607C
Population variation in phenotypic robustness to dietary perturbation. John C. Henderson, Laura Reed. University of Alabama, Dept. of Biological Sciences, Box 870344, Tuscaloosa AL 35487.

608A
The influence of mutant gene Cam on life span, moving activity and Ca2+ concentration in dystrophy mutants of Drosophila melanogaster. Nataliia Holub, Vasylyna Borutska, Khrystyna Dronska, Yaroslava Chernyk. Genetics & Biotechnology, National University, Lviv, Ukraine, Hrushevskogo Str., 4.

609B
Myopathic lamin mutations cause reductive stress and activate the CncC (Nrf2)/Keap-1 pathway. Grant H. Young1, George Dialynas2, Om K. Shrestha3, Jessica M. Ponce4, Dylan A. Thiemann1, Steven Moore5, Liping Yu1,6, Lori L. Wallrath1. 1) Department of Biochemistry, University of Iowa, Iowa City, IA 52242; 2) Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110; 3) Department of Biochemistry, University of Wisconsin, Madison, WI 53706; 4) Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52241; 5) Department of Pathology, University of Iowa, Iowa City, IA 52241; 6) NMR Facility, Carver College of Medicine, University of Iowa, Iowa City, IA 52241.

610C
Insulin-like Signaling Genes Chico and PGI Significantly Modify Neurotoxicity in Parkinson's Disease. Rami Ajjuri, Janis O'Donnell. The University of Alabama, Tuscaloosa, AL.

611A
Creb Binding Protein and histone acetylation levels in a Drosophila model of MJD. Colin Beals-Reid, John Warrick. Biology, University of Richmond, Richmond, VA.

612B
The role of the glutamine-glutamate cycle in neuronal. Paola Bellosta, Maria Enrica Pasini. Biosciences, University of Milan, Milan, Milan, Italy.

613C
The role of the glutamine-glutamate cycle in neuronal degeneration induced by the mutant human Huntington PolyQ protein. M. E. Pasini1,3, M. Raneli1, L. Vernizzi1, N. Trong Tue2, P. Bellosta1,3. 1) Dept of Biosciences, University of Milan, Milan, Italy; 2) Center for Gene-Protein Research Hanoi Medical University, Hanoi, Vietnam; 3) Ministero degli Affari Esteri e Cooperazione Internazionale Piazzale della Farnesina, 1 00135 Roma.

614A
Effects of nicotine on mitochondrial morphology and turnover in a Drosophila park25 mutant model of Parkinson's disease. Juliana M. Cackovic, Gerald Call, Krista Pearman, Justin Smith, Lori Buhlman. Biomedical Sciences, Midwestern University, Glendale, AZ.

615B
Study of APP protective pathway in Drosophila. Marlene Cassar, Jill Wentzell, Bonnie Bolkan, Katia Carmine-Simmen, Doris Kretzschmar. Oregon Institute of Occupational Health Sciences, OHSU, Portland, OR.

616C
The role of intracellular dopamine handling in selective degeneration of dopaminergic neurons in Drosophila Parkinson’s disease models. Antonio Tito1,3, Shebna Cheema4, Zhen Xu1, Yanning Rui1, Zhihua Chen1, Wen-Ting Li5, Mian Jiang4, Hugo Bellen6,7, Sheng Zhang1,2,3. 1) The Brown Foundation Inst. of Molecular Med; 2) Dept of Neurobiology and Anatomy; 3) Human & Molecular Genetics and Neuroscience, University of Texas Graduate School of Biomedical Sciences The University of Texas Medical School, UTHEALTH; 4) University of Houston- Downtown Houston, TX, 77030; 5) Rice University; 6) Program in Developmental Biology; 7) Dept. of Molecular & Human Genetics and Neuroscience Baylor College of Med. Jan and Dan Duncan Neurological Research Inst.

617A
Natural genetic modifiers of autosomal dominant retinitis pigmentosa. Clement Chow, Keegan Kelsey, Mariana Wolfner, Andrew Clark. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

618B
Enhanced protein degradation protects against neurodegeneration in a Drosophila model of c9orf72-ALS. Kathleen M. Cunningham1, Ke Zhang1, James Machamer1, Thomas Lloyd1,2. 1) Department of Neurology, Johns Hopkins University, Baltimore , MD; 2) The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD.

619C
Engineered Hsp70 suppresses amyloid-β neurotoxicity in Drosophila by binding extracellular amyloid-β aggregates. Pedro Fernandez-Funez, Jonatan Sanchez-Garcia, Lorena de Mena, Yan Zhang, Diego E. Rincon-Limas. Dept Neurology, Univ Florida, Gainesville, FL.

620A
Role of a soy protein Lunasin in Aβ42 mediated neurodegeneration in Alzheimer’s Disease. Angela Giaquinto1, Michael Moran1, Ankita Sarkar1, Gillian Jones2, Ajay Srivastava2, Maduri Kango-Singh1,3,4, Amit Singh1,3,4. 1) Department of Biology, University of Dayton, 300 College Park Drive, Dayton, OH; 2) Department of Biology and Biotechnology Center, Western Kentucky University, 1906 College Heights Blvd, Bowling Green, KY; 3) Premedical Program, University of Dayton,300 College Park Drive, Dayton,OH; 4) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

621B
Evaluating the potential therapeutic role of ACE inhibitors for Alzheimer’s Disease in Drosophila. Sarah M. Gomes1,2, Gabrielle L. Boulianne1,2. 1) The Hospital for Sick Children, Toronto, Canada; 2) University of Toronto, Toronto, Canada.

622C
Neuroinflammation and Hypoxia in a Neurodegenerative Disease Model. Marleshia Hall1, J. Gavin Daigle1,2, Rami Ajjuri1, O'Donnell Janis1. 1) Biological Sciences, University of Alabama, Tuscaloosa, AL; 2) Department of Human Genetics, LSU School of Medicine, New Orleans, LA.

623A
Direct regulation of a conserved axon regeneration pathway by Protein Kinase A. Yan Hao, Catherine Collins. MCDB, University of Michigan, Ann Arbor, MI.

624B
A high throughput screen for chemical modifiers of a Drosophila model for Niemann-Pick type C. Tom Hartl, Ethan Perlstein. Perlstein Lab PBC, San Francisco, CA.

625C
Tau-spliceosome interactions in Drosophila models of Alzheimer’s disease. Yi-Chen Hsieh1, Martin P. Powers1, Janson White1, Joshua M. Shulman1,2. 1) Baylor College of Medicine, Houston, TX; 2) Jan and Dan Duncan Neurological Research Institute, Houston, TX.

626A
Drosophila eye model to understand role of signaling pathways in Aβ42 mediated neurodegeneration. Madison Irwin1, Meghana Tare1,4, Michael Moran1, Madhuri Kango-Singh1,2,3, Amit Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton, OH; 3) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH; 4) Department of Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA.

627B
Aberrant immune activation in the Drosophila Adar mutant neurodegeneration. Liam Keegan1, Simona Paro2, Leeanne McGurk2, Xianghua Li2, Niamh Mannion2, Marion Hogg2, Robert Young2, Ian Adams2, Rui Zhang3, Jin-Billy Li3, Giusy Pemmetta4, Mary O,Connell1. 1) Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 5, 625 000 Brno, Czech Republic; 2) MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK; 3) Department of Genetics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA; 4) 3Centre for Integrative Physiology, Euan MacDonald Centre for Motor Neurone Disease Research, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh, EH8 9XD.

628C
Role of Dpp signaling pathway in promoting survival of retinal neurons in Aβ42 mediated neurodegeneration. James Kirwan1,2, Ankita Sarkar2, Madhuri Kango-Singh2,3,4, Amit Singh2,3,4. 1) Drexel University, School of Biomedical Engineering, Science, and Health Systems, 3141 Chestnut Street, Philadelphia, PA; 2) Department of Biology, University of Dayton, 300 College Park Drive, Dayton, OH; 3) Premedical Program, University of Dayton,300 College Park Drive, Dayton, OH; 4) Center for TissueRegeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

629A
Characterization of the molecular mechanisms underlying TARDBP mutation toxicity in drosophila. Magalie Lecourtois, Laetitia Miguel, Tracey Avequin, Thierry Frebourg, Dominique Campion. Inserm U1079, Normandie University, IRIB, Rouen, France.

630B
The calcineurin inhibitor, sarah, exasperates Aβ42 phenotypes in a Drosophila model of Alzheimer’s Disease. Soojin Lee, Se Min Bang, Yoon Ki Hong, Jang Ho Lee, Haemin Jeong, Seung Hwan Park, Kyoung Sang Cho. Biological sciences, Konkuk university, Seoul, Seoul, South Korea.

631C
Bcl-2 homologues, Buffy and debcl, influence Drosophila models of Parkinson Disease. P. Githure M'Angale, Brian E. Staveley. Biology Department, Memorial University Of NFLD, St. John's, NL, Canada.

632A
Quantitative analysis of climbing deficits and nicotine effects in homozygous parkin mutant flies. Brady Mannett1, John M. Grose2, Krista Pearman3, Lori M. Buhlman1, Gerald B. Call3. 1) Biomedical Sciences, College of Health Sciences, Midwestern University, Glendale, AZ; 2) Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ; 3) Dept of Pharmacology, AZCOM, Midwestern University, Glendale, AZ.

633B
Examining spargel, the homologue of PGC-1α, in Drosophila models of Parkinson Disease. Eric Merzetti, Brian Staveley. Biology, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

634C
Targeting the interaction of Ataxin-3 and Rad23 for therapeutic purposes in the neurodegenerative disease Spinocerebellar Ataxia Type 3. Joanna R. Miller, Jessica Blount, Wei-Ling Tsou, Sokol Todi. PHARMACOLOGY, WAYNE STATE UNIVERSITY, DETROIT, MI.

635A
Understanding the Molecular Pathology of Spinal and Bulbar Muscular Atrophy by Identifying Genetic Interactors of an AR-Humanized Fly. Shaza Mokhtar1,2, Mark Trifiro1,2,3, Miltiadis Paliouras1,2,3. 1) Human Genetics, McGill University, MONTREAL, QC, Canada; 2) Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada; 3) Department of Medicine, McGill University, Montreal, QC, Canada.

636B
Roles of reticulons and REEPs in organisation of axonal endoplasmic reticlum in Drosophila. Belgin Yalcin, Niamh C. O'Sullivan, Martin Stofanko, Zi Han Kang, Annika Hartwich, Matthew Thomas, Cahir J. O'Kane. Department of Genetics, University of Cambridge, Cambridge, United Kingdom.

637C
Activation of the wallenda/DLK pathway triggers adult photoreceptor degeneration. Kirk Mecklenburg2, Stephanie Freed1, Forrest Weghorst1, Joseph O'Tousa1. 1) Biology Dept., Indiana University at South Bend, South Bend, IN; 2) Dept. of Biological Sciences University of Notre Dame, Notre Dame, IN.

638A
Co-Expression of human APP and BACE impairs short term memory as measured by the Aversive Phototaxis Suppression Assay in a Drosophila model of Alzheimer’s Disease. Ashka Patel, Paddock Brie. Biology Dept, Arcadia University, Glenside,PA.

639B
The role of Synaptotagmin1 (SYT1) in a Drosophila model of MJD. Rachel Pearcy, John Warrick. University of Richmond, Richmond, VA.

640C
Cisplatin Induces Behavioral and Mitochondrial Changes in the Absence of Apoptosis in Drosophila Larvae Motor Neurons. Jewel Podratz, Han Lee, Patrizia Knorr, Stephanie Koehler, Steven Forsythe, Kelsey Lambreckt, Kiley Schmidt, Gabrielle Steinhoft, Goshya Yudinsev, Amy Yang, Eugenia Trushina, Anthony Windebank. Department of Neurology, Mayo Clinic, Rochester, MN.

641A
Alternative Splicing of Drosophila Nmnat Acts As A Switch Between NAD Synthetic and Neuroprotective Functions. K. Ruan, C. Li, RG. Zhai. Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL.

642B
Role of Signaling Pathways in Aβ42 mediated neurodegeneration. A. Sarkar1, A. Singh1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) 2)Premedical Program, University of Dayton,300 College Park Drive, Dayton,OH; 3) 3)Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

643C
The Effects of Copper on Larval Motility and Larval Learning and Memory in a Drosophila Model of Alzheimer's Disease. Courtney Schoff, Brie Paddock. Arcadia University, Biology Department, Glenside, PA, 19038.

644A
Probing integrin signaling in neuronal maintenance in flies. Mumine Senturk1, Shinya Yamamoto2, Manish Jaiswal3, Hugo Bellen1,2,3,4. 1) Developmental Biology, Baylor College of Medicine, Houston, TX; 2) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 3) HHMI; 4) Department of Neuroscience; Neurological Research Institute at Baylor College of Medicine, Houston, TX.

645B
The atrogin-nutcracker F-box protein family of genes in Drosophila models of degenerative disease. Brian Staveley, Eric Merzetti, Colleen Furlong, Poly Talukdar, Lindsay Dolomount, Maggie Hickey. Biology, Memorial Univ. of Newfoundland, St. John's, NL, Canada.

646C
A Drosophila Model of Radiation-Induced Neurological Damage. Lisa Sudmeier1, Steven Howard2, Barry Ganetzky1. 1) Dept. of Genetics, University of Wisconsin, Madison, WI; 2) Dept. of Human Oncology, University of Wisconsin SMPH, Madison, WI.

647A
Investigating the cell type specific roles of Neuropathy Target Esterase using Drosophila. Elizabeth Sunderhaus, Sudeshna Dutta, Doris Kretzschmar. Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR.

648B
Dysregulation of Dopamine Handling in Dopaminergic Neurons of Drosophila Parkinson’s disease models. Antonio Tito1,2,6, Shebna Cheema3, Zhen Xu2, Yanning Rui2, Sonal Jaiswal4, Zhihua Chen2, Wen-Ting Li5, Mian Jiang3, Hugo Bellen4,7, Sheng Zhang1,2,6. 1) Graduate Programs of Human Molecular Genetics & Neuroscience; 2) Institute of Molecular Medicine; 3) Department of Natural Sciences, UHD; 4) Program in Developmental Biology. BCM; 5) Department of Natural Sciences, Rice; 6) UT-GSBS. UT-Medical School. UTHEALTH; 7) Howard Hughes Medical Institute.

649C
Insights Into Ataxin-3’s Neuroprotective Function. Wei-Ling Tsou, Sokol Todi. PHARMACOLOGY & NEUROLOGY, WAYNE STATE UNIVERSITY, DETROIT, MI.

650A
Loss of isocitrate dehydrogenase 3α causes synaptic transmission defects in the fly visual system via reduced alpha-ketoglutarate levels. Berrak Ugur1, Hector Sandoval2, Nele Haelterman1, Manish Jaiswal2,4, Shinya Yamamoto1,2, Hugo Bellen1,2,3,4. 1) Developmental Biology, Baylor College of Medicine, Houston, TX; 2) Department of Molecular and Human Genetics,Baylor College of Medicine, Houston, TX; 3) Department of Neuroscience, Baylor College of Medicine, Houston, TX; 4) Howard Hughes Medical Institute.

651B
Imaging of sub-synaptic LRRK translocation using a tagged genomic knock in, created by MiMIC replacement. Sven Vilain1,2, Roeland Vanhauwaert1,2, Sandra Fausia Soukup1,2, Raquel da Cunha1,2, Patrik Verstreken1,2. 1) VIB Center for the Biology of Disease, 3000 Leuven, Belgium; 2) KU Leuven, Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium.

652C
Modeling TRPV4-mediated Hereditary Axonal Neuropathies in Drosophila. Brian M. Woolums, Morgan Yang, Catherine Mamah, Jeremy Sullivan, Amanda Le, Charlotte Sumner, Thomas Lloyd. Johns Hopkins School of Medicine, Baltimore, MD.

653A
α-Synuclein interacts with VPS35 in an improved Drosophila model of Parkinson’s Disease. Hui Ye1,2, Amit Chouhan1,2, Puja Yogi1,2, Elizabeth Kowalis1,2, Shreyasi Chatterjee3, George Jackson3, Joshua Shulman1,2. 1) Baylor College of Medicine, Houston, TX; 2) Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX; 3) University of Texas Medical Branch, Galveston, TX.

654B
Loss of Nardilysin, a mitochondrial peptidase, causes a slow progressive neurodegeneration and affects the Krebs cycle by modulating oxoglutarate dehydrogenase activity. W. H. Yoon1,5, H. Sandoval1, M. Jaiswal1,5, S. Jaiswal1, S. Yamamoto1,2,6, N. Putluri4, V. Putluri4, A. Sreekumar4, T. Donti1, B. Graham1, H. J. Bellen1,2,3,4,5,6. 1) Molecular and Human Genetics; 2) Program in Developmental Biology; 3) Department of Neuroscience; 4) Department of Molecular and Cellular Biology, Baylor College of Medicine; 5) Howard Hughes Medical Institute; 6) Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX.

655C
Expansion of polyglutamine repeats in huntingtin perturbs the motility of Rab4 and Rab11 containing vesicles in Drosophila larval axons. Katherine Zimmerman, Joseph White, Dr. Shermali Gunawardena. University at Buffalo, Buffalo, NY.

656A
Compensatory signaling mechanisms related to Parkinson's disease in a fly model of dopamine loss. Karol Cichewicz1, Emma Garren1, Martin Darvas2, Jay Hirsh1. 1) Biology Department, University of Virginia, Charlottesville, VA; 2) Pathology, University of Washington, Seattle, WA.

657B
Functional Studies of Spermine Synthase and Establishing a Drosophila Model for Snyder-Robinson Syndrome. C. Li, C. Bello, R. Zhai. Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL.

658C
KCNT1 in Epilepsy with ID and Psychiatric Features: Modeling Human Disease in Drosophila. Chiao Xin Lim1,2, Sarah E. Heron1,2, Michael G. Ricos1,2, Leanne M. Dibbens1,2. 1) School of Pharmacy & Medical Sciences, University of South Australia, Adelaide, SA, Australia; 2) Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.

659A
Adenosine suppresses seizure-like activity (SLA) and shortens recovery time in the Bang-sensitive (BS) paralytic mutants following mechanical shock. Chris Radlicz, Daniel Kuebler. Department of Biology, Franciscan University of Steubenville, Steubenville, OH.

660B
A Drosophila model of human DYT dystonia. Noriko Wakabayashi-Ito1, Rami Ajjuri2, Benjamin Henderson2, Olugbenga Doherty2, Xandra Breakefield1, Janis O'Donnell2, Naoto Ito1. 1) Neurology, Massachusetts General Hosp, Boston, MA; 2) Biological Science, University of Alabama, Tuscaloosa, AL.

661C
Dg-Dys-Syn1 signaling via microRNAs acts in a feedback loop to control the precision of Dystroglycan expression that is required for proper brain formation. Mariya M. Kucherenko, Andriy S. Yatsenko, April K. Marrone, Halyna R. Shcherbata. MPRG Gene expression and signaling, Max Planck Institute for biophysical chemistry, Goettingen, Lower Saxony, Germany.

662A
Fluorescent Imaging of the Drosophila Melanogaster Model of Human Nephrolithiasis. Sohrab Naushad Ali, Dajung Kim, Thomas Tailly, Hassan Razvi, Hon Leong. Division of Urology, University of Western Ontario, London, Ontario, Canada.

663B
Role of sodium-phosphate co-transporter MFS13 in Drosophila phosphate homeostasis. Clemens Bergwitz1,2, Jonathan Cohen2, Mark Wee2, Dana Drost1. 1) Medicine/Section Endocrinology, Yale School of Medicine, New Haven, CT; 2) Endocrine Unit, Massachusetts General Hospital, Boston, MA.

664C
Role of cellular phosphate uptake for Drosophila life span. Clemens Bergwitz1,2, Jonathan Cohen2, Mark Wee2, Dana Drost1. 1) Section Endocrinology/Dept. Medicine, Yale School of Medicine, New Haven, CT; 2) Endocrine Unit, Massachusetts General Hospital, Boston, MA.

665A
Drosophila Models of Genetic Renal Diseases. Margaret Nettleton, Fujian Zhang, Zhe Han. Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC.

666B
A fly model to identify new treatments for hyperuricemia, uric acid stones and gout. S. Lang1, H. Lu1, T. Chi2, A. Kahn1, D. Killilea3, M. Stoller2, P. Kapahi1. 1) Kapahi Laboratory, Buck Institute, Novato, CA; 2) Department of Urology, University of California San Francisco (UCSF), San Francisco, California; 3) Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, California.

667C
Toxicological and development effects of polymer-coated iron oxide nanoparticles in Drosophila. Evan A. Chavers1, Hunter B. Dean1,2, Ben W. Henderson1, Rami R. Ajjuri1, Yuping Bao2, Janis M. O'Donnell1. 1) Department of Biological Sciences, University of Alabama, Tuscaloosa, AL; 2) Department of Chemical Engineering, University of Alabama, Tuscaloosa, AL.

668A
Analysis of the mechanism of action of the anti-migration/anti-metastatic compound Dihydromotuporamine C, using a leg imaginal disc eversion assay. Corey Seavey1, Minpei Wang1, Aaron Muth2, Otto Phanstiel IV3, Laurence von Kalm1. 1) Department of Biology, University of Central Florida, Orlando, FL; 2) Department of Chemistry, University of Central Florida, Orlando, FL; 3) Department of Medical Education, College of Medicine, University of Central Florida, Orlando FL.

669B
A Drosophila model to address genetic mechanisms preventing age-related muscle fiber loss. Lizzet Castillo, Richard Cripps, Anton Bryantsev. Department of Biology, University of New Mexico, Albuquerque, NM.

670C
Representing Drosophila Models of Human Disease in FlyBase. P. McQuilton1, S. Tweedie1, G. Millburn1, A. Schroder2, J. Goodman3, H. Attrill1, S. Marygold1, L. Ponting1, R. Stefancsik1, N. Brown1, FlyBase Consortium. 1) FlyBase-Cambridge, Department of Genetics, University of Cambridge, Cambridge, CB2 3EH. United Kingdom; 2) FlyBase-Harvard, Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138. USA; 3) FlyBase-Indiana, Department of Biology, Indiana University, 1001 East 3rd Street, Bloomington, Indiana 47405-7005. USA.

671A
Investigating the mechanism of basement membrane repair and its implications in wound healing. William Ramos-Lewis1, Erica Shannon1, Andrea Page-McCaw1,2. 1) Cell and Developmental Biology, Vanderbilt University, Nashville, TN; 2) Cancer Biology, Vanderbilt University, Nashville, TN.

672B
The role of Drosophila clueless in regulating mitochondrial morphology. Zong-Heng Wang1, Erika Geisbrecht1,2. 1) School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO; 2) Department of Biochemistry and Biophysics, Kansas State University, Manhattan, KS.

Evolution and Quantitative Genetics


673C
In silico analysis of recombination rate variation across the Drosophila melanogaster genome based on multiple DNA motifs. Andrew Adrian, Josep Comeron. Biology, University of Iowa, Iowa City, IA.

674A
The effect of spatially varying selection on transposable element insertions in Drosophila. Jeffrey Adrion1, David Begun2, Matthew Hahn1. 1) Department of Biology, Indiana University, IN; 2) Department of Evolution and Ecology, UC Davis, CA.

675B
Annotation of Drosophila biarmipes contigs from euchromatic chromosome 3 as a control for the heterochromatic dot chromosome. Rachel Boody, Alexander Kneubehl, Lauren Guerriero, Jamie Sanford. Biological & Allied Health Sciences, Ohio Northern University, Ada, OH.

676C
Genome evolution in three species of cactophilic Drosophila. Fernando Peñaloza1, Javier Carpinteyro Ponce2, Nestor Nazario Yepiz2, Mariana Ramirez Loustalot-Laclette2, Luciano Matzkin3, Cei Abreu Goodger2, Alejandro Sanchez Flores1, Therese Markow1,4. 1) Unidad Universitaria de Apoyo Bioinformatico, Instituto de Biotecnologia, UNAM, Cuernavaca Morelos, Mexico; 2) LANGEBIO, CINVESTAV Irapuato, Irapuato, Guanajuato, Mexico; 3) Department of Biological Sciences, The University of Alabama Huntsville, Huntsville, AL; 4) Division of Biological Sciences, UCSD, La Jolla, CA.

677A
Population genomic analysis of the infectious and integrated Wolbachia pipientis genomes in Drosophila ananassae. Jae Young Choi, Jaclyn Bubnell, Charles Aquadro. Cornell University, Ithaca, NY.

678B
Evolutionary Analysis of the Drosophila Sex Peptide Network. Meaghan McGeary, Geoffrey Findlay. Department of Biology, College of the Holy Cross, Worcester, MA.

679C
Evolutionary and functional characterization of saturn, a newly evolved testis-expressed protein required for fertility in Drosophila melanogaster. Anna Gubala1, Tery Vinh1, Mariana Wolfner2, Geoffrey Findlay1,2. 1) Department of Biology, College of the Holy Cross, Worcester, MA; 2) Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.

680A
P-element invasion and the evolution of host repression. Yichen Zheng, Ricardo Azevedo, Erin Kelleher. Biology and Biochemistry, University of Houston, Houston, TX.

681B
The Responder satellite as a model for satellite DNA evolution in Drosophila. Daniel E. Khost, Amanda M. Larracuente. University of Rochester, Rochester, NY.

682C
The role of piRNA-mediated epigenetic silencing in the population dynamics of transposable elements in Drosophila melanogaster. Grace Yuh Chwen Lee. Ecology and Evolution, University of Chicago, Chicago, IL.

683A
Diversity of short sequences among genomes of inversion strains in Drosophila pseudoobscura. Megan Lee1, Sandra Duggan2, Dianhui Zhu2,3, Stephen Richards2, Stephen Schaeffer1. 1) The Pennsylvania State University, University Park, PA; 2) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030; 3) Chevron, 1500 Louisiana St, Houston, Texas, 77002.

684B
Recurrent gene duplication of a rapidly evolving suppressor of transposable elements. Mia Levine1, Emily Hsieh1, Helen Vander Wende1, Harmit Malik1,2. 1) Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; 2) Howard Hughes Medical Institute.

685C
D. pseudoobscura Inversion Breakpoint Sequence Evolution. Haley Randolph1, Megan Lee1, Geovanny Montoya1, Atousa Jahanshahi1, Sandra Duggan2, Dianhui Zhu2,3, Stephen Richards2, Stephen Schaeffer1. 1) The Pennsylvania State University, University Park, PA 16801; 2) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030; 3) Chevron, 1500 Louisiana St, Houston, Texas, 77002.

686A
Effect of sex biased expression or regulation of transposable elements on the Drosophila melanogaster genome. Christopher Savell, Brian Counterman. Biological Sciences, Mississippi State University, Starkville, MS.

687B
Evolutionary aspects of gene expression during Drosophila melanogaster spermatogenesis. Júlia Raíces, Maria Vibranovski. Genetics and Evolutionary Biology, University of Sao Paulo, Sao Paulo, SP, Brazil.

688C
Genetic architecture of parallel evolution of dark pigmentation in high-altitude populations of Drosophila melanogaster. Héloïse Bastide, Amir Yassin, John Pool. Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI.

689A
Genetic Variation in Local Populations of Drosophila suzukii. Matthew DiMeglio1, Philip Freda1,2, John Braverman1. 1) Saint Joseph's University, Philadelphia, PA; 2) Kansas State University, Manhattan, KS.

690B
Hybridization and the spread of Wolbachia through space and time in the yakuba complex of the Drosophila melanogaster subgroup. Brandon S. Cooper, Paul Ginsberg, Chenling Antelope, Michael Turelli. Evolution & Ecology, University of California, Davis, Davis, CA.

691C
Recombination rate variation among Drosophila melanogaster populations based on population genomic data. J. Cruz Corchado1, J. Comeron1,2. 1) Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA; 2) Department of Biology, University of Iowa, IA.

692A
Rates of crossing over gradually increase over time in Drosophila melanogaster females. Chad Hunter, Matthew Robinson, Nadia Singh. Program in Genetics, Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695.

693B
ConTExt: A Strategy for Studying the Structure and Population Dynamics of Transposable Element and Repeat Content. Michael P. McGurk, Daniel Barbash. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

694C
Sex determination and gene expression in the house fly, Musca domestica. Richard Meisel1, Jeffrey Scott2, Andrew Clark2. 1) University of Houston; 2) Cornell University.

695A
Population genetics of Drosophila eremophila in Mexico. Alejandra J. Vieyra-Ramirez, Therese A. Markow. LANGEBIO - CINVESTAV, Irapuato, Guanajuato, Mexico.

696B
Mating system of an invasive species, Zaprionus tuberculatus malloch, 1932, (diptera:Drosophilidae). Ergi D. özsoy1, Bahar Patlar1,2. 1) Hacettepe University, Department of Biology, 06800 beytepe campus, Ankara, Turkey; 2) Bielefeld University, Department of Evolutionary Biology, 33615, Bielefeld, Germany.

697C
Differential Gene Expression Patterns Of Chromosomal Inversion Karyotypes Provide Insight Into The Evolutionary Mechanisms Maintaining Third Chromosome Gene Arrangements of Drosophila pseudoobscura. Zach Fuller1, Gwilym Haynes1, Shannon Duggan2, Dianhuiz Zhu2, Stephen Richards2, Stephen Schaeffer1. 1) Biology, Penn State, University Park, PA; 2) Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX.

698A
Genomic evidence for non-neutral evolution of In(3R)Payne, a major clinal chromosomal inversion in Drosophila melanogaster. Martin Kapun1, Jérome Goudet1, Paul Schmidt2, Thomas Flatt1. 1) Department of Ecology and Evolution, University of Lausanne, Switzerland; 2) Department of Biology, University of Pennsylvania, Philadelphia, USA.

699B
Widespread transposon landscape diversity amongst Drosophila cell cultures and fly strains. Reazur Rahman, Yuliya Sytnikova, Nelson Lau. Biology, Brandeis University, Waltham, MA.

700C
The Molecular Basis of Segregation Distortion in Drosophila pseudoobscura. Randee E. Young1, Zachary L. Fuller2, Stephen W. Schaeffer2, Nitin Phadnis1. 1) Department of Biology, University of Utah, Salt Lake City, UT; 2) Department of Biology, Pennsylvania State University, University Park, PA.

701A
Dorsocross provides key to morphological divergence of extraembryonic development. F. Caroti, S. Lemke. Dept. of Molecular Developmental Biology and Physiology, Centre for Organismal Studies (COS), Heidelberg, Baden Württemberg, Germany.

702B
Exploring the origin of insect wings through functional analysis of vestigial in various insect species. C. M. Clark-Hachtel1, D. M. Linz1, X. Bellés2, E. Buschbeck3, Y. Tomoyasu1. 1) Department of Biology, Miami University, Oxford, OH; 2) Institut de Biologia Evolutiva, Barcelona, Spain; 3) Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio.

703C
Dissecting the genetic basis and evolution of form using haploid wasps. Lorna Cohen, Jeremy A. Lynch. University of Illinois at Chicago, Chicago, IL.

704A
Giant causes hybrid inviability in Drosophila. Jackie Gavin-Smyth1, Marty Kreitman1, John Reinitz1, Daniel Matute2. 1) Dept Ecology and Evolution, University of Chicago, Chicago, IL; 2) Biology Department, University of North Carolina, Chapel Hill, North Carolina.

705B
Conserved gene expression in the absence of sequence conservation: Uncovering a molecular mechanism by theoretical and experimental analysis of even-skipped expression from highly diverged sequences. Ah-Ram Kim1,2, Pengyao Jiang2, John Reinitz2. 1) Computer Science & Artificial Intelligence Laboratory, MIT, Cambridge, MA; 2) Department of Ecology and Evolution, Chicago Center for Systems Biology, University of Chicago, Chicago, IL.

706C
A re-evaluation of bicoid in Diptera. Jeff Klomp, Urs Schmidt-Ott. Organismal Biology and Anatomy, University of Chicago, Chicago, IL.

707A
Genetic basis of pigmentation divergence between closely related Drosophila species: interactions between tan and yellow. Abigail M. Lamb1, Alisha V. John1, Arielle M. Cooley2, Lisa L. Sramkoski1, Patricia J. Wittkopp1,2. 1) Department of Molecular, Cellular, & Developmental Biology, University of Michigan, Ann Arbor, MI; 2) Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI.

708B
Recapitulating the evolutionary origin of ventral furrow formation. Silvia Urbansky, Paula Gonzalez, Steffen Lemke. Centre for Organismal Studies, Universitaet Heidelberg, Heidelberg, Germany.

709C
Exploring the molecular basis of insect wing evolution: a transcriptomic approach. David Linz, Yoshinori Tomoyasu. Zoology Department, Miami University, Oxford, OH.

710A
The shared genetic architecture of sleep and reproductive fitness in Drosophila melanogaster. A. Lobell, R. Kaspari, S. Harbison. Laboratory of Systems Genetics, National Heart, Lung & Blood Institute, Bethesda, MD.

711B
The natural symbiosis of Drosophila and yeasts in a vineyard. Allison Quan1, Kelly Schiabor1, Michael Eisen1,2. 1) Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA; 2) Howard Hughes Medical Institute, Berkeley, CA.

712C
Next-generation approaches to understanding the evolution of insect germline. Honghu Quan, Jeremy Lynch. University of Illinois at Chicago, Chicago, IL.

713A
Convergent evolution of female-limited color dimorphism in Drosophila. Amir Yassin1, Héloïse Bastide1, Justin Lack1, Jean David2, John Pool1. 1) Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI; 2) Laboratoire Evolution, Génomes et Spéciation, CNRS, Gif-sur-Yvette, France.

714B
Scanning Electron Microscopy of immature stages of Drosophila willistoni group. Rebeca Zanini1,2, Maríndia Deprá1,2, Vera Valente1,2. 1) Programa de Pós-Graduação em Biologia Animal - UFRGS, Porto Alegre, Brazil; 2) Laboratório de Drosophila, Departamento de Genética - UFRGS, Porto Alegre, Brazil.

715C
Effects of space missions on stability of Drosophila estimated by fluctuating asymmetry. Denis V. Anisiforov, Alex M. Kulikov, Oleg E. Lazebny. Russian Academy of Sciences, Koltzov INSTITUTE of DEVELOPMENTAL BIOLOGY, Moscow, Russian Federation.

716A
Sexual traits as a measure of evolutionary divergence in Drosophila nasuta subgroup members. Shruthi Balachandra1, Kristipati Ravi Ram2, Saraf R. Ramesh1. 1) Department of Studies in Zoology, University of Mysore, Mysore, Karnataka, India; 2) Embryotoxicology, CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India.

717B
Mapping the genetic basis of wing rowing evolution in Drosophila yakuba and Drosophila santomea male courtship. Jessica Cande1, Gordon Berman2, Ugne Klibaite2, Benjamin Prud'homme3, Nicolas Gompel4, Joshua Shaevitz2, David Stern1. 1) Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA; 2) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ; 3) Institut de Biologie du Développement de Marseille-Luminy (IBDML), Marseille, France; 4) Ludwig Maximilian University, Munich, Germany.

718C
A genetic understanding of courtship song variation between Drososophila simulans and Drosophila mauritiana. Yun Ding, Augusto Berrocal, David Stern. Janelia Research Campus, HHMI, Ashburn, VA.

719A
Genetic determinants of RNA-editing levels of ADAR targets in Drosophila melanogaster. Yerbol Kurmangaliyev, Sammi Ali, Sergey Nuzhdin. Molecular and Computational Biology, University of Southern California, Los Angeles, CA.

720B
Complex genetic interactions characterize the rapid evolution of genital morphology in Drosophila. Stephen R. Frazee, Jessica Pagan, Brittany N. Smith, John P. Masly. Department of Biology, University of Oklahoma, Norman, OK.

721C
Genetic basis of genital evolution between Drosophila species. Maria D. S. Nunes1, Kentaro Tanaka1, Corinna Hopfen3, Matthew Herbert1, Christian Schloetterer2, John P. Masly4, Alistair P. McGregor1. 1) Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom; 2) Institute of Population Genetics, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria; 3) Max Planck Institute for Biology of Ageing, Cologne, Germany; 4) Department of Biology, University of Oklahoma, OK, US.

722A
Sexually dimorphic pigmentation in Drosophila: lineage sorting and independent comparisons in multiple phenotypic transitions. Sarah Signor1, Artyom Kopp2. 1) Molecular and Computational Biology, University of Southern California, Davis, CA; 2) Evolution and Ecology, University of California, Davis.

723B
Partial behavioral isolation between two divergent populations of Drosophila melanogaster and their mating potential with other wild type populations. Phillip Barnes, Phoebe Winn, Lucy Drayson, Melanie Argueta. Dept Biol, Connecticut Col, New London, CT.

724C
Identifying hybrid incompatibility genes in D. Pseudoobscura subspecies. Alyssa Black, Nitin Phadnis. Biology, University of Utah, Salt Lake City, UT.

725A
Presence of transposable elements is associated with the expression of hybrid incompatibility in Drosophila virilis-D. lummei hybrids with and without Penelope elements. Dean Castillo, Leonie Moyle. Biology Dept, Indiana University, Bloomington, IN.

726B
Two loci contribute to a male pheromonal polymorphism associated with ecological adaption in African D. melanogaster populations. Henry Chung1, John E. Pool2, David W. Loehlin1, Jocelyn G. Millar3, Sean B. Carroll1. 1) Laboratory of Molecular Biology, University of Wisconsin, Madison, WI; 2) Department of Genetics, University of Wisconsin, Madison, WI; 3) Department of Entomology, University of California, Riverside, CA.

727C
Revealing the Secrets of the X: Genomewide Expression Profiles in Drosophila. Danielle Herrig1, Ana Llopart1,2. 1) Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA; 2) Biology Department, University of Iowa, Iowa City, IA.

728A
Characterizing postzygotic isolation in the Drosophila nasuta species complex. Wynn Meyer, Doris Bachtrog. Integrative Biology, University of California, Berkeley, Berkeley, CA.

729B
Gene Expression Patterns Associated with Sex-Specific Pheromone Production in Drosophila simulans and D. sechellia. D. R. Swartzlander1, Jennifer M. Gleason2. 1) Molecular Biosciences, Univ of KS, Lawrence, KS; 2) Ecology and Evolutionary Biology, Univ of KS, Lawrence, KS.

730C
Phylogenetic Analysis of Abdominal Pigmentation Evolution in the Drosophila montium Subgroup. Mubasher Ahmed, Paul Ginsberg, Chenling Antelope, Emily Delaney, Michael Turelli, Artyom Kopp. Department of Evolution and Ecology, University of California, Davis.

731A
Ectoparasitic mites and their Drosophila hosts. Alejandra Pérez-Leaños1, Mariana Ramirez-Loustalot-Laclette1, Therese Markow1,2. 1) LANGEBIO, CINVESTAV , Irapuato, Guanajuato, México; 2) University of California, San Diego.

732B
Genes caught in the crossfire: Understanding the tension between genome defense and genomic "autoimmunity" by piRNAs. Alexandra Erwin, Michelle Wickersheim, Justin Blumenstiel. University of Kansas, Lawrence, KS.

733C
Molecular evolutionary analyses reveals positive selection in the rapidly-evolving synaptonemal complex in the Drosophila genus. Lucas Hemmer, Justin Blumenstiel. Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS.

734A
Soft shoulders ahead: spurious signatures of soft and partial selective sweeps result from linked hard sweeps. Daniel Schrider1, Fábio Mendes2, Matthew Hahn2, Andrew Kern1. 1) Department of Genetics, Rutgers University, Piscataway, NJ; 2) Department of Biology, Indiana University, Bloomington, IN.

735B
Ecological adaptations for pigmentation in two colonizing Drosophila species: evidence for genotype-environment interaction. Veer Bhan. Department of Biotechnology, UIET, M D University, Rohtak, Haryana, India.

736C
The hydrogen isotopes 2H/1H involvement across different generations of Drosophila: patterns of molecular variation on w1118 strain. Gallia Butnaru, Sorina Popescu, Ioan Sarac. Banat Univ Agricultural Sci. "Regele Mihai I al Romaniei" Timisoara, Romania, Box 136, PO1.

737A
Longitudinal ethanol withdrawal and ethanol intake in outbred Drosophila melanogaster raised with and without ethanol-containing food. Kairsten A. Fay1, Alexander Gearhart1, Megan Garlapow1, Trudy Mackay1,2. 1) Biological Sciences, program in genetics, North Carolina State University, Raleigh, NC; 2) W. M. keck Center for Behavioral Biology, North Carolina State University, Raleigh, 27695.

738B
The genetic basis of phenotypic plasticity in the Drosophila energy budget. Elizabeth G. King, Vince S. Farinella, Anna Perinchery, Patrick D. Stanley. Division of Biological Sciences, University of Missouri, Columbia, MO.

739C
Mitochondrial - nuclear interactions mediate genotype-specific transcriptional responses to hypoxia in Drosophila. Jim Mossman, Yawei Ge, Nan Li, Zhijin Wu, David Rand. Ecology and Evolutionary Biology, Brown University, Providence, RI.

740A
Enhanced sleep is an evolutionarily adaptive response to starvation stress in Drosophila. Melissa E. Slocumb1, Josue M. Regalado1, Masato Yoshizawa3, Greg G. Neely4, Pavel Masek1, Allen G. Gibbs2, Alex C. Keene1. 1) Biology, University of Nevada, Reno, Reno, NV; 2) School of Science, University of Nevada, Las Vegas, Las Vegas, NV; 3) Biology, University of Hawai'i, Manoa; 4) Neuroscience Division, Garvan Institution, Sydney Austraulia.

741B
Ontogeny of metabolic rate and mitochondrial physiology in Drosophila. Cole Julick, Omera Matoo, Kristi Montooth. School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE.

742C
The investigation of biological effects of Methotrexate and Aminopterin on example of Drosophila melanogaster. O. Antosyuk, A. Marvin, N. Marvin, S. Shihova. Biological sciences, Ural State University, Yekaterinburg, Russian Federation.

743A
Genome-wide test of a life-history model underlying seasonal adaptation in Drosophila. Alan Bergland1, Subhash Rajpurohit2, Dmitri Petrov1, Paul Schmidt2. 1) Dept. of Biology, Stanford University, Stanford, CA; 2) Dept. of Biology, University of Pennsylvania, Philadelphia, PA.

744B
Sperm transfer and the enigma of copulation duration in Drosophila melanogaster. Cynthia Castro. LANGEBIO, CINVESTAV Irapuato, Irapuato, Guanajuato, Mexico.

745C
Wing size evolution in high-altitude Ethiopian Drosophila melanogaster: developmental decanalization and the genetics of a complex adaptive trait. Justin Lack, Amir Yassin, John Pool. Genetics, University of Wisconsin-Madison, Madison, WI.

746A
Mutational paths to repeated evolution of Alcohol Dehydrogenase gene function. David Loehlin, Sean Carroll. Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI.

747B
Functional evolution of alcohol dehydrogeanse in Drosophila. Mohammad Siddiq, Joe Thornton. Ecology and Evolution, University of Chicago, Chicago, IL.

748C
The genomics of parthenogenesis: Insight from the facultative parthenogenetic fly Drosophila mercatorum. Craig Stanley1,6, Danny Miller2,3, Therese Markow4,5, R. Scott Hawley2,3, Rob Kulathinal1,6. 1) Department of Biology, Temple University, Philadelphia, PA, USA; 2) Stowers Institute for Medical Research, Kansas City, MO, USA; 3) Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA; 4) Laboratorio Nacional de Genomica de la Biodiversidad, CINVESTAV, Irapuato, Guanajuato CP, Mexico; 5) Univserity of California San Diego, San Diego California, La Jolla, CA, USA; 6) Center for Computational Genetics and Genomics, Temple University, Philadelphia, PA, USA.

749A
The genetic basis of a female-limited pigmentation polymorphism in the Drosophila montium subgroup. Emily K. Delaney1, Thaddeus Seher1, Nicholas Appleton2, Steve Chenoweth2, Artyom Kopp1. 1) Evolution and Ecology, University of California-Davis, Davis, CA; 2) University of Queensland, Australia.

750B
Quantitative genetics of food intake in Drosophila melanogaster. Megan Garlapow, Trudy Mackay. Department of Biological Sciences, Program in Genetics and W. M Keck Center for Behavioral Biology, NC State University, Raleigh, NC 27695-7614.

751C
Using artificial selection to validate single nucleotide polymorphisms affecting sleep duration in D. melanogaster. Susan Harbison1, Yazmin Serrano Negron1, Nancy Hansen2, Amanda Lobell1. 1) Laboratory of Systems Genetics, NHLBI, Bethesda, MD; 2) The NISC Consortium, NHGRI, Bethesda, MD.

752A
A Hidden Markov Model for testing GWAS association by the aggregate signal of multiple linked SNPs. Ziyad Knio, Keegan Kelsey, Andrew Clark. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.

753B
Investigating the female’s role in sperm competition in Drosophila melanogaster. Simone White, Jessica Sitnik, Clement Chow, Andrew Clark, Mariana Wolfner. Molecular Biology & Genetics, Cornell University, Ithaca, NY.

754C
Drosophila visual receptor diversity through the lens of the i5K project. Markus Friedrich1, Jeffery Jones2, Megan Porter3, Daniel Hughes4, Shwetha Murali4, Kim Worley4, Richard Gibbs4, Stephen Richards4. 1) Dept Biological Sciences, Wayne State University, Detroit, MI; 2) UC Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH; 3) Department of Biology, University of South Dakota, Vermillion, SD; 4) Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.

755A
Investigating sexual conflict in the facultative parthenogenetic species, Drosophila mercatorum. Nichole Rigby, Rob Kulathinal. Department of Biology, Temple University, Philadelphia, PA.

756B
The importance of forest patches to the maintenance of genetic diversity of Drosophila in the Brazilian pampas. Vera Valente, Jean Lucas Poppe, Hermes José Schmitz. GENETICA, UFRGS, Porto Alegre, Porto Alegre RS, Brazil.

757C
Detecting meiotic drive by whole-genome sequencing of pooled embryos. Kevin Wei, Shuqing Ji, Jimin Lee, Deanna Lin, Chandramouli Rathnam, Andrew Clark, Daniel Barbash. Molecular Biology and Genetics, Cornell, Ithaca, NY.

Pattern Formation


758A
Localised control of Torso receptor tyrosine kinase activation in Drosophila terminal patterning. Travis Johnson1,2, Michelle Henstridge1,2, James Whisstock1,3, Coral Warr2. 1) Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia; 2) School of Biological Sciences, Monash University, Clayton, Victoria, Australia; 3) Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.

759B
Maternal lolal regulates Dpp and Screw transcription in dorsal/ventral patterning. Janine C. Quijano1, Osamu Shimmi2, Theodor Haerry3, Stuart Newfeld1. 1) Arizona State University, Tempe, AZ; 2) Institute of Biotechnology, University of Helsinki, Helsinki Finland; 3) Center for Molecular Biology & Biotechnology, Florida Atlantic University, Boca Raton, FL.

760C
A gene expression approach to identify novel posterior signaling genes. Julia Wittes, Trudi Schüpbach. Department of Molecular Biology, Princeton University, Princeton, NJ.

761A
Dpp Signaling Directs Nuclear Migration to its Source in the Blastoderm Embryo. Yongqiang Xue, Juan Chahda, Claudia Mizutani. Biology Department, Case western Reserve University, Cleveland, OH.

762B
A dual-function motif explains dynamic positional specification in Drosophila melanogaster. Berta Verd1, Anton Crombach1, Nick Monk2, Johannes Jaeger1. 1) Centre for Genomic Regulation (CRG). C/ Dr. Aiguader 88, PRBB Building, 08003 Barcelona, Spain; 2) School of Mathematics and Statistics and Centre for Membrane Interactions and Dynamics. University of Sheffield. Hicks Building, Sheffield, S3 7RH, UK.

763C
Pax6 and the Polycomb Repressive Complex Promote Eye Formation by Repressing Alternate Non-Ocular Fates. Jinjin Zhu, Justin Kumar. Department of Biology, Indiana University Bloomington, Bloomington, IN.

764A
Eyeless Participates in the Establishment and Maintenance of Dorsal-Ventral Patterning Within the Developing Eye. Luke R. Baker, Bonnie M. Weasner, Justin P. Kumar. Dept Biol, Indiana University, Bloomington, IN.

765B
Putting the Teashirt Family of Genes into context: Their role in Eye Development and Tissue Fate Segregation. Sneha Palliyil and Justin P. Kumar, Department of Biology, Indiana University. Sneha Palliyil, Justin Kumar. Bio Dept, IU, Bloomington.

766C
A screen for Notch-target enhancers that integrate homeotic factors and other signaling pathways. Elizabeth Stroebele, Timothy Fuqua, Ana Castro, Christian Noblett, Albert Erives. Department of Biology, University of Iowa, Iowa City, IA.

767A
Combgap and Eyes absent balance regional identities during retinal development. Trevor Davis, Ilaria Rebay. Committee on Development, Regeneration, and Stem Cell Biology, University of Chicago, Chicago, IL.

768B
Role of dve in patterning and growth during eye development. N. Gogia1, A. Singh1,2,3. 1) DEPARTMENT OF BIOLOGY, UNIVERSITY OF DAYTON, DAYTON, OH; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton, OH; 3) Centre for Tissue Regeneration & Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

769C
Defining the role of Glass, a zinc finger transcription factor, in photoreceptor differentiation. Carolyn A. Morrison, Jessica E. Treisman. Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY.

770A
A screen for negative regulators of damage-induced notum-to-wing transdetermination. Melanie I. Worley, Larissa Alexander, Iswar K. Hariharan. Molec & Cell Biol, Univ California, Berkeley, Berkeley, CA.

771B
A self-regulatory BMP signaling circuit drives sequential serosa and amnion specification in the scuttle fly Megaselia abdita. Chun Wai Kwan, Urs Schmidt-Ott. Organismal Biology and Anatomy, University of Chicago, Chicago, IL.

772C
DV polarity establishment in the beetle Tribolium as revealed by RNAseq. Jeremy Lynch1, Siegfried Roth2. 1) Biological Sciences, University of Illinois at Chicago, Chicago, IL; 2) Institute for Developmental Biology University of Cologne Cologne, Germany.

773A
Genome-wide measurement of Bicoid binding states at single positions along the AP axis. Colleen E. Hannon, Shelby A. Blythe, Eric F. Wieschaus. Molecular Biology, Princeton University/HHMI, Princeton, NJ.

774B
Background subtraction via nuclear Cactus increases the signal-to-noise ratio of the Dorsal gradient. Michael O'Connell, Gregory Reeves. Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC.

775C
A mathematical approach to predicting the mechanisms underlying the evolution of eggshell patterning by the TGF-alpha-like ligand Gurken. Nicole Pope1, Nastassia Pouradier Duteil1, Matthew Niepielko1, Benedetto Picolli1, Nir Yakoby1,2. 1) Computational and Integrative Biology, Rutgers University, Camden, NJ; 2) Biology Department, Rutgers University, Camden, NJ.

776A
From cells to pattern: A NetLogo model of Notch signaling. Elaine Reynolds1, Ryan Himmelwright1, Christopher Sanginiti1, Jeffrey Pfaffmann2. 1) Neuroscience Program, Lafayette Col, Easton, PA; 2) Computer Science Dept, Lafayette Col, Easton PA.

777B
Evolution in silico of genes with multiple regulatory modules: gap genes vs pair-rule genes. Alexander Spirov1, David Holloway2. 1) Cntr Excellence in Wireless & Information Technol, State Univ New York, Stony Brook, NY; 2) Mathematics Department, British Columbia Institute of Technology, Burnaby, B.C., Canada.

778C
Robust patterning of the dorsal-ventral axis in the Drosophila melanogaster embryo. Sophia Carrell, Alexander Thomas, Jeramey Friedman, Gregory Reeves. Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC.

779A
The Instructive Epidermis: The Role of JNK Organizing Centers. Molly Jud, Anthea Letsou. Human Genetics, University of Utah, Salt Lake City, UT.

780B
Taranis buffers regenerating tissue from fate changes induced by the wound response in Drosophila. Keaton Schuster, Rachel Smith-Bolton. Cell & Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL.

Regulation of Gene Expression


781C
Identification of the specific de2f1 transcript that is required for the formation of imaginal discs. Mary-Rose Bradley-Gill, Nam-Sung Moon. Biology, McGill, Montreal, Quebec, Canada.

782A
Genome wide identification of Smad2 target genes mediating TGFβ function during Drosophila imaginal development. Covadonga F. Hevia, Jose F. de Celis. Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.

783B
The triia-s-2 gene encodes a male germ-line specific homolog of the small subunit of the TFIIA General Transcription Factor. Mark Hiller, Ashley Cowan, Leah Hirschman, Maura Coughlin. Dept of Biological Science, Goucher College, Baltimore, MD.

784C
The dosage compensation protein CLAMP is involved in non sex-specific histone transcript misprocessing. Leila Rieder1, Anna Zeidman1, Katy Curry2, Bob Duronio2, Erica Larschan1. 1) Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI; 2) Department of Genetics, University of North Carolina, Chapel Hill.

785A
Molecular Genetic Mechanism for Development of The Small Intestine in Drosophila Hindgut. Sarder Uddin1, Ryutaro Murakami2. 1) Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, Bangladesh; 2) Graduate School of Medicine, Yamaguchi University, Japan.

786B
A Role for Valois and Piwi in the Maternal to Zygotic Transition. Shelby Blythe, Eric Wieschaus. Molecular Biology, Princeton University/HHMI, Princeton, NJ.

787C
The role of SAGA subunits for its genome-wide recruitment to chromatin. G. Dialynas, S. Abmayr, A. Peak, A. Perera, C. Seidel, J. Workman. Stowers Institute For Medical Research, Kansas City , MO.

788A
Notch alleles encoding variant polyQ tracts disrupt anterior-posterior patterning in Drosophila embryos. Albert Erives, Clinton Rice, Danielle Beekman, Rachel Harney, Megan Bowman, Sarah Coe, Liping Liu, Megan Tobias, Mark Vaske. Department of Biology, University of Iowa, Iowa City, IA.

789B
COMPASS-like coactivator complex regulation of the bantam miRNA enhancer. David J. Ford1, Claudia B. Zraly2, John S. Perez2, Andrew K. Dingwall1,2,3. 1) Molecular Biology/Biochemistry Program; 2) Oncology Research Institute; 3) Department of Pathology. Loyola University Chicago-Stritch School of Medicine, Maywood, IL.

790C
Akirin-Mediated Gene Regulation during cardiac development. Austin M. Howard, Scott J. Nowak. Department of Biology and Physics, Kennesaw State University, Kennesaw, GA.

791A
The transcriptional network of rhabdomeric photoreceptor differentiation. Xulong Liang, Simpla Mahato, Savanna Brewski, Andrew Zelhof. Biology, Indiana University Bloomington, Bloomington, IN 47405, IN.

792B
Regulation of mitochondrial function by the transcriptional regulator KDM5. Xingyin Liu, Julie Secombe. Genetics, Albert Einstein Med College, Bronx, NY.

793C
Mapping the transcriptional network regulated by the conserved factor Grainyhead during embryonic development. Markus Nevil, Eliana Bondra, Melissa Harrison. Department of Biomolecular Chemistry, University of Wisconsin - Madison, Madison, WI.

794A
Klumpfuss/Wilms’ tumor suppressor controls stochastic gene expression in the fly eye. Caitlin C. Anderson1, Ben Mormann2, Daniel Vasiliauskas2, James Taylor1, Robert Johnston1. 1) Biology, Johns Hopkins University, Baltimore, MD; 2) Biology, New York University, New York, NY.

795B
Identification of the Lola Transcriptional Targets during Embryonic Development. Edwin Chaharbakhshi, Christopher Lenkeit, Jennifer Jemc, Safiyah Elahi. Loyola University Chicago, Chicago, IL.

796C
Identification of Transcriptional Targets of Longitudinals Lacking. Christopher P. Lenkeit, Jennifer Jemc, Edwin Chaharbahkshi. Loyola University Chicago, Chicago, IL.

797A
Instability element of retinoblastoma protein Rbf1 regulates apoptotic and developmental phenotypes. Rima Mouawad1, Jared Elenbaas2, Yiliang Wei2, Sandhya Payankaulam2, David Arnosti1,2. 1) Cell and Molecular Biology, Michigan State University, East lansing, MI; 2) Biochemistry and Molecular Biology, Michigan State University, East lansing, MI.

798B
Transcriptional regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein (Rbf1) in Drosophila melanogaster. Sandhya Payankaulam1, Kelvin Yeung2, Helen McNeill2, William Henry1, David Arnosti1. 1) Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48823, USA East Lansing, MI; 2) Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 881, Toronto, Ontario M5G1X5, Canada.

799C
Genome-wide effects of retinoblastoma family proteins on gene expression and chromatin state in Drosophila melanogaster development. Irina Pushel1, Sandhya Payankaulam1, Rima Mouawad2, David Arnosti1,2. 1) Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI; 2) Cellular & Molecular Biology, Michigan State University, East Lansing, MI.

800A
Identification of potential Stat92E target genes that affect hematopoietic output in Drosophila. Aditi Vyas, Soichi Tanda. Biological Sciences, Ohio University, Athens, OH.

801B
Groucho and Rpd3-Caf1 regulate EGFR signaling by repressing rhomboid expression during Drosophila development. T. Zhang, W. Du. University of Chicago, Chicago, IL.

802C
A novel 899bp enhancer regulates Vestigial expression in the myoblast population of the notal region of the wing disc. Elizabeth Clarke, Tyanna Lovato, Richard Cripps. Biology, University of New Mexico, Albuquerque, NM.

803A
Identification of an evolutionarily-conserved CRM that recapitulates Scr expression in the primordia of the T-row and sex comb bristles of T1 leg. Ece Eksi1, Christopher McCallough1, Artyom Kopp2, Olga Barmina2, Teresa Orenic1. 1) Biological Sciences, University of Illinois at Chicago, Chicago, IL; 2) Department of Evolution and Ecology, University of California, Davis.

804B
REDfly: The Regulatory Element Database for Drosophila. Marc S. Halfon1,2,3,4,5, Steven M. Gallo4,6. 1) Department of Biochemistry, University at Buffalo, Buffalo, NY; 2) Department of Biological Sciences, University at Buffalo, Buffalo, NY; 3) Department of Biomedical Informatics, University at Buffalo, Buffalo, NY; 4) New York Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY; 5) Department of Molecular and Cellular Biology and Program in Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY; 6) Center for Computational Research, University at Buffalo, Buffalo, NY.

805C
Do regulatory interactions that result in repression of transcription elongation dominantly interfere with activation by other enhancers at the same promoter? Michael Higgins1, Saiyu Hang2, Haiyue Zhang3, John Peter Gergen4. 1) Graduate Program in Biochemistry and Structural Biology, Stony Brook University, Stony Brook, NY; 2) Postdoctoral Fellow, Boston Children's Hospital, Boston, MA; 3) Nanjing University, Nanjing, China; 4) Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY.

806A
Expression of eyes absent in the developing retina is controlled by a single enhancer composed of 3 separate cis-regulatory elements. Bonnie M. Weasner, Brandon P. Weasner, Justin P. Kumar. Dept Biol, Indiana Univ, Bloomington, IN.

807B
Patched together: cis-regulatory control of the Hedgehog response. David Lorberbaum1,2, Andrea Ramos2, Scott Barolo1,2. 1) Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI; 2) Cell and Developmental Biology, University of Michigan, Ann Arbor, MI.

808C
A comparison of transvection effects at the Men and Tpi loci in Drosophila melanogaster. Patrick D. O'Donnell, Thomas J. S. Merritt. Laurentian University, Sudbury, Canada.

809A
Control of transcription dynamics by shadow enhancers of Kruppel. Clarissa Scholes1,2, Alvaro Sanchez3, Angela DePace1. 1) Graduate Program in Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138; 2) Department of Systems Biology, Harvard Medical School, Boston, MA 02115; 3) Rowland Institute at Harvard, Cambridge, MA 02142.

810B
Genome wide identification of cis-regulatory elements from small cell population: Insights from the drosophila cardiac tube. Denis Seyres1, Yad Ghavi-Helm2, Celine Guichard3, Magali Torres1, Charles Girardot2, Eileen Furlong2, Laurent Perrin1. 1) TAGC U1090, Marseille, cedex 9, France; 2) European Molecular Biology Laboratory (EMBL), MeyerhofstraBe 1, 69117 Heidelberg, Germany; 3) Child and hess institute [Mount Sinai], 1468 madisson avenue, New York, USA.

811C
Enhancers by design. Ben Vincent1, Meghan Bragdon1, Garth Ilsley2, Zeba Wunderlich1, Javier Estrada1, Angela DePace1. 1) Department of Systems Biology, Harvard Medical School, Boston, MA; 2) Okinawa Institute of Science and Technology Graduate University, Japan.

812A
A massively parallel reverse genetic screen for early embryonic patterning mutants. Peter Combs1, Michael Eisen2,3. 1) Biophysics Grad Group, UC Berkeley, Berkeley, CA; 2) Department of Molecular and Cell Biology, UC Berkeley, CA; 3) Howard Hughes Medical Institute, UC Berkeley, CA.

813B
A transcriptomic approach to sex determination and the maternal-to-zygotic transition in Nasonia. Deanna Arsala, Jeremy Lynch. Biological Sciences, University of Illinois at Chicago, Chicago, IL.

814C
Probing Structure/Function Relationships in the gurken 5’ UTR. Phillip A. Frankino1, Jacob A. Merle1, Ramses Rodriguez1, David DiPalma1, Allison H. H. Martin1, Matthew A. Fountain2, Scott B. Ferguson1. 1) Biology Department, Fredonia, NY; 2) Biochemistry and Chemistry Department, Fredonia, NY.

815A
Regulation of expression of RNP-4F splicing assembly factor in Drosophila melanogaster. Sushmita Ghosh, Lindsey Abraham, Jack Vaughn. Biology, Program in Cell Molecular and Structural Biology, Miami University, Oxford, OH.

816B
Measuring the impact of microRNAs on in vivo gene expression at single cell resolution: Can microRNAs suppress noise in gene expression? R. Giri, R. Carthew. Department of Molecular Biosciences, Northwestern University, Evanston, IL.

817C
Identifying Novel Drosophila Mutations That Affect gurken Translation in spindle B Mutants. John Hasper, Breanna Meyers, Malachi Blundon, Austie Lawrence, Scott Ferguson. Biology, SUNY Fredonia, Fredonia, NY.

818A
A heterodimer-based regulatory role for Drosophila truncated dADAR protein isoform function. Fatemeh Kohram, Sushmita Ghosh, Jack Vaughn. Biology, Program in Cell Molecular and Structural Biology, Miami University, Oxford, OH.

819B
The Wright stuff: reinventing path analysis reveals novel components of the sex determination hierarchy in D. melanogaster. Justin Fear1,2, Michelle Arbeitman3, Matthew Salomon4, Justin Dalton3, John Tower4, Sergey Nuzhdin4, Lauren McIntyre2. 1) Genetics & Genomics, Univ Florida, Gainesville, FL; 2) Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL; 3) Department of Biomedical Sciences, Florida State University, Tallahassee; 4) Molecular and Computational Biology, University of Southern California, Los Angeles, CA.

820C
Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data. Alan L. Hutchison1,2,3, Mark Maienschein-Cline4, Andrew H. Chiang3, S. M. Ali Tabei3, Herman Gudjonson2,3, Neil Bahroos4, Ravi Allada5, Aaron R. Dinner2,3,6. 1) Medical Scientist Training Program, University of Chicago, Chicago, IL; 2) Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL; 3) James Franck Institute, University of Chicago, Chicago, IL; 4) Center for Research Informatics, University of Illinois at Chicago, Chicago, IL; 5) Department of Neurobiology, Northwestern University, Evanston, IL; 6) Department of Chemistry, University of Chicago, Chicago, IL.

821A
Using structural equation modeling to detect regulatory interactions in the Inr/Tor pathway. Felicia New1, Michelle Arbeitman2, Nicole Newell2, Justin Fear1, Lauren McIntyre1. 1) Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL; 2) Department of Biomedical Sciences, Florida State University, Tallahassee, FL.

822B
An imaging-based approach to quantitative in vivo analysis of gene regulatory networks. Radoslaw Ejsmont, Bassem Hassan. VIB Center for the Biology of Disease, VIB, Leuven, Belgium.

823C
Metabolic gene linkages to long non-coding RNAs and allele-specific expression. Alison Gerken1, Justin Fear1,2, Sergey Nuzhdin3, Lauren McIntyre1. 1) Molecular Genetics and Microbiology, University of Florida, Gainesville, FL; 2) Genetics and Genomics Graduate Program, University of Florida, Gainesville, FL; 3) Molecular and Computational Biology, University of Southern California, Los Angeles, CA.

824A
Caudal drives Themira putris even-skipped stripe 2 expression in Drosophila melanogaster ? Ah-Ram Kim1, Pengyao Jiang2, Michael Ludwig2,3, John Reinitz2,3,4,5. 1) MIT Computational Biology Group, Massachusetts Institute of Technology, Cambridge, MA; 2) Ecology & Evolution, University of Chicago, Chicago, IL; 3) Institute for Genomics & Systems Biology, University of Chicago, Chicago, IL; 4) Department of Statistics, University of Chicago, IL; 5) Department of Molecular Genetics and Cell Biology, University of Chicago, IL.

825B
Dissecting Miscadestral pigmentation (Mcp) in the Abdominal-B (Abd-B) locus: establishment of a Recombination Mediated Cassette Exchange (RMCE) platform using the CRISPR/Cas9 method. Mario Metzler1,2, Martin Müller1, Markus Affolter1. 1) Biozentrum, Zellbiologie, Universität Basel, Basel, Switzerland; 2) Fellowships for Excellence, Biozentrum, Universität Basel, Basel, Switzerland.

826C
Evolutionary rates of redundant enhancers. Anne Sonnenschein, Ian Dworkin, David Arnosti. Michigan State University, East Lansing, MI.

827A
Determining the role of 3D nuclear architecture in stochastic gene expression. Kayla C. Viets, Robert J. Johnston Jr.. Department of Biology, The Johns Hopkins University, Baltimore, MD.

828B
Transcriptional regulation of the Insulin Receptor gene in Drosophila melanogaster. Y. Wei, R. Gokhale, W. Henry, D. Arnosti. Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI.

829C
Mechanism of repo Regulation in Glial Cells of Drosophila melanogaster. Jamie L. Wood, Bradley W. Jones. Dept. of Biology, University of Mississippi, University, MS.

830A
The cis-regulatory logic controlling Defective proventriculus (dve), a critical regulator of rhodopsin expression in the Drosophila eye. Jenny Yan1, Gregory Goldberg2, Robert Johnston1. 1) Biology, Johns Hopkins University, Baltimore, MD; 2) Immunology, Virology and Microbiology, The Rockerfeller University, New York, NY.

831B
Flexibility and Constraints of Hox complex configuration on Drosophila cis-regulatory modules. Arya Zandvakili, Juli Uhl, Ian Campbell, Yi Kuang, Brian Gebelein. Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

832C
Uncovering mechanisms that regulate miRNA expression. Victoria Church, Sigal Kellman-Pressman, Richard Carthew. Northwestern University, Evanston, IL.

833A
An in vitro study of Zelda as a pioneer factor. H. Crimmins, C. Rushlow, N. Kirov. Department of Biology, New York University, New York, NY.

834B
Hypergravity-induced transcriptome profiling in Drosophila pupae via deep mRNA sequencing. Ravikumar Hosamani1, Shannon Hateley2, Lior Pachter2, Sharmila Bhattacharya1. 1) Space Bioscience Division, NASA Ames Research Center, Mountain View, CA; 2) Department of Molecular and Cell Biology, University of California, Berkeley.

835C
Gene expression analysis of known CASK interacting proteins in CASK knockout fly lines. Alexander Kneubehl, Rachel Boody, Lauren Guerriero, Jamie Sanford. Ohio Northern University, 525 S. Main Street, Ada, OH 45810.

836A
Regulation of the Master Regulatory Helix-Loop-Helix Proteins in Drosophila. Ke Li, Nicholas Baker. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY.

837B
miR-184 regulates the level of Gliotactin, a tricellular marker, through BMP signaling. Zohreh Sharifkhodaei1, Mary Gilbert1, Mojgan Padash-Barmchi1, Gayathri Samarasekera1, Tudor A. Fulga2, David Van Vactor2, Vanessa Auld1. 1) Department of Zoology, University of British Columbia, Vancouver, Canada; 2) Department of Cell Biology, Harvard Medical School, Boston MA, USA.

838C
Stochastic spineless expression in natural Drosophila variants. Cyrus Zhou1, Annie Cho1, Haziq Siddiqi1, India Reiss1, Caitlin Anderson1, Cameron Avelis2, Elijah Roberts2, Robert Johnston1. 1) Department of Biology, Johns Hopkins, Baltimore, MD; 2) Department of Biophysics, Johns Hopkins, Baltimore, MD.

Chromatin and Epigenetics


839A
How does Ago2 contribute to dosage compensation in Drosophila melanogaster? Nikita Deshpande, Victoria Meller. Wayne State University, Detroit, MI.

840B
Identification and Characterization of a Novel Regulator of Interphase Chromosome Structure. Michael Nash, Nina Hann, Barbara Fasulo, Stephanie McClymont, John Tamkun. Molecular, Cell, & Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA.

841C
Zelda facilitates chromatin accessibility during the earliest stages of development. Katharine Schulz1, Eliana Bondra1, Jason Lieb2, Tommy Kaplan3, Daniel McKay4, Melissa Harrison1. 1) Biomolecular Chemistry, University of Wisconsin Madison, Madison, WI; 2) Department of Human Genetics, University of Chicago, Chicago, IL; 3) School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel; 4) Department of Biology, The University of North Carolina, Chapel Hill, NC.

842A
Do the physiological effects of exercise depend on genetic background. Louis Watanabe, Nicole Riddle. Biology, University of Alabama at Birmingham, Birmingham, AL.

843B
Precise induction of ectopic centromeres in Drosophila as a model for neocentromere formation. Jason Palladino, Barbara Mellone. Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT.

844C
The impact of ectopic piRNAs on hetrochromatin assembly at a PEV reporter site. Kiri Ulmschneider, Sarah C. R. Elgin. Dept Biol, Washington University, St. Louis, MO.

845A
New Evidence for Piwi Association with Specific Sites in the Drosophila Genome. N. Neuenkirchen, N. Liu, M. Zhong, H. Lin. Stem Cell Center and Department of Cell Biology, Yale University, New Haven, CT.

846B
Chromatin remodelers, nucleoplasm compartment and proteinopathies. Luca Lo Piccolo, Rosa Bonaccorso, Antonia Maria Rita Ingrassia, Maria Cristina Onorati. STEBICEF Dept, viale delle Scienze Edificio 16, Universita’ degli Studi di Palermo, 90128 Palermo.

847C
The effects of knocking down the expression of TnaA, a trithorax group protein with a putative SUMO E3 ligase function in Drosophila melanogaster. Marco Rosales-Vega, Zoraya Palomero, Mario Zurita, Martha Vázquez. Univ. Nacional Autónoma de México. Cuernavaca, Morelos. México.

848A
The newly identified HMG-box proteins tHMG-1 and tHMG-2 interact during chromatin remodeling in Drosophila spermatogenesis. Silke Rothenbusch, Stefanie M. K. Gärtner, Ina Theofel, Christina Rathke, Renate Renkawitz-Pohl. Philipps University, Marburg, Hessen, Germany.

849B
The dAdd1 proteins: The Drosophila orthologs of the amino-terminus of the ATRX vertebrate protein. Viviana Valadez1, Brenda López1, Silvia Meyer1, Benjamín Hernández1, Daniel Montero1, Adam Campos2, Enrique Rudiño2, Martha Vazquez1, Mario Zurita1. 1) Genetica del Desarrollo, Instituto de Biotecnologia, UNAM, Cuernavaca, Morelos, Mexico; 2) Medicina Molecular y Bioprocesos. Instituto de Biotecnología, UNAM, Cuernavaca, Morelos, México.

850C
Interactions between the Myb Oncoprotein and the Variant Histone H2A.V in the D.melanogaster Hematopoietic Organ. M. Grigorian1, H. DeBruhl2, J. Lipsick1. 1) Depts. of Pathology and Genetics, Stanford University, Stanford, Ca; 2) Dept. of Mol., Cell and Dev. Biology, University of California, Santa Cruz, Santa Cruz, Ca.

851A
An ancient centromeric histone duplication in Drosophila. Lisa E. Kursel1,2, Harmit Malik1,3. 1) Fred Hutchinson Cancer Research Center, Seattle, WA; 2) University of Washington Molecular and Cellular Biology; 3) HHMI.

852B
The Mof Acetyltransferase Is Required for JIL-1 H3S10 Kinase Stability in Drosophila Males. Yeran Li, Weili Cai, Chao Wang, Huai Deng, Xiaomin Bao, Weiguo Zhang, Jack Girton, Jorgen Johansen, Kristen Johansen. Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, IA.

853C
Sequence-independent transcription is required for centromeric CENP-A deposition by its assembly factor. Chin-Chi Chen1, Sarion Bowers1, Zoltan Lipinszki2,3, Jason Palladino1, Emily Bettini1, Sarah Trusiak1, Leah Rosin1, Marcin Przewloka2, David Glover2, Rachel O'Neill1,4, Barbara Mellone1,4. 1) Molecular and Cell Biology, University of Connecticut, Storrs, CT; 2) Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK; 3) Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, H-6701 Szeged, P.O. Box 521, Hungary; 4) Institute for Systems Genomics, University of Connecticut, Storrs, CT.

854A
Tip60 mediated epigenetic control of cognition-linked genes. Priyalakshmi Panikker, Elefant Felice. Department of Biology, Drexel University, Philadelphia, PA.

855B
Understanding Heterochromatin: Determination of DNA Elements That Influence Gene Expression. April Bauer, Sarah Elgin. Department of Biology, Washington University, St. Louis, MO.

856C
Comparative Genomics of the Muller F Element among Four Species. John Braverman1, Martin Burg2, Christopher Jones3, Nighat Kokan4, Leming Zhou5, Don Paetkau6, Joyce Stamm7, Christopher Shaffer8, Wilson Leung8, Sarah Elgin8, other faculty and students of the Genomics Education Partnership. 1) Saint Joseph's University, Philadelphia, PA; 2) Grand Valley State University, Allendale, MI; 3) Moravian College, Bethlehem, PA; 4) Cardinal Stritch University, Milwaukee, WI; 5) University of Pittsburgh, Pittsburgh, PA; 6) St. Mary’s College, St. Mary’s City, MD; 7) University of Evansville, Evansville, IN; 8) Washington University, St. Louis, MO.

857A
Investigation on the expansion of the Drosophila ananassae Muller F element. E. Chen, W. Leung, K. Ko, T. Quisenberry, S. Elgin. Washington University in St. Louis, Saint Louis, MO.

858B
HP1B, A Member of the Heterochromatin Protein 1 Family. Tandy L. Dolin Petrov, Nicole C. Riddle. Biology, University of Alabama at Birmingham, Birmingham, AL.

859C
Repeat-induced Chromatin Silencing in Fruit Flies (Drosophila melanogaster). Michael Lee1, Tingting Gu2, April Bauer1, Sarah Elgin1. 1) Department of Biology, Washington University in St. Louis, St. Louis, MO; 2) Nanjing Agricultural University, Nanjing, China.

860A
Comparative analysis of HP1a, HP1B, and HP1C functions in Drosophila melanogaster. Nicole Riddle. Biology, University of Alabama at Birmingham, Birmingham, AL.

861B
Heterochromatin spreading is a common signature of exposure to metals and organic compounds. Katherine Silkaitis1, Cristina Valente1,2, Alan Branco1, Bernardo Lemos1. 1) Environmental Health, MIPS, Harvard School of Public Health, Boston, MA; 2) Faculdade de Medicina, University of São Paulo, Brazil.

862C
Using FCS methods to study chromatin compaction and the dynamics of heterochromatin formation. Amy Strom1,2, Gary Karpen1,2. 1) UC Berkeley, Berkeley, CA; 2) Lawrence Berkeley National Laboratory, Berkeley, CA.

863A
Structure/Function dissection of the Fab-7 boundary within the context of the bithorax complex: the role of the GAGA factor. Fabienne Cléard, François Karch. Dept Genetic and Evolution, Univ Geneva, Geneva, Switzerland.

864B
The Bithorax Fab-7 insulator element: A paradigm for developmental modulation of insulator function. Daniel Wolle1, Fabienne Cleard2, Tsutomu Aoki1, Girish Deshpande1, Paul Schedl1, François Karch2. 1) Department of Molecular Biology, Princeton University, Princeton, NJ; 2) Department of Genetics and Evolution, University of Geneva, 30 quai E. Ansermet, 1211, Geneva-4, Switzerland.

865C
Deposition of the histone H3K27me3 mark during fly embryogenesis. Sarah Bowman1,2, Aimee Deaton1,2, Heber Domingues3, Robert Kingston1,2, Welcome Bender3. 1) Dept. of Molecular Biology, Massachusetts General Hospital, Boston, MA; 2) Dept. of Genetics, Harvard Medical School, Boston, MA; 3) Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.

866A
Sex combs on midleg (SCM) is a subunit of both PRC1 and PRC2, and is required for H3K27 trimethylation. Hyuckjoon Kang1,2, Kyle McElory1,2,3, Youngsook Jung2,4, Artyom Alekseyenko1,2, Peter Park2,4,5, Mitzi Kuroda1,2. 1) Genetics and Medicine, Harvard Medical School, Boston, MA; 2) Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA; 3) Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA; 4) Center for Biomedical Information, Harvard Medical School, Boston, MA; 5) Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA.

867B
A Positive Role of Polycomb in Transcription Regulation by Modulating H4K20me1 during Normal Development. Xiangdong Lv1, Zhijun Han2, Hao Chen1, Yuanxin Xia1, Yi Lu1, Chenyu Pan1, Lin Fu1, Hui Han1, Gang Wei2, Yun Zhao1. 1) State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, SIBS, CAS, Shanghai, China; 2) Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, SIBS, CAS, Shanghai, China.

868C
Physical and functional interaction between PIWI and PC is required for transcriptional silencing in Drosophila. Tanmoy Mondal1, Utpal Bhadra2, Sncvl Pushpavalli2, Manika Pal Bhadra1. 1) Centre for Chemical Biology, Indian Institute of Chemical Technology, Uppal Road, Hyderabad-500007, India; 2) Functional Genomics and Gene silencing Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, India.

869A
Combgap is a DNA binding protein required for Polycomb group silencing. P. Ray, S. De, J. Kassis. NICHD/NIH, Bethesda, MD.

870B
Role of epigenetic factors in aging. Dasari Vasanthi. CCMB, Hyderabad, India.

871C
Baseline X chromosome dosage compensation in heads. Zhen-Xia Chen, Brian Oliver. NIDDK, National Institute of Health, Bethesda, MD.

872A
The 1.688 satellite is required for targeting of POF to a transgenic recruitment element. M. Kim, J. Larsson. Umeå University, Umeå, Sweden.

873B
How does the fly identify X chromatin during dosage compensation? Victoria H. Meller, Debashish U. Menon. Biological Sciences, Wayne State University, Detroit, MI.

874C
New data suggests an ancient mechanism for a chromosome-specific factor. Anna Zeidman, Leila Rieder, Erica Larschan. Brown University, Providence, RI.

875A
The role of chromatin organization in regulating histone gene repeats. K. Boltz, R. Duronio. Lineberger Comprehensive Cancer Center, Univ of North Carolina, Chapel Hill, NC.

876B
The role of PIWI-interacting RNA pathway genes in cell survival after telomere loss. Ana C. Gonzalez, Rebeccah L. Kurzhals. Southeast Missouri State University, Cape Girardeau, MO 63701.

877C
Characterization of His2Av in cell survival after telomere loss. Lakshmi P. D. Pulavarthi, Rebeccah L. Kurzhals. Southeast Missouri State University, Cape Girardeau, MO.

878A
Developmental stability and the maintenance of chromatin structure. Frédérique Peronnet1, Delphine Cuménal1, Camille Dupont1, Valérie Ribeiro1, Vincent Debat2, Neel B. Randsholt1. 1) UMR7622 - Developmental Biology, Institute of Biology Paris Seine, CNRS - UPMC, Paris, France; 2) UMR7205 - OSEB, Systematic and Evolution, MNHN - CNRS, Paris France.

879B
Cosuppression of Adh gene in Drosophila melanogaster by insertion of inducible transgene follows typical RNAi pathway. Debabani Roy Chowdhury, Utpal Bhadra. Functional Genomics, Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India.

880C
Digitor, an Essential Protein with Homology to Mammalian ATMIN is Involved in Brain Development and Oxidative Stress Pathways in Drosophila. Saheli Sengupta, Changfu Yao, Uttama Rath, Jack Girton, Jorgen Johansen, Kristen Johansen. Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, IA.

RNA Biology


881A
A microRNA minimizes the phenotypic impact of genomic diversity. Justin Cassidy1, Aashish Jha2, Diana Posadas1, Ritika Giri1, Koen Venken3,4, Jingran Ji1, Hongmei Jiang5, Hugo Bellen3,4, Kevin White2, Richard Carthew1. 1) Molecular Biosciences, Northwestern University, Chicago, IL; 2) Institute for Genomics and Systems Biology, Departments of Human Genetics and Ecology and Evolution, University of Chicago, Chicago, IL; 3) Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Program in Developmental Biology, Baylor College of Medicine, Houston, TX; 4) Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX; 5) Department of Statistics, Northwestern University, Evanston, IL.

882B
piRNA-mediated repression during female germline development. Pauline Marie, Stéphane Ronsseray, Antoine Boivin. Developmental Biology Laboratory, IBPS, CNRS, Universite Pierre et Marie Curie, Paris, France.

883C
Subtelomeric regions and transposable element repression in D. melanogaster. Laure Teysset, Amna Asif-Laidin, Stephane Ronsseray. Developmental Biology Laboratory, IBPS, CNRS, Universite Pierre et Marie, Paris, France.

884A
Dynamic turnover of transposable elements in the Drosophila simulans clade supports an evolutionary arms race with the host silencing machinery. Jeffrey Vedanayagam, Daniel Garrigan. Department of Biology, University of Rochester, Rochester, NY.

885B
Tagging the iab-8ncRNA of the bithorax complex with mCherry. Yohan El bali, Dragan Gligorov, Robert Maeda, François Karch. Dept of Genetic and Evolution University of Geneva, Switzerland.

886C
Lobe-less RNA is a new member of Polycomb group genes and essential for mushroom body morphogenesis in Drosophila. Sachi Inagaki1, Masanao Sato3,4, Natsuki Nakamura2, Satoru Kobayashi3,4, Yuji Kageyama1,2. 1) Research Center for Environmental Genomics ,Kobe University, Kobe, Japan; 2) Department of Biology, Graduate School of Science, Kobe University, Kobe, Japan; 3) Okazaki Institute for Integrative Bioscience, Okazaki, Japan; 4) National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Japan.

887A
Role of specialized ribonucleoprotein granules in germline development in Drosophila. Alexey L. Arkov1, Ming Gao1, Travis C. Thomson2, T. Michael Creed1, Shikui Tu3, Sudan N. Loganathan1, Christina A. Jackson1, Nhan Huynh1, Jimiao Zheng1, Patrick McCluskey1, Yanyan Lin1, Scott E. Collier5, Jarred Koerner1, Zachary Ryne1, Zhiping Weng3, Paul Lasko4, Melanie D. Ohi5. 1) Department of Biological Sciences, Murray State University, Murray, KY; 2) Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA; 3) Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA; 4) Department of Biology, McGill University, Montreal, Canada; 5) Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN.

888B
Temporal and spatial control of the Smaug RNA binding protein in the early embryo. Wendy Cao1, Alexander Marsolais2, Matthew Cheng2, Najeeb Siddiqui1, Craig Smibert1,2, Howard Lipshitz1. 1) Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; 2) Biochemistry, University of Toronto, Toronto, Ontario, Canada.

889C
Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila. Marcus Stoiber1,2, Sara Olson3, Gemma May3, Michael Duff3, Jan Manent4, Robert Obar4, K. G. Guruharsha4,5, Spyros Artavanis-Tsakonas4,5, James Brown2,6, Brenton Graveley3, Susan Celniker2. 1) Department of Biostatistics, UC Berkeley, Berkeley, CA; 2) Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, CA; 3) Department of Genetics and Developmental Biology, Institute for Systems Genomics, University of Connecticut Health Center, Farmington, CT; 4) Department of Cell Biology, Harvard Medical School, Boston, MA; 5) Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142 USA; 6) Department of Statistics, University of California Berkeley, Berkeley, CA.

890A
The RNA interactome of early Drosophila embryo. Vasily Sysoev, Bernd Fischer, Christian Frese, Sophia Föhr, Alfredo Castello, Matthias Hentze, Jeroen Krijgsveld. European Molecular Biology Laboratory, Heidelberg, Germany.

891B
Isoform-specific function of Squid in bicoid mRNA localization. Evan Abbaszadeh, Elizabeth Gavis. Department of Molecular Biology, Princeton University, Princeton, NJ.

892C
Independent and coordinate trafficking of single germ plasm mRNAs. Shawn Little1,2, Kristina Sinsimer1, Jack Lee1, Eric Wieschaus1,2, Elizabeth Gavis1. 1) Department of Molecular Biology, Princeton University, Princeton, NJ; 2) Howard Hughes Medical Institute.

893A
Location, Location: whole genome study of subcellular RNA localization beyond the early Drosophila embryo. Ronit Wilk1,2, Jack Hu1, Henry Krause1,2. 1) The Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, ON, Canada; 2) Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

894B
Decreased expression of SR proteins alters lipid droplet morphology and triglyceride levels in Drosophila larvae. Leelabati Biswas1, Spencer Ng1, Bijal Kakrecha2, Alexis Nagengast1. 1) Biochemistry, Widener University, Chester, PA; 2) Biology, Widener University, Chester, PA.

895C
Using a histone replacement system to define co-transcriptional interactions between histone modifications and elongating RNA. Michael P. Meers1, A. Gregory Matera2. 1) Curriculum in Genetics and Molecular Biology; 2) Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

896A
The exon junction complex facilitates pre-mRNA splicing via modulation of transcription elongation. J. Akhtar1, N. Kreim1, F. Martini2, G. Mohana1, J. Mazur2, H. Binder2, JY Roignant1. 1) Institute of Molecular Biology, Mainz, Germany; 2) Institute for Medicine Biometrie, Epidemiologie and Informatic (IMBEI), Mainz, Germany.

897B
Tet, the 5-methylcytosine Oxidase, is Essential in Drosophila. F. Wang, S. Minakhina, R. Steward. Waksman Institute, Piscataway, NJ.

898C
The level of nuclear 80S ribosomes increases during cell stress. A. Abdullahi, S. Brogna. Bioscience, University of Birmingham, Birmingham, Birmingham, W. Midlands, United Kingdom.

899A
Translational regulation of the grk mRNA during Drosophila oogenesis. Ramses Rodriguez1, Jacob Merle1, Philip Frankino1, Danielle Hindes1, Malachi Blundon1, Maya Mills1, Matthew Fountain1,2, Scott Ferguson1. 1) Department of Biology, SUNY Fredonia, Fredonia, NY; 2) Department of Chemistry, SUNY Fredonia, Fredonia, NY.

900B
Long noncoding RNA-Proteins interaction module initiates heterochromain. Indira Bag1, Manika Pal Bhadra2, Utpal Bhadra1. 1) Centre for Cellular & Molecular Biology, Uppal Road, Hyderabad 500007, INDA; 2) Centre for Chemical Biology, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India.

901C
Genome editing in Drosophila to reconstruct the evolutionary change in the transcriptional control and processing of RNase P RNA, an essential ribozyme. Geeta Palsule1, Sathiya Manivannan1, Lien Lai2, Venkat Gopalan1,2, Amanda Simcox1. 1) Molecular Genetics, The Ohio State University, Columbus, OH; 2) The Department of Chemistry and Biochemistry, The Ohio State University,Columbus, OH.

Techniques and Resources


902A
On a wing and a chip - microfluidics for whole organ studies in Drosophila development. Cody Narciso1, Thomas Storey2, David Hoelzle2, Jeremiah Zartman1. 1) Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN; 2) Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN.

903B
A rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo. Xiaokun Shu, Tsz-Leung To, Beverly Piggott, Yuh-Nung Jan. Pharmaceutical Chemistry, UCSF, San Francisco, CA.

904C
High-throughput analysis of RNAi knockdown efficiency and off-target effects. Hangnoh Lee1, Michael Buckner2, Quentin Gilly2, Haiwang Yang1, Hina Sultana1, Cale Whitworth1, Maria Jaime1, Satish Kumar1, Harold Smith1, Yanhui Hu2, Stephanie Mohr2, Norbert Perrimon2, Brian Oliver1. 1) Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA; 2) Drosophila RNAi Screening Center, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

905A
The Transgenic RNAi Project: Reagents, Tools & Validation. Liz Perkins1, Claire Hu1, Laura Holderbaum1, J.-Q. Ni2, Shu Kondo3, Stephanie Mohr1, Norbert Perrimon1. 1) DRSC & TRiP, Harvard Medical School, Boston, MA; 2) TsingHua Univ, China; 3) NIG, Japan.

906B
CRISPR/Cas9 mediates efficient conditional mutagenesis in Drosophila. Zhaoyu Xue, Menghua Wu, Kejia Wen, Mengda Ren, Li Long, Xuedi Zhang, Guanjun Gao. School of Life Sciences, Tsinghua University, Beijing, Beijing, China.

907C
Toward a Complete Set of Germline Null and Modifiable Mutations in Drosophila. Graeme Mardon, Ming Fa, Min Li, Rui Chen. GenetiVision Corporation, Houston, TX.

908A
Anchoring proteins away: a fast and regulated method to deplete proteins in the cell. Pablo Sánchez Bosch, Julia Pepperl, Konrad Basler. University of Zürich, Zürich, Switzerland.

909B
Chemical control of gene expression in Drosophila melanogaster. Sachin Sethi, Jing W. Wang. Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA.

910C
To Apply the CRISPR/Cas9 System in Drosophila. Jin Sun1, Xingjie Ren1, Zhihao Yang1, Jiang Xu1,2, Lu-Ping Liu1,2, Jian-Quan Ni1. 1) School of Medicine, Tsinghua University, Beijing, China; 2) Tsinghua Fly Center, Tsinghua University, Beijing, China.

911A
Application of CRISPR/Cas9 system and efficient mutants screening in Drosophila species. J.-S. Chen, C.-T. Ting. Dept Life Sci, National Taiwan Univ, Taipei, Taiwan, ROC.

912B
Fly Facility: A resource to facilitate modern molecular genetics in Drosophila. Deepti Trivedi. Fly Facility, Centre for Cellular and Molecular Platforms, Bangalore, India.

913C
CoinFLP: A system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila. Justin A. Bosch, Ngoc Han Tran, Iswar K. Hariharan. Molecular and Cell Biology, University of California - Berkeley, Berkeley, CA.

914A
Resource Development for Investigation of Chromatin Modifying Proteins. Benjamin B. Mills. Biology Dept., University of Alabama at Birmingham, Birmingham, AL.

915B
QuantiFly 4D: Learning to Count in 4 Dimensions. Richard M. Parton1, Dominic Waithe2, Lu Yang1, Ilan Davis1. 1) Biochemistry Dept., University of Oxford, Oxford, United Kingdom; 2) Wolfson Imaging Centre, University of Oxford, Oxford, United Kingdom.

916C
Creation of a Drosophila ORFeome library. Johannes Bischof2, Emma Sheils1, Mikael Björklund1, Konrad Basler2. 1) University of Dundee, Dundee, United Kingdom; 2) Institute of Molecular Life Sciences, University of Zurich, Zürich, Switzerland.

917A
Towards an automated experimental platform for Drosophila melanogaster. Matt Zucker1, Dave Zucker2. 1) Swarthmore College, Swarthmore, PA; 2) FlySorter LLC, Cambridge, MA.

918B
An LD-based approach for increasing coverage in pooled sequence experiments without additional cost. Hussein Al-Asadi, Matthew Stephens. University of Chicago, Chicago, IL.

919C
A deep learning based universal representation for Drosophila Embryos Image Annotation. Qian Sun1, Wenlu Zhang2, Rongjian Li2, Sudhir Kumar3,4, Jieping Ye1, Shuiwang Ji2. 1) School of Computing, Informatics, and Decision Systems, Arizona State University, Tempe, AZ.Biodesign Institute, Arizona State University, Tempe, AZ; 2) Department of Computer Science, Old Dominion, Norfolk, VA; 3) Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA; 4) Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

920A
FlyBase: A new and improved website coming to a browser near you. Josh Goodman, Victor Strelets, Jim Thurmond, Gary Grumbling, Thomas Kaufman. FlyBase, Department of Biology, Indiana University, Bloomington, IN, USA.

921B
DRSC Informatics Tools for Functional Genomics Studies. C. Hu, I. Flockhart, C. Roesel, A. Vinayagam, B. Yilmazel, A. Comjean, L. Perkins, N. Perrimon, S. Mohr. Genetics, Harvard Medical School, Boston, MA.

922C
Gene Groups in FlyBase. Steven Marygold, Helen Attrill, FlyBase consortium. FlyBase, Dept. of Genetics, University of Cambridge, Cambridge, United Kingdom.

923A
UAS-driven Cerulean and Venus hybrid reporters provide calibration standards for FRET analysis in Drosophila tissues. K. Mecklenburg1, H. Xia2, S. Freed3, J. E. O'Tousa3, D. F. Ready4. 1) Indiana Univ. South Bend, IN; 2) Weill Cornell Med. Coll., NY; 3) Univ. of Notre Dame, IN; 4) Purdue Univ., IN.

924B
Targeted insertions in Drosophila cell lines using φC31 integrase. Lucy Cherbas1, Jennifer Hackney1,2, Lei Gong1,3, Claire Salzer1, Eric Mauser1, Dayu Zhang1, Peter Cherbas1. 1) Dept Biol and Drosophila Genomics Resource Center, Indiana Univ, Bloomington, IN; 2) School of Math and Nat Sci, New College, Arizona State Univ, Phoenix, AR; 3) Hangzhou School of Agr and Food Sci, Zhejiang Agr. and Forestry Univ, Zhejiang Lin’an, Hangzhou, China.

925C
A comprehensive and precise genome duplication kit in Drosophila. Ming Fa, Min Li, Rui Chen, Graeme Mardon. GenetiVision Corporation, Houston, TX.

926A
An in vivo reporter system to trace aged cells in Drosophila. Xingchen Liu1, Lei Liu1,2. 1) State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Peking University, Beijing 100871, China; 2) Beijing Institute for Brain Disorder and Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, China.

927B
BioTapestry: Modeling Gene Regulatory Networks for Development. Suzanne Paquette, Kalle Leinonen, William Longabaugh. Institute for Systems Biology, Seattle, WA.

928C
Manipulation of Gene Expression by Infrared Laser Heat Shock and Its Application to the Study of Tracheal Development in Drosophila. Guangxia Miao1,2, Shigeo Hayashi1,2. 1) Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan; 2) Department of Biology, Kobe University Graduate School of Science, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8051, Japan.

929A
New stocks at the Bloomington Drosophila Stock Center. Annette L. Parks, Kevin R. Cook, Thom C. Kaufman, Kathy A. Matthews. Bloomington Drosophila Stock Center, Dept. of Biology, Indiana University, Bloomington, IN.

Educational Initiatives


930B
Evidence-Based Inquiry Into the Remote: Using Drosophila's Phenoloxidase to Open the Door to Research-Based Experiences in a High School Classroom. Rebecca Steiger1, Nicole Green2, Erika Geisbrecht2, Carolyn Ferguson3. 1) Junction City High School, Geary Co. USD 475, Junction City, KS; 2) Bioch. & Mol. Biophysics Dept., Kansas State University, Manhattan, KS; 3) Biology Dept., Kansas State University, Manhattan, KS.

931C
The Council on Undergraduate Research- a resource for future faculty to integrate research and educational activities. Joyce Fernandes. Biology Dept, Miami Univ, Oxford, OH.

932A
An Undergraduate Course Combining Authentic Research and Scientific Writing. Sarah E. Hynek, Tomer Avidor-Reiss. Biological Sciences, University of Toledo, Toledo, OH.

933B
An Inquiry Based Genetics Laboratory Utilizing Randomly Mating Populations of Drosophila melanogaster. M. Kimble, A. Schirmer, T. Campbell. Dept of Biology, Northeastern Illinois University, Chicago, IL.

934C
The Genomics Education Partnership: Assessing and improving a research-based genomics project for undergraduates. D. W. Paetkau1, J. Braverman2, M. Burg3, J. DiAngelo4, C. Jones5, K. Jones6, L. Kadlec7, N. Kokan8, M. Manier9, A. Nagengast10, J. Sanford11, K. Saville12, C. Small13, R. Spokony14, J. Stamm15, C. Ting16, M. Wawersik17, L. Zhou18, W. Leung19, C. D. Shaffer19, S.C.R. Elgin19. 1) Saint Mary’s Col (IN); 2) St. Joseph U; 3) Grand Valley St U; 4) Hofstra U; 5) Moravian Col; 6) Huntingdon Col; 7) Wilkes U; 8) Cardinal Stritch U; 9) George Washington U; 10) Widener U; 11) Ohio Northern U; 12) Albion Col; 13) Medgar Evers Col; 14) Baruch Col; 15) U Evansville; 16) National Taiwan U; 17) Col of William and Mary; 18) U Pittsburgh; 19) Washington U at St. Louis.