Donate Today!   Join GSA      

Society Home | About GSA | Contact GSA      



2014 Important Dates

Abstract Submission Opens March 21
Conference Registration Opens March 28
Travel Award Application April 24
Abstract Submission Deadline April 24
DeadlineAbstract Revision Deadline April 25
Microphone Runner Application Deadline April 26
Platform/Poster Assignments Online June 8
Abstract Search and Program Planner Online June 25
Early Meeting Registration June 26
Housing Reservation June 26

Platform Session Listing


Tuesday, July 29   7:00 pm–7:15 pm
Meany Theater

Welcome and Opening Remarks

Trisha Davis, Meeting Organizer, University of Washington, Seattle

Adam Fagen, Executive Director
Genetics Society of America

Mark Johnston, GENETICS and Brenda Andrews, G3: Genes, Genome, Genetics

Tuesday, July 29   7:15 pm–8:15 pm
Meany Theater

Ira Herskowitz Award Lecture
Award recipient and speaker: Olga Troyanskaya, Princeton University
Introduction by Chad Myers

Wednesday, July 30   8:30 am–10:00 am
Meany Theater

Cell Cycle Transitions

Chair: Mark Rose

1 - 8:30
The structure of an Ndr/LATS kinase - Mob complex reveals a novel kinase-coactivator system and substrate docking mechanism. Kyle Schneider1, Gergõ Gógl2, Brian Yeh1, Nashida Alam1, Alex Nguyen Ba3, Alan Moses3, Csaba Hetenyi2, Attila Reményi2, Eric Weiss1. 1) Molecular Biosciences, Northwestern University, Evanston, IL; 2) Institute of Enzymology, Hungarian Academy of Sciences, Budapest; 3) Department of Cell & Systems Biology, University of Toronto.

2 - 8:45
Morphogenesis checkpoint kinase Swe1 is the executor of lipolysis-dependent cell cycle progression. Sepp D. Kohlwein, Neha Chauhan, Myriam Visram. Institute of Molecular Biosciences, University of Graz, Graz, Austria.

3 - 9:00
Compartmentalization of G1/S regulators allows signaling information to traverse a switch-like transition. Andreas Doncic, Jan M. Skotheim. Department of Biology, Stanford university, Stanford, CA.

4 - 9:15
Coordination of cell cycle-regulated gene expression by Cdk1. Benjamin Landry, Claudine Mapa, Heather Arsenault, Kristin Poti, Jennifer Benanti. Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA.

5 - 9:30
Understanding the Regulation, Composition and Function of P bodies and Stress Granules in Quiescent Cells. Khyati H. Shah, Paul K. Herman. Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210.

6 - 9:45
Novel pathways of transcription regulation during the transition from growth to quiescence. Shawna Miles, Amali P. Abeysinghe, Linda L. Breeden. Basic Sci Div, Fred Hutchinson Cancer Res Ctr, Seattle, WA.

Wednesday, July 30   10:30 am–11:15 am
Meany Theater

Environmental Sensing Networks

Chair: Brenda Andrews

7 - 10:30
The inferred stress-activated signaling network from yeast: coordination, interconnectivity, and a novel NaCl network hub, Cdc14 phosphatase. Yi-Hsuan Ho1,2, Deborah Chasman3, Matthew MacGilvray1, James Hose1, Anna Merrill4, Joshua Coon4,5, Mark Craven3,5, Audrey Gasch1,2,4. 1) Laboratory of Genetics; 2) Cellular and Molecular Biology; 3) Department of Computer Sciences; 4) Department of Chemistry; 5) Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI.

8 - 10:45
An integrated ‘omics approach to large-scale quantitative analysis of cellular metabolic regulation. Sean Hackett, Vito Zanotelli, David Perlman, Joshua Rabinowitz. Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.

9 - 11:00
The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity. Jagoree Roy1, Aaron Goldman1, Bernd Bodenmiller2, Stefanie Wanka2, Christian Landry3, Ruedi Aebersold4,5, Martha Cyert1. 1) Department of Biology, Stanford University, Stanford, CA; 2) Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland; 3) Institut de Biologie Intégrative et des Systèmes, Département de Biologie, Université Laval, Québec, Canada; 4) Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland; 5) Faculty of Science, University of Zürich, Zürich, Switzerland.

Wednesday, July 30   11:15 am–12:00 noon
Meany Theater

Lee Hartwell Lecture
Award recipient and speaker: George Church,
Harvard University
Introduction by Mike Snyder

Wednesday, July 30   2:00 pm–3:30 pm
Meany Theater

Temporal and Spatial Control of Chromatin

Chair: Toshi Tsukiyama

10 - 2:00
Heritable capture of heterochromatin dynamics in Saccharomyces cerevisiae. Anne Dodson, Ryan Janke, Kathryn Sieverman, Jasper Rine. Dept of Molecular and Cell Biology, UC Berkeley, Berkeley, CA.

11 - 2:15
Dissecting the crosstalk between histone H2B ubiquitination and histone H3 methylation. Hanneke Vlaming1, Tibor van Welsem1, Erik de Graaf2, Maarten Altelaar2, David Ontoso3, Pedro San-Segundo3, Fred van Leeuwen1. 1) Div Gene Regulation, Netherlands Cancer Inst, Amsterdam, The Netherlands; 2) Biomolecular Mass Spectrometry and Proteomics, Univ of Utrecht, The Netherlands; 3) Instituto de Biología Funcional y Genómica, Univ of Salamanca, Spain.

12 - 2:30
Identification of a nucleosome patch required for conserved histone modifications. Christine Cucinotta, Alexandria Young, Karen Arndt. Biological Sciences, University of Pittsburgh, Pittsburgh, PA.

13 - 2:45
Mitochondrial feedback control through global H3K4 demethylation. Maria Soloveychik1, Mengshu Xu1, Ashrut Narula1, Adam Rosebrock2, Amy Caudy2, Marc Meneghini1. 1) Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; 2) Donnelly Centre for Cellular and Biomolecular Research and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

14 - 3:00
Role of ATP-dependent chromatin remodeling enzyme Fun30 in co-transcriptional pre-mRNA splicing. Qiankun Niu, Wei Wang, Boseon Byeon, Yong Li, Asim Bikas Das, Wei-Hua Wu. Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA.

15 - 3:15
Gene Loops Facilitate mRNA Export in Yeast. Badri Nath Singh, Michael Hampsey. Dept Biochem and Mol Biol, Rutgers - R W Johnson Med Sch, Piscataway, NJ.

Wednesday, July 30   4:00 pm–5:30 pm
Meany Theater

Special Presentation by Jon Lorsch, Director of the National Institute of General Medical Sciences, NIH

Thursday, July 31   8:30 am–10:00 am
Meany Theater

Trafficking and Cellular Architecture

Chair: Liz Conibear

16 - 8:30
The budding yeast polo kinase, Cdc5, is a regulator of nuclear morphology. Alison D. Walters1, Christopher K. May1, Emma Dauster1, Bertrand P. Cinquin2, Elizabeth A. Smith2, Carolyn A. Larabell2, Orna Cohen-Fix1. 1) Laboratory of Cell and Molecular Biology, NIDDK/NIH, Bethesda, MD; 2) Dept of Anatomy, School of Medicine, UCSF, San Francisco, CA.

17 - 8:45
Surveying the Inner Nuclear Membrane Landscape. Christine J. Smoyer, Jennifer Gardner, Sreenivasulu Santharam Katta, Brian Slaughter, Jay Unruh, Dan Bradford, Scott McCroskey, Sue Jaspersen. Stowers Institute for Medical Research, Kansas City, MO. 64110.

18 - 9:00
SNAREs and the Dsl1 tethering complex mediate an alternative, Sey1p-independent ER fusion pathway. Jason V. Rogers1, Conor McMahon1, Anastasia Baryshnikova2,3,4, Michael Costanzo2, Charles M. Boone2,3, Frederick M. Hughson1, Mark D. Rose1. 1) Department of Molecular Biology, Princeton University, Princeton, NJ; 2) Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, M5S 3E1, Canada; 3) Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada; 4) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.

19 - 9:15
Plasma membrane localized KDEL receptors ensure endocytic entry and retrograde transport of a viral A/B toxin in yeast. B. Becker, A. Blum, D. Rammo, M. J. Schmitt. Molecular and Cell Biology, Saarland University, Saarbrücken, Saarbrücken, Germany.

20 - 9:30
Elucidating the architecture and function of the yeast exocyst complex. Mary Munson1, Margaret Heider1, Caroline Duffy1, Zhanna Hakhverdyan2, Raghav Kalia3, Nicholas Farrall3, Michael Rout2, Adam Frost3. 1) Biochemistry & Molecular Pharmacology, UMass Medical School, Worcester, MA; 2) Laboratory of Cellular and Structural Biology, The Rockefeller University, NY; 3) Department of Biochemistry, University of Utah, Salt Lake City, UT.

21 - 9:45
The molecular architecture of the Target Of Rapamycin Complex 2 reveals why it is insensitive to rapamycin. C. Gaubitz1,4, T. Maia de Olivera2,4, Manoël Prouteau1,4, A. Leitner3, M. Karuppasamy2, D. Rispal1, S. Eltschinger1, G. Robinson1, G. Konstantinidou1, S. Thore1, R. Aebersold3, R. Loewith1,5, C. Schaffitzel1,5. 1) Molecular Biology Dept, University of Geneva, Geneva, Switzerland; 2) EMBL, Grenoble, France; 3) Institute of Molecular Systems Biology, ETHZ, Zurich, Switzerland; 4) Co-first authors; 5) Co-last authors.

Thursday, July 31   10:30 am–12:00 noon
Meany Theater

Dissecting Complex Traits

Chair: Aimee Dudley

22 - 10:30
Higher-order epistasis between a mutation and four or more segregating variants generates a 'new' phenotype in a cross. Matthew Taylor, Ian Ehrenreich. University of Southern California, Los Angeles, CA.

23 - 10:45
A quantitative study of whether the HSP90 chaperone modulates robustness to new mutations, recombination, and standing variation in yeast. Kerry A. Geiler-Samerotte, Mark L. Siegal. Center for Genomics and Systems Biology, New York University, New York, NY.

24 - 11:00
Diversity across the Saccharomyces genus and the genomic tools to tap it. Chris Todd Hittinger1, William G. Alexander1, Drew T. Doering1, David Peris1, Kayla Sylvester1, Diego Libkind2, Paula Gonçalves3, José Paulo Sampaio3. 1) Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison; 2) Laboratorio de Microbiología Aplicada y Biotecnología, Instituto de Investigaciones en Biodiversidad y Medio-ambiente, INIBIOMA (CONICET-UNComahue), Bariloche, Argentina; 3) Centro de Recursos Microbiológicos, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal.

25 - 11:15
High-throughput functional screening of driver mutations. Celia Payen1, Anna Sunshine1, Giang Ong1, Wei Zhao2, Maitreya Dunham1. 1) Genome Sciences, University of Washington, Seattle, WA; 2) Biostatistics, Universty of Washington, Seattle, WA.

26 - 11:30
Genetic influences on translation in yeast. Frank W. Albert1, Dale Muzzey2,3, Jonathan S. Weissman2,3, Leonid Kruglyak1,3,4. 1) Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA; 2) Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA; 3) Howard Hughes Medical Institute; 4) Department of Biological Chemistry, University of California, Los Angeles, CA.

27 - 11:45
Analysis of transcription activation distance as a polygenic trait in Saccharomyces cerevisiae. Caitlin Reavey1, Mark Hickman2, David Botstein3, Fred Winston1. 1) Department of Genetics, Harvard Medical School, Boston, MA; 2) Department of Biochemistry, Rowan University, Glassboro, NJ; 3) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.

Friday, August 1   8:30 am–10:00 am
Meany Theater

Chromosome Dynamics

Chair: Bonny Brewer

28 - 8:30
Mapping Recombination in Single Meiotic Cells Reveals that Tel1/ATM Controls the Positioning and Fate of DNA Double-Strand Breaks. Carol Anderson, Ashwini Oke, Phoebe Yam, Jennifer Fung. UCSF, San Francisco, CA.

29 - 8:45
RAD51 and the DNA damage checkpoint are essential for increased chromosome mobility after DNA damage in diploid S. cerevisiae. Michael J. Smith1, Fraulin Joseph1, Marina Ermakova1, Ignacio Izeddin2, Vincent Recamier2,3, Xavier Darzacq2, Judith Mine-Hattab1,2,4, Rodney Rothstein1. 1) Department of Genetics & Development, Columbia University Medical Center, New York, NY, USA; 2) Institut de Biologie de l’École Normale Supérieure, Paris, France; 3) Laboratory Imaging, s. r. o., Prague,Czech Republic; 4) Institut Curie, Paris, France.

30 - 9:00
A combined genetic and biochemical analysis of yeast telomerase. Johnathan W. Lubin1,2, Timothy M. Tucey1,2, Lisa Nguyen1,2, Vicki Lundblad1. 1) Salk Institute for Biological Studies, La Jolla, CA; 2) University of California, San Diego, La Jolla, CA.

31 - 9:15
The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A. Gary M. Deyter, Sue Biggins. Basic Sciences Division, Fred Hutchinson Center, Seattle, WA.

32 - 9:30
Reconstitution of strong kinetochore attachments requires more than the microtubule binding components of the kinetochore. Emily M. Mazanka1, Neil T. Umbreit1, Alex Zelter1, Daniel R. Gestaut3, Charles L. Asbury2, Trisha N. Davis1. 1) Biochemistry, University of Washington, Seattle, WA; 2) Physiology and Biophysics, University of Washington, Seattle, WA; 3) Biology, Stanford University, Stanford, CA.

33 - 9:45
Specialization of kinetochores for segregation of maternal and paternal chromosomes during meiosis I. Adele Marston1, Eris Duro1, Krishna Sarangapani2, Nadine Vincenten1, Yi Deng2, Kwaku Opoku2, Flavia de Lima Alves1, Juri Rappsilber1, Qiaozhen Ye3, Kevin Corbett3, Sue Biggins4, Charles Asbury2. 1) Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, MIdlothian, United Kingdom; 2) Department of Physiology & Biophysics, University of Washington, Seattle, Washington 98195, USA; 3) Ludwig Institute for Cancer Research, San Diego CA, USA; 4) Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

Friday, August 1   10:30 am–11:15 am
Meany Theater


Chair: Martha Cyert

34 - 10:30
An Asymmetric Competition for Protons Promotes Aging but Facilitates Rejuvenation. Kiersten A. Henderson, Adam L. Hughes, Daniel E. Gottschling. Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

35 - 10:45
Yeast cells contain a heterogeneous population of peroxisomes that segregate asymmetrically during cell division. Sanjeev Kumar1,2, Ida J. van der Klei1,2. 1) Molecular Cell Biology, GBB, University of Groningen, Groningen, the Netherlands; 2) System Biology Center for Energy Metabolism and Ageing, Groningen, the Netherlands.

36 - 11:00
Translocation of cyclin C to the mitochondria mediates stress-induced fission and programmed cell death. Randy S. Strich, Katrina F. Cooper. Dept Molec Biol, Rowan University-SOM, Stratford, NJ.

Friday, August 1   11:15 am–12:00 noon
Meany Theater

Lifetime Achievement Award
Award recipient and speaker: Jeremy Thorner, University of California, Berkeley

Introduction by Martha Cyert

Friday, August 1   2:00 pm–3:30 pm
Meany Theater

Next Generation Genetics

Chair: Vivien Measday

37 - 2:00
Engineering of alcohol and stress tolerance traits in Saccharomyces cerevisiae using a novel synthetic biology approach for producing genetic diversity. Sabrina German1, Biranchi N. Patra2, Animesh Ray2, Helge Zieler1. 1) Primordial Genetics Inc., 3210 Merryfield Row, San Diego CA 92121; 2) School of Applied Life Sciences, Keck Graduate Institute, 535 Watson Drive, Claremont CA 91711.

38 - 2:15
Mapping genetic suppression interactions on a global scale. Jolanda van Leeuwen1, Joseph Mellor1,4, Guihong Tan1, Takafumi Yamaguchi1, Anastasia Baryshnikova2, Paul Bansal1,3, Michael Costanzo1, Brenda Andrews1,5, Frederick Roth1,3,5, Charles Boone1,5. 1) Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada; 2) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, USA; 3) Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Canada; 4) seqWell Inc, Beverly, MA, USA; 5) Department of Molecular Genetics, University of Toronto, Toronto, Canada.

39 - 2:30
Toward a complete reference eukaryotic genetic interaction network. Benjamin VanderSluis1, Michael Costanzo2,3, Elizabeth Koch1, Carles Pons1, Anastasia Baryshnikova4, Wen Wang1, Matej Usaj2,3, Brenda J. Andrews2,3, Charles Boone2,3, Chad L. Myers4. 1) Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN; 2) The Department of Molecular Genetics, University of Toronto, Toronto ON; 3) Donnelly Centre for Cellular and Biomolecular Research Toronto, ON; 4) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.

40 - 2:45
Global analysis of HAT and HDAC substrates in vivo. David Paul Toczyski, Michael Downey. Biochemistry, UCSF, San francisco, Ca.

41 - 3:00
Protein localization re-patterning during DNA replication stress. Nikko P. Torres, Grant W. Brown. Department of Biochemistry and Donnelly Centre, University of Toronto, 160 College St., Toronto, Ontario, Canada M5S 3E1.

42 - 3:15
High dimensional phenotyping reveals remarkable extent of haploinsufficiency in essential genes. Shinsuke Ohnuki, Yoshikazu Ohya. Department of Integrated Biosciences, University of Tokyo, Kashiwa, Chiba, Japan.

Friday, August 1   4:00 pm–5:30 pm
Meany Theater

Epigenetics and Post-Transcriptional Regulation

Chair: Fred Winston

43 - 4:00
Intrinsically disordered proteins drive heritable epigenetic switches that transform the phenotypic landscape of S. cerevisiae. Sohini Chakrabortee2, James Byers1, Susan Lindquist2, Daniel Jarosz1. 1) Stanford University, Stanford, CA; 2) Whitehead Institute, Cambridge, MA.

44 - 4:15
Cheaters Do Prosper: Reciprocal cheating drives epigenetic switching of facultative multicellularity. Sorna Kamara, Randal Halfmann. Dept Biochemistry, UT Southwestern Medical Ctr, Dallas, TX.

45 - 4:30
The PUF Protein Puf3 Toggles the Translational Fate of Bound mRNAs to Regulate Mitochondrial Biogenesis. Chien-Der Lee, Benjamin Tu. Biochemistry Dept, UTSW, Dallas, TX.

46 - 4:45
Genome-wide screen identifies pathways that govern tRNA splicing and intron turnover in Saccharomyces cerevisiae. Jingyan Wu, Yao Wan, Anita Hopper. Department of Molecular Genetics, The Ohio State University, Columbus, OH.

47 - 5:00
Heritable variation of mRNA decay rates in yeast. Jennifer M. Andrie, Jon Wakefield, Joshua M. Akey. Genome Sciences, University of Washington, Seattle, WA.

- 5:15
Tribute to Fred Sherman.

Saturday, August 2   8:30 am–10:00 am
Meany Theater

Spatial Relationships

Chair: Yoshi Ohya

48 - 8:30
A Stable Quasi-Filamentous Growth Pattern in Budding Yeast. Junwon Kim, Mark D. Rose. Molecular Biology, Princeton University, Princeton, NJ.

49 - 8:45
Gradient tracking in yeast: role of Gβγ polarity. Allison McClure1, Jayme Dyer1, Maria Minakova2, Timothy Elston2, Daniel Lew1. 1) Pharmacology and Cancer Biology, Duke University, Durham, NC; 2) Pharmacology, University of North Carolina, Chapel Hill, NC.

50 - 9:00
Spatial control of microtubule length and lifetime by opposing stabilizing and destabilizing functions of Kinesin-8. Yusuke Fukuda, Anna Luchniak, Erin Murphy, Mohan Gupta. University of Chicago, Chicago, IL.

51 - 9:15
Polarization of the Endoplasmic Reticulum by ER-Septin Tethering. Jesse T. Chao1, Andrew K. O. Wong1, Shabnam Tavassoli1, Barry P. Young1, Adam Chruscicki2, Nancy N. Fang2,3, LeAnn J. Howe2, Thibault Mayor2,3, Leonard J. Foster2,3, Christopher J. R. Loewen1. 1) Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada; 2) Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada; 3) Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, Canada.

52 - 9:30
Coordination between terminal septin subunits: both Cdc11 and Shs1 promote bud neck recruitment of the myosin II-binding factor Bni5. Gregory C. Finnigan, Julie Tagaki, Christina Cho, Elizabeth Booth, Jeremy Thorner. Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA.

53 - 9:45
A cytosolic chaperone network mediates quality control of higher-order septin assembly. C. Johnson1, A. Weems1, J. Brewer2, J. Thorner2, M. McMurray1. 1) Cell and Developmental Biology, Univ Colorado Anschutz Medical Campus, Aurora, CO; 2) Molecular and Cell Biology, Univ California, Berkeley, CA.

Saturday, August 2   10:30 am–12:00 noon
Meany Theater

Chromosome Rearrangements and Polyploidy

Chair: Audrey Gasch

54 - 10:30
Protein based interference of Ty1 retrotransposition in budding yeast: characterization of copy number control resistant mutants. J. A. Mitchell, A. Saha, Y. Nishida, M. Larango, L. Wachsmuth, E. Talevich, N. Kannan, D. J. Garfinkel. Biochemistry and Molecular Biology, University of Georgia, Athens, GA.

55 - 10:45
The impact of polyploidy on the rate and dynamics of adaptation. Anna M. Selmecki1, Yosef E. Maruvka2, Philip A. Richmond3, Marie Guillet1, Noam Shoresh4, Amber Sorenson3, Subho De2, Roy Kishony4, Franziska Michor2, Robin Dowell3, David Pellman1. 1) Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA; 2) Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; 3) BioFrontiers Institute, University of Colorado, Boulder, CO; 4) Systems Biology, Harvard Medical School, Boston, MA.

56 - 11:00
Polyploidy drives population heterogeneity through random and stepwise chromosome loss. Meleah A. Hickman, Carsten Paulson, Judith Berman. Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN.

57 - 11:15
Complex genetic interaction profiles reveal evolutionary fates of duplicated genes. Elena Kuzmin1,2, Benjamin VanderSluis4, Yiqun Chen2, Raamesh Deshpande4, Matej Usaj2, Alex Nguyen3, Alan Moses3, Michael Costanzo2, Chad L. Myers4, Brenda J. Andrews1,2, Charles Boone1,2. 1) Molecular Genetics, University of Toronto; 2) Donnelly Centre for Cellular & Biomolecular Research, Toronto, Canada; 3) Cell & Systems Biology. Ecology, Evolutionary Biology & Computer Science, University of Toronto; 4) Computer Science & Engineering, University of Minnesota-Twin Cities, Minneapolis, USA.

58 - 11:30
Sexual conflicts and chromosome rearrangements drive infertility. Sarah E. Zanders, Michael Eickbush, Jonathan Yu, JiWon Kang, Gerry Smith, Harmit Malik. Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

59 - 11:45
3D structure of yeast synthetic chromosomes. Heloise Muller1,2, Axel Cournac1,2, Romain Koszul1,2. 1) Genomes and Genetics, Institut Pasteur, Paris, France; 2) CNRS UMR3525, F-75015 Paris, France.

Saturday, August 2   2:00 pm–3:30 pm
Meany Theater

New Technologies

Chair: Sue Jasperson

60 - 2:00
Towards in vivo NMR: NMR of prion fibrils at endogenous levels in cellular lysates. Kendra K. Frederick1, Vladimir K. Michaelis2,3, Björn Corzilius2,3, Ta-chung Ong2,3, Jacavone Angela2,3, Robert G. Griffin2,3, Susan Lindquist1,4,5. 1) Whitehead Institute, Cambridge, MA; 2) Department of Chemistry, MIT, Cambridge, MA; 3) Francis Bitter Magnet Laboratory, MIT, Cambridge, MA; 4) Howard Hughes Medical Institute, Cambridge, MA; 5) Department of Biology, MIT, Cambridge, MA.

61 - 2:15
High level of chromosomal mosaicism in supposedly clonal yeast cell populations. Alexandre Gillet-Markowska, Gilles Fischer. UPMC-CNRS, Paris, Ile-de-france, France.

62 - 2:30
Structured metabolic response to cellular stress. Adam Rosebrock1, Julia Hanchard1,2, Olga Zaslaver1,2, Chris Go1,2, Ying Zhang1,2, Amy Caudy1,2. 1) Donnelly Centre, University of Toronto, Toronto, ON, Canada; 2) Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

63 - 2:45
The use of fluorescence cross-correlation spectroscopy to assay information about protein complexes in yeast. Brian Slaughter, Jay Unruh, Christine Smoyer, Sue Jasperson. Stowers Institute for Medical Research, Kansas City, MO.

Saturday, August 2   4:00 pm–5:30 pm
Meany Theater

Yeast and Human Disease

Chair: Jasper Rine

64 - 4:00
Quantifying the functional impact of all possible missense variants of BRCA1. Lea Starita1, Jacob Kitzman1, Justin Gullingsrud1, Jeffrey Parvin3, Jay Shendure1, Stanley Fields1,2. 1) Genome Sciences, University of Washington, Seattle, WA; 2) HHMI; 3) The Ohio State University, Columbus, OH.

65 - 4:15
Using DNA Repair Mutants for Cancer Drug Discovery and Identifying Chemoresistance Targets. Irene Ojini, Alison Gammie. Princeton University, Princeton, NJ.

66 - 4:30
Towards humanizing budding yeast. Aashiq H. Kachroo, Jon M. Laurent, Christopher Yellman, Edward M. Marcotte. Center for Systems and Synthetic Biology, The University of Texas at Austin, Austin, TX.

67 - 4:45
Organelle deterioration with age: The limits of an interconnected cellular system. Dan Gottschling. FHCRC - Seattle, WA.

68 - 5:00
Orphan Diseases: Identifying Genes and NovelTherapeutics to Enhance Treatment (IGNITE). Christopher McMaster. Dalhousie University, Halifax, NS, Canada.

69 - 5:15
Chromosome instability and synthetic cytotoxicity in yeast and cancer. Philip A. Hieter, Derek van Pel, Hunter Li, Noushin Moshgabadi, Melanie Bailey, Nigel O'Neil. Michael Smith Lab, Univ British Columbia, Vancouver, BC, Canada.