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Primers in GENETICS
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Primers in GENETICS

 

These Primers are a series of articles in the GSA Journal GENETICS designed to make current research articles useful in an undergraduate classroom or a senior seminar.  Each Research Primer is tied to a current article, and lays out necessary background, explains the hypothesis or approach, describes the methodology, guides the readers through the results, and sums up the discussion.  Each Model Organism Primer describes a genetic model system, including the organism's life cycle, history of use in the laboratory, available genetic and genomic tools, advantages of the system, discoveries made using the model organism, and more. Model Organism Primers would be especially useful for educators to assign to students along with a Research Primer featuring that model organism. They would also be quite useful for researchers in a new laboratory who would like to read up on their new study system.

 

In essence, the Primer is a road map that aids instructors wishing to use peer-reviewed articles as the vehicle with which to develop many of the core competencies in geneticsFor more information, see "The Other Life of Articles" (Hawley and Ruedi, 2012).

 

Research Primers

 

Primer Article Companion Research Article

"Suppressors, Screens, and Genes..."

E. A. de Stasio (2012) GENETICS, 191:4, 1031-1035.

+Core Concepts and Competencies

Core Concepts:

  • What is the molecular anatomy and function of genes and genomes?
  • How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?
  • How can gene activity be altered in the absence of DNA changes?
  • How do genes and genomes control development?
  • How do different types of mutations affect genes and the corresponding mRNAs and proteins?
  • How do the results of molecular genetic studies in model organisms help us understand aspects of human genetics and genetic diseases?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Developing and interpreting graphs
  • Applying statistical methods/Modeling
  • Scientific writing

"A Network of Genes Antagonistic to the LIN-35 Retinoblastoma Protein of Caenorhabditis elegans"

S. R. G. Polley and D. S. Fay (2012) GENETICS, 191:4, 1367-1380.

   

"Population Genetics and a Study of Speciation Using Next-Generation Sequencing..."

P. J. Wittkopp (2013) GENETICS, 193:3, 671-675. *

+Core Concepts and Competencies

Core Concepts:

  • What is the molecular anatomy and function of genes and genomes?
  • What are the mechanisms by which an organism's genome is passed on to the next generation?
  • How can gene activity be altered in the absence of DNA changes?
  • How do genes and genomes control development?
  • What are the processes that can affect the frequency of genotypes and phenotypes in a population over time?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Developing and interpreting graphs
  • Applying statistical methods/Modeling
  • Bioinformatics/Managing large data sets
  • Inter-disciplinary (i.e. physics/ chemistry)
  • Scientific writing

"Patterns of Transcriptome Divergence in the Male Accessory Gland of Two Closely Related Species of Field Crickets"

J. A. Andres, E. L. Larson, S. M. Bogdanowicz, and R. G. Harrison (2013) GENETICS, 193:2, 501-513. *

   

"To 'Bee or Not to Bee' Male or Female?..."

A.M. Schurko (2013) GENETICS, 193:4, 1019-1023. *

+Core Concepts and Competencies

Core Concepts:

  • What is the molecular anatomy and function of genes and genomes?
  • How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?
  • How can gene activity be altered in the absence of DNA changes?
  • How do genes and genomes control development?
  • How do different types of mutations affect genes and the corresponding mRNAs and proteins?
  • How do the results of molecular genetic studies in model organisms help us understand aspects of human genetics and genetic diseases?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Bioinformatics/Managing large data sets
  • Scientific writing
  • Relating to society or ethics

"The Am-tra2 Gene Is an Essential Regulator of Female Splice Regulation at Two Levels of the Sex Determination Hierarchy of the Honeybee"

I. Nissen, M. M??ller and M. Beye (2013) GENETICS, 192:3, 1015-1026.

   

"New Roles for Old Characters..."

A. A. Duina (2013) GENETICS, 194:1, 27-33. *

+Core Concepts and Competencies

Core Concepts:

  • How can gene activity be altered in the absence of DNA changes?
  • How do different types of mutations affect genes and the corresponding mRNAs and proteins?
  • How do the results of molecular genetic studies in model organisms help us understand aspects of human genetics and genetic diseases?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Developing and interpreting graphs
  • Applying statistical methods/Modeling
  • Scientific writing

"Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast"

N.A. Gaur, J. Hasek, et al. (2013) GENETICS, 193:3, 829-851. *

   

"Studying Recombination with High-Throughput Sequencing..."

C. S. Smukowski Heil and M. A. F. Noor (2013) GENETICS, 194:2, 335-339. *

+Core Concepts and Competencies

Core Concepts:

  • What are the mechanisms by which an organism's genome is passed on to the next generation?
  • How does the phenomenon of linkage affect the assortment of alleles during meiosis?
  • How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?
  • How do the results of molecular genetic studies in model organisms help us understand aspects of human genetics and genetic diseases?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Developing and interpreting graphs
  • Applying statistical methods/Modeling
  • Bioinformatics/Managing large data sets
  • Scientific writing

"Fine-Scale Heterogeneity in Crossover Rate in the garnet-scalloped Region of the Drosophila melanogaster X Chromosome"

N.D. Singh, E.A. Stone; C.F. Aquadro, and A.G. Clark (2013) GENETICS, 194:2, 375-387. *

   

"SMG-ly Knocking Out Gene Expression in Specific Cells..."

P. M. Meneely and J. C. Bloom (2013) GENETICS, 195:4, 1201-1207.

+Core Concepts and Competencies

Core Concepts:

  • How can one deduce information about genes, alleles, and gene functions from an analysis of genetic crosses and patterns of inheritance?
  • How can gene activity be altered in the absence of DNA changes?
  • How do different types of mutations affect genes and the corresponding mRNAs and proteins?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Scientific writing

"A Novel Strategy for Cell-Autonomous Gene Knockdown in Caenorhabditis elegans Defines a Cell-Specific Function for the G-Protein Subunit GOA-1"

K. N. Maher, A. Swaminathan, P. Patel, and D. L. Chase (2013) GENETICS, 194:2, 363-373. *

   

"Examining the Process of de Novo Gene Birth..." *

S. Frietze and J. Leatherman (2014) GENETICS, 196:3, 593-599.

+Core Concepts and Competencies

Core Concepts:

  • What is the molecular anatomy and function of genes and genomes?
  • How can gene activity be altered in the absence of DNA changes?
  • How do different types of mutations affect genes and the corresponding mRNAs and proteins?
  • How do the results of molecular genetic studies in model organisms help us understand aspects of human genetics and genetic diseases?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Developing and interpreting graphs
  • Scientific writing

"Integration of New Genes into Cellular Networks, and Their Structural Maturation"

G. Abrusán (2013) GENETICS, 195:4, 1407-1417. *

   

"A Roadmap to Understanding the Toll Pathway Changes..." *

R. L. Schmidt (2014) GENETICS, 196:4, 923-929.

+Core Concepts and Competencies

Core Concepts:

  • What is the molecular anatomy and function of genes and genomes?
  • How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?
  • How can gene activity be altered in the absence of DNA changes?
  • How do genes and genomes control development?
  • How do the results of molecular genetic studies in model organisms help us understand aspects of human genetics and genetic diseases?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Developing and interpreting graphs
  • Applying statistical methods/Modeling
  • Scientific writing

"Regulation of Toll Signaling and Inflammation by ß-Arrestin and the SUMO Protease Ulp1"

S. G. Anjum, W. Xu, N. Nikkholgh, et. al. (2013) GENETICS, 195:4, 1307-1317. *

   

 

Model Organism Primers

 

"Budding Yeast for Budding Geneticists: A Primer on the Saccharomyces cerevisiae Model System" *

A. A. Duina, M. E. Miller, and J. B. Keeney (2014) GENETICS, 197:1, 33-48.

+Core Concepts and Competencies

Core Concepts:

  • What is the molecular anatomy and function of genes and genomes?
  • What are the mechanisms by which an organism's genome is passed on to the next generation?
  • How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?
  • How can gene activity be altered in the absence of DNA changes?
  • How do different types of mutations affect genes and the corresponding mRNAs and proteins?
  • How do the results of molecular genetic studies in model organisms help us understand aspects of human genetics and genetic diseases?

Core Competencies:

  • Observational strategies/Hypothesis testing/Experimental Design
  • Evaluation of experimental evidence
  • Explain concepts to different audiences
  • Relating to society or ethics

 

 

 

 

 

 

 

 

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